LOCUS       NP_055514               1832 aa            linear   PRI 28-APR-2025
DEFINITION  zinc finger protein 646 [Homo sapiens].
ACCESSION   NP_055514
VERSION     NP_055514.3
DBSOURCE    REFSEQ: accession NM_014699.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1832)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (residues 1 to 1832)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1832)
  AUTHORS   Pankratz,N., Beecham,G.W., DeStefano,A.L., Dawson,T.M.,
            Doheny,K.F., Factor,S.A., Hamza,T.H., Hung,A.Y., Hyman,B.T.,
            Ivinson,A.J., Krainc,D., Latourelle,J.C., Clark,L.N., Marder,K.,
            Martin,E.R., Mayeux,R., Ross,O.A., Scherzer,C.R., Simon,D.K.,
            Tanner,C., Vance,J.M., Wszolek,Z.K., Zabetian,C.P., Myers,R.H.,
            Payami,H., Scott,W.K. and Foroud,T.
  CONSRTM   PD GWAS Consortium
  TITLE     Meta-analysis of Parkinson's disease: identification of a novel
            locus, RIT2
  JOURNAL   Ann Neurol 71 (3), 370-384 (2012)
   PUBMED   22451204
REFERENCE   4  (residues 1 to 1832)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135050.3 and BC035589.1.
            
            On Dec 5, 2008 this sequence version replaced NP_055514.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035589.1, SRR7346977.2340866.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300850.5/ ENSP00000300850.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1832
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     Protein         1..1832
                     /product="zinc finger protein 646"
                     /calculated_mol_wt=200695
     Region          10..31
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(10,13,26,31)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Site            order(15,17,19,21..22,25..26,29,55,57,61..62,65..66,69,82,
                     84,86,88..89,92..93,96)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          26..47
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15015.2)"
     Region          50..70
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          75..97
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Region          77..97
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          94..200
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15015.2)"
     Region          241..261
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(241,244,257,261)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Site            order(246,248,250,252..253,256..257,260,273,275,279..280,
                     283..284,287,301,303,305,307..308,311..312,315)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          268..288
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          296..316
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          313..346
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15015.2)"
     Region          376..396
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(376,379,392,396)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Site            order(381,383,385,387..388,391..392,395,408,410,414..415,
                     418..419,422,472,474,476,478..479,482..483,486)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          403..423
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          467..487
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          494..514
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          577..597
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(577,580,593,597)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Site            order(582,584,586,588..589,592..593,596,624,626,630..631,
                     634..635,638,651,653,655,657..658,661..662)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Site            612
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O15015.2)"
     Region          619..639
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          646..663
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          660..810
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15015.2)"
     Region          823..843
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(823,826,839,843)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Site            order(828,830,832,834..835,838..839,842,855,857,861..862,
                     865..866,869,888,890,892,894..895,898..899)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          850..870
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          883..901
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          901..931
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15015.2)"
     Region          1054..1074
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1081..1101
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1103..1148
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15015.2)"
     Region          1205..1225
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(1205,1208,1221,1225)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Region          1232..1252
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(1232,1235,1248,1252)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Site            order(1237,1239,1241,1243..1244,1247..1248,1251,1265,1267,
                     1271..1272,1275..1276,1279,1306,1308,1310,1312..1313,
                     1316..1317,1320)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          1260..1280
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1274..1294
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15015.2)"
     Region          1301..1321
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1328..1348
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1366..1386
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1377..1481
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15015.2)"
     Region          1509..1529
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15015.2)"
     Region          1533..1552
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(1533,1536,1549,1552)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Site            order(1538,1540,1542,1544..1545,1548..1549,1551,1564,1566,
                     1570..1571,1574..1575,1578,1592,1594,1596,1602..1603,
                     1606..1607,1610)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          1559..1579
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1587..1611
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1606..1672
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15015.2)"
     Region          1679..1699
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(1679,1682,1695,1699)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Site            order(1684,1686,1688,1690..1691,1694..1695,1698,1711,1713,
                     1717..1718,1721..1722,1725,1739,1741,1743,1745..1746,
                     1749..1750,1753)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          1706..1726
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1734..1754
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1781..1832
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15015.2)"
     CDS             1..1832
                     /gene="ZNF646"
                     /coded_by="NM_014699.4:290..5788"
                     /db_xref="CCDS:CCDS10702.1"
                     /db_xref="GeneID:9726"
                     /db_xref="HGNC:HGNC:29004"
                     /db_xref="MIM:619299"
ORIGIN      
        1 medtppslsc sdcqrhfpsl pelsrhrell hpspnqdsee adsiprpyrc qqcgrgyrhp
       61 gslvnhrrth etglfpcttc gkdfsnpmal kshmrthape grrrhrpprp keatphlqge
      121 tvstdswgqr lgssegwenq tkhteetpdc esvpdpraas gtwedlptrq reglashpgp
      181 edgadgwgps tnsarapplp ipassllsnl eqylaesvvn ftggqeptqs ppaeeerryk
      241 csqcgktykh agsltnhrqs htlgiypcai cfkefsnlma lknhsrlhaq yrpyhcphcp
      301 rvfrlprell ehqqsheger qeprweekgm pttnghtdes sqdqlpsaqm lngsaelsts
      361 geledsglee yrpfrcgdcg rtyrhagsli nhrkshqtgv ypcslcskql fnaaalknhv
      421 rahhrprqgv gengqpsvpp aplllaetth keeedptttl dhrpykcsec grayrhrgsl
      481 vnhrhshrtg eyqcslcprk ypnlmalrnh vrvhckaarr sadigaegap shlkvelppd
      541 pveaeaapht dqdhvckhee eatditpaad ktaahicsic gllfedaesl erhglthgag
      601 ekensrtett mspprafacr dcgksyrhsg slinhrqthq tgdfscgaca khfhtmaamk
      661 nhlrrhsrrr srrhrkragg asggreakll aaeswtrele dneglespqd psgesphgae
      721 gnlesdgdcl qaesegdkcg lerdethfqg dkesggtgeg lerkdaslld nldipgeegg
      781 gthfcdsltg vdedqkpatg qpnssshsan avtgwqagaa htcsdcghsf phatgllshr
      841 pchppgiyqc slcpkefdsl palrshfqnh rpgeatsaqp flcclcgmif pgragyrlhr
      901 rqahsssgmt egseeegeee gvaeaapars pplqlseael lnqlqrevea ldsagyghic
      961 gccgqtyddl gslerhhqsq ssgttadkap splgvagdam emvvdsvled ivnsvsgegg
     1021 daksqegagt plgdslciqg geslleaqpr pfrcnqcgkt yrhggslvnh rkihqtgdfl
     1081 cpvcsrcypn laayrnhlrn hprckgsepq vgpipeaags selqvgpipe ggsnkpqhma
     1141 eegpgqaeve klqeelkvep leevarvkee vweettvkge eieprletae kgcqteasse
     1201 rpfscevcgr sykhagslin hrqshqtghf gcqacskgfs nlmslknhrr ihadprrfrc
     1261 secgkafrlr kqlashqrvh merrggggtr katredrpfr cgqcgrtyrh agsllnhrrs
     1321 hetgqyscpt cpktysnrma lkdhqrlhse nrrrragrsr rtavrcalcg rsfpgrgsle
     1381 rhlreheete repangqggl dgtaaseanl tgsqgletql ggaepvphle dgvprpgers
     1441 qspiraasse apeplswgag kaggwpvggg lgnhsggwvp qfltrseepe dsvhrspcha
     1501 gdcqlngptl shmdswdnrd nssqlqpgsh sscsqcgkty cqsgsllnhn tnktdrhycl
     1561 lcskeflnpv atkshshnhi daqtfacpdc gkafeshqel ashlqaharg hsqvpaqmee
     1621 ardpkagtge dqvvlpgqgk aqeapsetpr gpgesverar ggqavtsmaa edkerpfrct
     1681 qcgrsyrhag sllnhqkaht tglypcslcp kllpnllslk nhsrthtdpk rhccsicgka
     1741 frtaarlegh grvhapregp ftcphcprhf rrrisfvqhq qqhqeewtva gsgapvapvt
     1801 grgdlplppp ptpttplldp spqwpadlsf sl
//
