LOCUS       NM_201269               5541 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger protein 644 (ZNF644), transcript variant
            1, mRNA.
ACCESSION   NM_201269
VERSION     NM_201269.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5541)
  AUTHORS   Gong,J., Zhao,S., Luo,S., Yin,S., Li,X. and Feng,Y.
  TITLE     Downregulation of circ-ZNF644 alleviates LPS-induced HK2 cell
            injury via miR-335-5p/HIPK1 axis
  JOURNAL   Environ Toxicol 37 (12), 2855-2864 (2022)
   PUBMED   36052886
  REMARK    GeneRIF: Downregulation of circ-ZNF644 alleviates LPS-induced HK2
            cell injury via miR-335-5p/HIPK1 axis.
REFERENCE   2  (bases 1 to 5541)
  AUTHORS   Conway,E., Jerman,E., Healy,E., Ito,S., Holoch,D., Oliviero,G.,
            Deevy,O., Glancy,E., Fitzpatrick,D.J., Mucha,M., Watson,A.,
            Rice,A.M., Chammas,P., Huang,C., Pratt-Kelly,I., Koseki,Y.,
            Nakayama,M., Ishikura,T., Streubel,G., Wynne,K., Hokamp,K.,
            McLysaght,A., Ciferri,C., Di Croce,L., Cagney,G., Margueron,R.,
            Koseki,H. and Bracken,A.P.
  TITLE     A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL
            Genes Balance PRC2 Subtype Activities
  JOURNAL   Mol Cell 70 (3), 408-421 (2018)
   PUBMED   29628311
REFERENCE   3  (bases 1 to 5541)
  AUTHORS   Wang,H., Su,S., Yang,M., Hu,N., Yao,Y., Zhu,R., Zhou,J., Liang,C.
            and Guan,H.
  TITLE     Association of ZNF644, GRM6, and CTNND2 genes with high myopia in
            the Han Chinese population: Jiangsu Eye Study
  JOURNAL   Eye (Lond) 30 (7), 1017-1022 (2016)
   PUBMED   27034204
  REMARK    GeneRIF: Our data suggested that genetic variants in GRM6 are
            associated with high myopia. The mechanism of GRM6 in the
            development of high myopia need to be further investigated.
REFERENCE   4  (bases 1 to 5541)
  AUTHORS   Bian,C., Chen,Q. and Yu,X.
  TITLE     The zinc finger proteins ZNF644 and WIZ regulate the G9a/GLP
            complex for gene repression
  JOURNAL   Elife 4, e05606 (2015)
   PUBMED   25789554
  REMARK    GeneRIF: Data indicate zinc finger proteins ZNF644 and WIZ as two
            core subunits in the histone-lysine N-methyltransferase G9a/GLP
            complex, and interact with the transcription activation domain of
            G9a and GLP.
            Erratum:[Elife. 2015 Apr 22;4. doi: 10.7554/eLife.08168.. PMID:
            25900010]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5541)
  AUTHORS   Jiang,D., Li,J., Xiao,X., Li,S., Jia,X., Sun,W., Guo,X. and
            Zhang,Q.
  TITLE     Detection of mutations in LRPAP1, CTSH, LEPREL1, ZNF644, SLC39A5,
            and SCO2 in 298 families with early-onset high myopia by exome
            sequencing
  JOURNAL   Invest Ophthalmol Vis Sci 56 (1), 339-345 (2014)
   PUBMED   25525168
  REMARK    GeneRIF: mutation in LRPAP1 is associated with high myopia. Further
            studies are expected to evaluate the pathogenicity of the variants
            in CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5541)
  AUTHORS   Tran-Viet,K.N., St Germain,E., Soler,V., Powell,C., Lim,S.H.,
            Klemm,T., Saw,S.M. and Young,T.L.
  TITLE     Study of a US cohort supports the role of ZNF644 and high-grade
            myopia susceptibility
  JOURNAL   Mol Vis 18, 937-944 (2012)
   PUBMED   22539872
  REMARK    GeneRIF: Two novel variants in ZNF644 are associated with
            high-grade myopia in a US cohort.
REFERENCE   7  (bases 1 to 5541)
  AUTHORS   Shi,Y., Li,Y., Zhang,D., Zhang,H., Li,Y., Lu,F., Liu,X., He,F.,
            Gong,B., Cai,L., Li,R., Liao,S., Ma,S., Lin,H., Cheng,J., Zheng,H.,
            Shan,Y., Chen,B., Hu,J., Jin,X., Zhao,P., Chen,Y., Zhang,Y.,
            Lin,Y., Li,X., Fan,Y., Yang,H., Wang,J. and Yang,Z.
  TITLE     Exome sequencing identifies ZNF644 mutations in high myopia
  JOURNAL   PLoS Genet 7 (6), e1002084 (2011)
   PUBMED   21695231
  REMARK    GeneRIF: ZNF644 might be a causal gene for high myopia in a
            monogenic form.
REFERENCE   8  (bases 1 to 5541)
  AUTHORS   Zabaneh,D. and Balding,D.J.
  TITLE     A genome-wide association study of the metabolic syndrome in Indian
            Asian men
  JOURNAL   PLoS One 5 (8), e11961 (2010)
   PUBMED   20694148
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5541)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   10 (bases 1 to 5541)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC150177.1, BC132776.1 and
            BX477299.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_201269.2.
            
            Summary: The protein encoded by this gene is a zinc finger
            transcription factor that may play a role in eye development.
            Defects in this gene have been associated with high myopia. Three
            transcript variants encoding two different isoforms have been found
            for this gene. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150177.1, SRR1660809.163813.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337393.10/ ENSP00000337008.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1027              BC150177.1         179-1205
            1028-5223           BC132776.1         1063-5258
            5224-5541           BX477299.1         16-333              c
FEATURES             Location/Qualifiers
     source          1..5541
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.2"
     gene            1..5541
                     /gene="ZNF644"
                     /gene_synonym="BM-005; MYP21; NatF; ZEP-2"
                     /note="zinc finger protein 644"
                     /db_xref="GeneID:84146"
                     /db_xref="HGNC:HGNC:29222"
                     /db_xref="MIM:614159"
     exon            1..46
                     /gene="ZNF644"
                     /gene_synonym="BM-005; MYP21; NatF; ZEP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            47..107
                     /gene="ZNF644"
                     /gene_synonym="BM-005; MYP21; NatF; ZEP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..4047
                     /gene="ZNF644"
                     /gene_synonym="BM-005; MYP21; NatF; ZEP-2"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger motif enhancer binding protein 2"
                     /codon_start=1
                     /product="zinc finger protein 644 isoform 1"
                     /protein_id="NP_958357.1"
                     /db_xref="CCDS:CCDS731.1"
                     /db_xref="GeneID:84146"
                     /db_xref="HGNC:HGNC:29222"
                     /db_xref="MIM:614159"
                     /translation="MRSFLQQDVNKTKSRLNVLNGLANNMDDLKINTDITGAKEELLD
                     DNNFISDKESGVHKPKDCQTSFQKNNTLTLPEELSKDKSENALSGGQSSLFIHAGAPT
                     VSSENFILPKGAAVNGPVSHSSLTKTSNMNKGSVSLTTGQPVDQPTTESCSTLKVAAD
                     LQLSTPQKASQHQVLFLLSDVAHAKNPTHSNKKLPTSASVGCDIQNSVGSNIKSDGTL
                     INQVEVGEDGEDLLVKDDCVNTVTGISSGTDGFRSENDTNWDPQKEFIQFLMTNEETV
                     DKAPPHSKIGLEKKRKRKMDVSKITRYTEDCFSDSNCVPNKSKMQEVDFLEQNEELQA
                     VDSQKYALSKVKPESTDEDLESVDAFQHLIYNPDKCGEESSPVHTSTFLSNTLKKKCE
                     ESDSESPATFSTEEPSFYPCTKCNVNFREKKHLHRHMMYHLDGNSHFRHLNVPRPYAC
                     RECGRTFRDRNSLLKHMIIHQERRQKLMEEIRELKELQDEGRSARLQCPQCVFGTNCP
                     KTFVQHAKTHEKDKRYYCCEECNFMAVTENELECHRGIAHGAVVKCPMVTSDIAQRKT
                     QKKTFMKDSVVGSSKKSATYICKMCPFTTSAKSVLKKHTEYLHSSSCVDSFGSPLGLD
                     KRKNDILEEPVDSDSTKTLTKQQSTTFPKNSALKQDVKRTFGSTSQSSSFSKIHKRPH
                     RIQKARKSIAQSGVNMCNQNSSPHKNVTIKSSVDQKPKYFHQAAKEKSNAKANSHYLY
                     RHKYENYRMIKKSGESYPVHFKKEEASSLNSLHLFSSSSNSHNNFISDPHKPDAKRPE
                     SFKDHRRVAVKRVIKESKKESSVGGEDLDSYPDFLHKMTVVVLQKLNSAEKKDSYETE
                     DESSWDNVELGDYTTQAIEDETYSDINQEHVNLFPLFKSKVEGQEPGENATLSYDQND
                     GFYFEYYEDTGSNNFLHEIHDPQHLETADASLSKHSSVFHWTDLSLEKKSCPYCPATF
                     ETGVGLSNHVRGHLHRAGLSYEARHVVSPEQIATSDKMQHFKRTGTGTPVKRVRKAIE
                     KSETTSEHTCQLCGGWFDTKIGLSNHVRGHLKRLGKTKWDAHKSPICVLNEMMQNEEK
                     YEKILKALNSRRIIPRPFVAQKLASSDDFISQNVIPLEAYRNGLKTEALSVSASEEEG
                     LNFLNEYDETKPELPSGKKNQSLTLIELLKNKRMGEERNSAISPQKIHNQTARKRFVQ
                     KCVLPLNEDSPLMYQPQKMDLTMHSALDCKQKKSRSRSGSKKKMLTLPHGADEVYILR
                     CRFCGLVFRGPLSVQEDWIKHLQRHIVNANLPRTGAGMVEVTSLLKKPASITETSFSL
                     LMAEAAS"
     exon            108..3145
                     /gene="ZNF644"
                     /gene_synonym="BM-005; MYP21; NatF; ZEP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3146..3751
                     /gene="ZNF644"
                     /gene_synonym="BM-005; MYP21; NatF; ZEP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3752..3854
                     /gene="ZNF644"
                     /gene_synonym="BM-005; MYP21; NatF; ZEP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3855..5541
                     /gene="ZNF644"
                     /gene_synonym="BM-005; MYP21; NatF; ZEP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5182..5187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF644"
                     /gene_synonym="BM-005; MYP21; NatF; ZEP-2"
                     /note="hexamer: AATAAA"
     polyA_site      5208
                     /gene="ZNF644"
                     /gene_synonym="BM-005; MYP21; NatF; ZEP-2"
                     /note="major polyA site"
     regulatory      5519..5524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF644"
                     /gene_synonym="BM-005; MYP21; NatF; ZEP-2"
                     /note="hexamer: AATAAA"
     polyA_site      5541
                     /gene="ZNF644"
                     /gene_synonym="BM-005; MYP21; NatF; ZEP-2"
ORIGIN      
        1 gcgtgctccc aacgtcgccc cggtttgacg cacacggcac caaactgttt gatttaattt
       61 tggatgagat cgttcttgca gcaagatgtt aataagacaa aatctagact aaatgtgtta
      121 aatgggcttg ccaacaatat ggatgatttg aagataaaca ccgatattac tggtgctaaa
      181 gaagaactcc tagatgacaa caattttatc tcagacaaag agagcggagt tcataagcca
      241 aaagattgtc aaacatcatt tcagaaaaat aatacgttga ctctgcctga agaactgtca
      301 aaggacaaat ctgaaaacgc cttaagtgga ggccagtcta gtctatttat acatgctggt
      361 gctcctactg tttctagtga aaactttatc ttgcctaaag gagctgctgt taatggacca
      421 gtttcacact cctccttaac taagacttcc aatatgaata aaggcagtgt ttcattaacc
      481 actggacagc ctgtggatca gccaacaaca gaatcttgtt caactttgaa ggtagcagct
      541 gatcttcagc tgtctacacc acagaaagca agtcaacacc aagttttatt tttgttatca
      601 gatgtagcac atgctaagaa tcccacccat tccaataaaa aactacctac ctctgcttca
      661 gttggttgtg acattcagaa ttcagtaggg agtaatataa agtcagatgg cactttaata
      721 aatcaagtag aggtgggtga ggatggtgaa gatttattgg tgaaagatga ttgtgtcaat
      781 acagtaacgg gaatttcctc aggtacagat ggatttaggt cagaaaatga tacaaactgg
      841 gatccccaaa aagagttcat tcaatttctt atgactaatg aggaaacagt agataaagct
      901 ccacctcatt ctaaaatagg tctagaaaaa aaaagaaagc gaaaaatgga tgtaagcaag
      961 ataactcgtt ataccgagga ttgctttagt gattctaatt gtgtacccaa taaatcaaaa
     1021 atgcaagaag tagactttct agaacaaaat gaagagctac aagcagtaga ctcacagaaa
     1081 tatgcattat caaaagtgaa gcctgaatca actgatgaag acttagaatc tgtggatgcc
     1141 ttccaacatc taatttataa cccagataag tgtggagaag agagttcacc tgttcatact
     1201 agcacttttc tttcaaatac cttaaaaaag aaatgtgaag agagtgattc tgagtcacct
     1261 gctactttca gtaccgaaga gccatcattc tacccctgta caaagtgcaa tgtgaatttt
     1321 agggagaaga agcacctcca caggcatatg atgtatcatt tagatgggaa tagtcacttt
     1381 cgccatctta atgtcccaag gccatatgct tgtagagaat gtggacggac atttcgagat
     1441 cgcaattcac ttctaaaaca tatgattatt caccaggaga gaagacagaa gttgatggag
     1501 gaaattcgtg aattgaaaga acttcaggat gaaggaagaa gtgcacgatt acagtgtcct
     1561 cagtgtgtgt ttggtaccaa ttgccctaaa acatttgtgc aacatgctaa aacccatgaa
     1621 aaagataaaa ggtactactg ctgtgaagag tgtaacttca tggcagtgac agaaaatgaa
     1681 ttggaatgcc atcgaggcat tgcacatggg gcagtggtaa aatgccctat ggtcacttct
     1741 gatattgccc agagaaaaac acaaaaaaag actttcatga aagactctgt agtaggatca
     1801 tccaaaaaat cagctaccta catatgtaag atgtgtcctt ttactacttc agccaaaagt
     1861 gttttaaaaa agcacacgga gtacttgcat tcatcatcat gtgttgattc atttggtagt
     1921 cctcttggac ttgataaaag aaaaaatgac atccttgaag aacctgtaga tagtgatagc
     1981 actaaaacat taactaaaca acagtcaacc acatttccaa agaactctgc tttaaaacaa
     2041 gatgtgaagc gaacatttgg atcaacctca caatcaagta gtttttcaaa aattcataag
     2101 cggccacaca gaatacagaa agctcggaaa agcattgccc aatcaggtgt aaacatgtgc
     2161 aatcaaaaca gctctcctca taagaatgtt acaattaaaa gcagcgttga ccaaaaacct
     2221 aagtatttcc atcaagcagc aaaagaaaag tctaatgcca aggcaaatag ccactatttg
     2281 tatagacaca aatatgaaaa ctataggatg atcaaaaaat caggtgaatc atatcctgtg
     2341 catttcaaaa aagaagaagc tagttcatta aattctttac acctgttttc atcatcaagt
     2401 aattctcaca acaattttat ttcagaccct cataagcctg acgccaaaag gcctgaaagc
     2461 ttcaaagatc acagacgtgt agctgtaaag agagtaatta aggaatctaa gaaggaaagt
     2521 tctgttggag gggaagactt ggatagctat ccagattttt tgcataaaat gactgttgtc
     2581 gttttgcaaa aacttaattc tgctgaaaag aaagatagtt atgaaacaga agatgaaagt
     2641 tcctgggata atgttgagtt aggagactac actacacagg ccatagaaga tgaaacctat
     2701 agtgatatta atcaagagca tgtaaattta ttccctttat ttaagagcaa agtggaaggt
     2761 caggagcctg gagaaaatgc tactcttagt tatgaccaaa acgatggctt ttattttgaa
     2821 tactatgaag atactggaag taacaacttt ttgcatgaga tacatgatcc tcagcattta
     2881 gaaactgcag atgcttcatt gtcaaagcat agttctgttt ttcattggac tgatttgtct
     2941 cttgagaaga aatcgtgtcc ttactgccca gcaacatttg aaacaggtgt tgggttatca
     3001 aatcatgtca gggggcatct tcacagagca ggattaagct atgaagcccg tcatgttgta
     3061 tcaccagaac aaatagccac aagtgacaaa atgcagcatt tcaaaagaac tggcacagga
     3121 acacctgtta aacgagttag aaaagctata gagaagtctg aaaccacttc tgaacacact
     3181 tgtcagctct gtggtggttg gtttgatact aaaattggat tatcaaatca tgttagaggc
     3241 cacttgaaaa gacttggaaa gacgaaatgg gatgctcaca aatctccaat ctgtgttctg
     3301 aatgagatga tgcaaaatga agaaaaatat gaaaaaatct taaaggcatt gaacagtcgt
     3361 cgtattattc ccagaccatt tgtagctcaa aaacttgcat caagtgatga ctttatatct
     3421 caaaatgtta tacctcttga agcataccgt aatggcctaa agactgaagc tctgtcagtg
     3481 tctgcatcag aagaagaagg gctgaatttc ttaaatgaat atgatgaaac aaaaccagaa
     3541 ctgcccagtg ggaaaaagaa tcagtctctt acactcatag aacttcttaa aaataaaagg
     3601 atgggagaag aaaggaattc tgctatttct cctcaaaaga tccataatca gacagcaaga
     3661 aagagattcg ttcagaaatg cgttcttcca ttaaatgagg atagtccgtt gatgtatcag
     3721 ccacaaaaaa tggacttgac tatgcactca gccttagatt gtaagcaaaa gaaatcaagg
     3781 tcaagatctg gaagcaagaa gaaaatgcta acattacctc atggtgctga cgaggtttac
     3841 attctccgat gcaggttttg tggcctagtc tttcgaggac ccttgtctgt tcaggaagac
     3901 tggattaagc acttacaacg acatattgta aacgctaatc ttccacggac tggagctggc
     3961 atggtggaag tcacgtcact acttaaaaag cctgcctcca ttacagaaac ttcattttct
     4021 ctactaatgg ccgaagcagc ttcatagaac caggaaacct tttaaatagc cagtttgaat
     4081 tggatgtaaa tttgaaattc ttttttttta agccacatta aattatctgt ttataaatac
     4141 taaagcagga aaatgggggg aaagtgaatt acagtgacat cagagcaaat tgaatactta
     4201 aaacagtaag tagtctatat attttatata gggtggaaga tgtgttttta aggtttatga
     4261 agttttgttg gttaactgtg ttcactcagt aaaagagcag tacatgtaag cagccattaa
     4321 taaactgttg cacatggata cttatagaca gacttattgg acaattatgt tttttgcagt
     4381 gttaccagaa tcaaggctct gtttattccc cacaagactt gcatagaaaa ataagatatt
     4441 atattttgtt tgtatgtatt tagtgttttg tataatacca agaaccgctg actaaattta
     4501 ctcaaattag ggcattaaat atcatgtact tcatagtttg agactgttca ctcaaatagg
     4561 gcagagtact attctatcta gatgtgtaag tgtttttttt aaaatcacat ggaacggttt
     4621 tttttatact aaaaagtgga gggagatttg tttaaacaag tatttctaaa agaaatatgt
     4681 acatagttct ggaaattatt tgtggtaagg aaatattctt tactccagtt gcatttctca
     4741 gacaataaag tggtgcatcc atgctacctc ctactttgtc aacaaagatg ctatttaccc
     4801 tttacatttt tgtatcataa tagattttaa aaatctaatg ttctttattg caagacattc
     4861 ttttgttaac aggtttgttt ctttttaatg ttttacctaa aatttgacat gcttacagga
     4921 caggtttgcc tcttacttta tttaacattg tagaaatgta attaataaac aatgctcact
     4981 acacagttta gaatagacgt tctcatttat attatcttcc aaatttgatc agttagcaaa
     5041 acttaataca ccaattaaaa tatttctaca tatgagaatg tttacaattt aaattttaga
     5101 acttgttttg gatgtgatta tatgtacgaa aatcgtgtaa cactatgctc atgctaagaa
     5161 ccgacataac agaattactg aaataaatgt gctgtgagga atggaaaata tggtgcaggt
     5221 gtcttggtca tgataaattg tgattctttt taaaaatttt ttccaaaaac aattaggtat
     5281 tttaatctga aatcagattc ctttacaaac aacaagtttt tgtatgcaag caccatttta
     5341 tttcatgtag tatggctaat actatagttg aaccaaggat atgcattgat tctttgcttc
     5401 gtatgtaaat aaagttaaaa acagttaaaa taaggagtat tttggtagag tatatacata
     5461 cctcactgcc agtgaaattg ctttcctatg gtatatctcc ttaccagaaa aatctctaaa
     5521 taaaaaaagg tttaaagaaa a
//
