LOCUS       NM_001172681            7227 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 641 (ZNF641), transcript variant
            2, mRNA.
ACCESSION   NM_001172681
VERSION     NM_001172681.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7227)
  AUTHORS   Yan,H., He,N. and He,S.
  TITLE     HCG15 is a hypoxia-responsive lncRNA and facilitates hepatocellular
            carcinoma cell proliferation and invasion by enhancing ZNF641
            transcription
  JOURNAL   Biochem Biophys Res Commun 608, 170-176 (2022)
   PUBMED   35427894
  REMARK    GeneRIF: HCG15 is a hypoxia-responsive lncRNA and facilitates
            hepatocellular carcinoma cell proliferation and invasion by
            enhancing ZNF641 transcription.
REFERENCE   2  (bases 1 to 7227)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 7227)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 7227)
  AUTHORS   Qi,X., Li,Y., Xiao,J., Yuan,W., Yan,Y., Wang,Y., Liang,S., Zhu,C.,
            Chen,Y., Liu,M. and Wu,X.
  TITLE     Activation of transcriptional activities of AP-1 and SRE by a new
            zinc-finger protein ZNF641
  JOURNAL   Biochem Biophys Res Commun 339 (4), 1155-1164 (2006)
   PUBMED   16343441
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC024257.25, BC018090.1 and AY842285.1.
            
            On Sep 12, 2018 this sequence version replaced NM_001172681.1.
            
            Transcript Variant: This variant (2) lacks an alternate exon and
            uses a downstream start codon, compared to variant 1. The resulting
            isoform (2) has a shorter N-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.268458.1,
                                           SRR1803613.62843.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267762 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000547026.6/ ENSP00000449974.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC024257.25        155642-155684       c
            44-192              BC018090.1         16-164
            193-193             AY842285.1         792-792
            194-807             BC018090.1         166-779
            808-7227            AC024257.25        141945-148364       c
FEATURES             Location/Qualifiers
     source          1..7227
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.11"
     gene            1..7227
                     /gene="ZNF641"
                     /note="zinc finger protein 641"
                     /db_xref="GeneID:121274"
                     /db_xref="HGNC:HGNC:31834"
                     /db_xref="MIM:613906"
     exon            1..134
                     /gene="ZNF641"
                     /inference="alignment:Splign:2.1.0"
     exon            135..343
                     /gene="ZNF641"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1434
                     /gene="ZNF641"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 641 isoform 2"
                     /protein_id="NP_001166152.1"
                     /db_xref="CCDS:CCDS53788.1"
                     /db_xref="GeneID:121274"
                     /db_xref="HGNC:HGNC:31834"
                     /db_xref="MIM:613906"
                     /translation="MLSEQTAALGTGWESMNVQLDGAEPQVERGSQEERPWRTVPGPL
                     EHLCCDLEEEPQSLQEKAQSAPWVPAIPQEGNTGDWEMAAALLAAGSQGLVTIKDVSL
                     CFSQEEWRSLDPSQTDFYGEYVMQENCGIVVSLRFPIPKLDMLSQLEGGEEQWVPDPQ
                     DLEERDILRVTYTGDGSEHEGDTPELEAEPPRMLSSVSEDTVLWNPEHDESWDSMPSS
                     SRGMLLGPPFLQEDSFSNLLCSTEMDSLLRPHTCPQCGKQFVWGSHLARHQQTHTGER
                     PYSCLKCEKTFGRRHHLIRHQKTHLHDKTSRCSECGKNFRCNSHLASHQRVHAEGKSC
                     KGQEVGESPGTRKRQRAPPVPKCHVCTECGKSFGRRHHLVRHWLTHTGEKPFQCPRCE
                     KSFGRKHHLDRHLLTHQGQSPRNSWDRGTSVF"
     exon            344..435
                     /gene="ZNF641"
                     /inference="alignment:Splign:2.1.0"
     exon            436..565
                     /gene="ZNF641"
                     /inference="alignment:Splign:2.1.0"
     exon            566..679
                     /gene="ZNF641"
                     /inference="alignment:Splign:2.1.0"
     exon            680..7227
                     /gene="ZNF641"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4258..4263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF641"
                     /note="hexamer: AATAAA"
     regulatory      4263..4268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF641"
                     /note="hexamer: AACAAG"
     polyA_site      4280
                     /gene="ZNF641"
                     /note="major polyA site"
     polyA_site      4290
                     /gene="ZNF641"
     regulatory      7203..7208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF641"
                     /note="hexamer: AATAAA"
     polyA_site      7227
                     /gene="ZNF641"
                     /note="major polyA site"
ORIGIN      
        1 gcctgccggg ccgccgtctc cgcctgtcgc tggctccgcc ggccgccggc tcccagacgc
       61 aagcggaggg cggaggggag gggcaggcgg cgcccgggag ggaggcaccg ggccgcgggc
      121 caagcctacc gggggtcaca atttgggtct gcagcagaaa tgctttcaga acagacagca
      181 gcgctgggga caggatggga atcaatgaat gtacagctgg atggagcaga gccccaggtg
      241 gaaaggggaa gccaggaaga gcggccatgg agaacagtac caggacctct ggagcacctg
      301 tgctgtgacc ttgaagagga gccacagtcc cttcaggaga aggctcagtc tgctccctgg
      361 gttcctgcaa ttccccagga ggggaacact ggagactggg agatggcagc tgcacttctt
      421 gcggctggat cacagggcct ggtaaccatc aaggatgtgt cactgtgctt ctctcaggag
      481 gagtggcgga gcctggaccc ctctcagaca gacttttatg gagaatatgt catgcaggaa
      541 aactgtggga tagtagtctc tctgagattt ccaattccca aactggacat gctttctcaa
      601 ctagaaggag gagaagaaca atgggtccct gacccccagg acttagagga gagggacatt
      661 ctgagggtca catatacagg agatggaagt gaacatgagg gggatacccc tgaactagaa
      721 gcagaacctc ccagaatgtt atccagcgtg tctgaagata ctgttctctg gaacccggag
      781 catgatgaga gctgggattc catgcccagc agctccagag gaatgctcct ggggccccct
      841 tttcttcagg aagatagttt ctcaaacctg ctgtgtagca cagagatgga ttccctgtta
      901 agaccccaca catgccccca gtgtgggaaa cagtttgtat ggggttccca ccttgccagg
      961 catcaacaaa cacacactgg ggagagaccc tacagctgcc tcaagtgtga gaagaccttt
     1021 gggcgaagac atcacctcat caggcaccag aaaacccacc tacatgacaa gaccagcagg
     1081 tgctctgagt gtggtaagaa tttccgatgc aactcccatc tggccagcca ccagagagtg
     1141 catgcagaag gcaaatcctg caaaggccaa gaggttggag agagccctgg cacaaggaaa
     1201 cggcagcgtg ccccaccagt gccaaagtgt cacgtgtgca ctgaatgtgg gaagagcttt
     1261 ggccgaaggc accaccttgt gagacactgg ctgacccaca ctggggagaa gcccttccag
     1321 tgccctcgct gtgagaagag ctttggccga aaacatcacc tggacaggca cctgctcacc
     1381 caccagggac aaagtccccg gaacagctgg gacagaggaa catctgtctt ttgaaatctg
     1441 tttccactac agctatggtc aagtctatca gccggtgcta ccaggagtca ctgccagggc
     1501 tgccgttctc ctgaacccca gtggccagaa tcataagccc tgaccccatc cctagaaaga
     1561 tgaggtccca gcaatggcca gagcatttct caccagttct gtgagatagc acataaaaat
     1621 agagttcttt gggcaaaact tttgggaagc aatgcatcct acatgggctg atattcagcc
     1681 tgagctgttc tcaagaggag agtggtactg gcagtttatg gctgaaatcc attctgattg
     1741 gttggagtct atgctatacc agttgttaaa cattttgagt atcactcttg catactgtta
     1801 ctattatatt ttctctatat atagacagaa aggccatttt agaatattaa aggctctgaa
     1861 aatttctgca gtagacccaa ctgaaggttc tattaaggca gtgtttccta aatgtatttg
     1921 acctcagtat cctttctatt tacatcccac agaactggtg actatgaaac actctggtga
     1981 acactgggtt agagagtaac aaggaaacaa gagatagtga tcaggcatcc agagccccct
     2041 tttttatcca tatgaaagcc aggggggcca gaccttgttc atgtgtgggt ctgtcttcct
     2101 tatgccaatc agcagtatat acatcacctc tcaccctcac ctgctgaaaa aataaccttt
     2161 ttacccatta ttcctactcc cttcatcctg cacatacata tatccagctg agagatcaca
     2221 ctacaaggct aagagatgat ctaatacccc caaatagccc tggcccacac agaaaaacag
     2281 aaaaacaaaa aaaactttat ccccttgaac agtcccctct ctcctcttga ctgtctttat
     2341 gtgtctgtgt atttgtgtgc agggtctttg aagacagcat gctatgtgca aactgtacaa
     2401 gctaggtttt ctaggggctg tgttctgggg atgagggtag tggggattat atggggtttt
     2461 ttctttgttt caagacagga agcagtctgg ttaagggaga actagtggaa agggttaaat
     2521 gacaggttaa gttgagtaca aagctttccc agtactgctg agattaagac aattgtggat
     2581 gtgtatgtct aggtttgaat ctctgggctg cagattgctt ttgccctggc agagaaagag
     2641 gagtctttgg ggaggtgagc tgtttcttgt tgatttcagg caagaggcac atagaaactt
     2701 tgtattgagt ggggattttg ttttaagtgc tggaaaatta gggcaggaat tacgtgtttg
     2761 caagttgttg ccatcactgg tttgaatttg actgcctcat caaggggcaa gagttattct
     2821 tgaagatctc attctcccag aaacagaact ttagggaaaa tggctgtggc ttagcttttc
     2881 agctgctgca gggtaataag ctttctggtt ggttttcctt ccaattctgg aaaggtgtcc
     2941 acactaagac ccttaactct agggcttgca taagtattct agcatcgtta gctaatgagt
     3001 tggtcattgt ttctctttat caataattgt gttaatacca atcttataat ttaaaaatta
     3061 tcttgtatgt aagagcagtt cggggttagg gaggaagagg agcaaagtgg gatattttct
     3121 ctttaatgct tagatactgt ttcttcccta agatgtgttt ctcaaccaca attggtggaa
     3181 tgaaccagag aggcaagagg aagtgaattg caccaattta gtttagcgac tgtgcctttt
     3241 gcaggaaaaa ctgggtgaat cacagctcct cagagtcctg gactcaacta gaattgaaga
     3301 tagacttatt ttgctgactg ggcttcttag agtttatgtg acttgaacag cttggcccct
     3361 gcctcccttc tgctactgtg agcagccttc cttcttcctt cattcttcct ggaatgcagt
     3421 tctcttgctt atgatcctat gaataaggca aaatggctgg tctttgtaag gcaggtcttg
     3481 ccctagcttc tcagaaacag gagcatttta ggatcagtat taggagatgc cccagggagt
     3541 aagaaagtat tgggttcagt gataaatctg gactctgaca tttcttttac tctccctctt
     3601 taatactaaa agctctgcat aagcaatggt tcagaacctg tcttgggtac agacctgttg
     3661 aatctgacag aaaccagaaa cgcacttttg agaaaaagac atttgtaatt cactcagttt
     3721 tccatacaca tttagcaggt tcaaagccca tctgtggaat ccctaaactg ccttcaaaga
     3781 aagggagttc cccgatctaa aatggtcatt atatatttgt gtcaagaatt agaaggcaag
     3841 ggtcactaaa tattttaagg attaaggtac cagaggcatc agtggtataa ggatggagtc
     3901 tggtctttaa ttacgacaag ggtattgctt acattctact ctctggtttt caaaaagatc
     3961 tgacatgctg acaaatccag ctcctcacaa atcttgtttg aaggacttgt gggaagtgat
     4021 attccttact attagatcac gccccttata actacatgtt aacatccagc cttttatctg
     4081 tttgagtaat tgtagggata gaaagtgaag cccccagagt taggtgcaag tatagcaccc
     4141 agctgaaagg catcatggag tctaagggcc ttctacagaa ggggcaatcc tttgggttat
     4201 ttctggtgta ccactgtctt ctctacctcg gtccaacacc acctctcttg gacaaaaaat
     4261 aaaacaagca acagccatca gatgagtgaa tagatttgaa tgatttttcc cacagggaat
     4321 cagcctcaaa tgttcatgtt tcaccccgtc ccctttaaat aaaaagaatc tctgtgttct
     4381 ctttgggcaa aatgtaaaac agggatatca tcttcaggaa cctgtcacat ttttccatct
     4441 ggtacctcca ccctattctg agtatcctcc cctttccacc ccaacatagt atctttcaaa
     4501 gaatcccttg cataggagac tgtaaccgaa agtgttagct tttcaccagg ctatttacac
     4561 tttacgcctt agttctaatt gtggaaggaa aaacttttcc cttgtcaaag taatgttatg
     4621 gcttcagaga accaaagagg tgataatttg ggacaaaatt cctccctttc caacattcct
     4681 gcaatcaaat cactgtttcc tatttccatc aagggcaggt cctgactcag acctacaaag
     4741 gccagaaggc cagttctttc catctctgaa ttaggatgca tgcactgaat gggagtgggt
     4801 ggggctgggc aatatcagaa aagtgaaatc cattccttta gatccttaga gagcctgagc
     4861 tagcaaaatt ttcctctttt cccttgtgag ccataccaaa ctgtggctct caaaatttgg
     4921 tctttgggcc agcagcataa atatcacctg gaaacttgtt tgaaatgcaa attcttagcc
     4981 cccgccccag gagaactact gaatcagaaa ctcgggaagg agctcaacgt tcagtctttt
     5041 aactaaatgc cctcctggat gtgtgataca agctaaagtt tgagaaccac tggctagggg
     5101 attcatattt caagcagtgg tacctcaccc ttttcggatg gatcttcaca ctcctgttgt
     5161 caggtttatt ctctgtagcc tcactaggct agacctcagt tccattcccc ttagttgcaa
     5221 ggtcttcttc cactcttaac tcagtaaaag aactggggct agtcaccaat atcagaaact
     5281 atggtggggc aactaccaag ctcctgtgat tcattggggc tggggcttcc aatatgggca
     5341 ctgaggatac ttgggtccag aaatctgaaa ggacagaaag gaataaacaa ctcaaaggtg
     5401 gaaaatccaa tgtaaaactg aaaaactgac atccgaggaa atgattctcc tttgccttgt
     5461 ccttttcact ggctcttcta ataagaggca ggtggagtgg gcatctagca caaaggtaga
     5521 gtaaggccta ccatgccaag cccttaagaa cccaagtttt ccaacataaa aattggatta
     5581 gagaccaacg aggggccatg gaagggattt ctaaccatga tttggcatac cctatgggca
     5641 agggcagcag gaacatcaga gtccccaggg cataagagag aactaggttt ttctagtaag
     5701 atttgacaca agcaagattt aaatccagac tctgcttact aggtagaggt tgtaaccaat
     5761 gaagccatgg tgcccaaaat gcattctgct gcttagaaga ttctgacaga ttcaggctgt
     5821 ggggaggaat ctgccttgca gtctctgacc ctgctacctc ctccagttcc tctcccaggc
     5881 gcacctatga ggacagactg aactgacagt tataaatctg cccacaggtc ttctccaagg
     5941 tcaaaagatt agaccccaag gctgagactt tcttcaactc caggcctcat gctgtctccc
     6001 tctttcctgc caccacctcc tttttcccaa caggcagcat tcttcctcta caatttgttc
     6061 atactctttt tcagattttt ttgtttgttt gagttttgct ttgttctgac tgagcaataa
     6121 catgcccttc caagggcatt tgttctctcc aacccccatt ccttcttcca ttctagttta
     6181 tctcttcaag cttctggcca attctattcc atcatgagtc cacttactac ctattcctct
     6241 gcctactgtc cagtttcttt tctatcagct ttaagcctac taagcagggg tcaattcata
     6301 cttaccactc tcatcctcca aattcttggc ttggctatag cagttcatca gccacctcac
     6361 cactctgccc ctttctcata cacactccca caggacacca ccactactcc accccctgcc
     6421 tagtactgcc aaatctggcc cctctactcc attccctaga ggttcttctt ccaatcaggt
     6481 aacttccaaa gttgttttcc acttttcacc atttttaatt tacttccttc cagtctcctg
     6541 tgactcctga gaatcaaact ctctcttttt ttttttttga gatggagtct tgctctgtca
     6601 cccaggctgg agtgcagtga cgcgatctcg gctcactgca agctccgcct cccaggttta
     6661 cgccattttc ttgcctcagc ctcccgagta gctgggacta caagcgccca ccaccacgcc
     6721 tatttttttt tttttttttg tatttttttt agtagagacg gggtttcacg gtgttagcca
     6781 ggatggtctc aatctcttga cctcgtgatc cacccacctt ggcctcccaa agtgctggga
     6841 ttacaggcct gagccaccgc gcccagccca aactctcaat tctacaagca attttttgtg
     6901 tccttattat gtgccaggca ctggcaattt caggcctggg agatcaaatg tgacccttgc
     6961 tcctgctctc agtgtgttct tcagccaagc cctcccccac caccactttc ctgccttgtc
     7021 tcttgccacc aggcacctgg gcatcctctt ccaggaaact ttggggatga atgcccactt
     7081 gccatgcagc ccaactgctc cgtgcctatc agatttctag ctattatctg aattggttcc
     7141 ttctgatgaa ctgtgaactt ccttgggtta cccaacaggg gacttatggt ccctgtcagt
     7201 tgaataaaag atgtattggc tgtgtca
//
