LOCUS       NM_001303426            5962 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 639 (ZNF639), transcript variant
            3, mRNA.
ACCESSION   NM_001303426
VERSION     NM_001303426.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5962)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5962)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 5962)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5962)
  AUTHORS   Bruce,J.W., Reddington,R., Mathieu,E., Bracken,M., Young,J.A. and
            Ahlquist,P.
  TITLE     ZASC1 stimulates HIV-1 transcription elongation by recruiting
            P-TEFb and TAT to the LTR promoter
  JOURNAL   PLoS Pathog 9 (10), e1003712 (2013)
   PUBMED   24204263
  REMARK    GeneRIF: ZASC1 as novel regulator of HIV-1 gene expression that
            functions through the DNA-dependent, RNA-independent recruitment of
            TAT/P-TEFb to the HIV-1 promoter.
REFERENCE   5  (bases 1 to 5962)
  AUTHORS   Chiang,W.F., Hung,P.S., Liu,S.Y., Yuan,T.C., Chang,K.W., Chen,Y.P.,
            Liu,Y.C. and Lin,S.C.
  TITLE     Increase of ZASC1 gene copy number in recurrent oral carcinoma
  JOURNAL   Oral Dis 17 (1), 53-59 (2011)
   PUBMED   20646234
  REMARK    GeneRIF: ZASC1 copy number that increased from primary to recurrent
            tumor suggested the importance of ZASC1 in tumor progression. The
            increase of ZASC1 gene copy number in recurrent tumors was
            associated with the consumption of betel quid in patients.
REFERENCE   6  (bases 1 to 5962)
  AUTHORS   Bruce,J.W., Hierl,M., Young,J.A. and Ahlquist,P.
  TITLE     Cellular transcription factor ZASC1 regulates murine leukemia virus
            transcription
  JOURNAL   J Virol 84 (15), 7473-7483 (2010)
   PUBMED   20484494
REFERENCE   7  (bases 1 to 5962)
  AUTHORS   Bogaerts,S., Vanlandschoot,A., van Hengel,J. and van Roy,F.
  TITLE     Nuclear translocation of alphaN-catenin by the novel zinc finger
            transcriptional repressor ZASC1
  JOURNAL   Exp Cell Res 311 (1), 1-13 (2005)
   PUBMED   16182284
REFERENCE   8  (bases 1 to 5962)
  AUTHORS   Imoto,I., Yuki,Y., Sonoda,I., Ito,T., Shimada,Y., Imamura,M. and
            Inazawa,J.
  TITLE     Identification of ZASC1 encoding a Kruppel-like zinc finger protein
            as a novel target for 3q26 amplification in esophageal squamous
            cell carcinomas
  JOURNAL   Cancer Res 63 (18), 5691-5696 (2003)
   PUBMED   14522885
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB457196.1, BC026181.1,
            AB097862.1, BP260931.1 and AC007823.38.
            
            On Nov 22, 2018 this sequence version replaced NM_001303426.1.
            
            Summary: This gene encodes a member of the Kruppel-like zinc finger
            family of proteins. Amplification and overexpression of this gene
            have been observed in esophageal squamous cell carcinoma. The
            encoded protein has been shown to bind DNA in a sequence-specific
            manner and may regulate HIV-1 gene expression. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Dec
            2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026181.1, ERR279857.594.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000496856.6/ ENSP00000417740.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               DB457196.1         41-196
            157-855             BC026181.1         162-860
            856-856             AB097862.1         958-958
            857-1993            BC026181.1         862-1998
            1994-2552           AB097862.1         2096-2654
            2553-2553           BP260931.1         144-144
            2554-2914           AB097862.1         2656-3016
            2915-5962           AC007823.38        87804-90851
FEATURES             Location/Qualifiers
     source          1..5962
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.33"
     gene            1..5962
                     /gene="ZNF639"
                     /gene_synonym="ANC-2H01; ANC_2H01; ZASC1"
                     /note="zinc finger protein 639"
                     /db_xref="GeneID:51193"
                     /db_xref="HGNC:HGNC:30950"
                     /db_xref="MIM:619214"
     exon            1..261
                     /gene="ZNF639"
                     /gene_synonym="ANC-2H01; ANC_2H01; ZASC1"
                     /inference="alignment:Splign:2.1.0"
     exon            262..332
                     /gene="ZNF639"
                     /gene_synonym="ANC-2H01; ANC_2H01; ZASC1"
                     /inference="alignment:Splign:2.1.0"
     exon            333..401
                     /gene="ZNF639"
                     /gene_synonym="ANC-2H01; ANC_2H01; ZASC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..1801
                     /gene="ZNF639"
                     /gene_synonym="ANC-2H01; ANC_2H01; ZASC1"
                     /note="zinc finger amplified in esophageal squamous cell
                     carcinomas 1"
                     /codon_start=1
                     /product="zinc finger protein 639"
                     /protein_id="NP_001290355.1"
                     /db_xref="CCDS:CCDS3227.1"
                     /db_xref="GeneID:51193"
                     /db_xref="HGNC:HGNC:30950"
                     /db_xref="MIM:619214"
                     /translation="MNEYPKKRKRKTLHPSRYSDSSGISRIADGFNGIFSDHCYSVCS
                     MRQPDLKYFDNKDDDSDTETSNDLPKFADGIKARNRNQNYLVPSPVLRILDHTAFSTE
                     KSADIVICDEECDSPESVNQQTQEESPIEVHTAEDVPIAVEVHAISEDYDIETENNSS
                     ESLQDQTDEEPPAKLCKILDKSQALNVTAQQKWPLLRANSSGLYKCELCEFNSKYFSD
                     LKQHMILKHKRTDSNVCRVCKESFSTNMLLIEHAKLHEEDPYICKYCDYKTVIFENLS
                     QHIADTHFSDHLYWCEQCDVQFSSSSELYLHFQEHSCDEQYLCQFCEHETNDPEDLHS
                     HVVNEHACKLIELSDKYNNGEHGQYSLLSKITFDKCKNFFVCQVCGFRSRLHTNVNRH
                     VAIEHTKIFPHVCDDCGKGFSSMLEYCKHLNSHLSEGIYLCQYCEYSTGQIEDLKIHL
                     DFKHSADLPHKCSDCLMRFGNERELISHLPVHETT"
     exon            402..512
                     /gene="ZNF639"
                     /gene_synonym="ANC-2H01; ANC_2H01; ZASC1"
                     /inference="alignment:Splign:2.1.0"
     exon            513..647
                     /gene="ZNF639"
                     /gene_synonym="ANC-2H01; ANC_2H01; ZASC1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..5962
                     /gene="ZNF639"
                     /gene_synonym="ANC-2H01; ANC_2H01; ZASC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1967..1972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF639"
                     /gene_synonym="ANC-2H01; ANC_2H01; ZASC1"
                     /note="hexamer: AATATA"
     polyA_site      1993
                     /gene="ZNF639"
                     /gene_synonym="ANC-2H01; ANC_2H01; ZASC1"
     regulatory      2396..2401
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF639"
                     /gene_synonym="ANC-2H01; ANC_2H01; ZASC1"
                     /note="hexamer: AATAAA"
     polyA_site      2422
                     /gene="ZNF639"
                     /gene_synonym="ANC-2H01; ANC_2H01; ZASC1"
                     /note="major polyA site"
     regulatory      2893..2898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF639"
                     /gene_synonym="ANC-2H01; ANC_2H01; ZASC1"
                     /note="hexamer: AATAAA"
     polyA_site      2916
                     /gene="ZNF639"
                     /gene_synonym="ANC-2H01; ANC_2H01; ZASC1"
     regulatory      5941..5946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF639"
                     /gene_synonym="ANC-2H01; ANC_2H01; ZASC1"
                     /note="hexamer: ATTAAA"
     polyA_site      5962
                     /gene="ZNF639"
                     /gene_synonym="ANC-2H01; ANC_2H01; ZASC1"
ORIGIN      
        1 gaggtgcgcg gcgcaggcgc ggagcgtggc ggccagggca gtgcggccgc ggagcctagg
       61 ccaggggcct ggcgctcagg gcgtggggcg cgcggggagg gagaggggtc ggcccagcac
      121 agcgtccggg agcgctaggg ccggagcagc gctgcccgcc gccgtgcgtc cgcgggaagg
      181 accgcgcggc ccctccgcct gcgctctcgg ccgccgccgc ctctgcgtgg gccggccggg
      241 agggcctcgg gggactgact ggcatttttt actgtctaca gaaacttatt gtaattcatt
      301 tttcctcact ccagtagtaa gaattatacc aaattgaaaa gatatgaatg agtatcctaa
      361 aaaaagaaaa aggaagactc tacacccttc tcgttattca gattcctctg gaataagcag
      421 aattgcagat ggattcaatg gaattttctc tgatcattgt tacagtgtct gttctatgag
      481 acagccagat ttaaaatatt ttgacaacaa agatgatgat tctgataccg agacgtcaaa
      541 tgacttgcca aaatttgcag atggaatcaa ggccagaaac agaaatcaga actacctggt
      601 tcccagtcct gtacttagaa ttctagacca cactgccttt tctacagaaa aatctgctga
      661 tattgtaatt tgtgatgaag agtgtgactc acctgaatca gtcaaccagc aaacccaaga
      721 ggagagtcct atagaagttc acactgctga agatgttcca attgctgtag aagtgcatgc
      781 gatttctgag gattatgata tagagacaga aaacaattcc tctgagagtc tccaagacca
      841 aactgatgaa gaaccgccag ctaaactttg taaaattctt gacaagagcc aagctttgaa
      901 tgtgactgcc cagcagaaat ggcctttact gagagctaat agcagtggcc tctataaatg
      961 tgaactttgt gagtttaaca gcaaatattt ttctgactta aagcagcata tgatcctgaa
     1021 gcataaacgt actgattcaa atgtgtgtcg agtatgcaag gaaagtttct ctaccaatat
     1081 gcttctgata gaacatgcca aactgcatga agaggatccc tacatttgta aatactgtga
     1141 ttataagaca gtaatttttg agaacctcag ccagcacatt gcagacaccc attttagtga
     1201 tcacctctat tggtgtgaac agtgtgatgt acagttctcc tcaagcagtg aactctacct
     1261 acatttccag gagcacagct gtgatgaaca gtacttgtgt cagttctgtg aacatgaaac
     1321 taatgatcca gaagacttgc atagccatgt ggtaaatgag catgcatgta aattaataga
     1381 gttaagtgat aagtataaca atggtgaaca tggacagtat agcctcttaa gcaaaattac
     1441 ctttgacaaa tgtaaaaact tctttgtatg tcaagtatgt ggttttcgga gtagacttca
     1501 cacaaatgtt aacaggcatg ttgctattga acatacaaaa atttttcctc atgtttgtga
     1561 tgactgtggg aaaggctttt caagtatgct agaatattgc aagcatttaa attcacattt
     1621 atctgaaggg atttatttat gtcaatattg tgaatattca acaggacaaa ttgaagatct
     1681 taaaattcat ctagatttca agcattcagc tgacttgcct cataaatgta gtgactgctt
     1741 gatgaggttt ggaaatgaaa gggaattaat aagtcacctt ccagtccatg agacaacttg
     1801 attattctct ttaacttaca gaatgttagt ttaaaataat aaattcatcc tttttttgga
     1861 gatgattaaa tggatgattg taaacacaac ttatgaaatc tgcctttaac aagtaacttt
     1921 tttaaattat aaaattttat tggcattgct ccattttctg tatataaata tatctttaat
     1981 gtggtatttt caattgcgtg atagtttgta gtttcaacca ctcttggtga ctgtcatcct
     2041 gtttcttcca tattctctga tttcatgaat tgaaaagaaa caaatgtatt gaagaagtga
     2101 gctacagttt tccttcctta accatgggtg ctagtaactt tttaaaactc aagacaagat
     2161 tagtttttta tgtgtgaagt cattaaatta ttacacgacc agaactaaaa tgcaatatac
     2221 agttaagtcc acggatactc ccattaatga gaaataacac taggaagcca ctattacagg
     2281 aagaaaagat ttggttttca tggcagtctg tttttttaaa aaaaaatttt tgagccacta
     2341 tctattgttg aatattttaa gatgggatga gggaggaact aataagggct tacacaataa
     2401 aaaataacta tatcataact cattcataac ttgatgtttc attttctgtt gaggaaccat
     2461 aaattcattc acagacttaa tatttttttc ttagagatgg tctcgttctg ttgtccagga
     2521 tggagtgcag tggttgatca tagctcccgg gctgtagtct cccaggctcg agcaatcctc
     2581 ccacttcacc ctcctgcata gctaggacta caggcatgtg gcaccatgcc cgctaagttt
     2641 ttaaatttct tgtagagatg agatctcgct atgttgccca ggccagtctc aaactcctgg
     2701 actcaagcaa tcctcccacc ttggccttcc aaatcactgg gattataggc atgagccatt
     2761 atgcctgact cttgcccaaa tttctgatgt caaattgttc attgacagaa aacccactga
     2821 agtatttaaa gttaggaaga tctgggagat aggggttgct ggcatgaaaa tgtataactt
     2881 acaacattta ttaataaaat gataaattag catcaatatt agttcgtatg gctgccataa
     2941 caaattacta caaactgagt tgcctaccta gcagaaattt atggtctcac agttgtgaag
     3001 gccagacatt caaaatggag ttattggcag ttggttcctt ctgagggttg tgggggaagg
     3061 atctgtttca ggtctgtcct tggcttgtag atggatagcc tcatgttcac atggtgttct
     3121 ccctgtgtgc aagtctgtcc cccaaatttc ctcttttttt tttttttttt gcttttttaa
     3181 ttttttgaga cagaatttca ctcttgtcgc ccaggctgga gtacagtggc gcgatctcag
     3241 ctcattgcaa cctccgcctc ccaggttcaa gtgattctgc tgcctcagct tcccaagtag
     3301 ctggggttaa caggcgtcag ccaccatgcc aggctaattt tgtattttta gtagaaacgg
     3361 ggtttcacca cgttggccag gctggtctca aattcctgac ctcaggtgat ccacctgcct
     3421 cagtctccca aagtgctggg attacaggca tgaggcaccg ccccaggcca aatttcttgt
     3481 ttttataaag actccagtca tattgattgg attagggccc ctcccaatgt cctcctttta
     3541 acttaaagac ctgatctcca aataaggtca tattctaagg tgctgaggtt taggacttca
     3601 acatatgaat ttgggaggga acacaattga gtagcagagt ctgaaacagc actataaaga
     3661 agatagaatt atatgtatca ttgccctcaa atttaacaag cactgctaac attatttttt
     3721 aggtttattg atataagtgg aagatcaatt tatgaccaat gattttccca cttcaagaat
     3781 ttagtctgtt tggacaatgg tggctgcaag tattcttaga aggtattatt tttatcccca
     3841 ctattttgtt gtatgtgcat acctgtgttc ctagcaactc acattccatc taattataac
     3901 attcctgtta cggctgataa caaatgtttc tcagaagact taaaattgta acagtttaaa
     3961 ttgtaagata accttagaaa gcatctggtc taaaccctcc agttttctaa gttccttgca
     4021 gaaatagaaa tgtagatagc tatgaggcca agtacatata accagttatg tctcatggga
     4081 gtgggatcca ggttatctgg tttactgtct agtgatgttt ccattacatc atgttacata
     4141 aacctaacct ttctccctgg gatgtttttt gtgactactt cacctaacaa ttaacctagt
     4201 tgttgataat tttgttttta tgctttttat acatctagct ccaggaattg gatttttgga
     4261 aaaacacctt aagtaatgcc ttggtttgtt tgttttcttt taatctattt gctgctttac
     4321 atttggatca agtgttagta attgaaaaga ttgcaggctg ggcgtggtgg cccacgcctc
     4381 taatcccagc actttgtggg tggctgagat gggcagatca cgaggtcagg agatccagac
     4441 catcctggct aacagtgaaa ccccgtctct actaaaaata caaaaaaaaa ttagctgggc
     4501 gtggtggtgg gcacctgtag tcccagctac tcgggaggct gaggcaggag aatggcgtga
     4561 acccgggagg tggagcttgc agtgagccga gatcgcgcca ccacattcca gcctgggtga
     4621 cagagtgaga ctgtctcaaa aaaaaaaaag aaaagaagaa aagattgcaa tgcagctact
     4681 caagagacat atatccaagt ttcagaacca tataattttg tacttttttt tttttcagac
     4741 agtcttgctc tgttgcccag gctggagtgt agtggcgtga tcttggctca aggcaacctc
     4801 cacctctcag gtgtaagcaa ttctcctgcc ttagcctccc aagtagctgg gattataggc
     4861 gtgtgccacc acacccggct aatttttgtg tttttaatag agacggggtt tcaccatgtt
     4921 gaccaggctg gtcttgaact cctgacctct tgtgatctgc ccacctcgac ctcccaaagt
     4981 gctaggatta caggcgtgag ccactgcacc cggcataatt ttggactttt tgatgaatct
     5041 gcagcttcag gacctatccc aatgacagtt tgtcccacaa aaccttttcg ccttggccca
     5101 gttttcaaat caatgattga ccataaattg cttgaagtag ttggtcttta tttatttatt
     5161 ttttgagatg gagccttgct ctgtcgccca gactggaatg cagtggcgtg atcttggctc
     5221 gctgcaacct ctgcctcccg ggtttaagca attctcctgc ctcagcctcc cgagtagctg
     5281 ggatacaggt gcccaccacc acacccagct aatttttcta tttttagtag agatggggtt
     5341 tcaccatctt ggccaggctg gtcttgaact cctgaccttg tgatccaccc acttcggcct
     5401 cccaaagtgc tgggattaca ggcctgagcc accacgcccg gccagtcttt atttttaact
     5461 taaagaactt cagaaaaaca aacctaccta aaaaaattaa cactcctggt tttgttttgt
     5521 tttttgtttt gttttacttc agagacagac attttcactg tatacttgtg acttgcacca
     5581 caattcaagt ctgagattac ctaactgatg atgtttatta acacttcagt agaattcttc
     5641 gcagcagtga acagtagtga caggtcatta tgtttttctt gctgttttaa atcttcatct
     5701 tacaatgagt tattttgaaa ttccaaaaca tttccctgta ttccagaaat tgaaaatggt
     5761 tgttcactaa aaagcctctt cttttcctgc ttataaattt gccaattttg ccattttaaa
     5821 tcacctttct tacgtttctc tgaattgtat attatttgtc aatttcacag tttctataat
     5881 ctattgtttg ctgaattgtt acagtctttt gtttttaata gactagcact attcctaatt
     5941 attaaatctg atttacaaag ca
//
