LOCUS       NM_014497               6487 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 638 (ZNF638), transcript variant
            1, mRNA.
ACCESSION   NM_014497
VERSION     NM_014497.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6487)
  AUTHORS   Das,A., Vijayan,M., Walton,E.M., Stafford,V.G., Fiflis,D.N. and
            Asokan,A.
  TITLE     Epigenetic Silencing of Recombinant Adeno-associated Virus Genomes
            by NP220 and the HUSH Complex
  JOURNAL   J Virol 96 (4), e0203921 (2022)
   PUBMED   34878926
  REMARK    GeneRIF: Epigenetic Silencing of Recombinant Adeno-associated Virus
            Genomes by NP220 and the HUSH Complex.
REFERENCE   2  (bases 1 to 6487)
  AUTHORS   Ni,W., Lin,S., Bian,S., Zheng,W., Qu,L., Fan,Y., Lu,C., Xiao,M. and
            Zhou,P.
  TITLE     USP7 mediates pathological hepatic de novo lipogenesis through
            promoting stabilization and transcription of ZNF638
  JOURNAL   Cell Death Dis 11 (10), 843 (2020)
   PUBMED   33040080
  REMARK    GeneRIF: USP7 mediates pathological hepatic de novo lipogenesis
            through promoting stabilization and transcription of ZNF638.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6487)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 6487)
  AUTHORS   Zhu,Y., Wang,G.Z., Cingoz,O. and Goff,S.P.
  TITLE     NP220 mediates silencing of unintegrated retroviral DNA
  JOURNAL   Nature 564 (7735), 278-282 (2018)
   PUBMED   30487602
  REMARK    GeneRIF: NP220 is the key protein that recruits the HUSH complex,
            SETDB1 and the histone deacetylases HDAC1 and HDAC4 to silence the
            unintegrated retroviral DNA; knockout of NP220 accelerates the
            replication of retroviruses; these experiments identify the
            molecular machinery that silences extrachromosomal retroviral DNA
REFERENCE   5  (bases 1 to 6487)
  AUTHORS   He,M., Xu,M., Zhang,B., Liang,J., Chen,P., Lee,J.Y., Johnson,T.A.,
            Li,H., Yang,X., Dai,J., Liang,L., Gui,L., Qi,Q., Huang,J., Li,Y.,
            Adair,L.S., Aung,T., Cai,Q., Cheng,C.Y., Cho,M.C., Cho,Y.S.,
            Chu,M., Cui,B., Gao,Y.T., Go,M.J., Gu,D., Gu,W., Guo,H., Hao,Y.,
            Hong,J., Hu,Z., Hu,Y., Huang,J., Hwang,J.Y., Ikram,M.K., Jin,G.,
            Kang,D.H., Khor,C.C., Kim,B.J., Kim,H.T., Kubo,M., Lee,J., Lee,J.,
            Lee,N.R., Li,R., Li,J., Liu,J., Longe,J., Lu,W., Lu,X., Miao,X.,
            Okada,Y., Ong,R.T., Qiu,G., Seielstad,M., Sim,X., Song,H.,
            Takeuchi,F., Tanaka,T., Taylor,P.R., Wang,L., Wang,W., Wang,Y.,
            Wu,C., Wu,Y., Xiang,Y.B., Yamamoto,K., Yang,H., Liao,M., Yokota,M.,
            Young,T., Zhang,X., Kato,N., Wang,Q.K., Zheng,W., Hu,F.B., Lin,D.,
            Shen,H., Teo,Y.Y., Mo,Z., Wong,T.Y., Lin,X., Mohlke,K.L., Ning,G.,
            Tsunoda,T., Han,B.G., Shu,X.O., Tai,E.S., Wu,T. and Qi,L.
  TITLE     Meta-analysis of genome-wide association studies of adult height in
            East Asians identifies 17 novel loci
  JOURNAL   Hum Mol Genet 24 (6), 1791-1800 (2015)
   PUBMED   25429064
REFERENCE   6  (bases 1 to 6487)
  AUTHORS   Meruvu,S., Hugendubler,L. and Mueller,E.
  TITLE     Regulation of adipocyte differentiation by the zinc finger protein
            ZNF638
  JOURNAL   J Biol Chem 286 (30), 26516-26523 (2011)
   PUBMED   21602272
  REMARK    GeneRIF: ZNF638 is a novel and early regulator of adipogenesis that
            works as a transcription cofactor of C/EBPs.
REFERENCE   7  (bases 1 to 6487)
  AUTHORS   Ng,E.K., Chan,K.K., Wong,C.H., Tsui,S.K., Ngai,S.M., Lee,S.M.,
            Kotaka,M., Lee,C.Y., Waye,M.M. and Fung,K.P.
  TITLE     Interaction of the heart-specific LIM domain protein, FHL2, with
            DNA-binding nuclear protein, hNP220
  JOURNAL   J Cell Biochem 84 (3), 556-566 (2002)
   PUBMED   11813260
REFERENCE   8  (bases 1 to 6487)
  AUTHORS   Eichmuller,S., Usener,D., Dummer,R., Stein,A., Thiel,D. and
            Schadendorf,D.
  TITLE     Serological detection of cutaneous T-cell lymphoma-associated
            antigens
  JOURNAL   Proc Natl Acad Sci U S A 98 (2), 629-634 (2001)
   PUBMED   11149944
REFERENCE   9  (bases 1 to 6487)
  AUTHORS   Okumara,K., Nogami,M., Matsushima,Y., Matsumura,K., Nakamura,K.,
            Taguchi,H. and Kitagawa,Y.
  TITLE     Mapping of human DNA-binding nuclear protein (NP220) to chromosome
            band 2p13.1-p13.2 and its relation to matrin 3
  JOURNAL   Biosci Biotechnol Biochem 62 (8), 1640-1642 (1998)
   PUBMED   9757574
REFERENCE   10 (bases 1 to 6487)
  AUTHORS   Inagaki,H., Matsushima,Y., Nakamura,K., Ohshima,M., Kadowaki,T. and
            Kitagawa,Y.
  TITLE     A large DNA-binding nuclear protein with RNA recognition motif and
            serine/arginine-rich domain
  JOURNAL   J Biol Chem 271 (21), 12525-12531 (1996)
   PUBMED   8647861
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP348645.1, D83032.1,
            BC143728.1, DB130984.1 and AI357871.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014497.4.
            
            Summary: The protein encoded by this gene is a nucleoplasmic
            protein. It binds cytidine-rich sequences in double-stranded DNA.
            This protein has three types of domains: MH1, MH2 (repeated three
            times) and MH3. It is associated with packaging, transferring, or
            processing transcripts. Multiple alternatively spliced transcript
            variants have been found for this gene, but the biological validity
            of some variants has not been determined. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) encodes isoform 1. Variants 1,
            2 and 3 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D83032.1, SRR1803615.35787.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264447.9/ ENSP00000264447.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BP348645.1         21-33
            14-468              D83032.1           33-487
            469-3313            BC143728.1         449-3293
            3314-3428           DB130984.1         182-296
            3429-6255           BC143728.1         3409-6235
            6256-6487           AI357871.1         13-244              c
FEATURES             Location/Qualifiers
     source          1..6487
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.2"
     gene            1..6487
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /note="zinc finger protein 638"
                     /db_xref="GeneID:27332"
                     /db_xref="HGNC:HGNC:17894"
                     /db_xref="MIM:614349"
     exon            1..94
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            95..1613
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..6233
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /note="isoform 1 is encoded by transcript variant 1; NP220
                     nuclear protein; CTCL tumor antigen se33-1; nuclear
                     protein 220; CTCL-associated antigen se33-1; zinc finger
                     matrin-like protein; cutaneous T-cell lymphoma-associated
                     antigen se33-1"
                     /codon_start=1
                     /product="zinc finger protein 638 isoform 1"
                     /protein_id="NP_055312.2"
                     /db_xref="CCDS:CCDS1917.1"
                     /db_xref="GeneID:27332"
                     /db_xref="HGNC:HGNC:17894"
                     /db_xref="MIM:614349"
                     /translation="MSRPRFNPRGDFPLQRPRAPNPSGMRPPGPFMRPGSMGLPRFYP
                     AGRARGIPHRFAGHESYQNMGPQRMNVQVTQHRTDPRLTKEKLDFHEAQQKKGKPHGS
                     RWDDEPHISASVAVKQSSVTQVTEQSPKVQSRYTKESASSILASFGLSNEDLEELSRY
                     PDEQLTPENMPLILRDIRMRKMGRRLPNLPSQSRNKETLGSEAVSSNVIDYGHASKYG
                     YTEDPLEVRIYDPEIPTDEVENEFQSQQNISASVPNPNVICNSMFPVEDVFRQMDFPG
                     ESSNNRSFFSVESGTKMSGLHISGGQSVLEPIKSVNQSINQTVSQTMSQSLIPPSMNQ
                     QPFSSELISSVSQQERIPHEPVINSSNVHVGSRGSKKNYQSQADIPIRSPFGIVKASW
                     LPKFSHADAQKMKRLPTPSMMNDYYAASPRIFPHLCSLCNVECSHLKDWIQHQNTSTH
                     IESCRQLRQQYPDWNPEILPSRRNEGNRKENETPRRRSHSPSPRRSRRSSSSHRFRRS
                     RSPMHYMYRPRSRSPRICHRFISRYRSRSRSRSPYRIRNPFRGSPKCFRSVSPERMSR
                     RSVRSSDRKKALEDVVQRSGHGTEFNKQKHLEAADKGHSPAQKPKTSSGTKPSVKPTS
                     ATKSDSNLGGHSIRCKSKNLEDDTLSECKQVSDKAVSLQRKLRKEQSLHYGSVLLITE
                     LPEDGCTEEDVRKLFQPFGKVNDVLIVPYRKEAYLEMEFKEAITAIMKYIETTPLTIK
                     GKSVKICVPGKKKAQNKEVKKKTLESKKVSASTLKRDADASKAVEIVTSTSAAKTGQA
                     KASVAKVNKSTGKSASSVKSVVTVAVKGNKASIKTAKSGGKKSLEAKKTGNVKNKDSN
                     KPVTIPENSEIKTSIEVKATENCAKEAISDAALEATENEPLNKETEEMCVMLVSNLPN
                     KGYSVEEVYDLAKPFGGLKDILILSSHKKAYIEINRKAAESMVKFYTCFPVLMDGNQL
                     SISMAPENMNIKDEEAIFITLVKENDPEANIDTIYDRFVHLDNLPEDGLQCVLCVGLQ
                     FGKVDHHVFISNRNKAILQLDSPESAQSMYSFLKQNPQNIGDHMLTCSLSPKIDLPEV
                     QIEHDPELEKESPGLKNSPIDESEVQTATDSPSVKPNELEEESTPSIQTETLVQQEEP
                     CEEEAEKATCDSDFAVETLELETQGEEVKEEIPLVASASVSIEQFTENAEECALNQQM
                     FNSDLEKKGAEIINPKTALLPSDSVFAEERNLKGILEESPSEAEDFISGITQTMVEAV
                     AEVEKNETVSEILPSTCIVTLVPGIPTGDEKTVDKKNISEKKGNMDEKEEKEFNTKET
                     RMDLQIGTEKAEKNEGRMDAEKVEKMAAMKEKPAENTLFKAYPNKGVGQANKPDETSK
                     TSILAVSDVSSSKPSIKAVIVSSPKAKATVSKTENQKSFPKSVPRDQINAEKKLSAKE
                     FGLLKPTSARSGLAESSSKFKPTQSSLTRGGSGRISALQGKLSKLDYRDITKQSQETE
                     ARPSIMKRDDSNNKTLAEQNTKNPKSTTGRSSKSKEEPLFPFNLDEFVTVDEVIEEVN
                     PSQAKQNPLKGKRKETLKNVPFSELNLKKKKGKTSTPRGVEGELSFVTLDEIGEEEDA
                     AAHLAQALVTVDEVIDEEELNMEEMVKNSNSLFTLDELIDQDDCISHSEPKDVTVLSV
                     AEEQDLLKQERLVTVDEIGEVEELPLNESADITFATLNTKGNEGDTVRDSIGFISSQV
                     PEDPSTLVTVDEIQDDSSDLHLVTLDEVTEEDEDSLADFNNLKEELNFVTVDEVGEEE
                     DGDNDLKVELAQSKNDHPTDKKGNRKKRAVDTKKTKLESLSQVGPVNENVMEEDLKTM
                     IERHLTAKTPTKRVRIGKTLPSEKAVVTEPAKGEEAFQMSEVDEESGLKDSEPERKRK
                     KTEDSSSGKSVASDVPEELDFLVPKAGFFCPICSLFYSGEKAMTNHCKSTRHKQNTEK
                     FMAKQRKEKEQNEAEERSSR"
     exon            1614..1675
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1714
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..2013
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2291
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2438
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2561
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2620
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            2621..2673
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..2724
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2796
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..2883
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..2952
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            2953..2993
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3125
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            3126..3254
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..3296
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            3297..3431
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            3432..3557
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            3558..3595
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            3596..4820
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            4821..4886
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            4887..5841
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            5842..5946
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            5947..6048
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            6049..6167
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     exon            6168..6487
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6455..6460
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /note="hexamer: AATAAA"
     polyA_site      6487
                     /gene="ZNF638"
                     /gene_synonym="NP220; ZFML; Zfp638"
                     /note="major polyA site"
ORIGIN      
        1 ggaggcggta gcgttttcgg cgtcgagact ggaggctgag tgctaaactg tgtggggcgc
       61 ggatgggatc cagctgttag tcgggtaggc atagctttgt gttattcttg gaaaatttcg
      121 caccacttgt gaattccttg aacctgggca ttgcaaaccc acttctgttg ggcccatctc
      181 ctttgcactt tgctcagatt aagactcagt tggcgcttca gcagctgaat gccgttgcct
      241 cacatggttc aacaccacct tatactttat taaatcaggc tttcttgaaa atagccatgt
      301 cgagacccag gtttaatcct cgaggagact ttccacttca aaggccacga gcacctaacc
      361 cttctgggat gaggcctcca ggaccattta tgaggcctgg atctatgggt ctcccaagat
      421 tttacccagc agggagagca cgtggaattc cacacagatt tgctggccat gaatcttatc
      481 agaacatggg gccacagaga atgaatgttc aggtaactca acacagaact gatccaagat
      541 tgaccaaaga aaaactggat tttcatgaag cacaacagaa gaaggggaag cctcatggta
      601 gccggtggga tgatgagcct catatatctg catcagtggc agtgaaacag agttctgtaa
      661 cacaggttac agagcagagt cccaaagtac agagccgcta tacaaaagag agtgcctcaa
      721 gtatcttagc aagttttgga ttatctaatg aagacctaga agaacttagt cgctatcctg
      781 atgaacaact aactcctgaa aatatgccat taattttgag ggatataaga atgcgaaaaa
      841 tggggcgccg attacctaat ttaccttctc agagcagaaa taaagaaaca cttggtagtg
      901 aagcagtttc aagtaatgtg atcgattatg ggcatgcaag caaatatggc tacacagaag
      961 atccacttga agtacgtatt tatgatcctg aaattccaac tgatgaggtc gagaatgaat
     1021 ttcagtcaca gcagaacatt tctgcatctg ttcccaatcc aaatgtgata tgtaattcta
     1081 tgtttcctgt tgaagacgta tttcgccaaa tggacttccc cggtgagtcc tccaataatc
     1141 ggtccttttt ctcagttgag agtggaacca agatgtcagg cttacacatt tcaggaggac
     1201 agtcagtcct tgaacccata aaatccgtca accaatccat taaccaaaca gttagccaga
     1261 caatgagtca atctctgatt cctccatcta tgaaccagca acctttttcg tcggaattaa
     1321 tttcatctgt aagccagcaa gagcggatcc cacatgaacc tgtgattaat tcatctaacg
     1381 tacatgttgg atcaagagga agtaaaaaga attaccagtc acaggctgac attcccattc
     1441 ggtctccctt tggtattgtg aaagcatcct ggctaccaaa gttttcacat gctgatgccc
     1501 agaagatgaa gagacttcca actccttcta tgatgaatga ttattatgca gcatctccaa
     1561 gaatatttcc acatttgtgt tctctgtgta acgtagaatg tagtcatttg aaggattgga
     1621 ttcagcatca aaatacatct actcatattg agagctgtcg acagttacgt caacagtatc
     1681 ctgattggaa tcctgagatc ctcccatcga gaagaaatga gggcaataga aaagaaaatg
     1741 aaactccacg aagacgttct cattccccca gtcctaggcg ttctagaaga tcaagctcaa
     1801 gtcacagatt ccgtcggtct cgaagcccaa tgcattacat gtataggccg agaagtcgaa
     1861 gtccaagaat ttgccatcgt ttcatttcta gatacagatc cagatccaga tcccgttcac
     1921 catatcgaat tagaaatcca tttagaggta gtccaaaatg ctttcgatca gttagccctg
     1981 agaggatgtc aaggagatca gtgagatcat cagatagaaa aaaagcatta gaagatgtag
     2041 tacaacgatc tgggcatggg acagaattta ataaacagaa gcatcttgaa gctgctgata
     2101 agggacattc accagcacaa aagcctaaaa ctagcagtgg aacaaaacca tcagttaaac
     2161 ctacaagcgc tacaaagagt gattcaaatc taggaggaca ttctattcgt tgtaaatcaa
     2221 agaatcttga agatgacact ttgtcagaat gtaaacaggt gtctgataaa gctgtttctc
     2281 tccagcgaaa gcttcggaaa gaacagtcat tgcattatgg ttcggttctt cttataactg
     2341 aattaccaga ggatggttgt actgaagaag atgtgagaaa attatttcaa ccatttggga
     2401 aagtgaatga tgtcctaatt gttccatata gaaaagaggc ttacctagaa atggaattta
     2461 aagaggcaat tactgcaatt atgaagtaca ttgaaacaac acctcttacg ataaaaggaa
     2521 aaagtgtgaa aatatgtgtt ccaggaaaga aaaaagcaca gaacaaagag gtgaagaaaa
     2581 agactttaga gtcaaagaaa gtatctgcat ctaccttaaa aagagatgca gatgcttcaa
     2641 aagctgttga aattgttact tcaacttctg ctgccaaaac tggacaagcc aaggcatctg
     2701 tagccaaagt aaacaaatct acagggaaat cagcaagttc tgtaaaatct gtggtaacgg
     2761 tagctgttaa aggtaataaa gcttcaatca aaacagcaaa atctggtgga aagaagtctc
     2821 tagaagccaa aaagactggg aatgtcaaaa acaaagactc taacaaacct gtgactatac
     2881 cagaaaactc tgaaataaag accagtattg aagtcaaagc cactgaaaac tgtgctaaag
     2941 aagctatttc tgatgctgct ttggaggcca cagagaatga accacttaac aaggaaacag
     3001 aagaaatgtg tgtgatgctt gtctctaatt tgcctaataa aggatattct gtagaagaag
     3061 tttatgactt agcaaaacca tttggtggtt taaaggatat cttgatttta tcatctcata
     3121 aaaaggcata tatagaaata aatagaaaag ctgctgagtc tatggtaaaa ttttatacct
     3181 gcttcccagt attgatggat ggaaatcaac tctcaataag tatggctcct gaaaacatga
     3241 atataaaaga tgaggaagct atatttataa ccttggtaaa agaaaatgac ccagaggcaa
     3301 acatagatac aatttatgat cgatttgtac atcttgataa tttaccggaa gatggacttc
     3361 agtgtgtact ttgtgttgga cttcagtttg gaaaagtgga tcaccatgta ttcataagta
     3421 atagaaacaa ggcaattctt cagttagata gtcctgaatc tgctcagtca atgtatagct
     3481 ttctgaaaca aaatccacaa aatattggtg accatatgtt gacctgctca ttatctccaa
     3541 agatagactt accagaggtg caaattgagc atgacccaga attagaaaaa gaaagccctg
     3601 gcttgaaaaa cagtccaatt gatgaaagtg aggtgcaaac agcaactgat agtccctctg
     3661 ttaaacctaa tgagcttgaa gaagaaagta ctcccagcat tcaaacagaa actttggtac
     3721 agcaggaaga gccttgtgag gaagaagctg aaaaagcaac atgtgattct gactttgctg
     3781 ttgaaacttt ggagcttgaa actcaaggag aggaggtcaa agaagaaatt cctcttgtag
     3841 catccgcttc agtcagtatt gaacaattca ctgaaaatgc cgaggagtgt gctttaaatc
     3901 agcagatgtt taacagtgac ttggagaaga aaggggcaga aattattaac cctaaaacag
     3961 cattgttacc atctgacagt gtgtttgcag aagaaaggaa cctcaaagga attctagaag
     4021 aatctccatc tgaagcagaa gatttcattt ctggaattac acagactatg gtagaagctg
     4081 tagctgaagt agaaaaaaat gaaactgttt cggaaatatt gccatcaact tgtattgtga
     4141 cgttagtacc aggaattccc actggggatg agaagacagt ggacaaaaag aatatttctg
     4201 aaaaaaaagg taacatggat gaaaaggagg agaaggaatt taatactaag gaaaccagaa
     4261 tggatcttca aataggaaca gagaaggctg aaaagaatga aggtaggatg gatgcagaaa
     4321 aggtggaaaa gatggcagca atgaaagaaa agcctgcaga aaacacttta ttcaaggcat
     4381 acccaaataa aggagtgggt caggctaata agcctgatga aactagtaaa actagtattc
     4441 tggctgtatc agatgtatct agcagtaaac caagcatcaa ggctgttata gtctcttctc
     4501 ctaaggcaaa agctacagtt tcaaaaactg aaaatcagaa aagttttcca aaatctgtgc
     4561 ccagagatca aataaatgct gaaaagaaac tttcagccaa ggaatttggt ctgcttaaac
     4621 ccacaagtgc caggtcaggc ttggcagaaa gcagcagtaa attcaaacct actcagagca
     4681 gtcttaccag aggaggcagt ggaaggatct cagccctgca aggcaagctt tctaaactgg
     4741 attacagaga tataacaaaa caatctcagg aaacagaggc tagaccttcc atcatgaaac
     4801 gggatgacag caacaataag actttggctg agcaaaacac taagaatcct aaaagcacta
     4861 ctggtagaag ttccaaatct aaagaggagc cattatttcc atttaatttg gatgaatttg
     4921 ttactgtgga tgaggttata gaagaagtga atccttctca ggccaagcag aatccactaa
     4981 agggaaaaag gaaagaaact ctcaaaaatg ttcctttctc tgaacttaac ttaaagaaga
     5041 aaaaggggaa aacttccact cctcgtggtg ttgagggaga actatctttt gtgacattgg
     5101 atgagattgg ggaagaggaa gatgcagctg cacatctagc acaagctcta gtcactgtgg
     5161 atgaagtaat tgatgaagaa gaactaaata tggaagaaat ggtaaaaaat tcaaattcac
     5221 tttttacatt agatgaatta attgaccaag atgattgcat ttcccacagt gaacctaaag
     5281 atgttactgt tctgtcagtg gctgaagaac aagatctcct caaacaggaa cgcttggtaa
     5341 ctgtggatga aattggagaa gtggaagagc tacctttgaa tgagtcagca gacataactt
     5401 ttgccacttt aaatactaaa ggaaatgaag gagatactgt aagggattcc attggcttca
     5461 tttcttctca ggtgcccgaa gacccttcta ctttagttac tgtagatgaa atacaagatg
     5521 acagcagtga tttgcattta gtgactttgg atgaagtaac tgaagaggat gaagactctc
     5581 tggcggattt taacaacctt aaagaagagc ttaattttgt tactgttgat gaagttggag
     5641 aggaggaaga tggagataat gatttaaaag ttgagttagc acaaagcaaa aatgaccatc
     5701 ccacagataa aaaagggaat agaaagaaga gagctgtgga cacaaaaaag acaaaacttg
     5761 aatccttgtc ccaagtgggt ccagtaaatg agaatgttat ggaagaagat ctaaaaacca
     5821 tgattgaaag acacttaaca gctaaaactc caaccaagag agttagaatt gggaaaactc
     5881 tgccatcaga aaaagctgtt gtgacagaac cagcaaaagg tgaagaggcc ttccagatga
     5941 gtgaagttga tgaggaatct ggattaaagg attcagaacc agagcgaaaa cgcaagaaga
     6001 ctgaagactc ttcttcaggc aaatcagtgg cgtctgatgt ccctgaggaa ttagactttc
     6061 ttgtacctaa ggctggattc ttctgtccaa tttgttccct cttctactca ggtgaaaaag
     6121 caatgacaaa tcactgcaag agtacacgtc ataagcaaaa tactgagaaa ttcatggcca
     6181 agcaaagaaa ggaaaaggag cagaatgagg ctgaagaaag aagctctagg tgattggggg
     6241 aaaggaaaga attcactaga aatttgttta gggtccagtt gatttgtgta tttttgttat
     6301 catttaattt gtaattttcg tttcagaagc aaatattcgt gttgtacaaa tttctgattg
     6361 ccctaaatgt agagagactg atggggaaag tatgatgggt ttgattttta tatcaaatca
     6421 tcaggcatgg agaaatatct tttagaagtg ttaaaataaa tgttcctact gtatatttaa
     6481 aatacca
//
