LOCUS       NM_145295               2803 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 627 (ZNF627), transcript variant
            1, mRNA.
ACCESSION   NM_145295 XM_371137
VERSION     NM_145295.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2803)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2803)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2803)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 2803)
  AUTHORS   Wu,N., Zhang,X., Jia,P. and Jia,D.
  TITLE     The SNP rs4804611 in ZNF627 gene and the risk of myocardial
            infarction: a meta-analysis
  JOURNAL   Int J Clin Exp Med 8 (4), 5520-5526 (2015)
   PUBMED   26131132
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2803)
  AUTHORS   Horne,B.D., Carlquist,J.F., Muhlestein,J.B., Nicholas,Z.P. and
            Anderson,J.L.
  CONSRTM   Intermountain Heart Collaborative Study Group
  TITLE     Associations with myocardial infarction of six polymorphisms
            selected from a three-stage genome-wide association study
  JOURNAL   Am Heart J 154 (5), 969-975 (2007)
   PUBMED   17967605
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 2803)
  AUTHORS   Sun,X.Y., Yu,L., Wu,G.J., Fan,Y.X., Zheng,Q.P., Hu,P.R., Zhang,M.,
            Jiang,Y., Liu,S., Xu,Y.F. and Zhao,S.Y.
  TITLE     [Isolation of novel expression sequences of C2H2 type zinc finger
            protein gene from human brain tissue according to the conservation
            of zinc finger motif]
  JOURNAL   Shi Yan Sheng Wu Xue Bao 31 (4), 377-378 (1998)
   PUBMED   12016960
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC098416.1, BC069232.1, AK074846.1 and AC104527.2.
            
            On Nov 23, 2018 this sequence version replaced NM_145295.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA583801.1, SRR1660809.170138.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361113.10/ ENSP00000354414.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-950               BC098416.1         35-984
            951-2777            BC069232.1         899-2725
            2778-2801           AK074846.1         2749-2772
            2802-2803           AC104527.2         30212-30213
FEATURES             Location/Qualifiers
     source          1..2803
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..2803
                     /gene="ZNF627"
                     /note="zinc finger protein 627"
                     /db_xref="GeneID:199692"
                     /db_xref="HGNC:HGNC:30570"
                     /db_xref="MIM:612248"
     exon            1..148
                     /gene="ZNF627"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1531
                     /gene="ZNF627"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 627 isoform 1"
                     /protein_id="NP_660338.1"
                     /db_xref="CCDS:CCDS42502.1"
                     /db_xref="GeneID:199692"
                     /db_xref="HGNC:HGNC:30570"
                     /db_xref="MIM:612248"
                     /translation="MDSVAFEDVAVNFTLEEWALLDPSQKNLYRDVMRETFRNLASVG
                     KQWEDQNIEDPFKIPRRNISHIPERLCESKEGGQGEETFSQIPDGILNKKTPGVKPCE
                     SSVCGEVGMGPSSLNRHIRDHTGREPNEYQEYGKKSYTRNQCGRALSYHRSFPVRERT
                     HPGGKPYDCKECGETFISLVSIRRHMLTHRGGVPYKCKVCGKAFDYPSLFRIHERSHT
                     GEKPYECKQCGKAFSCSSYIRIHERTHTGDKPYECKQCGKAFSCSKYIRIHERTHTGE
                     KPYECKQCGKAFRCASSVRSHERTHTGEKLFECKECGKALTCLASVRRHMIKHTGNGP
                     YKCKVCGKAFDFPSSFRIHERTHTGEKPYDCKQCGKAFSCSSSFRKHERIHTGEKPYK
                     CTKCGKAFSRSSYFRIHERTHTGEKPYECKQCGKAFSRSTYFRVHEKIHTGEKPYENP
                     NPNASVVPVLS"
     exon            149..275
                     /gene="ZNF627"
                     /inference="alignment:Splign:2.1.0"
     exon            276..336
                     /gene="ZNF627"
                     /inference="alignment:Splign:2.1.0"
     exon            337..2803
                     /gene="ZNF627"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2744..2749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF627"
                     /note="hexamer: AATAAA"
     regulatory      2757..2762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF627"
                     /note="hexamer: AATAAT"
     polyA_site      2767
                     /gene="ZNF627"
     regulatory      2776..2781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF627"
                     /note="hexamer: CATAAA"
     polyA_site      2781
                     /gene="ZNF627"
                     /note="major polyA site"
     polyA_site      2803
                     /gene="ZNF627"
ORIGIN      
        1 gtttctggcg accgtcccca cccgggctcg cgtctccgtt tctccgagag gcccaaggtg
       61 tctccgccgc agcctctgtc gcgccgtgac ctgtacaggt cgcgggagtc gtagggagga
      121 cgccgggaca cctggaagcc gagaaatgga ttcagtggcc tttgaggatg tggctgtgaa
      181 cttcaccctg gaggagtggg ctttgctgga tccttcccag aagaatctct acagggatgt
      241 gatgcgggaa accttcagga acctggcttc tgtaggaaaa caatgggaag accagaacat
      301 tgaagaccca ttcaaaattc ccaggagaaa tataagtcat attccagaga gactctgtga
      361 aagtaaagaa ggtggtcaag gtgaagaaac cttcagccag attccagatg gtattctgaa
      421 caagaaaact cctggagtaa aaccgtgtga aagcagtgtg tgtggagaag ttggcatggg
      481 tccttcatca cttaataggc acatcagaga tcacactgga cgtgaaccaa atgaatatca
      541 ggaatatgga aagaagtcat atacacgtaa ccagtgtgga cgagccttga gttatcatcg
      601 ctcttttcca gtacgtgaaa ggactcatcc tggaggaaag ccctatgatt gtaaggaatg
      661 tggagaaacc tttatttctc ttgtaagcat tcgaagacac atgttaacgc ataggggagg
      721 tgtaccttac aaatgtaagg tgtgtgggaa agcctttgat tatcccagtt tatttcgtat
      781 acatgaaaga agtcacactg gagagaaacc ttatgaatgc aagcaatgtg ggaaagcctt
      841 cagttgttcc agttacatta gaatacatga aaggactcac actggagata aaccctatga
      901 atgcaagcag tgtgggaaag ctttcagttg ttccaagtac attcgaatcc atgaacgaac
      961 tcacacagga gagaaaccct acgaatgtaa acagtgcggt aaagccttta ggtgcgccag
     1021 ttctgttcga agtcacgaga ggactcacac cggagagaaa ctttttgaat gtaaggaatg
     1081 cgggaaggct ttgacttgtc ttgcaagtgt tagaagacac atgataaagc acactggcaa
     1141 tggaccttat aaatgtaagg tgtgtgggaa agcctttgat ttccccagtt catttcgaat
     1201 ccatgaaagg acccacactg gagagaaacc ctatgattgt aagcaatgtg ggaaagcctt
     1261 cagttgttcc agttcgtttc gaaaacatga aagaattcac actggagaga aaccctataa
     1321 atgtacaaaa tgtgggaaag ccttcagtcg ttccagttac ttccgaatcc atgaaagaac
     1381 tcacactgga gagaaaccct atgaatgtaa gcaatgtggg aaagccttca gtcgatccac
     1441 ttactttcga gtacatgaaa aaattcatac tggagagaaa ccctatgaga accctaaccc
     1501 taacgcttca gttgtcccag ttctttcatg agcatgaaag gagtcacata gagaaacccc
     1561 atgaaagtaa gaaatttggg aaagccttca gtcctttctg tttctttcaa ctacgtgaaa
     1621 ggattcacag tggagaaaga ccctgtaaga taattggctt taaattacga gagacttgtg
     1681 ataggacagt aaaacctaga gttggagttg gatctctgga ttgtgttatg tcagtgttgg
     1741 taggttagga actagatttc ccagaatcca ttccatttgt gattccatga tacaattcac
     1801 cagtaaccta tcttacatga gattcggaag taagttaaga aggcattagt catggtttgg
     1861 aagcaccata cagggagaca gctgtgtgaa tacaggctgt atggacactt gcttccatcc
     1921 cattttcctg cttctttggg ttgccaatca agagtatcct caaaacgact tgactttaat
     1981 tttctcggag gtgataggct tccacacagg tctccagaag ccctgcattg aatatccatc
     2041 cacactttgg ttttccttca gacattatta tgtctgtact aggcaactaa ttcagactgt
     2101 cctggttggg aatattctgt gatgctctga ctcccctagt ctgtagacgg aattggcata
     2161 cggtctaatt tgtgtagtaa gcacctttgt tcatactagt agtgactgta ttcttgattc
     2221 agcctgatag ctaccatgct gctgtcaaaa ccaaccagag gggagcttgt tcttctgctg
     2281 tagtgtgcag tgactggcct cacccaggac tttgatgtga gaatgagcac tttcctctat
     2341 caggaaattt caagtgtttc ctgttattcg tagctcaatg taatgcctca gttcattttc
     2401 agttgtttga ttatatgtga ctaatatgta ttttttattc aaacaagact tctgtacatg
     2461 tttcttcaaa acagtttatt aactgtcttc agtcttggat tacatcaagt ttataatttt
     2521 ggcaaattgt taagacactg tgaagtcagc gttaaccatg tgcatacaac ttaaggaatt
     2581 ttttcctcct catgtaaatt ttacttttca tgcttatata gtttcaactt ttatcttcat
     2641 agtaatttct catctactca taataccaaa agttaagtca tgctgttttg tgtgctctct
     2701 tgctaaagac cgcagagacc atacctgttg tcaaagaggg tgtaataaac tgtaataata
     2761 atcatgacca caaaccataa aggactgtgt gatgtatcag taa
//
