LOCUS       NM_001076675            6063 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens zinc finger protein 626 (ZNF626), transcript variant
            1, mRNA.
ACCESSION   NM_001076675
VERSION     NM_001076675.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6063)
  AUTHORS   Del-Aguila,J.L., Beitelshees,A.L., Cooper-Dehoff,R.M.,
            Chapman,A.B., Gums,J.G., Bailey,K., Gong,Y., Turner,S.T.,
            Johnson,J.A. and Boerwinkle,E.
  TITLE     Genome-wide association analyses suggest NELL1 influences adverse
            metabolic response to HCTZ in African Americans
  JOURNAL   Pharmacogenomics J 14 (1), 35-40 (2014)
   PUBMED   23400010
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010636.6.
            
            On Nov 22, 2018 this sequence version replaced NM_001076675.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.128093.1,
                                           SRR1803611.194313.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144, SAMN03267765
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000601440.6/ ENSP00000469958.1
            RefSeq Select criteria :: based on manual assertion
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               AC010636.6         1570-1697
            129-255             AC010636.6         16736-16862
            256-351             AC010636.6         17362-17457
            352-6063            AC010636.6         37491-43202
FEATURES             Location/Qualifiers
     source          1..6063
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p12"
     gene            1..6063
                     /gene="ZNF626"
                     /note="zinc finger protein 626"
                     /db_xref="GeneID:199777"
                     /db_xref="HGNC:HGNC:30461"
     exon            1..128
                     /gene="ZNF626"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1712
                     /gene="ZNF626"
                     /note="isoform 1 is encoded by transcript variant 1;
                     CTC-513N18.7"
                     /codon_start=1
                     /product="zinc finger protein 626 isoform 1"
                     /protein_id="NP_001070143.1"
                     /db_xref="CCDS:CCDS42535.1"
                     /db_xref="GeneID:199777"
                     /db_xref="HGNC:HGNC:30461"
                     /translation="MGPLQFRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFLG
                     ITVSKPDLITCLEQGRKPLTMKRNEMIAKPSVMCSHFAQDLWPEQSMKDSFQKVVLRR
                     YEKCEHDNLQLKKGCISVDECKVHKEGYNELNQCLTTTPRKICQCDKYVKVLHQFPNS
                     NGQKRGHTGKKPFKYIECGKAFKQFSTLTTHKKIHTGGKPYKCEECGKAFNHSCSLTR
                     HKKIHTGEKPYKCEECGKAFKHSSTLTTHKRNHTGEKPYKCDKCGKAFMSSSTLSKHE
                     IIHTEKKPYKCEECGKAFNRSSTLTTHKIIHTGEKPYKCEECDKAFKYSYTLTTHKRI
                     HTEDKPYKCEECGKAFKYSSTLTTHKRIHTGEKPYKCEECGKAFKRSSDLTTHKIIHT
                     GEKPYKCEECGKAFKYSSNLTTHKKIHTGERPYKCEECGKAFNQSSILTTHRRIHTGE
                     KFYKCEECGKAFKCSSNLTTHKKIHTGERPYKCEECGKAFNQSSILTTHERIILERNS
                     TNVKNVAKPSSGPHTLLHIR"
     exon            129..255
                     /gene="ZNF626"
                     /inference="alignment:Splign:2.1.0"
     exon            256..351
                     /gene="ZNF626"
                     /inference="alignment:Splign:2.1.0"
     exon            352..6063
                     /gene="ZNF626"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3730..3735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF626"
                     /note="hexamer: AATAAA"
     polyA_site      3753
                     /gene="ZNF626"
                     /note="major polyA site"
     regulatory      5856..5861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF626"
                     /note="hexamer: AATAAA"
     polyA_site      5878
                     /gene="ZNF626"
     regulatory      5908..5913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF626"
                     /note="hexamer: AATAAA"
     polyA_site      5931
                     /gene="ZNF626"
                     /note="major polyA site"
     regulatory      6040..6045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF626"
                     /note="hexamer: AATAAA"
     polyA_site      6063
                     /gene="ZNF626"
ORIGIN      
        1 gtctctcgct gcagtcagag ctccaggtct ggttcttctc ctaaaggccc aggctgtgtg
       61 gccccgtgtc ctgcaggtat tgggagatcc acagctaaga caccgggacc tcctggaagc
      121 caaaaatggg accattgcaa tttagagatg tggccataga attctctctg gaggagtggc
      181 attgcctgga cactgcacag cggaatttat ataggaatgt gatgttagag aactacagta
      241 acctggtctt ccttggtatt actgtttcta agccagacct gatcacctgt ctggagcaag
      301 gaagaaaacc tttgaccatg aagagaaatg agatgatagc caaaccctca gtaatgtgtt
      361 ctcattttgc ccaagacctt tggccagagc agagcatgaa agattctttc caaaaagtgg
      421 tactgagaag atatgaaaaa tgtgaacatg acaatttaca gttaaaaaaa ggatgtataa
      481 gtgtggatga gtgtaaggtg cacaaagaag gttataatga acttaaccaa tgtttgacaa
      541 ctaccccaag aaaaatatgt caatgtgata aatatgtgaa agtccttcat caatttccaa
      601 attcaaacgg acaaaagaga ggacatactg ggaaaaaacc tttcaaatat atagaatgtg
      661 gcaaagcttt taagcagttc tcaactctta ctacacataa gaaaattcat actggaggga
      721 aaccctacaa atgtgaagaa tgtggcaaag cctttaacca ctcttgtagc cttactagac
      781 ataagaaaat tcatactgga gagaaaccct acaaatgtga agaatgtggc aaagccttta
      841 agcactcctc cactcttact acacataaga gaaatcatac tggagagaaa ccctacaagt
      901 gtgataaatg tggcaaagcc tttatgtcat cctcaaccct tagtaaacat gagataattc
      961 atacggaaaa gaaaccctac aaatgtgaag aatgtggcaa agccttcaac cggtcctcaa
     1021 cccttactac acataagata attcatactg gagaaaaacc ctacaaatgt gaagaatgtg
     1081 acaaagcctt taagtactcc tataccctta ctacacataa aagaattcat actgaagaca
     1141 aaccctacaa atgtgaagaa tgtggcaaag cctttaagta ctcctctacc cttactacac
     1201 ataagagaat tcatactgga gagaaaccct acaaatgtga agaatgtggc aaagccttca
     1261 agcggtcttc agaccttact acgcataaga taattcatac tggagagaaa ccctacaaat
     1321 gtgaagaatg tggcaaagct tttaagtact cctctaacct tactacacat aagaaaattc
     1381 atactggaga gagaccctac aaatgtgaag aatgtggcaa agccttcaac cagtcctcaa
     1441 tccttactac acataggaga attcatactg gagagaaatt ctacaaatgt gaagaatgtg
     1501 gcaaagcttt taagtgctcc tctaacctta ctacacataa gaaaattcat actggagaga
     1561 gaccctacaa atgtgaagaa tgtggcaaag ccttcaacca gtcctcaatc cttactacac
     1621 atgagagaat catactggag agaaattcta caaatgtgaa gaatgtggca aagccttcaa
     1681 gcggtcctca caccttacta cacataagat aattcatact ggagagaaat tctacaaatg
     1741 tgaagaatgt gacaaagctt ttaagcattt ctctaacctt actacacata agaaaattca
     1801 tactggaaaa aaaccctaca gatgtgaaga atgtggcaaa gcctttaagc actcctctaa
     1861 acttactaca cataagagat ttcatactgg agagaaaccc tacagatgtg aataatgtgg
     1921 taaagctttt cacctatcct cacaccttac tgcacataag ataattcata ctggagagaa
     1981 accatgtgaa tgtgatgaat ggggaaaatc ttttaaccag ccctcaattt ctaactaaga
     2041 attgatatga aatataaact ctacaaatat aaagaatgtg acagattttt taaggaactt
     2101 ctcaaccttt attacacata attcatactg gaaagaaacc ctacaagtgt gaagaatgtg
     2161 gcaaagcata taacaagttc tgtctttttt tttttttttt tgagatggag tttcaactct
     2221 tgtcacccag tctggtgtgc aatagcacag tctcggctca ctgcaacctc cgccttctgg
     2281 gttcaatcca ttctcctgcc tcaacctccc aagtaagggg gattacaggt gcccaccccc
     2341 atgcccagct aacttttgta tttttagtag agacaaggtt acaccatgtt tgtcaggctg
     2401 gtatccaacc cctgacctca catgatccac ccacctcagc ctcctaaagt gttgcaatta
     2461 caggcatgag ccaccatgcc tggccacaag ttcttactat taagagacat ggtgataatt
     2521 cattctgaag aggaactcta caaacctgaa agatgtgaca gtgctttttt caacacttcc
     2581 atcctttcta tacataaaaa atttatacta gtgtgaaacc ctagaaatat ataaaatgtg
     2641 aaacagcctt tatatggttg ccacatttga tagtaagata attcatactg gcaaaattcc
     2701 tacaagcatg aagaatgtgg caaaaccttt aatcaatgtg tacatcttat tttgcaggaa
     2761 agctattatc cttgagaaaa attgtacaaa tataaagaat atggaaaacc cattaatgcc
     2821 tactcacatc ttactcaaca taagaaggtt catagttaat gaaagcatta aaagtgcaat
     2881 tactgtcaaa aaatctttca gaaaatataa gcctttaaag tgaagaagag tatttattct
     2941 gaagacaacc attacaaata tacaggaggt ttattacaca cattttgtac tagaggaaaa
     3001 tcctgaagca gttgctcaag ctttgctcaa catcagagaa cttatattgg agaagggtcc
     3061 tgcaaatgta atgaatttgg aaacacttta aaaaaaaaaa actacagctt agaaaacagc
     3121 agagtttata ctaaaatata tttttgcaga tgcagtaaac atgaaaaaat atttaattca
     3181 aaattaattg tatgtaaata tcagaattta cagaataact aaggcactga cacttcagac
     3241 attacattaa ataagagtgt tgagtatata aatgaattca caactaaagt tgttaaattt
     3301 gtatataagt ttgtataaat tagtatataa ctttaaaagg agattttttg aagctttgta
     3361 tttacattga aagtatattt gtttccttga aaacaatttt tttgaaaagt gaatgatgta
     3421 atacagcttt caaattatgc tgttacttta ttatattcac gtgaaagtat gtgatcaatt
     3481 gttgctgcat cagagatatt agagattctt tatgagttgg gcattcttta tgaccttttc
     3541 tataaaacag taaggacatt aaaatgtaag atgcatgacg aaaatataag tggagaggct
     3601 cattgtagtt aacctatatt aagtaatgtt taaggtaggt gttcagagta atacttttct
     3661 acattatact gagagaaaga aattataaat taaagtatat caattatttt actaatttta
     3721 ctgttacgta ataaaatgca atatatttaa aaattgttag atgatgtgtg aacttaactt
     3781 atattttatt tacttactta acttttcttt tgagatggag tcttgctctg tcacccaggc
     3841 tggagggcag cagtgcagtc tcagcacaat gactgcaacc tccacctccc aagttcaaga
     3901 aattctcctg cctcagcctc ccgagtagtg gggactacag gtgcgtgaca ccacgcctgg
     3961 ctaattttta tatttttaat agacatgggg tttccccata ttggtcaggc tagtctcaaa
     4021 ctcctgagct caagcgatcc acccacctca ggctctcaaa gtgttgggat tataggtgtg
     4081 agccaatatg tccagcctaa ttttatttta ttttttacca tcttaaaact attgtgcatt
     4141 taatgaagca ttattatgcc actaacttta acctatccgg ccttactcaa atggtgtaag
     4201 caaaagatgg aagaagtata ctatttggta tgtagtggaa tgtcatcact agtaatcact
     4261 ttgccagtaa actgcaaatg aagaatattg ttcccgttag ttaaattttt aatctttttt
     4321 cttaatttat tattactatc tgtgagtata tagtatgtgt atatatgtct tatagagaat
     4381 attttgattc aggcatacaa tatgtagtaa ttacattagg gtaaataagg tatctgtcac
     4441 ctctagcatt tatcctttct aatccaaaca gtgtaattat acacttttag ttacttttaa
     4501 atgtccaatt aaattgtaat tgactacagg gtgattttta tggtcataat aaaaattata
     4561 cagaaatata aatagaatat gggctggacg cagtggctca tgcctgtaat cccagcactt
     4621 tggtaggcga cgtcgggcag atcatgaggt caggagttca agaccagcct gaccaacatt
     4681 gtgaaactct ctactaaaac aacaaaaatt agttgggcat ggtggtgcac ccgtattcct
     4741 agctactcgg gaagctgagg caggagaatg gcttgaacct gggaggtgga ggtttcagtg
     4801 agctgagata gcaccactgc actccagcct gggtgacaga cggacactcc atctcaaaaa
     4861 gaaagaaaaa agccaggaca gtggcttaca cctgtaatcc cagcactttg ggaggcccag
     4921 gcaggtggat catgaggtca ggagatcaag accatcctgg ctaacacgtt gaaaccctgt
     4981 ctctactaaa aataaattag ctgggcgtgg tggtgggcgc ctgtagtccc agctactcca
     5041 gaggctgagg cgggagaatg gtgtaaccca ggaggcagag gttgcagtga gccgagatcg
     5101 tgccactgca ctccagcctg ggcaacagag caagactccg tcacaaaaaa aaaaagaaaa
     5161 aatacggcca tgtgcagtgc ctcatgccta ttatcccagc aatttcggag gctgaggcag
     5221 gtgtgttgct tgagctcagg agttcaagac cagcctcgcc aatgtggtga aaccctgtct
     5281 ctactaaaaa tagaaaaatt agccagtcat ggtggcgcac acctggaggc tgaggtagga
     5341 gaatcacttg aacttgggag gtggagattg cagtgagcca agattgtgct gctgcactcc
     5401 agcctgggtg acagagtgat gagactcctc aaaggaaaaa aaattacatt tctgagtcct
     5461 gaaaaattat taataaatat ttgttatata gtttctttga acatgtggtc actctgcctg
     5521 caaacgtaaa gacttttaat tttcatagag tgaaatatac acatattcct ctgaagataa
     5581 accttaggtg taagaaaatt atgaaatgag tgtttggtaa atatgcattt gtacatattt
     5641 tcagaagaaa acgcaattat tggaacaaaa taagttttta ggtgattaat ggaaaactaa
     5701 acaccttgaa tatgctgaaa gcaaatgtat actttctgct ttgtatggaa tttattaata
     5761 taaaatttta tggcttatgg ctcggattct ccccagaatc cgtgtattaa agcacaggca
     5821 actttgtctc cagaaataac actcttgagt acaacaataa aagccctctt caaacacact
     5881 caaaaaatta tttttaacgc ttattttaat aaaaatttaa ccaaaattga ataattggat
     5941 acatttttat tgttctatgt gtgtgtgaat gtataaaatg acacataaag gaataataat
     6001 ttaagccaga aaaaaagatg ttagttaata tttgtaatga ataaaactgg aaagtagtta
     6061 tta
//
