LOCUS       NM_033414               1707 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 622 (ZNF622), mRNA.
ACCESSION   NM_033414
VERSION     NM_033414.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1707)
  AUTHORS   Lv,K., Gong,C., Antony,C., Han,X., Ren,J.G., Donaghy,R., Cheng,Y.,
            Pellegrino,S., Warren,A.J., Paralkar,V.R. and Tong,W.
  TITLE     HectD1 controls hematopoietic stem cell regeneration by
            coordinating ribosome assembly and protein synthesis
  JOURNAL   Cell Stem Cell 28 (7), 1275-1290 (2021)
   PUBMED   33711283
REFERENCE   2  (bases 1 to 1707)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1707)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1707)
  AUTHORS   Hasegawa,Y., Taylor,D., Ovchinnikov,D.A., Wolvetang,E.J., de
            Torrente,L. and Mar,J.C.
  TITLE     Variability of Gene Expression Identifies Transcriptional
            Regulators of Early Human Embryonic Development
  JOURNAL   PLoS Genet 11 (8), e1005428 (2015)
   PUBMED   26288249
  REMARK    GeneRIF: Results from a study on gene expression variability
            markers in early-stage human embryos shows that ZNF622 is a
            putative expression variability marker for the 3-day, 8-cell embryo
            stage.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1707)
  AUTHORS   Seong,H.A., Jung,H., Manoharan,R. and Ha,H.
  TITLE     Positive regulation of apoptosis signal-regulating kinase 1
            signaling by ZPR9 protein, a zinc finger protein
  JOURNAL   J Biol Chem 286 (36), 31123-31135 (2011)
   PUBMED   21771788
  REMARK    GeneRIF: ZPR9 was found to physically interact with ASK1 through a
            disulfide linkage;ZPR9 functions as a novel positive regulator of
            ASK1.
REFERENCE   6  (bases 1 to 1707)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 1707)
  AUTHORS   Seong,H.A., Kim,K.T. and Ha,H.
  TITLE     Enhancement of B-MYB transcriptional activity by ZPR9, a novel zinc
            finger protein
  JOURNAL   J Biol Chem 278 (11), 9655-9662 (2003)
   PUBMED   12645566
  REMARK    GeneRIF: ZPR9 plays an important role in modulation of the
            transactivation by B-MYB and cellular growth of neuroblastoma cells
REFERENCE   8  (bases 1 to 1707)
  AUTHORS   Seong,H.A., Gil,M., Kim,K.T., Kim,S.J. and Ha,H.
  TITLE     Phosphorylation of a novel zinc-finger-like protein, ZPR9, by
            murine protein serine/threonine kinase 38 (MPK38)
  JOURNAL   Biochem J 361 (Pt 3), 597-604 (2002)
   PUBMED   11802789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020980.6 and BC008752.2.
            
            On Nov 22, 2018 this sequence version replaced NM_033414.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.49304.1,
                                           SRR1803617.87846.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308683.3/ ENSP00000310042.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC020980.6         164809-164823       c
            16-1707             BC008752.2         1-1692
FEATURES             Location/Qualifiers
     source          1..1707
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.1"
     gene            1..1707
                     /gene="ZNF622"
                     /gene_synonym="ZPR9"
                     /note="zinc finger protein 622"
                     /db_xref="GeneID:90441"
                     /db_xref="HGNC:HGNC:30958"
                     /db_xref="MIM:608694"
     exon            1..760
                     /gene="ZNF622"
                     /gene_synonym="ZPR9"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1569
                     /gene="ZNF622"
                     /gene_synonym="ZPR9"
                     /note="zinc finger-like protein 9"
                     /codon_start=1
                     /product="cytoplasmic 60S subunit biogenesis factor
                     ZNF622"
                     /protein_id="NP_219482.1"
                     /db_xref="CCDS:CCDS3886.1"
                     /db_xref="GeneID:90441"
                     /db_xref="HGNC:HGNC:30958"
                     /db_xref="MIM:608694"
                     /translation="MATYTCITCRVAFRDADMQRAHYKTDWHRYNLRRKVASMAPVTA
                     EGFQERVRAQRAVAEEESKGSATYCTVCSKKFASFNAYENHLKSRRHVELEKKAVQAV
                     NRKVEMMNEKNLEKGLGVDSVDKDAMNAAIQQAIKAQPSMSPKKAPPAPAKEARNVVA
                     VGTGGRGTHDRDPSEKPPRLQWFEQQAKKLAKQQEEDSEEEEEDLDGDDWEDIDSDEE
                     LECEDTEAMDDVVEQDAEEEEAEEGPPLGAIPITDCLFCSHHSSSLMKNVAHMTKDHS
                     FFIPDIEYLSDIKGLIKYLGEKVGVGKICLWCNEKGKSFYSTEAVQAHMNDKSHCKLF
                     TDGDAALEFADFYDFRSSYPDHKEGEDPNKAEELPSEKNLEYDDETMELILPSGARVG
                     HRSLMRYYKQRFGLSRAVAVAKNRKAVGRVLQQYRALGWTGSTGAALMRERDMQYVQR
                     MKSKWMLKTGMKNNATKQMHFRVQVRF"
     exon            761..1021
                     /gene="ZNF622"
                     /gene_synonym="ZPR9"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1184
                     /gene="ZNF622"
                     /gene_synonym="ZPR9"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1297
                     /gene="ZNF622"
                     /gene_synonym="ZPR9"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1441
                     /gene="ZNF622"
                     /gene_synonym="ZPR9"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1707
                     /gene="ZNF622"
                     /gene_synonym="ZPR9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1689..1694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF622"
                     /gene_synonym="ZPR9"
                     /note="hexamer: AATAAA"
     polyA_site      1707
                     /gene="ZNF622"
                     /gene_synonym="ZPR9"
                     /note="major polyA site"
ORIGIN      
        1 agtgacaatc aggaagtcgg cgtgtcgagt ggctcttcct ggctgctgag gcgggttaag
       61 gtctgagggt cttgtggggc cacggcgctg atcaccaggt gtttggcttg gtcggttctt
      121 atttctcgcc tggcaatggc gacgtacacc tgcataactt gccgggtggc gttccgcgac
      181 gcggacatgc agcgggccca ctataagacg gactggcacc gctacaacct gcggcggaag
      241 gtggccagca tggccccagt gaccgccgag ggcttccagg agcgagtgcg ggcgcagcgg
      301 gccgtcgcgg aggaggagag caagggctcg gccacctact gcaccgtttg cagtaagaag
      361 tttgcctctt tcaacgccta cgagaaccac ctcaagtccc ggcgtcacgt tgagctggag
      421 aagaaggccg tgcaggcagt gaatcggaaa gtggagatga tgaatgaaaa gaacttggag
      481 aaaggactgg gcgtggacag tgtggacaag gatgccatga acgcggccat ccagcaggcc
      541 atcaaggccc agccgtccat gtctcccaag aaggcgcccc cagcgcctgc aaaggaggcc
      601 aggaatgtcg tggccgtggg tactggtggc cgtgggaccc acgaccgaga cccgagtgag
      661 aaaccacccc ggctccagtg gtttgaacag caggcgaaga agttggcaaa gcagcaggag
      721 gaggacagcg aggaggagga agaggacctg gatggagacg attgggaaga tattgattct
      781 gatgaagaat tggaatgtga ggatactgaa gcaatggacg atgtggtgga gcaggatgca
      841 gaggaggaag aggctgagga aggcccaccc cttggtgcca tccctatcac ggactgctta
      901 ttttgttccc atcattccag ctcgctgatg aagaatgtgg ctcacatgac caaagaccac
      961 agtttcttta ttcctgatat agaatatctt tcagatatta agggactgat taaatacttg
     1021 ggagagaaag ttggtgttgg caagatttgc ttgtggtgca acgagaaagg gaagtccttc
     1081 tactccacag aagctgtaca ggcacatatg aatgacaaaa gccactgtaa gctcttcaca
     1141 gatggcgatg ctgctttgga atttgcagac ttctatgatt ttaggagtag ctatccagat
     1201 cacaaggaag gggaggaccc caataaggct gaggagttgc cctcagaaaa gaacttggaa
     1261 tatgatgatg aaaccatgga attgattctg ccttctggtg ccagagtggg tcatcgctcc
     1321 ttgatgagat actacaaaca gcgatttggc ttgtcaagag ctgtggcagt tgccaaaaat
     1381 cggaaggccg tgggccgagt acttcagcag tacagagccc tgggatggac tggcagcaca
     1441 ggagcggctc ttatgcgaga gcgagacatg cagtatgtcc aaaggatgaa atcaaaatgg
     1501 atgctgaaga caggaatgaa gaacaatgcc accaagcaga tgcactttcg ggtccaagtg
     1561 agattctgag agtctgctgg gattgagcaa tcatctcctg cccaagtttc ctccttgccc
     1621 tgaggaccag tgaaagacag atcataggag agaccctttt gctgctactt cattcgttct
     1681 gacctaataa taaaagttag aaccata
//
