LOCUS       NM_198484               8389 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 621 (ZNF621), transcript variant
            1, mRNA.
ACCESSION   NM_198484 XM_209541
VERSION     NM_198484.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8389)
  AUTHORS   Li,J., Li,Y., Liu,L., Wu,D., Yang,T. and Fan,Y.
  TITLE     LINC01140 Regulates Radiosensitivity of Nasopharyngeal Carcinoma
            Cells Through the ceRNA Network
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 68 (4), 75-85 (2022)
   PUBMED   35988287
  REMARK    GeneRIF: LINC01140 Regulates Radiosensitivity of Nasopharyngeal
            Carcinoma Cells Through the ceRNA Network.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8389)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK127181.1, AC122683.4 and N51540.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198484.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Both variants 1 and
            2 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.46357.1,
                                           SRR1803612.69928.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339296.10/ ENSP00000340841.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AK127181.1         83-135
            54-315              AC122683.4         4221-4482
            316-401             AC122683.4         4987-5072
            402-528             AC122683.4         8527-8653
            529-636             AC122683.4         9417-9524
            637-8049            AC122683.4         11238-18650
            8050-8389           N51540.1           14-353              c
FEATURES             Location/Qualifiers
     source          1..8389
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.1"
     gene            1..8389
                     /gene="ZNF621"
                     /note="zinc finger protein 621"
                     /db_xref="GeneID:285268"
                     /db_xref="HGNC:HGNC:24787"
     exon            1..315
                     /gene="ZNF621"
                     /inference="alignment:Splign:2.1.0"
     exon            316..401
                     /gene="ZNF621"
                     /inference="alignment:Splign:2.1.0"
     CDS             378..1697
                     /gene="ZNF621"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 621 isoform 1"
                     /protein_id="NP_940886.1"
                     /db_xref="CCDS:CCDS2693.1"
                     /db_xref="GeneID:285268"
                     /db_xref="HGNC:HGNC:24787"
                     /translation="MLQTTWPQESVTFEDVAVYFTQNQWASLDPAQRALYGEVMLENY
                     ANVASLVAFPFPKPALISHLERGEAPWGPDPWDTEILRGISQGGESWIKNEGLVIKQE
                     ASEETELHRMPVGGLLRNVSQHFDFKRKALKQTFNLNPNLILRGGMKFYECKECGKIF
                     RYNSKLIRHQMSHTGEKPFKCKECGKAFKSSYDCIVHEKNHIGEGPYECKECGKGLSS
                     NTALTQHQRIHTGEKPYECKECGKAFRRSAAYLQHQRLHTGEKLYKCKECWKAFGCRS
                     LFIVHQRIHTGEKPYQCKECGKAFTQKIASIQHQRVHTGEKPYECKVCGKAFKWYGSF
                     VQHQKLHPVEKKPVKVLGPSLVSPQCSSPAIPPVLLQGSCSASAVAVPSLTFPHAVLI
                     PTSGNFFMLLPTSGIPSSSAQIVRVFQGLTPTVKPSPVILTPSSHSS"
     exon            402..528
                     /gene="ZNF621"
                     /inference="alignment:Splign:2.1.0"
     exon            529..636
                     /gene="ZNF621"
                     /inference="alignment:Splign:2.1.0"
     exon            637..8389
                     /gene="ZNF621"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8136..8141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF621"
                     /note="hexamer: AATAAA"
     polyA_site      8159
                     /gene="ZNF621"
                     /note="major polyA site"
     regulatory      8373..8378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF621"
                     /note="hexamer: AAGAAA"
     polyA_site      8389
                     /gene="ZNF621"
ORIGIN      
        1 cttccggctc ggcctttagt tagtgaccag ctcctcggcg ttctgcagag cgtgggtttc
       61 agcgagttct acgtgccagg tccgcccggt gccggcttcc tcgctgcccc tggcggctcg
      121 tcagccccca ctacccctga acttggtccc aatggcggcc cgcccctcct tcacccggac
      181 cgtgggcatc tgggcctcgc cgaagccgtc aaggtggctg ctcgggcttc tagagcccgt
      241 gtccagccct ttgccaccga ggcctgatcc tcttttctgc cctaaagaac ttgccctgac
      301 agcctctggc tcccgctctt gaggatcttg cttgtccaaa cccagaagac agtgcatgaa
      361 gccaggggac atccgccatg ctccaaacaa cttggcctca ggagtcagtg acctttgagg
      421 atgtggctgt ttacttcacc cagaatcaat gggccagcct cgaccctgcg cagagggccc
      481 tgtacgggga ggtgatgctg gagaattatg caaatgtggc ttctctggta gcgtttccat
      541 tccccaaacc tgctctgatc tcccacctgg agagagggga agcaccatgg ggcccagatc
      601 cctgggacac cgagattctg agaggcatca gtcaaggtgg tgagtcctgg atcaaaaatg
      661 aagggctagt tataaagcag gaagcctctg aagaaacaga gttgcacaga atgccagtag
      721 gaggacttct caggaacgtt tctcagcact ttgattttaa aaggaaggca ctgaagcaga
      781 ctttcaatct aaatccaaat ctgatacttc gaggtggaat gaagttctat gaatgtaaag
      841 aatgtgggaa aatcttccga tataactcaa agcttattcg gcatcagatg agtcatactg
      901 gggaaaagcc ctttaagtgt aaggagtgtg gcaaagcttt caagtccagc tatgattgta
      961 ttgtacatga gaaaaaccac attggagaag ggccctatga atgtaaggag tgtggcaaag
     1021 gtttgagttc caacacagcc ttgactcaac atcagaggat ccacactgga gagaaaccct
     1081 atgaatgtaa agagtgtgga aaggctttcc gtaggagtgc ggcatacctg cagcatcaga
     1141 gattacacac gggagagaaa ctctataaat gtaaggaatg ttggaaagct ttcggttgta
     1201 ggtcactttt tattgtccat cagagaattc atactgggga gaaaccttat caatgtaagg
     1261 agtgtggcaa agccttcacc cagaaaatag cctccattca gcatcagaga gttcacactg
     1321 gggagaagcc ttatgaatgt aaggtgtgtg ggaaagcctt caaatggtat ggaagttttg
     1381 ttcagcatca gaaattgcac cctgtggaga agaagccagt caaggtcctt gggccatccc
     1441 tggtcagtcc ccagtgctcc tctccagcca tacctcctgt tcttctccag ggatcctgtt
     1501 ctgcttcagc cgtagctgtg ccttcactga cctttccaca tgctgtgctc attcctacct
     1561 ctgggaattt tttcatgctg ctgcctacat ctggaatacc ttcttcatct gcccaaatag
     1621 tgcgtgtctt ccagggtctt actcccactg tgaaaccttc cccagttatt ctcacccctt
     1681 cttctcactc ctcatgagct ttatcttggc agtcttacgg ctcttatgcc tagcaaatct
     1741 ccagcctaat tttatatatt tttttgagaa agggtcttgc tctgtcaccc aggctagagt
     1801 gcggtggtgt gatcttggct cactgcaacc tccccctcct gggttcaagc gattctcctc
     1861 cttcagactc tcgaatagct gggattacag gcacgcctca ccacgcccag ctaatttctg
     1921 tatttttaga agagatgggg tttcgccatc ttggccaggc tggtctcaaa cacctgacct
     1981 caagtgatcc gcctgccttg gccccccaaa gtgctgggat tacaggagtg agccactgtg
     2041 cccagcctcc aacctaattt gagtttcatt tgtatttttt tcatcacctt acatgtgtta
     2101 acagctgttt caacataaac tccattataa tctatataca tttaaagacc gtgtttacat
     2161 aatctcttct gggtagaaaa tggaaatact taacctttgc attggtccct ttcaggcttg
     2221 aacaacagtg gctgtatctg catcgtgggg ttgctggtgg tagaacactt tggtgttagg
     2281 aaagtttgga aaagaggata tccctgtatt aggccattat gattagagat aagcagcctg
     2341 ggagaaacat acaagacctg tggctactgg tagagaattg gaataagctt ccaacaatgg
     2401 actgtagaga ttaatggaga ttgtttagtg ggcccatggc taggtggggt attaatacag
     2461 ttgaagttat gttgcccttg gcacagatct ttgagaatct catacatctg tgaaaaagat
     2521 aatgtgaaat aaacagtaaa aaaaaaaagt atgttgatgg cagtgagagt aatcatgtct
     2581 ttaaacgtga agtttttttt tctttagttt tgctcttgat agctagatgt ttcttttaac
     2641 ttttatttcg taagtaaata tacacaaagg cattcatctt tgttgaatct gttgtgcaga
     2701 tttttcttga tgagcattct gttttttttt ctttgtgagc actggcttct atattttatt
     2761 tcatatttat gaattataaa tatgaattta attactaaag aaataaaaat aatggtgtaa
     2821 agccaactcg aggggaatct gaataagctt ccaaaatttt tttttttaag aaataaaggg
     2881 agctgtgtag tgggtcagtg gctaggtagg ttagtgaagt ggaatttggg gttgctcttg
     2941 gaagtggcct tgatgaggat cctttacaac tattcagagg actgtgtgaa gtagttactg
     3001 gaaaaagaac ttgaattatg catttattgg cattaatgta aacagtaagt cctaagcttt
     3061 gatggaaggg tccatacatt tttttttttt ttttgctgat gttgctatct agatgtttct
     3121 ctatagcaat taatagcaaa acctttacat tcttggtttt taaactttac catgtgtctg
     3181 aattacatag tgtgcttgta aaaagaagag ttttctctct tgcacaaatt ctgattttgg
     3241 ctatctgtgg tgatggccag atctttagca tggaccatac tttgagagat atgcttcaaa
     3301 cagaaaatgc ccacccctcc tcctttaccc agcataaact ctatggttaa ttcttaaaat
     3361 aatgccttac agtctccatt aactcccttg cccttctctt gctttgtcat gctcgcttgg
     3421 caaaacctca tctctgacta aatgcagttc tttgccttct ctgttcctgc accaaaaatg
     3481 atcaggagaa agcatattac caggctgaac tgtcacttta aattcatgac cagtaacttc
     3541 atggaggccc ttaacgtttc ctgatggtca tactacaatt tttggagtcc acttaactcc
     3601 cctgctttcc taggccacta ctttatactt tctctcttct gtaacttcca aagcatccct
     3661 ctcagttctc atgctcagct gatggttatg tttctgcctt cggcgagaga acagcaagct
     3721 ccagaaagtg gctgcgcctt cagccccgtg ctagaatgag aacatatgga gccaacttga
     3781 gttcggaagg gctgtggcca cctcgtttcg cccatctact tttcaccttg ccgtatctga
     3841 ttcttcacca ccgtattctc agtcacttcc actaaacagt gccagtgttt taaggttctg
     3901 tcacactcag taacccactt ctggttcctc attccgtgtc agtgatcagc agtagactga
     3961 agaatctacc ttagatttgc tccatactat taattagctt acaaaatgtc taagaggagc
     4021 taagctggga tgccacatag gcagaagcca ggaaaaatga ccaaccacag aaccaagtgg
     4081 ttccagtgga aactcagcag ctgctggtgc ctgctactgg actgccaccc cccattgaag
     4141 agactggacc accaggaagg tcgtttcaca ttctgtagta aaaatacccc tacaatcatt
     4201 ttggtagggt cttctgtctt cagccagggt gtacctgctc ggtgggagtt ggttatatat
     4261 gtatgtccaa gttgcagggg cttctgggaa atacaggttt tggattctgc ctgggaagag
     4321 agtcatagta tgaagaagtc tgaaaatggg gaagggattt tcagaatatg ttgagcagct
     4381 gtaaaatatc agatacccat tataggcatt gaaggttacc taaatgacag aaggatgcac
     4441 tatattcatg ggtaggaaag attagtttca tcaagatttc aatttttatc aattcataaa
     4501 ttaaaaacaa tataaaaatt ccagaggggt gtgtgtatag agaggcaaag gacacagagt
     4561 agctaaccta gttttgaaga acaagatggg gggttttatg ctaccagata ttatatacaa
     4621 tgatcatcaa acacagaaca aagcaaaaaa caaactcccc aaacccaagt tgaaacaaaa
     4681 aaaaccccca gactgtaata gtattattat tattttttaa gatggaatct tgctctgttg
     4741 ctcaggctgg agtgcagtgg tgcaatcttg gctcactgca acctacacct cccgggttca
     4801 agtgattctc ttgcctcagc ctcctgagta gtgtgtgcca ccacgcccag ctaatttttt
     4861 aatttttagt agagacaggg tttcaccatg ttggccaggc tggtcttgaa ctcctggcag
     4921 cctcaagtga tccacccacc tcggtctccc aaagtgttgg gattacaggc gtgagccact
     4981 gcacctggcc tgtaacatga tttgctgaaa tttttaaaaa tcttaaataa tgtactgttt
     5041 agaaatatac atattttata caaaattata aagaaagcat agagaggtaa gcattagtgg
     5101 cacagctgag aaaatataaa aggtagttct gtctctatcc tgtctccttt attctgctac
     5161 tgctctcatt ctgtctcatc ccaggaatcc agtcccaagt gctgcctgcc aatcgtccag
     5221 caccctccac ctttgccacc tatttcttgt tgtaaaacag atgtttgttt ctaaaatata
     5281 atgaattaat gattatcaaa gtacaggcat acctcatttt attgcagttt gttttattgt
     5341 gtcttgcgga tattgcattt tttacaaact gaaggtttgt ggcaggcctg tgttgagcaa
     5401 gactatcagt gccatttttt ttcaacagca tgtgctcatt tcatttttct gtgtcttaca
     5461 cagaaactta aaatatttca aacttttcat tatatgtgtt ttggtgatta gtgactttta
     5521 tgtttctatt gtaattgttt tggggtgcca cagactgcat ccatctaaga cagtgagctt
     5581 agttgatgtg tgtgtgtgtg ttctgattac tccactaact gatggttccc catctctctc
     5641 cctctcctca gacctcacta ttctctcaga cacaacagta ttgaaattag accaattgat
     5701 aaccttacaa acacctttaa gtgtttaagt gaaaaagtca catgcctctc actttaaatc
     5761 aaaagctaga aatgattaag cttagtgagg aaggctaatg tcaacagctg agataggcca
     5821 aaagctagac tgcttctgcc aaacagtcaa gttgtgaatg caaaagaaaa gttcttgaag
     5881 gaaatgaaaa gtacttctcc agggaacaca tgaacgataa taaagtggcc aggtgcagtg
     5941 gctgacacct agaatcccag cacttcgggg agccaaagcg ggaggatccc ctgaagccag
     6001 gagtccgaga ccagcttggg ccacaaagtg agacccctgt ctctacaaaa aattaaaaat
     6061 ttagctgggt gtggttgtgc atgcctgtag tccgatctac ttgggaggct gaagtgagag
     6121 gatcccttta gccagggagt tcgagactgc agtgagctat gattgtgcca ctgcactcta
     6181 gcctgtgtga cagaatgaaa ccaaaaaaag tgaaacagca ttattactga tatggagaaa
     6241 gttttagggg tctggatcaa accaaccaca aattccctta agccaaaacc taatccagag
     6301 caaggccata actgccattg tatgaaggct gagagaagtg aggaagctgc aggaaagttt
     6361 gaagctagca gaggttggtt catgaggttt aagaagtcat cttatcataa aagtgcaagg
     6421 tgaagcagca agtgctggtg tagaagctgt agcaatttat ccagatctag ctaagttaat
     6481 tgatgaagtt gctacaccac gagattttca gtgtattcca aacagccttc ttttggaaga
     6541 agaaaccatc taggactttc atggagaaga gaagttaatc cctggcttaa aagcatcaaa
     6601 ggacagctcg tctctcttgt taggggttca tgcagctggt aactttaagt tgaagccaat
     6661 gctcatttac cattcagaaa atcctagggc ccataagaat tatgctaaat ccactctgcc
     6721 tgtgctctag aaatggaaga tcaaagcctg gatgacagca catctgttta cagcatggat
     6781 tactgaatat tttaagccca ctgttgagac ctactaaata ttaggaaaaa agaattctgt
     6841 caggtgtggt ggctcacact tgtaatccca acactttggg aggccaaggc aggtggatca
     6901 gttgaggtca ggagtttgag accagcctga ccaacatgga gaaaccctat ctctactaaa
     6961 aatacaaaaa ttagctggat gtggtggtgt gtgcctgtaa tcccagctac ttgggaggct
     7021 gaggcaggag aattgcttga atccagaggc agaggttgca gtgagctgag gttgcaccac
     7081 tgtgcttcag cctgggtaac agagtgagac tgtctcaaaa aaaaaaaaaa tttagttcca
     7141 aatattactg ctcgttgata atgtgtctgg tcacccaaga gttctgatgg agatgtacaa
     7201 agagattaat gtttttatgt ctgctaaaca acatccattc tgcaggatcc attactccat
     7261 gggtcaagga gtaattttga ctttcaagta ttatttaagg aatacatttt gtaaggctgt
     7321 ggctgccata gtggttgttc tgtacaaagt aacttgaaaa ccttctggaa aggattcatc
     7381 attctagatg ccattaagga catttgtgat tcatgggaga aggtcaaaat atcaacatta
     7441 acaggagttc agaagacatt gacctcaacc ctgatggatg atcttgaggg gttcaagact
     7501 tcagtggacg aagtaactgc agatgtggtg gaaatagcaa gataactaga cttagaagtg
     7561 gaacctgcat atgtgactga attgctgcaa tctcatgata aaacgtgaac aaatgaggag
     7621 ttgcttctaa tataagagcc acaaaagtgg tttcttgaga tggaaactac tcctggtgaa
     7681 gatcctgtga ccattgttga aatgacaaca aaggacttag aatattacat aaacttagtt
     7741 gataaaacag cagcagagtt tgagaggatt gacttcaatt ttgaagaatg ttccactgtg
     7801 ggtaaaaggc tatccaacag caacacatgc tacagataaa tctttcggaa aggaagagtc
     7861 agttgatgtt gcagccttcc ttgttgtctc atttaaagaa atctctagag ccacactaac
     7921 cttcagcaac caccacaccg atcattcagc agccatcaac agtgaggcaa gactgtcttc
     7981 cagcaacaaa gactcactga agacttagat tatcgttaac atcttttagc aataaaatat
     8041 ttttaaatta aagtatgtac attgtcagat ataatgctat tgcaaactta atagactata
     8101 atatagatta aacataactt ttataggtac tggaaaataa aaataattgt gtgactccct
     8161 ttattgtgtt aaacatttta ttacagttgt ctggaagcaa acctgcaata tctccaagat
     8221 atgcctgtat ttttcaaaat gtggtctttt aacattgcta tgaagtttat cagtaataat
     8281 atcttatttc atggttgtcc agaagttaca taacttgtct taatctaaaa atcatatcat
     8341 ttaaaaagcc tgatgattta atatttttca taaagaaaac ttttgacaa
//
