LOCUS       NM_001145093            4841 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 619 (ZNF619), transcript variant
            2, mRNA.
ACCESSION   NM_001145093
VERSION     NM_001145093.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4841)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121754.6.
            
            On May 17, 2019 this sequence version replaced NM_001145093.3.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the central coding region, compared to variant 1, resulting
            in an isoform (2) that is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            CCDS Note: This CCDS representation is supported by the splicing
            pattern of BC143304.1. It should be noted that this mRNA is 5'
            partial and does not encode the first 4 aa of the protein.
            Therefore, this representation includes a 5' extension based on
            other transcript data at this locus. This extension completes an
            N-terminal KRAB box, as found in many other zinc finger proteins.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.94193.1,
                                           SRR1660805.258809.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000432264.4/ ENSP00000388710.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               AC121754.6         2353-2588
            237-322             AC121754.6         3149-3234
            323-476             AC121754.6         7094-7247
            477-593             AC121754.6         7819-7935
            594-4841            AC121754.6         12037-16284
FEATURES             Location/Qualifiers
     source          1..4841
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.1"
     gene            1..4841
                     /gene="ZNF619"
                     /note="zinc finger protein 619"
                     /db_xref="GeneID:285267"
                     /db_xref="HGNC:HGNC:26910"
     exon            1..236
                     /gene="ZNF619"
                     /inference="alignment:Splign:2.1.0"
     exon            237..322
                     /gene="ZNF619"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..2029
                     /gene="ZNF619"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 619 isoform 2"
                     /protein_id="NP_001138565.1"
                     /db_xref="CCDS:CCDS46803.1"
                     /db_xref="GeneID:285267"
                     /db_xref="HGNC:HGNC:26910"
                     /translation="MLQTVWFQGLGRNLLFQEPVTFEDVAVYFTQNEWASLHPTQRAL
                     YREVMLENYANVTSLSAFPFPKPDLIFQLEQGEAAWGPDPWTLAGGEALRGMCTGGKT
                     KTENEEKTAQLNISKESESHRLIVEGLLMDVPQHPDFKDRLEKSQLHDTGNKTKIGDC
                     TDLTVQDHESSTTEREEIARKLEESSVSTHLITKQGFAKEQVFYKCGECGSYYNPHSD
                     FHLHQRVHTNEKPYTCKECGKTFRYNSKLSRHQKIHTGEKPYSCEECGQAFSQNSHLL
                     QHQKLHGGQRPYECTDCGKTFSYNSKLIRHQRIHTGEKPFKCKECGKAFSCSYDCIIH
                     ERIHNGEKPYECKECGKSLSSNSVLIQHQRIHTGEKPYECKECGKAFHRSSVFLQHQR
                     FHTGEQLYKCNECWKTFSCSSRFIVHQRIHNGEKPYECQECGKTFSQKITLVQHQRVH
                     TGEKPYECKECGKAFRWNASFIQHQKWHTRKKLINGTGLSAVKPYCPCAILSPLPPQH
                     TCSALAPPGPPLSSSHAVVLPPSVPFFLLLPSSEKANPSPVQIAHFFQDLAFPGKSSL
                     QSPNPLSHSL"
     exon            323..476
                     /gene="ZNF619"
                     /inference="alignment:Splign:2.1.0"
     exon            477..593
                     /gene="ZNF619"
                     /inference="alignment:Splign:2.1.0"
     exon            594..4841
                     /gene="ZNF619"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4000..4005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF619"
                     /note="hexamer: AATAAA"
     polyA_site      4025
                     /gene="ZNF619"
                     /note="major polyA site"
     regulatory      4816..4821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF619"
                     /note="hexamer: AATAAA"
     polyA_site      4841
                     /gene="ZNF619"
                     /note="major polyA site"
ORIGIN      
        1 gtagggaccg acggccggcc agctaatgct tccgtcttgg ccaccttgcg agcgctcggg
       61 ttgagtttcc cgggcttccc tgactcggct acctgttctg gaggtcaggc tttgggccct
      121 tgcagaggtc gccgaggggc ccgcgccgcc gccagagcct gggcccagtc cccagtcttc
      181 agagacgccc tcgaccttcc tgctccgagg agctggcctg atgtcctcgg gtcgcgctcc
      241 gcaggttctt actttttcaa acctagaggg cagtgcatga agccaggggt catcagccat
      301 gctccagaca gtgtggttcc agggcttggg caggaacctg ttgtttcagg agccagtaac
      361 ctttgaggat gtggctgtgt acttcaccca gaatgaatgg gccagcctgc accctacgca
      421 gagggcccta tacagggagg tgatgctgga gaattatgca aatgtgactt ccttgtcagc
      481 atttccattc cccaaaccag atctgatatt ccagctggag caaggagaag cagcatgggg
      541 cccagatccc tggacacttg ctgggggaga ggccctgaga ggcatgtgca caggtggtaa
      601 aaccaagact gagaatgagg aaaaaactgc acagctaaac atttctaaag aatcagagtc
      661 ccacagactg atagtggagg gactgctgat ggacgttccc cagcaccctg acttcaagga
      721 caggttagag aagtcacagc tacatgatac agggaataaa acaaagatag gggattgcac
      781 agatttgaca gtccaggatc atgaatcttc caccactgaa agggaggaga tagccaggaa
      841 attggaagaa agtagtgtca gcacacatct cattacaaag cagggttttg ccaaagaaca
      901 ggtgttttat aaatgtggtg agtgtggcag ttactacaac ccacattcag actttcacct
      961 gcatcagaga gttcacacta atgagaagcc ctacacatgc aaagaatgtg ggaaaacctt
     1021 cagatataac tcaaaactgt cacggcatca gaaaatccac actggagaga aaccatactc
     1081 atgtgaggaa tgtggacaag ccttcagtca aaattcccac cttcttcagc atcagaagct
     1141 ccatggtgga cagaggccct atgaatgtac tgactgtggt aaaaccttca gttataattc
     1201 aaaactgatt cggcatcaga gaatccatac tggggagaag ccctttaaat gtaaggaatg
     1261 tgggaaagcc ttcagttgta gctatgactg catcatccat gaacgaattc acaatgggga
     1321 gaagccctat gaatgtaagg agtgtgggaa gagtttgagt tctaattcag ttctgattca
     1381 gcatcagaga atccacactg gggagaaacc ttatgaatgt aaagagtgtg gcaaggcctt
     1441 ccaccgcagt tcggtatttc ttcagcacca gaggttccac actggggaac aactctacaa
     1501 atgtaatgaa tgttggaaaa ctttcagctg tagctcccgc ttcatagtgc atcagagaat
     1561 ccacaatggg gagaaaccct atgaatgcca ggaatgtggg aagacattca gtcaaaagat
     1621 cactctggtt cagcatcagc gagttcacac tggggagaaa ccttatgagt gtaaggagtg
     1681 cgggaaagcc ttcagatgga atgcaagttt catccagcat cagaagtggc atactaggaa
     1741 gaaactcatc aatggaacag ggctatccgc agttaagccc tactgtccct gcgccatcct
     1801 ctctcctctg cctccccaac atacctgctc tgccctagcc ccaccagggc ctcccttatc
     1861 ttcttcacat gcagtggtac ttcctccctc tgtgcctttc ttcctgctgc ttccctcatc
     1921 tgaaaaggcc aacccttcac ctgtccaaat agcacatttt tttcaggatc tcgcttttcc
     1981 tgggaagtca tcccttcaga gcccgaatcc tttgtctcac tccctgtaag ccccgtcacg
     2041 ttctcaaaat cctttgcacc tcaagttagg gattccactg gtctcctgat tgtgtctatt
     2101 gatattcctc tggtcttgtc ttgtataagt tgttactgtt ttcctaactt cattttaaat
     2161 tctcacgctt aaggaccatg tttgattagt ttcttttatc ccccggtagg aaatggcagt
     2221 acttattctt tatcgtgtcc acatttgggc tgtattatca gtctgcatct ctcttctggg
     2281 gctactggag ttggaagagt ttgcagaaca ttttggggtt tagggcatat ggcattatga
     2341 ttatgatgag atggggcatt ataattagag actaggagaa atgcaaagcc tatgggagaa
     2401 cataatcaga taaagtgtcc aatgattgct ttcaagagct tttttttttt tagggggtgg
     2461 ggggtggtgc cggagtttca ctcttgtcac ccaggctgtt tgcagtggtg tgatcttggc
     2521 tcactgcaac ctctgcctcc agggttcaag tgattctcat gcctcagcct cccgagtagc
     2581 tgggaccaca ggcatgcacc accacgcccc gctaattttg tatttttagt agagacaggg
     2641 tttcaccatg ttggccaggc tggtctcaaa atcctgacct caggtgattc acctgcctca
     2701 gtctcccaag tgctgggatt acaggcatga gccactgcat ctggcctgct ttcaggagtt
     2761 aaggagggcc atttggtgga ccaggggcaa ggctcactga aagaatgtaa gacttggaat
     2821 tttttattac cttgatagta taaaaaatta tgagggtcct tttatgcaaa aagaaaatga
     2881 agtgatgagt tggcattgat agcaataatg taaaattatg tctttgagct ttattggaag
     2941 gggatatggt ttttcaattt gggttccttc tctattttca ttttcctttt ttttttgaga
     3001 caggttcttg ttctgtcatc caggctggat tgcagtagtg cgatcatgga tcactgcagt
     3061 gtgttgacct tccaggctca agcaatcctc ccacctcagc ttcccaagaa gctgggaggt
     3121 agtgcagcct cccagtttct cagagggctg aggtgggagg attgcttgag ccctgggggc
     3181 atacaccacc acacccagct aatttttgta ttttttgtag agacagagtt ttgccatgtt
     3241 gcccaggctg gtctcaaaac tcctggactc aaatgatcct cccacttcag cctcccaaag
     3301 tgctgggatt acaggcttga gccaccatgt ccagcctcta ttccttttca tatctgttga
     3361 atttcagtac ccactcatat atgtaggtac aaaaagtgac ttggacttgt accctttagg
     3421 gtagatgcct gagtatagta atctctaaag ctgtacatgg atggaacttg ttggcatcac
     3481 actggtgagc accagaggca aagaagagaa acctgaccat gacttgctgt agtttctcag
     3541 aagtgagtcc attcctgatg agttactatg caggcccttg gatatgtcct cacacctact
     3601 ccagatttcc ctatgattaa atctgaattt tattggtggc acttttaaat tagttttata
     3661 aagaactgtt ttgatgacac caagaaatgt tttcagtgtg cagattgcta ttgtttgaat
     3721 atccccagca aaattcttgt tgaaacttaa tccccattgt aacagtactg ggtggggggt
     3781 ctttaagagg tgatcaggat tagccaagtt catcagggtg gagcctccat gatgggactg
     3841 gtggctttat gaggagagga agagcaactg gaactgggac acatgcttgc tctgtcttgc
     3901 cttttgatgc ctcctgccat gtcatgatgc agcaagtaag cccttaccag atgcctgcac
     3961 ctttatattg gacttcttag ccttcagaac tgtgaactaa ataaacctct attctgtata
     4021 aattacccag tctatggtat tcagttagag ccacacaaaa tgtaacaaga cagaatattg
     4081 atagccataa gtaggtttgc tgctctgaca tttacataaa aatgtagaag tggctttgga
     4141 actgagtaat gggtagaggc ttgaaaaatc tggaagatca ggtcagacaa agcctgtatt
     4201 atctaatgga gcattaaggg tgattttggc caaggcttag aagagaagac tagggaaagt
     4261 ctgaaccttc ttagagatta caggaggtcc ttgaacaact tgggtttcaa ctgtgtgggt
     4321 ccacttatgg actttcttct gcctctgtca cccctgagat ggcaagacca gtctccctcc
     4381 tctccccttc tcagcctgct taacaaaatg acaaggatac agacctttat gatgatccat
     4441 ataatatagt gaattatatt tactaaatat aatttctctt atgattttct taatattttc
     4501 tctagcttta ttataagaat atagtgtcta atatgtataa cataaaaaat atgtgttaat
     4561 cgactgtttc agtaaggctc tggtcaacag tagactatta gtagttacat ttttggggag
     4621 ttaaaagtta tacatggcat gggggttggt gcccatatga tgggactgat ggctttataa
     4681 gaagaggaag ggagacctga gctgacatgc atgctcttgc catcttgcca tgtgatgctt
     4741 tccatcatgt tatgacacag caagaaggcc agatacggcc cctccacagt tcccagccct
     4801 cggaaccatg agctaaataa acttcttttc tttataaatt a
//
