LOCUS       NM_015042               9006 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens zinc finger protein 609 (ZNF609), mRNA.
ACCESSION   NM_015042 XM_011521386 XM_042833
VERSION     NM_015042.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9006)
  AUTHORS   Gao,J., Wang,C., Zhang,J., Shawuti,Z., Wang,S., Ma,C. and Wang,J.
  TITLE     CircZNF609 inhibits miR-150-5p to promote high glucose-induced
            damage to retinal microvascular endothelial cells
  JOURNAL   Mol Cell Endocrinol 590, 112261 (2024)
   PUBMED   38679361
  REMARK    GeneRIF: CircZNF609 inhibits miR-150-5p to promote high
            glucose-induced damage to retinal microvascular endothelial cells.
REFERENCE   2  (bases 1 to 9006)
  AUTHORS   Ouyang,X., He,Z., Fang,H., Zhang,H., Yin,Q., Hu,L., Gao,F., Yin,H.,
            Hao,T., Hou,Y., Wu,Q., Deng,J., Xu,J., Wang,Y. and Chen,C.
  TITLE     A protein encoded by circular ZNF609 RNA induces acute kidney
            injury by activating the AKT/mTOR-autophagy pathway
  JOURNAL   Mol Ther 31 (6), 1722-1738 (2023)
   PUBMED   36110046
  REMARK    GeneRIF: A protein encoded by circular ZNF609 RNA induces acute
            kidney injury by activating the AKT/mTOR-autophagy pathway.
            Erratum:[Mol Ther. 2022 Nov 2;30(11):3500. doi:
            10.1016/j.ymthe.2022.09.021.. PMID: 36202101]
REFERENCE   3  (bases 1 to 9006)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 9006)
  AUTHORS   Guan,C., Liu,L., Zhao,Y., Zhang,X., Liu,G., Wang,H., Gao,X.,
            Zhong,X. and Jiang,X.
  TITLE     YY1 and eIF4A3 are mediators of the cell proliferation, migration
            and invasion in cholangiocarcinoma promoted by circ-ZNF609 by
            targeting miR-432-5p to regulate LRRC1
  JOURNAL   Aging (Albany NY) 13 (23), 25195-25212 (2021)
   PUBMED   34898474
  REMARK    GeneRIF: YY1 and eIF4A3 are mediators of the cell proliferation,
            migration and invasion in cholangiocarcinoma promoted by
            circ-ZNF609 by targeting miR-432-5p to regulate LRRC1.
REFERENCE   5  (bases 1 to 9006)
  AUTHORS   Wang,J., Lin,Y., Jiang,D.H., Yang,X. and He,X.G.
  TITLE     CircRNA ZNF609 promotes angiogenesis in nasopharyngeal carcinoma by
            regulating miR-145/STMN1 axis
  JOURNAL   Kaohsiung J Med Sci 37 (8), 686-698 (2021)
   PUBMED   33943007
  REMARK    GeneRIF: CircRNA ZNF609 promotes angiogenesis in nasopharyngeal
            carcinoma by regulating miR-145/STMN1 axis.
REFERENCE   6  (bases 1 to 9006)
  AUTHORS   Xiong,Y., Zhang,J. and Song,C.
  TITLE     CircRNA ZNF609 functions as a competitive endogenous RNA to
            regulate FOXP4 expression by sponging miR-138-5p in renal carcinoma
  JOURNAL   J Cell Physiol 234 (7), 10646-10654 (2019)
   PUBMED   30478938
  REMARK    GeneRIF: our current study reveals the role of the
            circ-ZNF609/miR-138-5p/FOXP4 regulatory network in renal carcinoma
            and provides a new perspective for the pathogenesis of renal
            carcinoma.
REFERENCE   7  (bases 1 to 9006)
  AUTHORS   Legnini,I., Di Timoteo,G., Rossi,F., Morlando,M., Briganti,F.,
            Sthandier,O., Fatica,A., Santini,T., Andronache,A., Wade,M.,
            Laneve,P., Rajewsky,N. and Bozzoni,I.
  TITLE     Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions
            in Myogenesis
  JOURNAL   Mol Cell 66 (1), 22-37 (2017)
   PUBMED   28344082
  REMARK    GeneRIF: Circular RNA circ-ZNF609 is associated with heavy
            polysomes, and it is translated into a protein in a
            splicing-dependent and cap-independent manner, resulting in a
            protein that controls myoblast proliferation.
REFERENCE   8  (bases 1 to 9006)
  AUTHORS   Peng,L., Chen,G., Zhu,Z., Shen,Z., Du,C., Zang,R., Su,Y., Xie,H.,
            Li,H., Xu,X., Xia,Y. and Tang,W.
  TITLE     Circular RNA ZNF609 functions as a competitive endogenous RNA to
            regulate AKT3 expression by sponging miR-150-5p in Hirschsprung's
            disease
  JOURNAL   Oncotarget 8 (1), 808-818 (2017)
   PUBMED   27903978
  REMARK    GeneRIF: these findings illustrated that cir-ZNF609 took part in
            the onset of HSCR through the crosstalk with AKT3 by competing for
            shared miR-150-5p.
REFERENCE   9  (bases 1 to 9006)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   10 (bases 1 to 9006)
  AUTHORS   Zody,M.C., Garber,M., Sharpe,T., Young,S.K., Rowen,L., O'Neill,K.,
            Whittaker,C.A., Kamal,M., Chang,J.L., Cuomo,C.A., Dewar,K.,
            FitzGerald,M.G., Kodira,C.D., Madan,A., Qin,S., Yang,X., Abbasi,N.,
            Abouelleil,A., Arachchi,H.M., Baradarani,L., Birditt,B., Bloom,S.,
            Bloom,T., Borowsky,M.L., Burke,J., Butler,J., Cook,A.,
            DeArellano,K., DeCaprio,D., Dorris,L. 3rd, Dors,M., Eichler,E.E.,
            Engels,R., Fahey,J., Fleetwood,P., Friedman,C., Gearin,G.,
            Hall,J.L., Hensley,G., Johnson,E., Jones,C., Kamat,A., Kaur,A.,
            Locke,D.P., Madan,A., Munson,G., Jaffe,D.B., Lui,A., Macdonald,P.,
            Mauceli,E., Naylor,J.W., Nesbitt,R., Nicol,R., O'Leary,S.B.,
            Ratcliffe,A., Rounsley,S., She,X., Sneddon,K.M., Stewart,S.,
            Sougnez,C., Stone,S.M., Topham,K., Vincent,D., Wang,S.,
            Zimmer,A.R., Birren,B.W., Hood,L., Lander,E.S. and Nusbaum,C.
  TITLE     Analysis of the DNA sequence and duplication history of human
            chromosome 15
  JOURNAL   Nature 440 (7084), 671-675 (2006)
   PUBMED   16572171
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091231.10 and AC090543.12.
            
            On or before Aug 7, 2019 this sequence version replaced
            XM_011521386.2, NM_015042.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.2695100.1,
                                           ERR4352444.168347.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326648.5/ ENSP00000316527.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               AC091231.10        71310-71570         c
            262-1135            AC091231.10        31982-32855         c
            1136-1361           AC090543.12        141097-141322
            1362-1449           AC090543.12        188616-188703
            1450-3790           AC090543.12        192186-194526
            3791-4157           AC090543.12        196386-196752
            4158-4333           AC090543.12        198455-198630
            4334-4550           AC090543.12        198916-199132
            4551-4629           AC090543.12        199579-199657
            4630-9006           AC090543.12        199962-204338
FEATURES             Location/Qualifiers
     source          1..9006
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..9006
                     /gene="ZNF609"
                     /note="zinc finger protein 609"
                     /db_xref="GeneID:23060"
                     /db_xref="HGNC:HGNC:29003"
                     /db_xref="MIM:617474"
     exon            1..261
                     /gene="ZNF609"
                     /inference="alignment:Splign:2.1.0"
     exon            262..1135
                     /gene="ZNF609"
                     /inference="alignment:Splign:2.1.0"
     CDS             389..4624
                     /gene="ZNF609"
                     /codon_start=1
                     /product="zinc finger protein 609"
                     /protein_id="NP_055857.1"
                     /db_xref="CCDS:CCDS32270.1"
                     /db_xref="GeneID:23060"
                     /db_xref="HGNC:HGNC:29003"
                     /db_xref="MIM:617474"
                     /translation="MSLSSGASGGKGVDANPVETYDSGDEWDIGVGNLIIDLDADLEK
                     DQQKLEMSGSKEVGIPAPNAVATLPDNIKFVTPVPGPQGKEGKSKSKRSKSGKDTSKP
                     TPGTSLFTPSEGAASKKEVQGRSGDGANAGGLVAAIAPKGSEKAAKASRSVAGSKKEK
                     ENSSSKSKKERSEGVGTCSEKDPGVLQPVPLGGRGGQYDGSAGVDTGAVEPLGSIAIE
                     PGAALNPLGTKPEPEEGENECRLLKKVKSEKMESPVSTPAVLPIHLLVPVVNNDISSP
                     CEQIMVRTRSVGVNTCDVALATEPECLGPCEPGTSVNLEGIVWQETEDGMLVVNVTWR
                     NKTYVGTLLDCTRHDWAPPRFCDSPTSDLEMRNGRGRGKRMRPNSNTPVNETATASDS
                     KGTSNSSKTRAGANSKGRRGSQNSSEHRPPASSTSEDVKASPSSANKRKNKPLSDMEL
                     NSSSEDSKGSKRVRTNSMGSATGPLPGTKVEPTVLDRNCPSPVLIDCPHPNCNKKYKH
                     INGLKYHQAHAHTDDDSKPEADGDSEYGEEPILHADLGSCNGASVSQKGSLSPARSAT
                     PKVRLVEPHSPSPSSKFSTKGLCKKKLSGEGDTDLGALSNDGSDDGPSVMDETSNDAF
                     DSLERKCMEKEKCKKPSSLKPEKIPSKSLKSARPIAPAIPPQQIYTFQTATFTAASPG
                     SSSGLTATVAQAMPNSPQLKPIQPKPTVMGEPFTVNPALTPAKDKKKKDKKKKESSKE
                     LESPLTPGKVCRAEEGKSPFRESSGDGMKMEGLLNGSSDPHQSRLASIKAEADKIYSF
                     TDNAPSPSIGGSSRLENTTPTQPLTPLHVVTQNGAEASSVKTNSPAYSDISDAGEDGE
                     GKVDSVKSKDAEQLVKEGAKKTLFPPQPQSKDSPYYQGFESYYSPSYAQSSPGALNPS
                     SQAGVESQALKTKRDEEPESIEGKVKNDICEEKKPELSSSSQQPSVIQQRPNMYMQSL
                     YYNQYAYVPPYGYSDQSYHTHLLSTNTAYRQQYEEQQKRQSLEQQQRGVDKKAEMGLK
                     EREAALKEEWKQKPSIPPTLTKAPSLTDLVKSGPGKAKEPGADPAKSVIIPKLDDSSK
                     LPGQAPEGLKVKLSDASHLSKEASEAKTGAECGRQAEMDPILWYRQEAEPRMWTYVYP
                     AKYSDIKSEDERWKEERDRKLKEERSRSKDSVPKEDGKESTSSDCKLPTSEESRLGSK
                     EPRPSVHVPVSSPLTQHQSYIPYMHGYSYSQSYDPNHPSYRSMPAVMMQNYPGSYLPS
                     SYSFSPYGSKVSGGEDADKARASPSVTCKSSSESKALDILQQHASHYKSKSPTISDKT
                     SQERDRGGCGVVGGGGSCSSVGGASGGERSVDRPRTSPSQRLMSTHHHHHHLGYSLLP
                     AQYNLPYAAGLSSTAIVASQQGSTPSLYPPPRR"
     exon            1136..1361
                     /gene="ZNF609"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1449
                     /gene="ZNF609"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..3790
                     /gene="ZNF609"
                     /inference="alignment:Splign:2.1.0"
     exon            3791..4157
                     /gene="ZNF609"
                     /inference="alignment:Splign:2.1.0"
     exon            4158..4333
                     /gene="ZNF609"
                     /inference="alignment:Splign:2.1.0"
     exon            4334..4550
                     /gene="ZNF609"
                     /inference="alignment:Splign:2.1.0"
     exon            4551..4629
                     /gene="ZNF609"
                     /inference="alignment:Splign:2.1.0"
     exon            4630..9006
                     /gene="ZNF609"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8177..8182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF609"
                     /note="hexamer: AATAAA"
     polyA_site      8205
                     /gene="ZNF609"
     regulatory      8977..8982
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF609"
                     /note="hexamer: AATAAA"
     polyA_site      9006
                     /gene="ZNF609"
                     /note="major polyA site"
ORIGIN      
        1 ggttgtcccg gatcgcggcg gcggcggcgg tggcggcggc tgagggaccc gcggccccgg
       61 acacagcggc accggccggg cggggcggag aggcgcgggg agggggcaga gagccagagc
      121 cggagccgga gccggagccg gggtggggtg ggggggaggg gccgcgggaa cggatggcgg
      181 cctgggcccc gtagcagcgg cggctctacg gcccggggcc ccgggcgggc ggaggtggcg
      241 gctcccggga ccggccgcgc gcaatgatgt tgtccactgg gcatgtactg accaatgtgg
      301 caggtctgag aacatagctg aagctgaaaa taggaaagct gggggcaagg aagagccttg
      361 aatcttgagg tgggacgttg actctaagat gtccttgagc agtggagcct ccggagggaa
      421 aggagtggat gcaaacccgg ttgagacata cgacagtggg gatgaatggg acattggagt
      481 agggaatctc atcattgacc tggacgccga tctggaaaag gaccagcaga aactggaaat
      541 gtcaggctca aaggaggtgg ggataccggc tcccaatgct gtggccacac taccagacaa
      601 catcaagttt gtgaccccag tgccaggtcc tcaagggaag gaaggcaaat caaaatccaa
      661 aaggagtaag agtggcaaag acactagcaa acccactcca gggacttccc tgttcactcc
      721 aagtgagggg gcagctagca agaaagaggt gcaggggcgc tcaggagatg gtgccaatgc
      781 tggaggcctg gttgctgcta ttgctcccaa gggctcagag aaggcggcta aggcatcccg
      841 cagtgtagcc ggttccaaaa aggagaagga gaacagctca tctaagagca agaaggagag
      901 aagcgaagga gtggggactt gttcagaaaa ggatcctggg gtcctccagc cagttccctt
      961 gggaggacgg ggtggtcagt atgatggaag tgcaggggtg gatacaggag ctgtggagcc
     1021 acttgggagt atagctattg agcctggggc agcgctcaat cctttgggaa ctaaaccgga
     1081 gccagaggaa ggggagaatg agtgtcgcct gctaaagaaa gtcaagtctg aaaagatgga
     1141 gtcccctgtt tccacaccag cagtgctgcc aatacacctt ttggtgccag tggtcaacaa
     1201 tgacatctca tctccctgtg agcagatcat ggttcgtacc cgatcagttg gggtcaacac
     1261 atgtgatgtg gctctggcca cagagcctga gtgcttgggc ccctgtgaac ctggaactag
     1321 cgtcaacctt gaaggcatcg tgtggcagga aacagaagat gggatgttgg tggtaaatgt
     1381 aacgtggagg aacaagacat atgtaggtac actccttgac tgcacacgac atgattgggc
     1441 acccccaagg ttctgtgact ccccgaccag tgacctggaa atgcgcaatg gccggggtag
     1501 aggcaaacgc atgcgtccca acagtaatac acctgtcaat gagacagcca cagcctctga
     1561 cagcaaaggg accagtaaca gcagcaaaac ccgggcagga gccaatagca aaggccgtcg
     1621 gggcagccag aattcttcag agcaccgccc acctgccagc agcacttctg aggatgtcaa
     1681 ggccagccct tcctcagcta ataagcggaa aaacaaaccc ctttcagaca tggagctgaa
     1741 ttctagctca gaggactcca aagggagcaa gcgtgtccgt actaattcca tgggctcagc
     1801 cactggcccc cttcctggga caaaggtaga acccactgtt ctggacagaa actgcccctc
     1861 ccccgtccta attgactgtc cccacccaaa ctgcaacaag aagtacaagc acatcaatgg
     1921 acttaagtac caccaagctc atgcccatac agatgatgac agcaagccgg aagcggatgg
     1981 ggacagtgag tacggagagg aacctattct ccatgcagat cttgggagct gcaacggtgc
     2041 atctgtctca caaaaaggtt ccttgtcccc tgcccgctca gctaccccca aagttcgact
     2101 tgtagagccc catagccctt ctccttcaag caaattcagc acaaaaggcc tctgtaagaa
     2161 aaagttgagt ggggaagggg acacagacct tggggcctta tccaatgatg gctctgatga
     2221 tggaccctca gtgatggatg aaacaagcaa tgatgccttt gattctttag aaaggaagtg
     2281 tatggaaaaa gaaaaatgta aaaaaccctc tagtttaaaa cctgaaaaga ttccttccaa
     2341 gagcctaaag tcagcccgtc ccattgcccc tgccatcccc ccacagcaaa tctacacctt
     2401 ccagacagcc accttcacag cagcgagccc aggctcttcc tcaggcttga ccgccacagt
     2461 ggcacaagcc atgcccaaca gtccccaact caagcccatt cagcccaagc ccactgttat
     2521 gggagaacct ttcacagtca accctgcctt gactccagcc aaggacaaga aaaagaaaga
     2581 caaaaaaaag aaggaatctt caaaggaact tgaaagtcct ctgacccctg ggaaggtgtg
     2641 tcgagcagag gaaggcaaaa gcccattcag ggaatcttca ggagatggga tgaaaatgga
     2701 ggggctccta aatggctcat cagaccccca ccaaagccga ctggctagca tcaaggctga
     2761 agccgacaag atctacagtt tcacggacaa tgcccccagc ccttccattg gaggcagtag
     2821 ccgccttgaa aacactaccc ctactcagcc cctgactccc ttacatgtgg tgacccagaa
     2881 tggagctgaa gccagctcag tcaaaaccaa cagccctgca tactctgaca tctctgatgc
     2941 tggggaggat ggggagggca aggtagacag tgtcaaatca aaggacgccg aacagttggt
     3001 taaagaaggg gctaagaaaa ctctttttcc ccctcagcct cagagcaaag actcaccata
     3061 ttaccaaggc tttgagagtt actattctcc aagttatgca cagtccagcc ctggggctct
     3121 gaaccccagc agccaggcag gagtggagag ccaggccctg aagacaaaaa gggatgagga
     3181 acctgagagc atagaaggga aagtgaagaa cgatatctgt gaagaaaaga agcccgagct
     3241 gagcagttcc agtcagcagc cctcggtcat ccagcagcgt cccaatatgt acatgcagtc
     3301 cctgtactac aaccagtatg cctatgtacc cccctatggc tacagcgacc agagttacca
     3361 cacccacctt ctgagcacta acacggctta ccggcagcag tacgaagaac agcagaaacg
     3421 ccagagctta gagcagcagc agcggggagt ggacaagaag gcagagatgg gcctgaagga
     3481 gcgggaggca gcactcaagg aagagtggaa gcaaaagccg tcaattccac caactctcac
     3541 caaggccccc agcctgacag acctggtgaa atcaggacct ggcaaggcca aggagccagg
     3601 ggctgaccca gccaaatcag tcatcattcc caagttagat gactcttcaa aactcccggg
     3661 ccaggcccct gaaggcctta aagtgaagct gagtgatgcc agccacctaa gcaaggaggc
     3721 ctctgaggcc aagacaggtg ctgagtgtgg tcgacaggca gagatggatc caatactctg
     3781 gtaccgacag gaggcagagc cccggatgtg gacatatgtt tatcctgcca agtactcaga
     3841 catcaagtca gaggatgagc ggtggaagga ggagcgggac cgcaaattga aggaggaaag
     3901 gagtcggagt aaggactctg tccccaagga agatgggaag gaaagcacaa gtagtgactg
     3961 caagctgccc acgtcagagg agtctcgcct tgggagcaag gagccccggc caagtgtcca
     4021 tgtgcctgtg tcctccccac ttacccagca ccagtcctac atcccctaca tgcacggcta
     4081 ttcctacagt cagtcctacg accccaacca ccccagctac cggagcatgc ctgctgtgat
     4141 gatgcagaac tacccaggtt cctacctgcc ttccagctac tctttttccc catatggcag
     4201 caaggtctca ggtggtgaag atgctgacaa ggcacgagcc agccccagtg tgacttgtaa
     4261 atccagctca gagtccaaag ccctggacat cttgcagcag catgccagtc actacaagag
     4321 caagtctccc acgataagtg ataaaacttc tcaggagaga gatcgaggag gctgtggggt
     4381 ggttgggggt ggtggcagct gtagcagcgt cgggggagca agtgggggtg aacggagtgt
     4441 tgaccggccc cgcacctctc cttcccagcg cctgatgtcc acacaccacc accaccacca
     4501 cttggggtac tcattgctcc cagcacagta caacttaccc tatgcagcag ggctttcttc
     4561 tacagccatt gttgccagcc aacaaggctc aactccctca ctctacccac cccccaggag
     4621 gtgagaatga caccaagtgc ccggataaag tcagcttcac gggcccggac tggcttaccc
     4681 aaggaggtgc tgaaggtgcc gtttagacat cagttaaatg gtgttgatca tcctgtttgc
     4741 cgtttccacc atgactgaag gcagaccctt ggctatctca cctccaccag acctccggac
     4801 tacctgaccc tacctcttcc tcaggagctg gagagctggt acttagcaaa aatatttatt
     4861 ctctcagcca cagttatgac tattgtggcc tctgtggaga tgaaggcacg ggaagcaacc
     4921 aggggaacat ggcctcagcc cagagaagcc actgctctgt tccccaagcc cttggtctgc
     4981 tgctggagca gtaccagccc ccccgcccac cagggaggga cccccacccc caagcactgg
     5041 gtaaggtctg aagacagcac agcagccata cccctcacca tcattaccac catcaccaga
     5101 ttctgcatct ccctagtgct ttgcaccctg ggaattggca gcatgtggag gaactagaat
     5161 ctcaggaaag aaattggggg ttgttttcta cataattgtg aaaacaaggt cttcaaatgt
     5221 ggagacttct ccccatttac atgagcacat ataaacgctc acaacctagc ctggaaagga
     5281 agaccaaggc atctgcccca acatggcctt gagctgcctg tgaggcaggg ggcaggggtt
     5341 ccaacaccag cacagggctc cccagggaca ctgggagcaa gctggtgctg gagcatgaat
     5401 gacgtctgtg aagtagaacc tgcgtcccca ctaagtcctg ctgcttctta ttccccaact
     5461 ccttgccctt ttcccttccc tcctaacccc ttggtgcctt tcccaggggg atccccacac
     5521 tggtcttgcc tcttcttttc cactgcttgg ctcttaagcc tcaggcagat aaactagtat
     5581 tccccccagc ttggggaacc ttggagtctg ccaggtcacc ttagggcaag gcccagaagg
     5641 cagcccctgg gagcacccag cagttcttgg agatgtcctg tcatctagcc atctgatatc
     5701 ttcctcattt gaggccacag atatatacag cccaattcct ctgtctacaa gtacatgatt
     5761 ttatatagct cagtctataa cctccatgtg ggccaatata agctgtgttt cttggtaaca
     5821 catattttgt ttgaggggcc actggccatg ggaggttatt tgttccttag accctggaat
     5881 aacacatcca agccattact tattagagtc tcagaatgta ctcagtggag ctgtgctttg
     5941 aggcagccaa catttctctg ctctccttag aaatgcagtc tcccaatgga agctttatac
     6001 tctttgtact gggaaagtga ggatgatttg gtagctttat tggggtcatg tcttccccaa
     6061 ggtgtgggga gcttagctta cttggctttt gaggtatcat ccctctgttc tcccctccta
     6121 tctttccatg accctctgga ttgagagaga gagataaaga ctgacagaca ccagtgtagg
     6181 ctggaaaagg gagtgtgtga ccagagtgcc aaaagtgact aggagcagga acttggctcc
     6241 gactcagttt ggaaaatggg aaatagggga cagtaagcac aatgcccagt agtagttgat
     6301 ttccaaggac cctggaaccc tacacttgag aggcttaggg tcaccatctg ctcaagagga
     6361 tcccctctga tctacaggcc ttttccctag gtttctgcct cctcgttttt gttcaagttg
     6421 ggttctgagt cctccccaaa aaccattgtt ttagacctct tggcagggcc ccaaaacagc
     6481 ctccctcata cccatcattc cctctgcctt ctgctgccct catgggcagt gctctgagca
     6541 gtgacctccc tttcctccgt ggaagtagct agtgcagaca ccgtcatccc accccacctg
     6601 agtcacccca accaagaggg tgactgaatt tcagcctgat tatgccctcc tggggctcct
     6661 gtgaggtgga gccaaggttc cctctctgtt cctgtttgtt tttaaatatt gttgtgtgtt
     6721 ttgtatctgt ggcactggcc tgcagcatac tctgtatata ttgtaaagaa accgttagga
     6781 gtaattttct tttgcattgg gcaggcatgg ccctgcattc ctgccctttc cactcattct
     6841 gtaacacaga ggacgaactt ctgtattagc tgggcagcct tgggttctcc agaagagaac
     6901 aggtttttct tttccttttt aatttttctt cttaaacatt tggctctttg atcctcatat
     6961 ccaagtctcc cctgaagagt aggagctgct cagaagagca ggtgaaagcc accatggcag
     7021 atcctgatgc ctgccgggcc tagtcttccc tctgaaataa catgaagcag cagctgtgga
     7081 gattcttgac aagtgctgag tgaaagattt gctgcccacc tctacatggg gaggagaaac
     7141 acaggtggga gctacctgtg gcatccatga cctagtcaga gggatgagat gctcagcagg
     7201 ggtccccatc ctatcccacc ccacaaacaa aggctggaaa aatttgctac caagggccaa
     7261 gaccaccaga ccaagcctgt ttatgagcca cccctgccca ggccctcaca gacattgctc
     7321 acggggcttc ccatagagga gaagctaaag agggaggggg cctcatcccc agatagatca
     7381 ggcaaggctt ggagagctgc tctttaggat ccacatcaac tacttcctca ttttaaggta
     7441 tggcagttcc cttcatcccc ttttcctgcc ttgtacatgt acatgtatga aatttccttc
     7501 tcttaccgaa ctctctccac acatcacaag gtcaaagaac cacacgctta gaagggtaag
     7561 agggcaccct atgaaatgaa atggtgattt cttgagtctc ttttttccac gtttaagggg
     7621 ccatggcagg acttagagtt gcgagttaag actgcagagg gctagagaat tatttcatac
     7681 aggctttgag gccacccatg tcacttatcc cgtataccct ctcaccatcc ccttgtctac
     7741 tctgatgccc ccaagatgca actgggcagc tagttggccc cataattctg ggcctttgtt
     7801 gtttgtttta attacttggg catcccagga agctttccag tgatctccta ccatgggccc
     7861 ccctcctggg atcaagcccc tcccaggccc tgtccccagc ccctcctgcc ccagcccacc
     7921 cgcttgcctt ggtgctcagc cctcccattg ggagcaggtt ggggcgagct ggaggcccgg
     7981 gctggagggg cagtgttgct gttcatagat tttgttccat tggcgttgct ctgttgaatt
     8041 taatttcagt cttcctgatt cttcccttct gtaaagtgta cattaccaag ttccttgttt
     8101 ttttatatat atatataaat atatatatat acaaactgta ctctttttgc ctttgtacat
     8161 tcaggcaaga agagaaaata aatcttttta agagacaatc acaaatctgt gagggctgct
     8221 ggttatttct cctggagttt gctgctgagc tgcctcttcc ttcctcccaa ttttcctgtt
     8281 ctccctcagc tctcctgatc ttcctggccc tgctccatat gcatcctcag cttcactttc
     8341 cctggctgat ggcaagctgt tgaatccagt gtccagacta cctgccttgt aacccttttc
     8401 tgcccagcat tgttttctgg cttggccact ggcttagccc aggagcttta ctctgtgccc
     8461 tggcctcccc tctcttcacc tttagatttc cattcaccga agtggctttg gacccctggg
     8521 tactctggga cctgtttcct ggaggccctg gcttgggaca ctcacctgtg aaactatgca
     8581 gctgggagct ctctgcctaa gagtttgcac tatttaaacc tgcctgggag ttaggacgga
     8641 tggttttagg aatgaccgga aaactacccc taaaactccc ccgacattcc agcctctaga
     8701 atgctctgat ccagagctca gtggatgatt cccagctggt ggactcctgt ggctacccca
     8761 tcagaacaag ggctaagggt ttatgggtca agagtatttg atcagaattt taaagggtgg
     8821 tatactctga aacacagccc aaccaaacca ttgtttggcc gctttctctt ttcctctacc
     8881 ttcctcatcc ccactttttt ccctttctct ctacttcctc ttcttaattg gctttggaat
     8941 tgaaatatat ttttaaatta tttgttgtat ttattgaata aagtttttaa tgtccctgtt
     9001 cttaaa
//
