LOCUS       NM_020747               6152 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens zinc finger protein 608 (ZNF608), transcript variant
            1, mRNA.
ACCESSION   NM_020747 XM_005272037 XM_114432
VERSION     NM_020747.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6152)
  AUTHORS   Baez-Vega,P.M., Echevarria Vargas,I.M., Valiyeva,F.,
            Encarnacion-Rosado,J., Roman,A., Flores,J., Marcos-Martinez,M.J.
            and Vivas-Mejia,P.E.
  TITLE     Targeting miR-21-3p inhibits proliferation and invasion of ovarian
            cancer cells
  JOURNAL   Oncotarget 7 (24), 36321-36337 (2016)
   PUBMED   27166999
  REMARK    GeneRIF: Data indicate RNA Binding Protein with Multiple Splicing
            (RBPMS), Regulator of Chromosome Condensation and POZ Domain
            Containing Protein 1 (RCBTB1), and Zinc Finger protein 608 (ZNF608)
            as miR-21-3p target genes.
REFERENCE   2  (bases 1 to 6152)
  AUTHORS   Lemaitre,R.N., King,I.B., Kabagambe,E.K., Wu,J.H., McKnight,B.,
            Manichaikul,A., Guan,W., Sun,Q., Chasman,D.I., Foy,M., Wang,L.,
            Zhu,J., Siscovick,D.S., Tsai,M.Y., Arnett,D.K., Psaty,B.M.,
            Djousse,L., Chen,Y.D., Tang,W., Weng,L.C., Wu,H., Jensen,M.K.,
            Chu,A.Y., Jacobs,D.R. Jr., Rich,S.S., Mozaffarian,D., Steffen,L.,
            Rimm,E.B., Hu,F.B., Ridker,P.M., Fornage,M. and Friedlander,Y.
  TITLE     Genetic loci associated with circulating levels of very long-chain
            saturated fatty acids
  JOURNAL   J Lipid Res 56 (1), 176-184 (2015)
   PUBMED   25378659
REFERENCE   3  (bases 1 to 6152)
  AUTHORS   Ma,R.C., Lee,H.M., Lam,V.K., Tam,C.H., Ho,J.S., Zhao,H.L., Guan,J.,
            Kong,A.P., Lau,E., Zhang,G., Luk,A., Wang,Y., Tsui,S.K., Chan,T.F.,
            Hu,C., Jia,W.P., Park,K.S., Lee,H.K., Furuta,H., Nanjo,K.,
            Tai,E.S., Ng,D.P., Tang,N.L., Woo,J., Leung,P.C., Xue,H., Wong,J.,
            Leung,P.S., Lau,T.C., Tong,P.C., Xu,G., Ng,M.C., So,W.Y. and
            Chan,J.C.
  TITLE     Familial young-onset diabetes, pre-diabetes and cardiovascular
            disease are associated with genetic variants of DACH1 in Chinese
  JOURNAL   PLoS One 9 (1), e84770 (2014)
   PUBMED   24465431
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6152)
  AUTHORS   Graff,M., Ngwa,J.S., Workalemahu,T., Homuth,G., Schipf,S.,
            Teumer,A., Volzke,H., Wallaschofski,H., Abecasis,G.R., Edward,L.,
            Francesco,C., Sanna,S., Scheet,P., Schlessinger,D., Sidore,C.,
            Xiao,X., Wang,Z., Chanock,S.J., Jacobs,K.B., Hayes,R.B., Hu,F., Van
            Dam,R.M., Crout,R.J., Marazita,M.L., Shaffer,J.R., Atwood,L.D.,
            Fox,C.S., Heard-Costa,N.L., White,C., Choh,A.C., Czerwinski,S.A.,
            Demerath,E.W., Dyer,T.D., Towne,B., Amin,N., Oostra,B.A., Van
            Duijn,C.M., Zillikens,M.C., Esko,T., Nelis,M., Nikopensius,T.,
            Metspalu,A., Strachan,D.P., Monda,K., Qi,L., North,K.E.,
            Cupples,L.A., Gordon-Larsen,P. and Berndt,S.I.
  CONSRTM   GIANT Consortium
  TITLE     Genome-wide analysis of BMI in adolescents and young adults reveals
            additional insight into the effects of genetic loci over the life
            course
  JOURNAL   Hum Mol Genet 22 (17), 3597-3607 (2013)
   PUBMED   23669352
REFERENCE   5  (bases 1 to 6152)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   6  (bases 1 to 6152)
  AUTHORS   Kerns,S.L., Ostrer,H., Stock,R., Li,W., Moore,J., Pearlman,A.,
            Campbell,C., Shao,Y., Stone,N., Kusnetz,L. and Rosenstein,B.S.
  TITLE     Genome-wide association study to identify single nucleotide
            polymorphisms (SNPs) associated with the development of erectile
            dysfunction in African-American men after radiotherapy for prostate
            cancer
  JOURNAL   Int J Radiat Oncol Biol Phys 78 (5), 1292-1300 (2010)
   PUBMED   20932654
REFERENCE   7  (bases 1 to 6152)
  AUTHORS   Speliotes,E.K., Willer,C.J., Berndt,S.I., Monda,K.L.,
            Thorleifsson,G., Jackson,A.U., Lango Allen,H., Lindgren,C.M.,
            Luan,J., Magi,R., Randall,J.C., Vedantam,S., Winkler,T.W., Qi,L.,
            Workalemahu,T., Heid,I.M., Steinthorsdottir,V., Stringham,H.M.,
            Weedon,M.N., Wheeler,E., Wood,A.R., Ferreira,T., Weyant,R.J.,
            Segre,A.V., Estrada,K., Liang,L., Nemesh,J., Park,J.H.,
            Gustafsson,S., Kilpelainen,T.O., Yang,J., Bouatia-Naji,N., Esko,T.,
            Feitosa,M.F., Kutalik,Z., Mangino,M., Raychaudhuri,S., Scherag,A.,
            Smith,A.V., Welch,R., Zhao,J.H., Aben,K.K., Absher,D.M., Amin,N.,
            Dixon,A.L., Fisher,E., Glazer,N.L., Goddard,M.E., Heard-Costa,N.L.,
            Hoesel,V., Hottenga,J.J., Johansson,A., Johnson,T., Ketkar,S.,
            Lamina,C., Li,S., Moffatt,M.F., Myers,R.H., Narisu,N., Perry,J.R.,
            Peters,M.J., Preuss,M., Ripatti,S., Rivadeneira,F., Sandholt,C.,
            Scott,L.J., Timpson,N.J., Tyrer,J.P., van Wingerden,S.,
            Watanabe,R.M., White,C.C., Wiklund,F., Barlassina,C., Chasman,D.I.,
            Cooper,M.N., Jansson,J.O., Lawrence,R.W., Pellikka,N.,
            Prokopenko,I., Shi,J., Thiering,E., Alavere,H., Alibrandi,M.T.,
            Almgren,P., Arnold,A.M., Aspelund,T., Atwood,L.D., Balkau,B.,
            Balmforth,A.J., Bennett,A.J., Ben-Shlomo,Y., Bergman,R.N.,
            Bergmann,S., Biebermann,H., Blakemore,A.I., Boes,T.,
            Bonnycastle,L.L., Bornstein,S.R., Brown,M.J., Buchanan,T.A.,
            Busonero,F., Campbell,H., Cappuccio,F.P., Cavalcanti-Proenca,C.,
            Chen,Y.D., Chen,C.M., Chines,P.S., Clarke,R., Coin,L., Connell,J.,
            Day,I.N., den Heijer,M., Duan,J., Ebrahim,S., Elliott,P.,
            Elosua,R., Eiriksdottir,G., Erdos,M.R., Eriksson,J.G.,
            Facheris,M.F., Felix,S.B., Fischer-Posovszky,P., Folsom,A.R.,
            Friedrich,N., Freimer,N.B., Fu,M., Gaget,S., Gejman,P.V.,
            Geus,E.J., Gieger,C., Gjesing,A.P., Goel,A., Goyette,P.,
            Grallert,H., Grassler,J., Greenawalt,D.M., Groves,C.J.,
            Gudnason,V., Guiducci,C., Hartikainen,A.L., Hassanali,N.,
            Hall,A.S., Havulinna,A.S., Hayward,C., Heath,A.C., Hengstenberg,C.,
            Hicks,A.A., Hinney,A., Hofman,A., Homuth,G., Hui,J., Igl,W.,
            Iribarren,C., Isomaa,B., Jacobs,K.B., Jarick,I., Jewell,E.,
            John,U., Jorgensen,T., Jousilahti,P., Jula,A., Kaakinen,M.,
            Kajantie,E., Kaplan,L.M., Kathiresan,S., Kettunen,J., Kinnunen,L.,
            Knowles,J.W., Kolcic,I., Konig,I.R., Koskinen,S., Kovacs,P.,
            Kuusisto,J., Kraft,P., Kvaloy,K., Laitinen,J., Lantieri,O.,
            Lanzani,C., Launer,L.J., Lecoeur,C., Lehtimaki,T., Lettre,G.,
            Liu,J., Lokki,M.L., Lorentzon,M., Luben,R.N., Ludwig,B.,
            Manunta,P., Marek,D., Marre,M., Martin,N.G., McArdle,W.L.,
            McCarthy,A., McKnight,B., Meitinger,T., Melander,O., Meyre,D.,
            Midthjell,K., Montgomery,G.W., Morken,M.A., Morris,A.P., Mulic,R.,
            Ngwa,J.S., Nelis,M., Neville,M.J., Nyholt,D.R., O'Donnell,C.J.,
            O'Rahilly,S., Ong,K.K., Oostra,B., Pare,G., Parker,A.N., Perola,M.,
            Pichler,I., Pietilainen,K.H., Platou,C.G., Polasek,O., Pouta,A.,
            Rafelt,S., Raitakari,O., Rayner,N.W., Ridderstrale,M., Rief,W.,
            Ruokonen,A., Robertson,N.R., Rzehak,P., Salomaa,V., Sanders,A.R.,
            Sandhu,M.S., Sanna,S., Saramies,J., Savolainen,M.J., Scherag,S.,
            Schipf,S., Schreiber,S., Schunkert,H., Silander,K., Sinisalo,J.,
            Siscovick,D.S., Smit,J.H., Soranzo,N., Sovio,U., Stephens,J.,
            Surakka,I., Swift,A.J., Tammesoo,M.L., Tardif,J.C.,
            Teder-Laving,M., Teslovich,T.M., Thompson,J.R., Thomson,B.,
            Tonjes,A., Tuomi,T., van Meurs,J.B., van Ommen,G.J., Vatin,V.,
            Viikari,J., Visvikis-Siest,S., Vitart,V., Vogel,C.I., Voight,B.F.,
            Waite,L.L., Wallaschofski,H., Walters,G.B., Widen,E., Wiegand,S.,
            Wild,S.H., Willemsen,G., Witte,D.R., Witteman,J.C., Xu,J.,
            Zhang,Q., Zgaga,L., Ziegler,A., Zitting,P., Beilby,J.P.,
            Farooqi,I.S., Hebebrand,J., Huikuri,H.V., James,A.L., Kahonen,M.,
            Levinson,D.F., Macciardi,F., Nieminen,M.S., Ohlsson,C.,
            Palmer,L.J., Ridker,P.M., Stumvoll,M., Beckmann,J.S., Boeing,H.,
            Boerwinkle,E., Boomsma,D.I., Caulfield,M.J., Chanock,S.J.,
            Collins,F.S., Cupples,L.A., Smith,G.D., Erdmann,J., Froguel,P.,
            Gronberg,H., Gyllensten,U., Hall,P., Hansen,T., Harris,T.B.,
            Hattersley,A.T., Hayes,R.B., Heinrich,J., Hu,F.B., Hveem,K.,
            Illig,T., Jarvelin,M.R., Kaprio,J., Karpe,F., Khaw,K.T.,
            Kiemeney,L.A., Krude,H., Laakso,M., Lawlor,D.A., Metspalu,A.,
            Munroe,P.B., Ouwehand,W.H., Pedersen,O., Penninx,B.W., Peters,A.,
            Pramstaller,P.P., Quertermous,T., Reinehr,T., Rissanen,A.,
            Rudan,I., Samani,N.J., Schwarz,P.E., Shuldiner,A.R., Spector,T.D.,
            Tuomilehto,J., Uda,M., Uitterlinden,A., Valle,T.T., Wabitsch,M.,
            Waeber,G., Wareham,N.J., Watkins,H., Wilson,J.F., Wright,A.F.,
            Zillikens,M.C., Chatterjee,N., McCarroll,S.A., Purcell,S.,
            Schadt,E.E., Visscher,P.M., Assimes,T.L., Borecki,I.B.,
            Deloukas,P., Fox,C.S., Groop,L.C., Haritunians,T., Hunter,D.J.,
            Kaplan,R.C., Mohlke,K.L., O'Connell,J.R., Peltonen,L.,
            Schlessinger,D., Strachan,D.P., van Duijn,C.M., Wichmann,H.E.,
            Frayling,T.M., Thorsteinsdottir,U., Abecasis,G.R., Barroso,I.,
            Boehnke,M., Stefansson,K., North,K.E., McCarthy,M.I.,
            Hirschhorn,J.N., Ingelsson,E. and Loos,R.J.
  CONSRTM   MAGIC; Procardis Consortium
  TITLE     Association analyses of 249,796 individuals reveal 18 new loci
            associated with body mass index
  JOURNAL   Nat Genet 42 (11), 937-948 (2010)
   PUBMED   20935630
REFERENCE   8  (bases 1 to 6152)
  AUTHORS   Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
            Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
            and Old,L.J.
  TITLE     Antigens recognized by autologous antibody in patients with
            renal-cell carcinoma
  JOURNAL   Int J Cancer 83 (4), 456-464 (1999)
   PUBMED   10508479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113398.3 and AC112196.3.
            
            On or before Jul 21, 2020 this sequence version replaced
            XM_005272037.3, NM_020747.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853559.26331.1,
                                           ERR4352444.350447.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000513986.2/ ENSP00000421899.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-445               AC113398.3         100174-100618       c
            446-1534            AC113398.3         98063-99151         c
            1535-1790           AC112196.3         152823-153078       c
            1791-1878           AC112196.3         101419-101506       c
            1879-4333           AC112196.3         98488-100942        c
            4334-4751           AC112196.3         96053-96470         c
            4752-4924           AC112196.3         95320-95492         c
            4925-5078           AC112196.3         93061-93214         c
            5079-5160           AC112196.3         90942-91023         c
            5161-6152           AC112196.3         88724-89715         c
FEATURES             Location/Qualifiers
     source          1..6152
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.2"
     gene            1..6152
                     /gene="ZNF608"
                     /gene_synonym="NY-REN-36"
                     /note="zinc finger protein 608"
                     /db_xref="GeneID:57507"
                     /db_xref="HGNC:HGNC:29238"
                     /db_xref="MIM:620972"
     exon            1..445
                     /gene="ZNF608"
                     /gene_synonym="NY-REN-36"
                     /inference="alignment:Splign:2.1.0"
     exon            446..1534
                     /gene="ZNF608"
                     /gene_synonym="NY-REN-36"
                     /inference="alignment:Splign:2.1.0"
     CDS             629..5167
                     /gene="ZNF608"
                     /gene_synonym="NY-REN-36"
                     /note="isoform 1 is encoded by transcript variant 1; renal
                     carcinoma antigen NY-REN-36"
                     /codon_start=1
                     /product="zinc finger protein 608 isoform 1"
                     /protein_id="NP_065798.2"
                     /db_xref="CCDS:CCDS34219.1"
                     /db_xref="GeneID:57507"
                     /db_xref="HGNC:HGNC:29238"
                     /db_xref="MIM:620972"
                     /translation="MSVNISTAGKGVDPNTVDTYDSGDDWEIGVGNLIIDLDADLEKD
                     RQKFEMNNSTTTTSSSNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETS
                     KSKVKRSKTSKDANKSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSG
                     GSGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRKDKHDLL
                     QGHQNGSGSQAPSGGHLYGFGAKSNGGGASPFHCGGTGSGSVAAAGEVSKSAPDSGLM
                     GNSMLVKKEEEEEESHRRIKKLKTEKVDPLFTVPAPPPPISSSLTPQILPSYFSPSSS
                     NIAAPVEQLLVRTRSVGVNTCEVGVVTEPECLGPCEPGTSVNLEGIVWHETEEGVLVV
                     NVTWRNKTYVGTLLDCTKHDWAPPRFCESPTSDLEMRGGRGRGKRARSAAAAPGSEAS
                     FTESRGLQNKNRGGANGKGRRGSLNASGRRTPPNCAAEDIKASPSSTNKRKNKPPMEL
                     DLNSSSEDNKPGKRVRTNSRSTPTTPQGKPETTFLDQGCSSPVLIDCPHPNCNKKYKH
                     INGLRYHQAHAHLDPENKLEFEPDSEDKISDCEEGLSNVALECSEPSTSVSAYDQLKA
                     PASPGAGNPPGTPKGKRELMSNGPGSIIGAKAGKNSGKKKGLNNELNNLPVISNMTAA
                     LDSCSAADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKATNCKTDKNLSKLKSARPIAP
                     APAPTPPQLIAIPTATFTTTTTGTIPGLPSLTTTVVQATPKSPPLKPIQPKPTIMGEP
                     ITVNPALVSLKDKKKKEKRKLKDKEGKETGSPKMDAKLGKLEDSKGASKDLPGHFLKD
                     HLNKNEGLANGLSESQESRMASIKAEADKVYTFTDNAPSPSIGSASRLECSTLVNGQA
                     PMAPLHVLTQNGAESSAAKTSSPAYSDISDAADDGGSDSRSEGMRSKASSPSDIISSK
                     DSVVKGHSSTTAQSSQLKESHSPYYHSYDPYYSPSYMHPGQVGAPAAGNSGSTQGMKI
                     KKESEEDAEKKDKAEQLDSKKVDHNSASLQPQHQSVITQRHPALAQSLYYGQYAYGLY
                     MDQKSLMATSPAYRQQYEKYYEDQRLAEQKMAQTGRGDCERKSELPLKELGKEETKQK
                     NMPSATISKAPSTPEPNKNHSKLGPSVPNKTEETGKSQLLSNHQQQLQADSFKAKQME
                     NHQLIKEAVEMKSVMDSMKQTGVDPTSRFKQDPDSRTWHHYVYQPKYLDQQKSEELDR
                     EKKLKEDSPRKTPNKESGVPSLPVSLTSIKEEPKEAKHPDSQSMEESKLKNDDRKTPV
                     NWKDSRGTRVAVSSPMSQHQSYIQYLHAYPYPQMYDPSHPAYRAVSPVLMHSYPGAYL
                     SPGFHYPVYGKMSGREETEKVNTSPSVNTKTTTESKALDLLQQHANQYRSKSPAPVEK
                     ATAEREREAERERDRHSPFGQRHLHTHHHTHVGMGYPLIPGQYDPFQGLTSAALVASQ
                     QVAAQASASGMFPGQRRE"
     exon            1535..1790
                     /gene="ZNF608"
                     /gene_synonym="NY-REN-36"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1878
                     /gene="ZNF608"
                     /gene_synonym="NY-REN-36"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..4333
                     /gene="ZNF608"
                     /gene_synonym="NY-REN-36"
                     /inference="alignment:Splign:2.1.0"
     exon            4334..4751
                     /gene="ZNF608"
                     /gene_synonym="NY-REN-36"
                     /inference="alignment:Splign:2.1.0"
     exon            4752..4924
                     /gene="ZNF608"
                     /gene_synonym="NY-REN-36"
                     /inference="alignment:Splign:2.1.0"
     exon            4925..5078
                     /gene="ZNF608"
                     /gene_synonym="NY-REN-36"
                     /inference="alignment:Splign:2.1.0"
     exon            5079..5160
                     /gene="ZNF608"
                     /gene_synonym="NY-REN-36"
                     /inference="alignment:Splign:2.1.0"
     exon            5161..6152
                     /gene="ZNF608"
                     /gene_synonym="NY-REN-36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6125..6130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF608"
                     /gene_synonym="NY-REN-36"
                     /note="hexamer: ATTAAA"
     polyA_site      6152
                     /gene="ZNF608"
                     /gene_synonym="NY-REN-36"
                     /note="major polyA site"
ORIGIN      
        1 gttactagcg gacgcctgta ggtttgctac atgggatcat tactgatcac ggtgactctg
       61 aagtctggaa ctgaaggcgg aatgagaagt tgggaaaact tttttctcta aactctctgt
      121 tttttaaaaa actattattc tcgatgcttg ttaagaggaa aaaaaaacct ttggtgcttc
      181 tgttgtgaat gtgaaacatt attttccagc tgtacagtga cacatttttt ttaaggagaa
      241 aaggactgat tcgtttgcca aaaggggggt ggggaggtgg aataatgtta tcgagtgatt
      301 attctggctg agatgtgtta tttggtttct tccttcttga tcatttggtg tttaagtaaa
      361 atgaggcaca ggcttgtttg ccgagtggag tgggaaaggc attttgattt gctggcctaa
      421 ttaaaaaatg ataaaggatt aaaaggaaaa ggtggacctg gactgagggt gtaaaatccc
      481 tggacacatt cgtggggcag gaaaaagaag aggaagatta gaagattttt tttttctttg
      541 agagaaagcc cagcggagat aaacgaatgt cccctcatct ccaaagaaaa gttcatcgga
      601 tttttattct agagagctca tcttcaggat gtcagtgaac atttctactg caggaaaagg
      661 tgtggatcca aatacagttg atacttatga cagtggcgat gattgggaaa tcggggttgg
      721 aaatttaata attgatttgg acgctgattt ggagaaggac agacagaaat ttgagatgaa
      781 taattccacc accaccacta gtagcagcaa ctccaaggat tgtggaggtc cggcctccag
      841 tggggctggt gctaccgcag ccttagctga tggcctaaaa tttgcttctg ttcaggcctc
      901 tgctccccag gggaattcac acaaagagac cagcaaatca aaagtgaaaa ggagtaaaac
      961 ttctaaggat gctaataaat ctctgccttc tgctgccttg tatgggattc ccgagatcag
     1021 cagcactggc aagaggcagg aagtccaagg gcgccctgga gaggcaactg gcatgaattc
     1081 agcgctgggt caaagtgtga gcagcggcgg cagcggcaac ccaaacagca atagtaccag
     1141 caccagcacc tctgccgcca ccgcgggggc aggctcctgt gggaaaagca aagaggagaa
     1201 gccaggtaaa agccagagca gccgaggcgc caagcgggat aaggatgcgg ggaaatccag
     1261 gaaggacaag cacgacctgc ttcagggcca ccagaatggc agtggcagcc aggccccttc
     1321 cggggggcac ctctatggct ttggggccaa gagcaatgga ggtggcgcga gccccttcca
     1381 ctgcgggggc actgggagtg gcagcgtcgc cgctgcaggg gaagttagca aaagtgcccc
     1441 ggattcaggg ctcatgggaa actctatgtt ggtaaagaag gaagaggagg aggaggagag
     1501 ccacaggcga atcaagaaac tgaaaactga gaaggttgac cccctgttta cagtgccagc
     1561 gccaccaccg ccgatttcca gcagtctcac gcctcagatt ctaccctcct acttttcccc
     1621 atcttcatcc aatattgcag caccggttga acagcttttg gttcggactc gttctgtggg
     1681 tgtcaataca tgtgaagttg gagtagtgac agagccagag tgtcttgggc cctgtgaacc
     1741 tgggaccagt gtgaatttgg aagggatcgt gtggcatgaa acagaagaag gtgtcctagt
     1801 ggtcaatgtc acgtggagga acaaaacgta cgtgggaacc ctactggact gcaccaagca
     1861 cgactgggcc cctcccaggt tttgtgagtc accgacaagt gacctggaga tgagaggggg
     1921 ccggggcaga gggaagagag cgaggtctgc tgctgctgcc ccgggctccg aggccagctt
     1981 cacagagtcc agagggctgc agaataagaa cagagggggg gccaatggga aagggaggcg
     2041 gggcagcctc aatgccagcg gacgaaggac acccccaaat tgtgctgctg aggatatcaa
     2101 agccagccct tcctccacca acaaaaggaa aaacaagcct ccaatggagc tggacctgaa
     2161 ctccagctct gaggacaata agcctggaaa gcgtgtccgc acaaattcca gaagcactcc
     2221 cactacccct caagggaaac cagagactac ttttttggac caaggctgct cttctccagt
     2281 gttaatcgac tgtccccacc caaactgcaa caaaaagtac aagcacatta acggcctgag
     2341 gtaccaccag gctcatgcac acttagaccc agaaaacaag ctggagttcg agcctgacag
     2401 tgaggacaag atctcggact gtgaggaagg attgagtaat gtggcacttg aatgcagtga
     2461 gccaagcaca agtgtatctg cttatgacca gttgaaggca ccggcatccc ctggtgctgg
     2521 aaacccacct gggaccccaa agggaaagag agagctgatg agcaatggcc caggttccat
     2581 tattggtgct aaagctggga agaattctgg caaaaagaag ggccttaaca atgaactgaa
     2641 caaccttcca gtaatctcca acatgacggc tgcgttagac agttgctcgg cagcagacgg
     2701 cagtttggct gctgagatgc ctaaactgga agcagaagga ttaattgaca agaaaaattt
     2761 aggagataaa gaaaagggca aaaaagctac caactgcaaa acggacaaaa acctctctaa
     2821 actgaaaagt gcccggccca ttgcccctgc cccagccccc actcccccgc agctaatcgc
     2881 tatacccact gcaaccttta caacgaccac cactgggaca atacccggac tgccctccct
     2941 cacaacaact gttgttcagg ctacaccaaa gagtcctccg ttaaaaccca ttcaaccaaa
     3001 gcccacaatt atgggagagc ccatcaccgt gaacccagct ctggtgtcac tcaaagacaa
     3061 aaagaaaaag gagaagcgaa agctaaagga caaagaaggg aaagagacgg gaagcccaaa
     3121 aatggatgcc aagctgggga aactagagga ctccaagggg gccagcaaag atttacctgg
     3181 gcatttttta aaggatcatc tcaacaagaa tgaagggctg gcaaatggac tgtcggagtc
     3241 tcaggagagc cgcatggcca gtatcaaagc tgaggccgat aaggtttaca ctttcacaga
     3301 caacgctccc agcccttcca tagggagcgc ctcgaggctg gaatgcagca ctttggtgaa
     3361 cgggcaggca ccaatggcac ctctgcatgt gttgacccag aatggggcag agagttcagc
     3421 tgcaaagaca agcagcccgg cctattcaga catatctgat gctgctgacg atggtggttc
     3481 tgacagcagg tcggagggta tgagatcaaa ggccagttcc ccatcagata ttatttctag
     3541 taaggacagt gttgtaaaag ggcattcttc aactacagca caatcatctc aactgaaaga
     3601 gtcccattct ccctattacc acagctatga tccttattat tctccaagtt acatgcaccc
     3661 tgggcaggtc ggtgcccctg cagctggaaa tagtgggagc acgcagggaa tgaagatcaa
     3721 gaaggagtct gaggaagatg ctgaaaagaa agacaaggca gagcagttag attctaagaa
     3781 agtggaccac aattctgcat ccttacagcc tcagcaccag tcggtgatca cacaaagaca
     3841 tcctgccctg gctcagtcac tttattatgg ccagtatgca tatgggctct atatggacca
     3901 gaagtctctg atggccacca gccctgccta tagacagcag tatgagaagt actatgagga
     3961 ccagaggctg gcagagcaga aaatggccca gactgggaga ggagactgtg aaaggaaaag
     4021 tgagctcccc ttgaaagagc tgggcaagga ggaaactaaa cagaaaaata tgccatcggc
     4081 cacaatctca aaagctccct ctactccgga gcctaacaaa aaccattcta aactagggcc
     4141 atcagtgcct aataaaactg aggagacagg taaatcgcag cttctctcca atcaccagca
     4201 gcagcttcag gccgacagct tcaaagctaa gcagatggaa aaccaccagc ttattaagga
     4261 ggctgtagaa atgaagtctg tcatggactc tatgaagcag acaggtgtag acccaacctc
     4321 gagatttaaa caagacccag attcaagaac atggcatcat tatgtatacc agcccaaata
     4381 tctggatcag caaaagtcag aagaacttga tagagagaag aaattaaaag aggatagtcc
     4441 gaggaaaact cctaataaag agagtggtgt gcccagcctt cctgtatcgt taacaagcat
     4501 taaagaggag cccaaagagg ccaagcatcc tgattctcaa tcaatggagg agagcaagct
     4561 gaaaaatgat gatcgaaaga ctcctgtgaa ctggaaggac tctcggggaa caagagtggc
     4621 tgtctcctca cccatgagtc agcatcagtc atacatacag tacttgcatg cttatcctta
     4681 cccacagatg tacgacccca gccatcctgc ataccgggct gtttctcccg tcctaatgca
     4741 cagttatcct ggggcatatc tctctccagg atttcattat cctgtttatg ggaagatgtc
     4801 agggagagaa gagacagaga aagtcaatac cagccctagc gtcaacacga aaacaaccac
     4861 tgaatctaaa gcactggatt tgctccagca gcatgctaac caataccgca gcaagtctcc
     4921 tgctcctgtg gaaaaggcta cagctgagcg ggaacgggag gcagaaaggg aaagggatcg
     4981 ccactccccc ttcggccagc ggcacctgca cacgcaccac cacacccacg ttggcatggg
     5041 ttacccgcta atcccgggtc aatatgaccc ttttcaaggc ttgacctctg ctgcccttgt
     5101 tgcctctcag caggtggctg cccaggcatc tgcatctgga atgtttcctg gacaaagaag
     5161 agaataacaa gattggacat gtacattgtc atgtgactgg atcacatggg gaagcgcttt
     5221 atacagacat cagttccatg gtgttaattt gaaatgcctt aatggcaggc aaaaaccagt
     5281 catttcattt ttgtaaatta cagattttat cacagagtaa caaatgttgc tgtaattaaa
     5341 cttctgtttt atatatatat acgtatacat atctgtatat atacatatat atatatataa
     5401 atataaatat attctttact ttttgtatca gtaaccaggc tcgcacacac agggtctgct
     5461 gccacgtcgc aaaccactca gtaaaggaaa ttaaaaatgt atttgtcatg ttaaaaagtg
     5521 ttagccacaa aaggctactt actttctttt ccttttcctt taaaattgta aataaataat
     5581 gttatgtatc agtgtgcctg aaccttgcat atccttcaca tatttcccat aagcccctca
     5641 gaaaggctaa ctgtgatgat gacactttgg tacaatttag atgtctattt ggtggctcct
     5701 gttaaagacg caccagtgta aaatgttcct gtagtcactg tttgtacttg tgtattgtgg
     5761 aaaaagtact tttggaaggc atggggttgc cagtaccaca aaaactgtgt tgtatataat
     5821 gtaaagatta aaatggggaa ataatgagca tctgtgaata atgaggtgtc attttttgat
     5881 aatcttgaat ggcaaataac ccaatagcct gcgtaccaga gacatctgtg attgttctat
     5941 tacttgaata gttctacagt cttttttttt ttttaatgtt tacaattatc cagttttaga
     6001 agagagagac tttaacgcca ttgcctggtt acttgtttta tgctgtaatc tagtttattt
     6061 tatgtaaaat gtatattgaa tgctttcctt ttttatacct gccttaaata atttggcaat
     6121 cagaattaaa aagttttttt ttttttaaat aa
//
