LOCUS       NM_032689               4327 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 607 (ZNF607), transcript variant
            1, mRNA.
ACCESSION   NM_032689 NM_032841
VERSION     NM_032689.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4327)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4327)
  AUTHORS   Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Association of genetic variants with hemorrhagic stroke in Japanese
            individuals
  JOURNAL   Int J Mol Med 25 (4), 649-656 (2010)
   PUBMED   20198315
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 4327)
  AUTHORS   Oguri,M., Kato,K., Yokoi,K., Yoshida,T., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Assessment of a polymorphism of SDK1 with hypertension in Japanese
            Individuals
  JOURNAL   Am J Hypertens 23 (1), 70-77 (2010)
   PUBMED   19851296
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093227.3.
            
            On Nov 23, 2018 this sequence version replaced NM_032689.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131557.1, SRR1660805.6905.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267750, SAMN03267755
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355202.9/ ENSP00000347338.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-493               AC093227.3         83267-83759         c
            494-576             AC093227.3         75608-75690         c
            577-703             AC093227.3         73694-73820         c
            704-802             AC093227.3         71912-72010         c
            803-4327            AC093227.3         60369-63893         c
FEATURES             Location/Qualifiers
     source          1..4327
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..4327
                     /gene="ZNF607"
                     /note="zinc finger protein 607"
                     /db_xref="GeneID:84775"
                     /db_xref="HGNC:HGNC:28192"
     exon            1..493
                     /gene="ZNF607"
                     /inference="alignment:Splign:2.1.0"
     exon            494..576
                     /gene="ZNF607"
                     /inference="alignment:Splign:2.1.0"
     CDS             568..2658
                     /gene="ZNF607"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 607 isoform 1"
                     /protein_id="NP_116078.4"
                     /db_xref="CCDS:CCDS33006.1"
                     /db_xref="GeneID:84775"
                     /db_xref="HGNC:HGNC:28192"
                     /translation="MSYGSITFGDVAIDFSHQEWEYLSLVQKTLYQEVMMENYDNLVS
                     LAGHSVSKPDLITLLEQGKEPWMIVREETRGECTDLDSRCEIISDGKMQLYRKHSCVT
                     LHQRIHNGQKPYECKQCQKSFSHLTELMVHQTIHTSEEPDQCEKFRKAFSHLTDLRKH
                     QKINAREKPYECEECGKVFSYPANLAQHGKVHVEKPYECKECGEAFRTSRQLTVHHRF
                     HYGEKPYECKECGKAFSVYGRLSRHQSIHTGEKPFECNKCGKSFRLKAGLKVHQSIHT
                     GEKPHECKECGKAFRQFSHLVGHKRIHTGEKPYECKECGKGFTCRYQLTMHQRIYSGE
                     KHYECKENGEAFSSGHQLTAPHTFESVEKPYKCEECGKAFSVHGRLTRHQGIHSGKKP
                     YECNKCGKSFRLNSSLKIHQNIHTGEKPYKCKECGKAFSQRAHLAHHNRIHTGYKPFE
                     CKECGKSFRCASYLVIHERIHTGEKPYVCQECGKGFSYSHKLTIHRRVHTGEKPYECK
                     ECGKAFSVSGQLTQHLSIHSGKKPFECNKCGKSFRFISVLKAHQNIHSAEKPYECKEC
                     GKAFRHATSLIYHDRTHAGEKSYECKECGETFSHASHLIIHERIHTSDKPYECKRCGK
                     AFHCASYLVRHESVHADGNPYMCEECGKAFNSSHELSIHHRVHTGEKPFKCNKCRRSF
                     RLRSILEVHQRIHI"
     exon            577..703
                     /gene="ZNF607"
                     /inference="alignment:Splign:2.1.0"
     exon            704..802
                     /gene="ZNF607"
                     /inference="alignment:Splign:2.1.0"
     exon            803..4327
                     /gene="ZNF607"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4202..4207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF607"
                     /note="hexamer: AGTAAA"
     polyA_site      4242
                     /gene="ZNF607"
     regulatory      4303..4308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF607"
                     /note="hexamer: AATAAA"
     polyA_site      4327
                     /gene="ZNF607"
                     /note="major polyA site"
ORIGIN      
        1 ggccactccc agaagtctcc ggggctcgag cggtgggtgg gaggcgcggt ccaagtggtc
       61 gctgccgtat ttctcgtagg tttttaggat tctggactcc atttctcacc ggtacctgcg
      121 gtcctgactg ttctggcttg gactacatat tacaaaggca acggagaaaa cttggacccc
      181 tggctccggt tccgggacct tttggttcca cctgaagaag gcggcgcagg tcactgcggg
      241 agcctctgca gccccagccc gccgcccgcg tggtaccctg cgtggcggtg agagtggggc
      301 tgcaggaggc gctcagagcg cggaggcccc caggcgggcc gggcgagtct cccgcctcct
      361 caggccctag ggtgctggag ctgcggagga ggggcccgtc tctaggagac aggcggggag
      421 cgtgagagac cgcgcagcgg cgacaggacc ggcttgcctg tgtgacgtgg gtgcagttgc
      481 gggactgtga ggggtcttgg ttcttttgac tttgctcttc tggtagagaa acgccaagga
      541 ctgatcaact cttgccagtc tcaaaccatg tcctatggat caataacatt cggggatgtg
      601 gccatagact tctctcatca ggagtgggaa tatctcagcc tggttcagaa gaccttgtac
      661 caggaggtga tgatggagaa ctatgacaac ttagtctcat tggcaggaca ttccgtatct
      721 aagccagatt taatcacctt attggagcaa ggaaaagagc catggatgat tgtgagggaa
      781 gaaacaagag gagagtgtac agatttggat tcaagatgtg aaataatcag cgatgggaaa
      841 atgcagcttt ataggaaaca ctcatgtgtt actctccatc agagaattca taatggacag
      901 aaaccatatg agtgtaagca atgtcagaag tcctttagtc atcttacaga actcatggta
      961 catcaaacaa ttcatactag tgaggaacct gatcaatgtg aaaagtttag gaaggcattt
     1021 agccatctta cagaccttag aaagcatcag aaaattaatg ctcgtgagaa accttatgaa
     1081 tgtgaagaat gtgggaaggt cttcagttat cctgcaaacc ttgctcaaca tgggaaagtt
     1141 catgttgaga aaccctatga atgtaaagag tgtggggaag cttttaggac tagccgtcaa
     1201 cttactgtac atcatagatt tcattatggt gagaaaccct acgaatgtaa ggaatgtggc
     1261 aaggccttta gtgtgtatgg acgacttagt cgacatcaga gtattcacac tggtgagaag
     1321 ccctttgaat gtaacaaatg tgggaagtcc tttaggctca aagcaggcct taaagtacat
     1381 cagagtattc atactggaga gaagccacat gaatgtaagg aatgtggaaa ggcctttcgt
     1441 cagttttccc accttgtggg tcataaaaga attcatactg gagaaaaacc ctatgaatgc
     1501 aaggaatgcg ggaagggctt tacatgtagg tatcaactta ccatgcatca gagaatttat
     1561 tcaggggaga aacactatga atgtaaagaa aatggggagg cttttagtag tggccatcaa
     1621 cttactgcac ctcatacatt tgaaagtgtt gagaaacctt ataagtgtga ggaatgtggg
     1681 aaagccttta gtgtgcatgg acgacttact cgacatcagg gtattcatag tggtaagaaa
     1741 ccctatgaat gtaacaaatg tgggaagtcc tttaggctca attcatccct taaaatacat
     1801 caaaatattc ataccggtga gaaaccctac aaatgtaagg aatgtgggaa ggccttcagt
     1861 cagcgtgcac accttgccca tcataacaga attcatactg gttacaaacc ctttgaatgt
     1921 aaagaatgtg ggaagtcctt tcgttgtgcc tcatatcttg ttatacatga gagaattcat
     1981 acaggagaga aaccctatgt atgtcaagag tgtgggaagg gttttagtta tagccataaa
     2041 ctcactatac atcgcagagt tcatactggt gagaaacctt atgaatgtaa ggaatgtggg
     2101 aaggccttta gtgtatctgg acaacttact cagcatctga gtattcacag tggtaagaaa
     2161 ccctttgaat gcaacaaatg cgggaagtct tttaggttca tttctgtact taaagcccat
     2221 cagaatattc atagcgctga gaaaccctac gaatgtaagg aatgtggcaa ggcctttcgt
     2281 catgccacaa gcctcatata tcatgaccga actcatgctg gtgaaaagtc ctatgaatgt
     2341 aaagaatgtg gggaaacttt tagtcatgct tcacatctta ttattcatga gagaattcat
     2401 accagtgata aaccctatga atgtaaaaga tgtgggaagg catttcactg tgcctcatat
     2461 cttgttagac atgaaagcgt tcatgctgat ggaaatccct atatgtgtga agagtgtggg
     2521 aaagctttta atagtagcca tgaacttagt atacatcata gagttcatac tggtgagaaa
     2581 ccctttaaat gtaacaaatg cagaaggtcc tttaggctta gatccatcct tgaagtacat
     2641 cagagaattc atatttgata gagaaattgt ggcatataca ggtagtaaag aaagcacatt
     2701 gtgtcaatgg atttatccca ctgaacaatt tgaatgaaga caatgtggaa tggctttgag
     2761 atacagttca gtttttatta ggcatcaatt tgtattggtg tgaacttttc aaaatgtaaa
     2821 tcatatatgc agtttctttg gtatgacctg tgttaactca gattcagaga atttataatg
     2881 tattttttta ataacataag aaaacttttc tgatattcct ctagttttgg attgccaaaa
     2941 tattcacagt agaggaaaac tgagaaaacg taggaaacca ttctttatac ttgcatgtaa
     3001 acatcttcca gcaacaatca tttattgtta aacctggaaa aagccattac acaggaaacc
     3061 tctgttgata taagcgatga tgggaaaggc tatttagcca ctctgcatat ttaatgctca
     3121 tgatcaacat ctgcttccta tagctgggat gatatggggg aagatattta tcccttctgg
     3181 ggatcatata taaatgatga tagtagtacc tacagtatag tgctgttaga attacatgag
     3241 ttagatgtgg aggtcagagt ggaagcaggt gtgagagggt cccgcagaag aaaacatggc
     3301 tgccaaagtg tttgagtcca tcggcaagtt tggcctggcc ttagctgttg caggaggcat
     3361 ggtgaactct gccttatgta atgtggatgc tgggcacaga gctgccatct ttgaccaatt
     3421 ccgtggagta cagaacattg tggtagggga agggactcac tttctcatcc catgtgtaca
     3481 aaaaccaatt atctttgact gctgttctca accacgtagt gcgccagtca tcactggtag
     3541 caaagattta cagaatgtca acatcacact gtgcatcctc ttccggccca tcactagcca
     3601 gcttcctcgc atcttcacca gcattggaga ggactacgat gagtgtgtgc tgccgttcat
     3661 taccacggag atcctcaagt cactggtggc tcgctttgat gctggagaac taatcaccca
     3721 gagggagctg gtctccagcc aggtgagcaa caaccttatg gagtgagcag ccacctttgg
     3781 gctcattctg gacgacgtgt ctttgacaca tctgaccttc ttgaaggagt taacagacag
     3841 gtggcccccc aggaagcaga gagcgccaga tttgtggtgg aaaaggcggc catcatctct
     3901 gctgagggtg actccaaggc agctgagctg atcgccaact cactggccac tgcaggggac
     3961 ggccagagcg agctgtgcaa gctggaagct gcagaagaca ttgcatacca gctctcatgc
     4021 tctcggaaca tcacctgcct gccggcaggg cagtccgtgc tcctccagct gccctagtga
     4081 ggccccagcc tacctgcacc tccgtgaggc aactgggcca cagccccgat gattcgtaac
     4141 accacctttc gccctcaccc cagaaatcac tgaaatttca tgattggctt aaagtgaagg
     4201 aagtaaaggt aaaatcactt cagatctcta aaaaacaaag aattacatga gttagtacat
     4261 gaaaaaatta tgggaaacta catgaaatat actgttacgt tcaataaaca ttagcttctg
     4321 tatataa
//
