LOCUS       NM_001348022            4080 bp    mRNA    linear   PRI 16-FEB-2024
DEFINITION  Homo sapiens zinc finger protein 606 (ZNF606), transcript variant
            2, mRNA.
ACCESSION   NM_001348022 XM_005259276
VERSION     NM_001348022.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4080)
  AUTHORS   Guo,J., Wang,Q., Liu,Y., Lu,L., Hua,Y., Hu,R., Wang,M., Li,Z.,
            Wang,X., Wang,B.H., Fu,Q. and Chen,A.
  TITLE     Association of expression of ZNF606 gene from monocytes with the
            risk of coronary artery disease
  JOURNAL   Clin Biochem 60, 44-51 (2018)
   PUBMED   30130524
  REMARK    GeneRIF: findings suggest that it is novel and specific for the
            association of ZNF606 gene expression from monocytes with the risk
            of CAD, especially in patients with multiple coronary artery
            stenosis
REFERENCE   2  (bases 1 to 4080)
  AUTHORS   Zhou,Z., Yu,H., Wang,Y., Guo,Q., Wang,L. and Zhang,H.
  TITLE     ZNF606 interacts with Sox9 to regulate chondrocyte differentiation
  JOURNAL   Biochem Biophys Res Commun 479 (4), 920-926 (2016)
   PUBMED   27634221
  REMARK    GeneRIF: ZNF606 prevents Sox9 binding to the enhancers of its
            target gene col2a1. Importantly, the interaction between ZNF606 and
            Sox9 was decreased during chondrocyte differentiation.
REFERENCE   3  (bases 1 to 4080)
  AUTHORS   Ou,Y., Wang,S., Cai,Z., Wang,Y., Wang,C., Li,Y., Li,F., Yuan,W.,
            Liu,B., Wu,X. and Liu,M.
  TITLE     ZNF328, a novel human zinc-finger protein, suppresses
            transcriptional activities of SRE and AP-1
  JOURNAL   Biochem Biophys Res Commun 333 (3), 1034-1044 (2005)
   PUBMED   15964554
  REMARK    GeneRIF: results suggest that ZNF328 protein may act as a
            transcriptional repressor in mitogen-activated protein kinase
            (MAPK) signaling pathway to mediate cellular functions
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA800130.1, AB058755.1,
            AK024322.1 and AI766866.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_001348022.2.
            
            Summary: This gene encodes a zinc finger protein containing a
            Kruppel-associated box (KRAB) domain at its N-terminus, followed by
            contiguous C2H2 zinc finger motifs. The encoded protein is a
            nuclear protein that can act as a transcriptional repressor of
            growth factor-mediated signaling pathways in a reporter gene assay.
            This protein has been shown to interact with the SRY-box 9 gene
            product, and suppresses its transcriptional activity by inhibiting
            its DNA binding activity. Reduced expression of this gene promotes
            chondrocyte differentiation. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Dec 2016].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.144926.1,
                                           ERR4352442.338477.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000551380.7/ ENSP00000446972.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-460               DA800130.1         3-462
            461-3807            AB058755.1         606-3952
            3808-4077           AK024322.1         2172-2441
            4078-4080           AI766866.1         27-29               c
FEATURES             Location/Qualifiers
     source          1..4080
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..4080
                     /gene="ZNF606"
                     /gene_synonym="ZNF328"
                     /note="zinc finger protein 606"
                     /db_xref="GeneID:80095"
                     /db_xref="HGNC:HGNC:25879"
                     /db_xref="MIM:613905"
     exon            1..425
                     /gene="ZNF606"
                     /gene_synonym="ZNF328"
                     /inference="alignment:Splign:2.1.0"
     exon            426..507
                     /gene="ZNF606"
                     /gene_synonym="ZNF328"
                     /inference="alignment:Splign:2.1.0"
     CDS             477..2855
                     /gene="ZNF606"
                     /gene_synonym="ZNF328"
                     /note="isoform 1 is encoded by transcript variant 2; zinc
                     finger protein 328"
                     /codon_start=1
                     /product="zinc finger protein 606 isoform 1"
                     /protein_id="NP_001334951.1"
                     /db_xref="CCDS:CCDS12968.1"
                     /db_xref="GeneID:80095"
                     /db_xref="HGNC:HGNC:25879"
                     /db_xref="MIM:613905"
                     /translation="MAAINPWASWGALTDQSWGMTAVDPWASWALCPQYPAWHVEGSL
                     EEGRRATGLPAAQVQEPVTFKDVAVDFTQEEWGQLDLVQRTLYRDVMLETYGHLLSVG
                     NQIAKPEVISLLEQGEEPWSVEQACPQRTCPEWVRNLESKALIPAQSIFEEEQSHGMK
                     LERYIWDDPWFSRLEVLGCKDQLEMYHMNQSTAMRQMVFMQKQVLSQRSSEFCGLGAE
                     FSQNLNFVPSQRVSQIEHFYKPDTHAQSWRCDSAIMYADKVTCENNDYDKTVYQSIQP
                     IYPARIQTGDNLFKCTDAVKSFNHIIHFGDHKGIHTGEKLYEYKECHQIFNQSPSFNE
                     HPRLHVGENQYNYKEYENIFYFSSFMEHQKIGTVEKAYKYNEWEKVFGYDSFLTQHTS
                     TYTAEKPYDYNECGTSFIWSSYLIQHKKTHTGEKPYECDKCGKVFRNRSALTKHERTH
                     TGIKPYECNKCGKAFSWNSHLIVHKRIHTGEKPYVCNECGKSFNWNSHLIGHQRTHTG
                     EKPFECTECGKSFSWSSHLIAHMRMHTGEKPFKCDECEKAFRDYSALSKHERTHSGAK
                     PYKCTECGKSFSWSSHLIAHQRTHTGEKPYNCQECGKAFRERSALTKHEIIHSGIKPY
                     ECNKCGKSCSQMAHLVRHQRTHTGEKPYECNKCGKSFSQSCHLVAHRRIHTGEKPYKC
                     NQCERSFNCSSHLIAHRRTHTGEKPYRCNECGKAFNESSSLIVHLRNHTGEKPYKCNH
                     CEKAFCKNSSLIIHQRMHSGEKRFICSECGKAFSGHSALLQHQRNHSEEKLN"
     exon            508..564
                     /gene="ZNF606"
                     /gene_synonym="ZNF328"
                     /inference="alignment:Splign:2.1.0"
     exon            565..653
                     /gene="ZNF606"
                     /gene_synonym="ZNF328"
                     /inference="alignment:Splign:2.1.0"
     exon            654..780
                     /gene="ZNF606"
                     /gene_synonym="ZNF328"
                     /inference="alignment:Splign:2.1.0"
     exon            781..876
                     /gene="ZNF606"
                     /gene_synonym="ZNF328"
                     /inference="alignment:Splign:2.1.0"
     exon            877..4080
                     /gene="ZNF606"
                     /gene_synonym="ZNF328"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4057..4062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF606"
                     /gene_synonym="ZNF328"
                     /note="hexamer: AAGAAA"
     polyA_site      4080
                     /gene="ZNF606"
                     /gene_synonym="ZNF328"
                     /note="major polyA site"
ORIGIN      
        1 ggtcgacgcc ggggaagcag ccgccattgt ccgcggctga ggtgaggcct ttgctcaggc
       61 tgtggggccg ccgtagctgc ggggcttggg gggtcaggag agccggctgg gagaggcggc
      121 gtcagggtgg gtcctgcgcc tgccctttcc gcgccggctt tgcgccgtcg ttgccgtcgg
      181 ttctccagcc agcagcctgc ctccggcctc ccgcctccgg gcgttcttcg ttttctggtc
      241 ggacgggcct gggtgaactc tgctgcacgt cggctccgcg ggcctttgtc cccgaggccg
      301 cgccgggagc tcccaagcgc actcctgggc cggacctcgg cgcgggacaa aagccaaacg
      361 ccccaggcgg gcagaccccg atcctgctgc gccgccttca agggggaccg ccggccgcga
      421 gccaggttgg gatttgctgt gttcctgggc aggtgcctgg tcaatcagtc ctcgggatgg
      481 cagccatcaa cccgtgggcc tcctggggtg cccttacgga ccaatcttgg gggatgacag
      541 ctgttgaccc atgggcctcc tgggctctgt gtcctcagta tcctgcctgg cacgtggagg
      601 gaagcctgga ggaggggagg agggccactg ggctcccagc agcccaggtt caggaaccag
      661 tgaccttcaa ggacgtggcc gtggacttca cccaagaaga gtgggggcag ctggaccttg
      721 ttcagaggac cctgtaccgt gatgtgatgc tggagaccta tggtcacctg ctctctgtgg
      781 gaaatcagat tgccaagcct gaggtcatct ccctgttgga gcaaggagaa gagccgtggt
      841 cagtggagca ggcatgtcct caacgcactt gtccagaatg ggtgagaaat cttgaaagca
      901 aagcattgat cccagcacag agcatttttg aggaagaaca atcccatggc atgaagttgg
      961 aaagatatat atgggatgat ccttggttct ccaggttaga agttttggga tgtaaagacc
     1021 aattagaaat gtaccacatg aaccagagta cagctatgag gcagatggtc ttcatgcaaa
     1081 agcaagtact atcccagaga agctctgaat tctgtggact tggggcagag tttagccaga
     1141 acttaaactt tgttccatct cagagagttt ctcagataga acatttctat aagcctgata
     1201 cacatgctca aagttggaga tgtgactcag ccataatgta tgcagataag gttacctgtg
     1261 aaaataatga ttatgacaaa actgtttatc agtccattca acctatttac cctgcaagaa
     1321 tacaaactgg agataatctt ttcaaatgta ctgatgctgt taaatctttc aatcatataa
     1381 tacattttgg tgatcataaa ggaattcaca caggagaaaa actctatgaa tataaggaat
     1441 gccatcaaat ctttaaccag agcccatcat ttaatgaaca cccaaggctt catgttggag
     1501 aaaaccagta taattacaaa gaatatgaga atatctttta tttctcatcc tttatggaac
     1561 atcaaaaaat tggtactgta gagaaagcgt ataaatacaa tgaatgggag aaagtctttg
     1621 ggtatgactc tttccttact caacatacaa gcacttacac tgcagagaaa ccctatgact
     1681 acaatgaatg tgggacgtct ttcatctgga gctcttacct tattcaacat aagaaaactc
     1741 atactggaga aaaaccctat gaatgtgata aatgtggaaa agtttttagg aatcgctcag
     1801 cccttacgaa acatgaacgg actcacactg gaataaaacc ctatgaatgt aataaatgtg
     1861 gaaaagcctt cagctggaat tctcatctta ttgtacataa gagaattcat acaggagaaa
     1921 aaccttatgt ttgtaatgag tgtgggaaat ctttcaactg gaactctcat cttattggac
     1981 atcagaggac tcatacagga gagaaacctt ttgaatgtac tgaatgtggg aaatcattca
     2041 gctggagctc ccatcttatt gcccatatga gaatgcatac tggagagaaa ccctttaaat
     2101 gtgatgaatg tgaaaaagct tttagggact actcagccct tagtaaacat gaaagaactc
     2161 attctggagc aaaaccatat aaatgtactg aatgtggaaa atccttcagc tggagctccc
     2221 atcttattgc ccatcagaga actcacacgg gagagaaacc atataactgt caggaatgtg
     2281 gcaaagcatt cagagaacgc tcagccctca ctaaacatga gataattcat tctggaatta
     2341 agccctatga atgtaataaa tgtggaaaat cctgtagcca gatggctcac cttgttagac
     2401 atcaaaggac tcatactgga gaaaaaccct atgaatgcaa taaatgtgga aaatccttca
     2461 gtcagagctg tcaccttgtt gctcatcgga gaattcacac tggtgagaaa ccctataaat
     2521 gtaatcagtg tgaaagatcc tttaactgta gttctcacct cattgcacac cggagaactc
     2581 atactggaga gaaaccatac aggtgtaatg aatgtgggaa agcatttaat gagagttcat
     2641 cccttattgt acacctaaga aaccatactg gagaaaagcc ctacaaatgt aatcattgtg
     2701 aaaaagcatt ttgtaagaat tcttccctta ttattcatca gagaatgcat agtggagaga
     2761 aacgctttat atgcagtgaa tgtggaaaag cctttagtgg tcactcagcc ctacttcaac
     2821 accagagaaa tcacagtgaa gagaaactga attgaattta tgcgagtttt tcgtttcttg
     2881 tacatttgac aacacattga ggaaaaccct ataaacataa tcaagagggg acatttttca
     2941 ttaagagttc agtaagactt ctcccacatt atttactaga aaatatcatc ttagaagaaa
     3001 ccccatgaag gaaaagaata gggaaaagct ttcagcagtt atttagccct tactcaaaat
     3061 cagataatta acaatgaagg aaactctaaa ctccccttat ggtctaccag taattcatac
     3121 ttgaggacca tgactgtggg gaatgaggca tcttttagca agagctctca ccaattgtag
     3181 attggtgtga attgctaagg gaaaaacctt atgcagagaa aagtttttga ctggaaatac
     3241 actgttttgc atcaagctgg agtactggat ggaaaactct acaataacat tttgtgcata
     3301 attgtagaaa tacagatttt gttgttataa ggggagggtc tgggtgccca ggagtagaat
     3361 atgaagtgct aaatctgaat gtaagaaaaa taatagtatt gaatggggta tttactgttg
     3421 attaacctcc ttagagaaaa ttaatgaatg agatgactaa cggtagaaaa gttattgcct
     3481 aggagtgtga gactgatgtt gctggacaga aagtgatcct tagcccagtg tgtcagcgtc
     3541 cattgttact catcactgca ttgttgggca attagtttgt aatttgtttt aggcaatcac
     3601 tataaattat aattatggac actgcatcag tatacataac atgaaggaat aaaaaggata
     3661 cagaattgta tatacatact tactgtaaca catctaaaaa aatgtatatg ggtaaggacc
     3721 tgaaagatcc atggaaaagt taacccagtt gagattttta aaaagtttta caaatacata
     3781 taacacttat gtgctgggct ttcttttaaa tgctttccaa gtgttaactt gtttagtccc
     3841 ctttactctg agataggtac tgttacccca gttttacaaa tggctaagct gaagcagaga
     3901 tgttgaagga tcctacctaa ggggcacaac tagtaaggga gtagagctga gattggctcc
     3961 agagttcttg ttttcagcca ccattttatg ctgcctctcc agtgattttt tttcccattt
     4021 tcttcagtgt ttctatagca gagatttgat aataaaaaga aaatcctaaa caatgagaaa
//
