LOCUS       NM_001321866            4618 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens zinc finger protein 600 (ZNF600), transcript variant
            2, mRNA.
ACCESSION   NM_001321866
VERSION     NM_001321866.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4618)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4618)
  AUTHORS   Demirkan,A., van Duijn,C.M., Ugocsai,P., Isaacs,A.,
            Pramstaller,P.P., Liebisch,G., Wilson,J.F., Johansson,A., Rudan,I.,
            Aulchenko,Y.S., Kirichenko,A.V., Janssens,A.C., Jansen,R.C.,
            Gnewuch,C., Domingues,F.S., Pattaro,C., Wild,S.H., Jonasson,I.,
            Polasek,O., Zorkoltseva,I.V., Hofman,A., Karssen,L.C.,
            Struchalin,M., Floyd,J., Igl,W., Biloglav,Z., Broer,L., Pfeufer,A.,
            Pichler,I., Campbell,S., Zaboli,G., Kolcic,I., Rivadeneira,F.,
            Huffman,J., Hastie,N.D., Uitterlinden,A., Franke,L., Franklin,C.S.,
            Vitart,V., Nelson,C.P., Preuss,M., Bis,J.C., O'Donnell,C.J.,
            Franceschini,N., Witteman,J.C., Axenovich,T., Oostra,B.A.,
            Meitinger,T., Hicks,A.A., Hayward,C., Wright,A.F., Gyllensten,U.,
            Campbell,H. and Schmitz,G.
  CONSRTM   DIAGRAM Consortium; CARDIoGRAM Consortium; CHARGE Consortium;
            EUROSPAN consortium
  TITLE     Genome-wide association study identifies novel loci associated with
            circulating phospho- and sphingolipid concentrations
  JOURNAL   PLoS Genet 8 (2), e1002490 (2012)
   PUBMED   22359512
REFERENCE   3  (bases 1 to 4618)
  AUTHORS   Yang,X.O., Doty,R.T., Hicks,J.S. and Willerford,D.M.
  TITLE     Regulation of T-cell receptor D beta 1 promoter by KLF5 through
            reiterated GC-rich motifs
  JOURNAL   Blood 101 (11), 4492-4499 (2003)
   PUBMED   12576331
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008813.6.
            
            On May 11, 2021 this sequence version replaced NM_001321866.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.3540039.1,
                                           SRR7346977.961784.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000692063.1/ ENSP00000509267.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               AC008813.6         75186-75382
            198-345             AC008813.6         80513-80660
            346-820             AC008813.6         80922-81396
            821-902             AC008813.6         83070-83151
            903-1029            AC008813.6         87276-87402
            1030-4618           AC008813.6         94205-97793
FEATURES             Location/Qualifiers
     source          1..4618
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..4618
                     /gene="ZNF600"
                     /gene_synonym="KR-ZNF1"
                     /note="zinc finger protein 600"
                     /db_xref="GeneID:162966"
                     /db_xref="HGNC:HGNC:30951"
     exon            1..197
                     /gene="ZNF600"
                     /gene_synonym="KR-ZNF1"
                     /inference="alignment:Splign:2.1.0"
     exon            198..345
                     /gene="ZNF600"
                     /gene_synonym="KR-ZNF1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..820
                     /gene="ZNF600"
                     /gene_synonym="KR-ZNF1"
                     /inference="alignment:Splign:2.1.0"
     exon            821..902
                     /gene="ZNF600"
                     /gene_synonym="KR-ZNF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             840..3215
                     /gene="ZNF600"
                     /gene_synonym="KR-ZNF1"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger protein KR-ZNF1"
                     /codon_start=1
                     /product="zinc finger protein 600 isoform 2"
                     /protein_id="NP_001308795.1"
                     /db_xref="CCDS:CCDS92675.1"
                     /db_xref="GeneID:162966"
                     /db_xref="HGNC:HGNC:30951"
                     /translation="MLCEEAAQKRKGKEPGMALPQGRLTFRDVAIEFSLAEWKCLNPS
                     QRALYREVMLENYRNLEAVDISSKRMMKEVLSTGQGNTEVIHTGTLQRYQSYHIGDFC
                     FQEIEKEIHDIEFQCQEDERNGHEAPMTKIKKLTGSTDQHDHRHAGNKPIKDQLGSSF
                     YSHLPELHIIQIKGKIGNQFEKSTSDAPSVSTSQRISPRPQIHISNNYGNNSPNSSLL
                     PQKQEVYMREKSFQCNESGKAFNCSSLLRKHQIPHLGDKQYKCDVCGKLFNHKQYLTC
                     HCRCHTGEKPYKCNECGKSFSQVSSLTCHRRLHTAVKSHKCNECGKIFGQNSALVIHK
                     AIHTGEKPYKCNECDKAFNQQSNLARHRRIHTGEKPYKCEECDKVFSRKSTLESHKRI
                     HTGEKPYKCKVCDTAFTWNSQLARHKRIHTGEKTYKCNECGKTFSHKSSLVCHHRLHG
                     GEKSYKCKVCDKAFAWNSHLVRHTRIHSGGKPYKCNECGKTFGQNSDLLIHKSIHTGE
                     QPYKYEECEKVFSCGSTLETHKIIHTGEKPYKCKVCDKAFACHSYLAKHTRIHSGEKP
                     YKCNECSKTFRLRSYLASHRRVHSGEKPYKCNECSKTFSQRSYLHCHRRLHSGEKPYK
                     CNECGKTFSHKPSLVHHRRLHTGEKSYKCTVCDKAFVRNSYLARHTRIHTAEKPYKCN
                     ECGKAFNQQSQLSLHHRIHAGEKLYKCETCDKVFSRKSHLKRHRRIHPGKKPYKCKVC
                     DKTFGSDSHLKQHTGLHTGEKPYKCNECGKAFSKQSTLIHHQAVHGVGKLD"
     exon            903..1029
                     /gene="ZNF600"
                     /gene_synonym="KR-ZNF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..4618
                     /gene="ZNF600"
                     /gene_synonym="KR-ZNF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3283..3288
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF600"
                     /gene_synonym="KR-ZNF1"
                     /note="hexamer: AATAAA"
     regulatory      3294..3299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF600"
                     /gene_synonym="KR-ZNF1"
                     /note="hexamer: AACAAG"
     regulatory      3303..3308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF600"
                     /gene_synonym="KR-ZNF1"
                     /note="hexamer: AATAAA"
     polyA_site      3304
                     /gene="ZNF600"
                     /gene_synonym="KR-ZNF1"
                     /note="major polyA site"
     polyA_site      3312
                     /gene="ZNF600"
                     /gene_synonym="KR-ZNF1"
     polyA_site      3331
                     /gene="ZNF600"
                     /gene_synonym="KR-ZNF1"
     regulatory      4596..4601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF600"
                     /gene_synonym="KR-ZNF1"
                     /note="hexamer: ATTAAA"
     polyA_site      4618
                     /gene="ZNF600"
                     /gene_synonym="KR-ZNF1"
ORIGIN      
        1 agtcctgggc gcgcacaaac ccggaagcgg atcgcgtgga gtgaaggtcc taccacggcg
       61 cgtgagtttt gctctgcctt ggattaagtc tgcacttccc aggtccccgg cgcttctgcc
      121 cctgggacgt gggatcccca cggacctgga aattctcgcc tgtcttccct tcacccagag
      181 caaattgaga cgtcccggag gaagaccaag gcagcctatt gggccttcca ggcaatcaca
      241 tgggaatcag ccacacgtcc ttcctcctca cctcagaaca tctcagaata acttggtgaa
      301 atgtctccca ctgtgagcct cagtgagccc acctgtaaca tagaggcctc gcccctgagc
      361 tctacaatcc tgtgtccagt tgtctcctca gctgtctcct gggtcatcaa acaggcatcc
      421 ccaccttcag gtgtccacga gtggctttct aaacccccaa acacatttcc ttgcagtctg
      481 cacatctcag atgagggtga ctacgtactt ccggaaacgg ccgaacttga cagcatgtat
      541 tttaaatttg tgaaataaat tactttattt gtaagtgttg taatttataa tataaagaga
      601 aacttagatg tatacgtgaa aagagtgaga agatacatca cttccaattt ttgtttgttt
      661 gtttgttttt ttgagaggaa ttttcactct tgtggctgag gctggagtgc aatgccatga
      721 tatcagctca ctgcaacctc tgactcctgg gatcaaggga ttctccttcc tcagactccc
      781 gagtagctgg gatcacagtc gactttcaaa attctttaag gattgattcc taaagactca
      841 tgttatgtga agaagcagct cagaagagga aaggaaagga gccaggcatg gctcttcctc
      901 agggacgctt gactttcagg gatgtggcta tagaattctc attggcagag tggaaatgcc
      961 tgaacccttc gcagagggct ttgtacaggg aagtgatgtt ggagaactac aggaacctgg
     1021 aagctgtgga tatctcttcc aaacgcatga tgaaggaggt cttgtcaaca gggcaaggca
     1081 atacagaagt gatccacaca gggacattgc aaagatatca aagttatcac attggagatt
     1141 tttgcttcca ggaaattgag aaagaaattc atgatattga gtttcagtgt caagaagatg
     1201 aaagaaatgg ccatgaagca cccatgacaa aaataaaaaa gttgactggt agcacagacc
     1261 aacatgatca caggcatgct ggaaacaagc ctattaaaga tcagcttgga tcaagctttt
     1321 attcacatct gcctgaactc cacataattc agatcaaagg taaaattggt aatcaatttg
     1381 agaagtctac cagtgatgct ccctcggttt caacatccca aagaatttct cctaggcccc
     1441 aaatccatat ttctaataac tatgggaata attccccgaa ttcttcacta ctcccacaaa
     1501 aacaggaagt atacatgaga gaaaaatctt tccaatgtaa tgagagtggc aaagccttta
     1561 attgtagctc actcttaagg aaacaccaga taccccattt aggagacaaa caatataaat
     1621 gtgatgtatg tggcaagctc tttaatcaca agcaatacct tacatgccat tgtagatgtc
     1681 acactggaga gaaaccttac aagtgtaatg agtgtggaaa gtccttcagt caggtatcat
     1741 cccttacatg ccatcgtaga cttcacactg cagtaaaatc tcacaagtgt aatgagtgtg
     1801 gcaagatctt tggtcaaaat tcagcccttg taattcataa ggcaattcat actggagaaa
     1861 aaccttacaa gtgtaatgaa tgtgacaaag cttttaatca gcaatcaaac cttgcacgtc
     1921 atcgtagaat tcatactgga gagaaacctt acaaatgtga agaatgtgac aaagttttca
     1981 gtcggaaatc aacccttgag tcacataaga gaattcatac tggagagaaa ccatacaaat
     2041 gtaaggtttg tgacacagct ttcacatgga attctcagct ggcaagacat aaaagaattc
     2101 acactggaga gaaaacttac aagtgtaatg agtgtggcaa gaccttcagt cacaagtcat
     2161 cccttgtatg ccatcataga cttcatggtg gagagaaatc ttacaaatgt aaggtctgtg
     2221 acaaggcttt tgcgtggaat tcacacctgg taagacatac tagaattcat agtggaggaa
     2281 aaccttacaa gtgtaatgaa tgtgggaaga cctttggtca aaattcagat cttctaattc
     2341 ataagtcaat tcatactgga gagcaacctt acaaatatga agaatgtgaa aaggttttca
     2401 gttgtggatc aacccttgag acacataaga taattcacac cggagagaaa ccatacaaat
     2461 gtaaggtttg tgacaaggct tttgcgtgtc attcctatct ggcaaaacat actagaattc
     2521 atagtggaga gaaaccttac aagtgtaatg agtgcagcaa gaccttccgt ctgaggtcat
     2581 accttgcaag ccatcgcaga gttcatagtg gtgagaaacc ttacaagtgt aatgagtgca
     2641 gcaagacctt cagtcagagg tcataccttc attgccatcg tagacttcat agtggtgaga
     2701 aaccttacaa gtgtaatgag tgtggcaaga ccttcagtca caagccatcc cttgttcacc
     2761 atcgtagact tcatactgga gagaaatctt acaaatgtac ggtttgtgac aaggctttcg
     2821 tgcgtaattc atacctggca agacatacca gaattcacac tgcagagaaa ccttacaagt
     2881 gtaatgaatg tgggaaggct tttaatcaac aatcacaact ttcacttcat catagaattc
     2941 atgctgggga gaaactttac aaatgtgaaa catgtgacaa agttttcagt cgcaaatcac
     3001 accttaaaag acataggaga attcatcctg gaaagaaacc atacaaatgt aaggtttgtg
     3061 acaagacttt tgggagtgat tcacacctga aacaacatac tggacttcac actggagaga
     3121 aaccttacaa gtgtaatgag tgtggcaaag cctttagcaa gcagtcaaca cttattcacc
     3181 atcaggcagt tcatggtgta gggaaacttg actaatgtaa tgattgtcac aaagtcttca
     3241 gtaacgctac aaccattgca aatcattgga gaatctataa tgaataaaga tctaacaagt
     3301 gtaataaatg tggcaaattt ttcagacatc attcatacat tgcagttcat tgacacactc
     3361 atactggaga gaaaccttac aaatgtcatg actgtggcaa ggtcttcagt caagcttcat
     3421 cctatgcaaa acataggaga attcatacag gagagaaacc tcacatgtgt gatgattgtg
     3481 gcaaagcctt tacttcatgt tcacacctca ttagacatca gagaatccct actggacaga
     3541 aatcttacaa atgtcagaag tgtggcaagg tcttgagtcc gaggtcactc cttgcagaac
     3601 atcagaaaat tcatttttga gataactgtt cccaatgcag tgagtatagc aaaccatcaa
     3661 gcattaattg acactagagt cagtccagca ttgacttgag tttgtgttga cttaacattg
     3721 agttcaaccc ttaattgaca ttcaagtgtt tatgttaaga ggattgggcc aggtgtggtt
     3781 tctcacacct gtaattccag cacggttgga ggccaaggca cataggtcac ttgaggtcag
     3841 aagtttgaaa ccagcatggc caacagatgt cagccacttt tcccagcctg ttttttgatt
     3901 cttattttct atttttcttt tttgagatag tactttttaa agagatagta cttttttgat
     3961 atagtacttt ataaaaggga gatcaggcca ggcacggagg ctcatgtaag taatcccagc
     4021 actttgggag gccgagacgg gcccatgaca aggtcaggag atcgagaccg tcctggctaa
     4081 cacggtgaaa ccccatctct actaaaaata taaaatatta gccaggcgtg gtggcaggtg
     4141 cctgtagtcc tagctgcttg ggaggctgag gcaggagaat ggtgtgaatc ctggagacgg
     4201 agcttgcagg gagccaacat cgtgccactg cactccggcc tgggcgacag tgagaatctg
     4261 tctcaaaaaa aaaaaaaaaa aaaggatatc aaagctggat ggtggctcat ccctgcaatc
     4321 acaacacttt ggtagactga tgtgagtgga tcacctaagg tcagaagttc aagagcaccc
     4381 tggctaacat ggtgaaaccc catctctact aaaaatacaa aagttagccg gggggtggtg
     4441 gtgtgcacct ttagttccag ctacttgaga ggctgaggca caagagtcgc ttaaacctgg
     4501 gaggtagagg ttgccgtgag gcaaaatcgt gccactgccc tcagcctggg cagtagagtc
     4561 agtctccatc tcaaagaaac cagcaaacaa aaaatattaa aaaaaaacat taaaaatg
//
