LOCUS       NM_178167               3365 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 598, E3 ubiquitin ligase (ZNF598),
            transcript variant 1, mRNA.
ACCESSION   NM_178167
VERSION     NM_178167.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3365)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 3365)
  AUTHORS   Narita,M., Denk,T., Matsuo,Y., Sugiyama,T., Kikuguchi,C., Ito,S.,
            Sato,N., Suzuki,T., Hashimoto,S., Machova,I., Tesina,P.,
            Beckmann,R. and Inada,T.
  TITLE     A distinct mammalian disome collision interface harbors K63-linked
            polyubiquitination of uS10 to trigger hRQT-mediated subunit
            dissociation
  JOURNAL   Nat Commun 13 (1), 6411 (2022)
   PUBMED   36302773
  REMARK    GeneRIF: A distinct mammalian disome collision interface harbors
            K63-linked polyubiquitination of uS10 to trigger hRQT-mediated
            subunit dissociation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3365)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 3365)
  AUTHORS   Park,J., Lee,J., Kim,J.H., Lee,J., Park,H. and Lim,C.
  TITLE     ZNF598 co-translationally titrates poly(GR) protein implicated in
            the pathogenesis of C9ORF72-associated ALS/FTD
  JOURNAL   Nucleic Acids Res 49 (19), 11294-11311 (2021)
   PUBMED   34551427
  REMARK    GeneRIF: ZNF598 co-translationally titrates poly(GR) protein
            implicated in the pathogenesis of C9ORF72-associated ALS/FTD.
REFERENCE   5  (bases 1 to 3365)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3365)
  AUTHORS   Morita,M., Ler,L.W., Fabian,M.R., Siddiqui,N., Mullin,M.,
            Henderson,V.C., Alain,T., Fonseca,B.D., Karashchuk,G.,
            Bennett,C.F., Kabuta,T., Higashi,S., Larsson,O., Topisirovic,I.,
            Smith,R.J., Gingras,A.C. and Sonenberg,N.
  TITLE     A novel 4EHP-GIGYF2 translational repressor complex is essential
            for mammalian development
  JOURNAL   Mol Cell Biol 32 (17), 3585-3593 (2012)
   PUBMED   22751931
REFERENCE   7  (bases 1 to 3365)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   8  (bases 1 to 3365)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   9  (bases 1 to 3365)
  AUTHORS   Tao,W.A., Wollscheid,B., O'Brien,R., Eng,J.K., Li,X.J.,
            Bodenmiller,B., Watts,J.D., Hood,L. and Aebersold,R.
  TITLE     Quantitative phosphoproteome analysis using a dendrimer conjugation
            chemistry and tandem mass spectrometry
  JOURNAL   Nat Methods 2 (8), 591-598 (2005)
   PUBMED   16094384
REFERENCE   10 (bases 1 to 3365)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005606.3 and ABBA01030283.1.
            
            On Apr 29, 2022 this sequence version replaced NM_178167.4.
            
            Summary: Zinc-finger proteins bind nucleic acids and play important
            roles in various cellular functions, including cell proliferation,
            differentiation, and apoptosis. This protein and Grb10-interacting
            GYF protein 2 have been identified as a components of the mammalian
            4EHP (m4EHP) complex. The complex is thought to function as a
            translation repressor in embryonic development. [provided by
            RefSeq, Oct 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050477.1, SRR11853566.9783.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000710288.1/ ENSP00000518178.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC005606.3         68885-68912         c
            29-199              ABBA01030283.1     1320-1490
            200-294             AC005606.3         68615-68709         c
            295-407             AC005606.3         62707-62819         c
            408-537             AC005606.3         62082-62211         c
            538-749             AC005606.3         61612-61823         c
            750-967             AC005606.3         61297-61514         c
            968-1085            AC005606.3         60674-60791         c
            1086-1273           AC005606.3         60095-60282         c
            1274-1364           AC005606.3         59482-59572         c
            1365-2125           AC005606.3         58587-59347         c
            2126-2282           AC005606.3         58056-58212         c
            2283-2433           AC005606.3         57793-57943         c
            2434-3365           AC005606.3         56745-57676         c
FEATURES             Location/Qualifiers
     source          1..3365
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..3365
                     /gene="ZNF598"
                     /gene_synonym="HEL2"
                     /note="zinc finger protein 598, E3 ubiquitin ligase"
                     /db_xref="GeneID:90850"
                     /db_xref="HGNC:HGNC:28079"
                     /db_xref="MIM:617508"
     exon            1..294
                     /gene="ZNF598"
                     /gene_synonym="HEL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..2787
                     /gene="ZNF598"
                     /gene_synonym="HEL2"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; E3
                     ubiquitin-protein ligase ZNF598"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase ZNF598 isoform 1"
                     /protein_id="NP_835461.2"
                     /db_xref="GeneID:90850"
                     /db_xref="HGNC:HGNC:28079"
                     /db_xref="MIM:617508"
                     /translation="MAAAGGAEGRRAALEAAAAAAPERGGGSCVLCCGDLEATALGRC
                     DHPVCYRCSTKMRVLCEQRYCAVCREELRQVVFGKKLPAFATIPIHQLQHEKKYDIYF
                     ADGKVYALYRQLLQHECPRCPELPPFSLFGDLEQHMRRQHELFCCRLCLQHLQIFTYE
                     RKWYSRKDLARHRMQGDPDDTSHRGHPLCKFCDERYLDNDELLKHLRRDHYFCHFCDS
                     DGAQDYYSDYAYLREHFREKHFLCEEGRCSTEQFTHAFRTEIDLKAHRTACHSRSRAE
                     ARQNRHIDLQFSYAPRHSRRNEGVVGGEDYEEVDRYSRQGRVARAGTRGAQQSRRGSW
                     RYKREEEDREVAAAVRASVAAQQQEEARRSEDQEEGGRPKKEEAAARGPEDPRGPRRS
                     PRTQGEGPGPKETSTNGPVSQEAFSVTGPAAPGCVGVPGALPPPSPKLKDEDFPSLSA
                     STSSSCSTAATPGPVGLALPYAIPARGRSAFQEEDFPALVSSVPKPGTAPTSLVSAWN
                     SSSSSKKVAQPPLSAQATGSGQPTRKAGKGSRGGRKGGPPFTQEEEEDGGPALQELLS
                     TRPTGSVSSTLGLASIQPSKVGKKKKVGSEKPGTTLPQPPPATCPPGALQAPEAPASR
                     AEGPVAVVVNGHMEGPAPARSAPKEPPGLPRPLGSFPCPTPQEDFPALGGPCPPRMPP
                     PPGFSAVVLLKGTPPPPPPGLVPPISKPPPGFSGLLPSPHPACVPSPATTTTTKAPRL
                     LPAPRAYLVPENFRERNLQLIQSIRDFLQSDEARFSEFKSHSGEFRQGLISAAQYYKS
                     CRDLLGENFQKVFNELLVLLPDTAKQQELLSAHTDFCNREKPLSTKSKKNKKSAWQAT
                     TQQAGLDCRVCPTCQQVLAHGDASSHQALHAARDDDFPSLQAIARIIT"
     exon            295..407
                     /gene="ZNF598"
                     /gene_synonym="HEL2"
                     /inference="alignment:Splign:2.1.0"
     exon            408..537
                     /gene="ZNF598"
                     /gene_synonym="HEL2"
                     /inference="alignment:Splign:2.1.0"
     exon            538..749
                     /gene="ZNF598"
                     /gene_synonym="HEL2"
                     /inference="alignment:Splign:2.1.0"
     exon            750..967
                     /gene="ZNF598"
                     /gene_synonym="HEL2"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1085
                     /gene="ZNF598"
                     /gene_synonym="HEL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1273
                     /gene="ZNF598"
                     /gene_synonym="HEL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1364
                     /gene="ZNF598"
                     /gene_synonym="HEL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..2125
                     /gene="ZNF598"
                     /gene_synonym="HEL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2282
                     /gene="ZNF598"
                     /gene_synonym="HEL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2433
                     /gene="ZNF598"
                     /gene_synonym="HEL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..3365
                     /gene="ZNF598"
                     /gene_synonym="HEL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3339..3344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF598"
                     /gene_synonym="HEL2"
                     /note="hexamer: AATAAA"
     polyA_site      3365
                     /gene="ZNF598"
                     /gene_synonym="HEL2"
                     /note="major polyA site"
ORIGIN      
        1 ggaaggggcg ggcccgccgg gagccaggcc gcgcggcgcc gcgccggccg agagggggcc
       61 ggatcccgga ccatggcggc ggcggggggc gccgaggggc ggcgcgcggc cctggaggcg
      121 gcggcggcgg cagctcctga gcggggaggc gggagctgcg tgctgtgctg cggagacctg
      181 gaggccacgg cgctgggccg ctgcgaccac ccggtgtgct accgctgctc taccaagatg
      241 cgggtgctct gcgagcagcg ctactgcgcc gtgtgccgcg aggagctgcg ccaggtggtc
      301 tttgggaaga agcttcctgc ctttgccacc atccccatcc accagctgca gcatgagaag
      361 aaatatgata tctactttgc agatggaaag gtgtacgcat tgtacaggca gctgctgcag
      421 cacgagtgcc cgcggtgccc cgagctgcca cctttcagcc tcttcgggga cctggagcag
      481 cacatgcgga ggcagcatga gctcttctgc tgccgtctgt gcctccagca cctccagatc
      541 ttcacatatg agcgcaagtg gtactcgcgc aaggacctgg cccggcatcg catgcagggt
      601 gaccccgatg acacgtcgca ccgtgggcac ccgctctgca agttctgtga cgagcgctac
      661 ctggacaatg atgagctgct taagcacctg cgccgcgacc actacttctg ccacttctgc
      721 gactcggacg gggcccagga ctactacagc gactatgcct acctgcgtga gcacttccgg
      781 gagaagcact ttctgtgtga ggaaggccgc tgcagcacgg agcagttcac ccacgccttc
      841 cgcaccgaga tcgacctcaa ggcccacagg acggcctgcc acagtcgcag ccgcgccgag
      901 gcacgccaga accgccacat cgacctgcag ttcagctacg cgccacggca ctcgcgccgg
      961 aacgaggggg tcgttggtgg cgaagactac gaggaggtgg acaggtacag ccgccagggc
     1021 cgagtggccc gggctggcac tcgcggagcc cagcagagcc gccgaggaag ctggaggtac
     1081 aaaagggaag aagaggaccg agaagtagca gctgctgtcc gggcctccgt ggccgcacag
     1141 cagcaggagg aggctcgcag gagtgaggat caggaggaag gcggtaggcc caagaaggag
     1201 gaggcagcgg cgcggggacc tgaggatccc cgtggccccc ggcgctcacc ccggactcag
     1261 ggcgaaggcc caggccccaa ggaaacctcg acaaatggtc ctgtaagcca agaagccttc
     1321 tcggtgacag gcccagccgc cccagggtgt gtgggggtgc caggcgccct cccaccaccc
     1381 agcccgaagc tcaaggacga agacttcccc agcctctctg cctccacttc ctcctcctgc
     1441 tccactgcag caaccccggg ccctgtgggg ttggcgctgc cgtacgccat ccctgccaga
     1501 ggcaggagtg ccttccagga ggaggacttc cccgccctgg tgtcctcggt gcccaagcct
     1561 ggcaccgccc ccaccagcct tgtctctgcc tggaacagca gcagtagcag caagaaggta
     1621 gcacagcccc cactctcggc gcaggctacc ggcagcggcc agcccaccag gaaggctggg
     1681 aaggggagca ggggcggcag gaagggcggc ccgcccttca cacaggagga ggaggaggac
     1741 ggcggcccgg ccctgcagga gcttctgagc acacgcccca cgggctccgt ctcctccaca
     1801 ctggggctgg cctccatcca accctctaaa gttgggaaga agaagaaagt gggctcggag
     1861 aagccaggca ccacattgcc acagcccccg cccgctacct gtcccccagg ggctttgcag
     1921 gccccggaag ctcctgccag cagagccgag gggccagttg ccgtcgtcgt taatggacac
     1981 atggagggcc cggcccctgc tcggagtgcc cccaaggaac cccctgggct cccaaggccc
     2041 ctggggtcct tcccctgccc cacgccacag gaggacttcc cagcgctcgg cggcccctgc
     2101 ccaccccgga tgccgccgcc cccaggcttc agcgctgtgg tgctcctgaa gggcacgcct
     2161 cccccacccc cgccgggcct ggtgccccca atcagcaagc cgccccctgg cttctctggc
     2221 cttctgccta gcccccaccc ggcctgtgtc cccagccccg ccaccaccac caccacaaaa
     2281 gcacccaggc tgctgcctgc cccacgggcg tacctagtcc ccgagaactt ccgggagagg
     2341 aaccttcagc tcatccagtc catcagggac ttcctgcaga gcgacgaggc ccgcttcagc
     2401 gagttcaaga gccactcagg ggagttcaga cagggcctga tctccgcagc ccagtattac
     2461 aagagttgcc gggacctgct gggggagaat ttccagaagg tctttaatga gctgctggtc
     2521 ctgctgcccg acacggccaa gcagcaggag ctcctgtctg cacacacgga cttctgcaac
     2581 cgcgagaagc ctctgagcac caagtccaag aagaacaaga agagcgcgtg gcaggccacc
     2641 acccagcagg cgggcctgga ctgccgtgtg tgccccacct gccagcaggt gctcgcgcat
     2701 ggcgatgcca gcagccacca ggcgctgcat gctgcccggg acgacgactt cccctccctg
     2761 caagccatcg ccaggatcat cacgtagctc ccgccagcgt ggccagagct gtcgcaccgt
     2821 gagcgtcctt cctccttcct ctccgggctg ccaggcagcc aggtaaggcc tggtgaggcc
     2881 acttggcctc ttggttggcc aggcccacca ggaagtcacc aggacagtcc acccgccctg
     2941 ttggcacact caagcgggag tccacccctg cctcagtggt gggccagtct cggtttgcat
     3001 tcttgtgctt ttgggaggtg ccaggggagg gaagggctgg gatgctggga cctgttgttg
     3061 ctggcaaagc cagaggtcac agtggcctga tctgggccct cccaaagctg agggctgcag
     3121 cccgtggggc ctcagagctg aaagctgcgg cgccactggt gccagagtca gatgtcacag
     3181 atgtgttgtg taaacagttg gctgtttcat gcttcaagaa tgttcaggat taaaagcaga
     3241 caagaaattg tgctacttga agttgaatct ttttatgaga caagctgaat ctgggatctc
     3301 aaattgcctc tgacctttta taagacagtt tatcttcaaa taaatttatt ttgcaatacc
     3361 acgca
//
