LOCUS       NM_152457               5483 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 597 (ZNF597), mRNA.
ACCESSION   NM_152457
VERSION     NM_152457.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5483)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 5483)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5483)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   4  (bases 1 to 5483)
  AUTHORS   Nakabayashi,K., Trujillo,A.M., Tayama,C., Camprubi,C., Yoshida,W.,
            Lapunzina,P., Sanchez,A., Soejima,H., Aburatani,H., Nagae,G.,
            Ogata,T., Hata,K. and Monk,D.
  TITLE     Methylation screening of reciprocal genome-wide UPDs identifies
            novel human-specific imprinted genes
  JOURNAL   Hum Mol Genet 20 (16), 3188-3197 (2011)
   PUBMED   21593219
REFERENCE   5  (bases 1 to 5483)
  AUTHORS   Choufani,S., Shapiro,J.S., Susiarjo,M., Butcher,D.T.,
            Grafodatskaya,D., Lou,Y., Ferreira,J.C., Pinto,D., Scherer,S.W.,
            Shaffer,L.G., Coullin,P., Caniggia,I., Beyene,J., Slim,R.,
            Bartolomei,M.S. and Weksberg,R.
  TITLE     A novel approach identifies new differentially methylated regions
            (DMRs) associated with imprinted genes
  JOURNAL   Genome Res 21 (3), 465-476 (2011)
   PUBMED   21324877
REFERENCE   6  (bases 1 to 5483)
  AUTHORS   Tanabe,Y., Hirano,A., Iwasato,T., Itohara,S., Araki,K.,
            Yamaguchi,T., Ichikawa,T., Kumanishi,T., Aizawa,Y., Takahashi,H.,
            Kakita,A. and Nawa,H.
  TITLE     Molecular characterization and gene disruption of a novel
            zinc-finger protein, HIT-4, expressed in rodent brain
  JOURNAL   J Neurochem 112 (4), 1035-1044 (2010)
   PUBMED   19968752
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025283.6, AL701654.1 and
            AI038687.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_152457.2.
            
            Summary: This gene encodes a protein with multiple zinc finger
            domains. Loss of the related gene in rodents results in defects in
            neural development and embryonic lethality in mutant homozygotes.
            This gene is adjacent to a differentially methylated region (DMR)
            and is imprinted and maternally expressed. [provided by RefSeq, Nov
            2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA329623.1, SRR1660809.236239.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 21593219
            MANE Ensembl match     :: ENST00000301744.7/ ENSP00000301744.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AC025283.6         140990-141073       c
            85-512              AL701654.1         1-428
            513-5062            AC025283.6         130404-134953       c
            5063-5475           AI038687.1         9-421               c
            5476-5483           AC025283.6         129983-129990       c
FEATURES             Location/Qualifiers
     source          1..5483
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..5483
                     /gene="ZNF597"
                     /gene_synonym="HIT-4"
                     /note="zinc finger protein 597"
                     /db_xref="GeneID:146434"
                     /db_xref="HGNC:HGNC:26573"
                     /db_xref="MIM:614685"
     exon            1..145
                     /gene="ZNF597"
                     /gene_synonym="HIT-4"
                     /inference="alignment:Splign:2.1.0"
     exon            146..231
                     /gene="ZNF597"
                     /gene_synonym="HIT-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1473
                     /gene="ZNF597"
                     /gene_synonym="HIT-4"
                     /codon_start=1
                     /product="zinc finger protein 597"
                     /protein_id="NP_689670.1"
                     /db_xref="CCDS:CCDS10505.1"
                     /db_xref="GeneID:146434"
                     /db_xref="HGNC:HGNC:26573"
                     /db_xref="MIM:614685"
                     /translation="MASMPPTPEAQGPILFEDLAVYFSQEECVTLHPAQRSLSKDGTK
                     ESLEDAALMGEEGKPEINQQLSLESMELDELALEKYPIAAPLVPYPEKSSEDGVGNPE
                     AKILSGTPTYKRRVISLLVTIENHTPLVELSEYLGTNTLSEILDSPWEGAKNVYKCPE
                     CDQNFSDHSYLVLHQKIHSGEKKHKCGDCGKIFNHRANLRTHRRIHTGEKPYKCAKCS
                     ASFRQHSHLSRHMNSHVKEKPYTCSICGRGFMWLPGLAQHQKSHSAENTYESTNCDKH
                     FNEKPNLALPEETFVSGPQYQHTKCMKSFRQSLYPALSEKSHDEDSERCSDDGDNFFS
                     FSKFKPLQCPDCDMTFPCFSELISHQNIHTEERPHKCKTCEESFALDSELACHQKSHM
                     LAEPFKCTVCGKTFKSNLHLITHKRTHIKNTT"
     exon            232..358
                     /gene="ZNF597"
                     /gene_synonym="HIT-4"
                     /inference="alignment:Splign:2.1.0"
     exon            359..5483
                     /gene="ZNF597"
                     /gene_synonym="HIT-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4463..4468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF597"
                     /gene_synonym="HIT-4"
                     /note="hexamer: AATAAA"
     polyA_site      4482
                     /gene="ZNF597"
                     /gene_synonym="HIT-4"
                     /note="major polyA site"
     regulatory      5456..5461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF597"
                     /gene_synonym="HIT-4"
                     /note="hexamer: ATTAAA"
     polyA_site      5483
                     /gene="ZNF597"
                     /gene_synonym="HIT-4"
ORIGIN      
        1 ggcttttccc gcagctcctg cgtaaaggag catgagagcg tgggagtttt gcagtggccg
       61 tggcgttctt cgtcgcgtct cggtcgggcg tcgctttctg cagctcctgt cagggagcgc
      121 gaggcctgtt attaaccgcg gagcgctttg tcacgaagtc cctgtggcgt cttgaagaag
      181 gcattcccca cccgccaaat ggcgtccatg cccccgacgc ccgaggccca gggaccaata
      241 ctctttgagg atctggctgt gtatttttct caagaggagt gcgtgactct gcaccctgcc
      301 cagaggtccc tcagcaaaga tggtacaaaa gagtctttgg aggatgcggc tttgatggga
      361 gaggaaggca agcctgagat taatcagcag ttaagcctag agtctatgga acttgacgag
      421 cttgccttag aaaagtaccc cattgctgca ccccttgtcc cttacccaga aaaatcctct
      481 gaggatggag ttggaaaccc tgaagcgaaa atattaagtg gaactcccac ttacaagaga
      541 agggtcatca gccttttagt taccattgaa aaccacaccc cattagtaga actctctgaa
      601 tatttaggaa ccaacacact ttctgaaatt cttgattctc cctgggaagg agccaaaaat
      661 gtgtacaaat gtcctgagtg tgaccaaaac ttcagcgatc attcatacct agttttgcat
      721 cagaaaattc attcaggaga gaaaaaacat aaatgtggtg actgtggaaa gatcttcaat
      781 catagagcca acctgaggac acacaggaga atccatactg gtgagaaacc ttataagtgt
      841 gccaagtgca gtgccagctt tcgccagcac tctcatctat cccgacacat gaatagccac
      901 gtaaaggaga agccctatac atgtagcata tgtggtagag gttttatgtg gctcccagga
      961 ttggcacagc atcagaaaag ccacagtgct gaaaacacct acgaatctac taactgtgat
     1021 aaacatttta atgagaaacc aaatcttgct ttgcctgagg aaacattcgt atcaggcccc
     1081 cagtaccagc acactaagtg catgaagagc ttcaggcagt ccttatatcc tgccctttcc
     1141 gagaagagcc acgacgagga ctctgaacgc tgcagcgatg atggggacaa tttcttctca
     1201 ttctcaaaat tcaagccctt acagtgtcct gactgtgaca tgacctttcc ttgtttctct
     1261 gagcttattt cccatcagaa cattcataca gaggaaaggc cccataagtg caaaacatgc
     1321 gaggaaagtt ttgctttgga ctcagaactt gcatgccacc agaagagcca catgctagcg
     1381 gaacctttta aatgtaccgt gtgtgggaaa actttcaagt cgaatttgca tctcattact
     1441 cataagcgaa ctcacataaa aaacaccacg taaagtaaat ataacaaatt gttattagtg
     1501 attgggcttt tcagtatctg tatggtggga agcagttact gtatatgtcc caggcaatgt
     1561 gctaagcact ttacacacat tcccatgtaa tacttaattc tcagcacaac cgtgatttag
     1621 gcagtatcat ttccatttta taagtaggga tgcaaaatcc gtgtcactaa actagtgaat
     1681 gaacccagga tttgaactca gttactgtac aactgtgagc cagaagaaga tacacaactt
     1741 ttgtttaaat tcaattttca ttaaaatgaa ggctcttgct aaagttattt taattttgtt
     1801 tacgtagttt ctgactttta gaaggaggag aatttattta tattttgcca gttctgcaga
     1861 catatctagg aaagtaaatg cttttatatg ttttatactt ttttttgcta taactatttg
     1921 aatgtaatac ttgtataaga ttgctgttct acatgtgaat tcccacaggc gttcagaagt
     1981 ttttttctgc cctgtaaaag ttcccaaatg ggtagactag tttatatttt gatggccatt
     2041 agtatccgga gttctctgtc atggttctga tgccaggggc acatactggc atttaggacc
     2101 caattgtttg caaggagttt tggaagtcta actgcagccc ttttctggag gctggacttg
     2161 acttggggag ggggagaagt acttgctctt ttctaagatt tgcctccaaa ttgctactga
     2221 agcacattac ctgtcttact atgaataatt gtaattgttt ctcagtgagc atgctagcta
     2281 ctttagatat attatgtaat ttaatcttca gaatctgtga cagagaaaaa aaatctttgt
     2341 ttcataaacg aggaaactga agtcctcaga gggtaaagtc agttctttgc ccagcacaca
     2401 aatcacattg tggtgaaact gacattaagc ttgggtttct ctgactccaa aggccatgca
     2461 gtctgcaaga ctgcggcatt tgttggcatt tgcaccacgt agtagcactg caggcagcca
     2521 gggaaagggg agctgagata ggtgagggtg gtcctcatgg aggcgattct gtgtgcttgc
     2581 atcctggaac cccttcattc cctttgtgct gtacccaaag cctgactaac atatacagtt
     2641 acaaagcagc agaagactct ccaggacttc aggtttgaat tcttgtccct ctaatcagat
     2701 gagagatttc acacttggca gagtacaata ctgaaggtct taactgggtt ttggtttttt
     2761 aaaaaacacc cataacattt cctctccatc tccaaagaaa atgcatatag aaaattgtta
     2821 gattttaacc aaaatacttg ataatatata gatctttaga tattgctatt atagataaat
     2881 actggagcaa aatattatta aatggtatgg ttattaatgt taaagaacca cagaatgttg
     2941 taaatataga ttcatataca atttctcatt aaagtcgatt gtatgcctat cagcaaaaca
     3001 atatttacat gggttttgat taggatggaa gaatgctctc attctattta aatagacagt
     3061 ataaaagtac aatatttgct aaaattgaat tgttgctggg aatttttgct gggagaaaag
     3121 ataaaggact cttgaggact aattatatgg aaggtagcag aaggtggtcc tacagaacag
     3181 cagattgagg actaaatata caaaaaatgc tggctactca gctaagctct tattactgag
     3241 tagaggcagg aagatactgt tcaggtgaga gaaaaactga aactaacaaa aacatcccta
     3301 acccagagag agtttctctc tctttgtcat tcttgtcttg tttcttgttt gcagatccac
     3361 agttgagaca atgtgctgct ctgtatgtca aggtcagact ttggctgttt gtttctgatg
     3421 tctccactct taggagacag gacaccagct tccaggtttc tctgaggtgc tttgaaatgt
     3481 gtagaaagat agtctccagt tagattactt attaggcaac tctgagatac catgaccttt
     3541 gttaaataac aagaacacca cctccttgct ctcctgcttc tgccctcagt gggagaaact
     3601 ggcaggagcc tcatcagcac atatcagggg ccctaagagt tcagtcaaag atctaatgag
     3661 tcacaggatg ggggatgaaa ttgggaaagg tctggattag cagagttgct gcagaaagaa
     3721 gtagagggga atatcttaga aggcacttgg acagaatggg ggtgatataa aagatgtatg
     3781 ctgtcatttt tgttttggct cctagaaaat atagcagaaa gtgagaattt gtgccataca
     3841 tcctgttctg caccttaata tggaagtttg cctttccaca cgagtcttcc ttcacaatta
     3901 acctctaatt tttttttttg cagttttctc cagattttgg aagattacga caaacttcct
     3961 aaaagattag aaaaaatagc ccttttcaga aacattaaca tacgtgtggg tagaactaaa
     4021 atggcttttt ggtataatac tgttaatgat tagtatgcag aaaaaaatga aaaccccgga
     4081 agtgtcagtt actgtgaaag aggcatattt tcagttgtgc ttattgtgca gttgtactta
     4141 aatacatttg ctagatgtaa ttcaagctgc tttaccccca gggaattgaa ggaaaagata
     4201 tatctgctgg tgagcttcag gctttttatg atgatggcat ttcacccttc tgtttacagt
     4261 gtcaactgat ggagataaat tccataaaat tgtcattaac tcagatacta gccttccatg
     4321 ttaggtgcta ttcacaaata ctggataaaa gttaatatgg gaatgaaaaa ctaaatgcaa
     4381 gagtttattg ctatgaatga ttggttaact gcattttgca gcatggaaat caacacacta
     4441 tgagagtgaa aactttgtgc tgaataaatt gactcagaca aatttctccg tttttgtcgt
     4501 tgatgcagtg atgaaaatgt atatccaaca gttccttaac atgattgctg gaatagttaa
     4561 acagtctttt aaacagtcgt cattgatgaa aacagcattt ttccaatgga attcagatgt
     4621 cagcagttta cattttataa tttaagaaat tgtggaatgt agttgttttg aatgaggtcg
     4681 actcagaata gttttattta gagctttgtt gctacaggtg gtagtctatt gacacctcct
     4741 catttaacat agaaaatgac taacccaata attcagggag ttaaaactca aatgacattt
     4801 cacagcaaat gccattttga gtctttgcct cctgagtttc catataatta agtggcaatg
     4861 ttctagtgac tgcagcataa gatgtcatac aatctgaaac tgcagagttt gatcaaagta
     4921 atctgcaatt tactgcctat gtgtacaaag ggagacatag caggttatag tttatatgaa
     4981 tagtctattt tgaatgttca ttaaacttgt tatccctgtg ggattttagt aggaaagtgt
     5041 atttgctttg accatctgtt taacaaaatg atgttcatta cattagaagt gtatgtattc
     5101 atctggttta gttttgtaat ttagaagagc tattgatctg attcaaagat aaccattacc
     5161 catctttcca aggcccatct aagtagtaca ggtgttttgt cttttaaaat tgacagtcct
     5221 ctttgcatta agtctgtagg gggggaatac aatataaata ttcttctgtg taaacgtaag
     5281 aatgtgctgt aatctccagt tcctttggat acctcagaat tctatttatt gtatacactt
     5341 atactgttta ttcaatgttt tgggtcttac tctttttgac gtattctcat cagtcttcac
     5401 tctagtttgc aagctctgaa gttattgatt acgtctaatg tgcaatttgg cttctattaa
     5461 atgctatttt atgatgatgg caa
//
