LOCUS       NM_001042416            2803 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 596 (ZNF596), transcript variant
            1, mRNA.
ACCESSION   NM_001042416
VERSION     NM_001042416.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2803)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2803)
  AUTHORS   Chi,C., Shao,X., Rhead,B., Gonzales,E., Smith,J.B., Xiang,A.H.,
            Graves,J., Waldman,A., Lotze,T., Schreiner,T.,
            Weinstock-Guttman,B., Aaen,G., Tillema,J.M., Ness,J., Candee,M.,
            Krupp,L., Gorman,M., Benson,L., Chitnis,T., Mar,S., Belman,A.,
            Casper,T.C., Rose,J., Moodley,M., Rensel,M., Rodriguez,M.,
            Greenberg,B., Kahn,L., Rubin,J., Schaefer,C., Waubant,E.,
            Langer-Gould,A. and Barcellos,L.F.
  TITLE     Admixture mapping reveals evidence of differential multiple
            sclerosis risk by genetic ancestry
  JOURNAL   PLoS Genet 15 (1), e1007808 (2019)
   PUBMED   30653506
  REMARK    GeneRIF: a genome-wide search of association between European
            ancestry and Multiple sclerosis (MS) revealed a region of interest
            close to the ZNF596 gene on chromosome 8 in Hispanics; cases had a
            significantly higher proportion of European ancestry compared to
            controls.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2803)
  AUTHORS   Nusbaum,C., Mikkelsen,T.S., Zody,M.C., Asakawa,S., Taudien,S.,
            Garber,M., Kodira,C.D., Schueler,M.G., Shimizu,A., Whittaker,C.A.,
            Chang,J.L., Cuomo,C.A., Dewar,K., FitzGerald,M.G., Yang,X.,
            Allen,N.R., Anderson,S., Asakawa,T., Blechschmidt,K., Bloom,T.,
            Borowsky,M.L., Butler,J., Cook,A., Corum,B., DeArellano,K.,
            DeCaprio,D., Dooley,K.T., Dorris,L. 3rd, Engels,R., Glockner,G.,
            Hafez,N., Hagopian,D.S., Hall,J.L., Ishikawa,S.K., Jaffe,D.B.,
            Kamat,A., Kudoh,J., Lehmann,R., Lokitsang,T., Macdonald,P.,
            Major,J.E., Matthews,C.D., Mauceli,E., Menzel,U., Mihalev,A.H.,
            Minoshima,S., Murayama,Y., Naylor,J.W., Nicol,R., Nguyen,C.,
            O'Leary,S.B., O'Neill,K., Parker,S.C., Polley,A., Raymond,C.K.,
            Reichwald,K., Rodriguez,J., Sasaki,T., Schilhabel,M., Siddiqui,R.,
            Smith,C.L., Sneddon,T.P., Talamas,J.A., Tenzin,P., Topham,K.,
            Venkataraman,V., Wen,G., Yamazaki,S., Young,S.K., Zeng,Q.,
            Zimmer,A.R., Rosenthal,A., Birren,B.W., Platzer,M., Shimizu,N. and
            Lander,E.S.
  TITLE     DNA sequence and analysis of human chromosome 8
  JOURNAL   Nature 439 (7074), 331-335 (2006)
   PUBMED   16421571
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA714658.1, AK313454.1, BC026190.1, AC004908.1 and DB514599.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001042416.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 through 6 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.9323.1,
                                           SRR1660809.150083.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398612.3/ ENSP00000381613.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-522               DA714658.1         36-557
            523-1309            AK313454.1         323-1109
            1310-2145           BC026190.1         1110-1945
            2146-2509           AC004908.1         123308-123671
            2510-2798           BC026190.1         2310-2598
            2799-2803           DB514599.1         393-397
FEATURES             Location/Qualifiers
     source          1..2803
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.3"
     gene            1..2803
                     /gene="ZNF596"
                     /note="zinc finger protein 596"
                     /db_xref="GeneID:169270"
                     /db_xref="HGNC:HGNC:27268"
     exon            1..239
                     /gene="ZNF596"
                     /inference="alignment:Splign:2.1.0"
     exon            240..323
                     /gene="ZNF596"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..1826
                     /gene="ZNF596"
                     /EC_number="2.1.1.354"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 596 isoform 1"
                     /protein_id="NP_001035881.1"
                     /db_xref="CCDS:CCDS5951.2"
                     /db_xref="GeneID:169270"
                     /db_xref="HGNC:HGNC:27268"
                     /translation="MPSPDSMTFEDIIVDFTQEEWALLDTSQRKLFQDVMLENISHLV
                     SIGKQLCKSVVLSQLEQVEKLSTQRISLLQGREVGIKHQEIPFIQHIYQKGTSTISTM
                     RSHTQEDPFLCNDLGEDFTQHIALTQNVITYMRTKHFVSKKFGKIFSDWLSFNQHKEI
                     HTKCKSYGSHLFDYAFIQNSALRPHSVTHTREITLECRVCGKTFSKNSNLRRHEMIHT
                     GEKPHGCHLCGKAFTHCSDLRKHERTHTGEKPYGCHLCGKAFSKSSNLRRHEMIHTRE
                     KAQICHLCGKAFTHCSDLRKHERTHLGDKPYGCLLCGKAFSKCSYLRQHERTHNGEKP
                     YECHLCGKAFSHCSHLRQHERSHNGEKPHGCHLCGKAFTESSVLKRHERIHTGEKPYE
                     CHVCGKAFTESSDLRRHERTHTGEKPYECHLCGKAFNHSSVLRRHERTHTGEKPYECN
                     ICGKAFNRSYNFRLHRRVHTGEKPYVCPLCGKAFSKFFNLRQHERTHTKKAMNM"
     exon            324..450
                     /gene="ZNF596"
                     /inference="alignment:Splign:2.1.0"
     exon            451..534
                     /gene="ZNF596"
                     /inference="alignment:Splign:2.1.0"
     exon            535..617
                     /gene="ZNF596"
                     /inference="alignment:Splign:2.1.0"
     exon            618..2803
                     /gene="ZNF596"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2087..2092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF596"
                     /note="hexamer: AATAAA"
     polyA_site      2115
                     /gene="ZNF596"
                     /note="major polyA site"
     regulatory      2685..2690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF596"
                     /note="hexamer: AATAAA"
     polyA_site      2706
                     /gene="ZNF596"
     regulatory      2780..2785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF596"
                     /note="hexamer: ATTAAA"
     polyA_site      2803
                     /gene="ZNF596"
ORIGIN      
        1 agttcccttc ctgcggcgtc ctccacaccc ggggtctgct ggtctccgcg gatgtcacag
       61 gctcggcaac cgccctcctg tcggcgggga gtcccgcgac gcccggaaat gctccgaagc
      121 ctgtcgccca gctgccagat ctgcgtctgt gtccggttcc gtcactgagg tcgcccctgt
      181 ccggcccttc caccctagtt ctcttcaccg tccgcccatc ctatcgcgcg cggcctcaga
      241 tttgtcttct tagtgcttgg atggtgtgag tgaaaaccca gaggaataca tttggtggct
      301 gagctagtac aatgccatca ccggattcca tgaccttcga ggatatcatt gtagacttca
      361 ctcaagaaga gtgggccctg ctggacacat cccagagaaa gctgtttcaa gatgtgatgt
      421 tggagaacat cagtcatctg gtctctattg gcaaacagct ctgcaaatca gttgtgcttt
      481 cccaattgga gcaagtagag aaactttcaa cacaaagaat aagcttactg caaggtagag
      541 aagttggcat taaacatcaa gagataccat tcattcaaca tatctatcag aagggcacgt
      601 ccaccatcag cacaatgaga tctcatactc aagaggatcc ttttctatgc aatgacttag
      661 gagaagattt cactcaacat atagcattga ctcaaaatgt gattacctac atgagaacga
      721 aacactttgt aagcaaaaag tttgggaaaa tcttcagtga ctggttatcc tttaatcaac
      781 acaaggaaat tcacaccaaa tgtaaatcat atggaagtca tctatttgat tatgccttta
      841 tccaaaactc tgcccttaga ccacacagtg tgactcacac tagagagata acattggaat
      901 gtcgtgtgtg tgggaaaacc tttagcaaaa attctaatct taggcgacat gagatgattc
      961 acactggaga gaaaccacac ggatgtcatc tatgtgggaa agcctttact cattgctctg
     1021 atcttcgaaa acatgagaga actcacactg gagagaagcc atatggatgt catctatgtg
     1081 ggaaagcctt cagtaaaagt tctaacctta gacgacatga gatgattcac actagagaaa
     1141 aagcacagat atgccatcta tgtgggaaag ccttcactca ttgctctgac cttagaaaac
     1201 atgagagaac tcacttagga gataaaccat atggatgtct cctatgtggg aaggctttca
     1261 gtaaatgttc ttaccttaga caacatgaaa gaactcacaa tggagagaaa ccatatgaat
     1321 gtcatctatg tggaaaagcc ttctctcatt gttctcacct tagacaacat gagcgaagtc
     1381 acaatggaga gaaaccacat ggatgtcatc tatgtgggaa agcattcact gaatcttctg
     1441 tgcttaaacg acatgagaga attcacactg gagagaaacc atatgagtgc catgtatgtg
     1501 ggaaagcctt cactgaatct tctgacctca gacgacatga gagaactcac actggagaaa
     1561 aaccatatga atgccatcta tgcggaaaag ccttcaatca ctcttctgtc cttagacgac
     1621 atgagagaac tcacactgga gagaaaccat atgaatgcaa tatatgtggt aaagccttca
     1681 atagaagtta caactttaga cttcatagaa gagttcacac tggagagaaa ccatatgtat
     1741 gtcctctatg tgggaaagcc tttagtaaat tttttaacct tagacaacat gagagaactc
     1801 acactaaaaa agcaatgaat atgtaagaat catcagctgt agcgttaaca ctaaatacac
     1861 caaggacaaa catactacag gaatattatg tctgtaatca gtgtggaaaa gcctttattt
     1921 atatttacca ctttgctcaa cctaaatgaa ttcaaggtag agagaatcca gatgtattta
     1981 atgtttatgg cacaaacttc agactctagg ctgaccatat acaacgtgag agaatgaaac
     2041 tatagatcaa aggaatgtgg aggagtcttc atccacagct ctgttaaata aatgggagaa
     2101 atcacatcac gaaaattctg tgcctgtcgt cagtgtgaaa atgcctttgc tgataattta
     2161 tcctctaaac aaatgagtaa aatccacagg caagcaacca tatgtctgta attgctgtgc
     2221 actctcattc agctaagcac caattttggt gtgtgcaaga aaattcatta taaggtaact
     2281 gataaaaaca ggaaatatgt gaaaatattt tttattaggt ggatgaggcc tcttgaacaa
     2341 ttccagacat tcatagtgga gaagttattc aatgaaaact catgagaaat ccttttctta
     2401 atacagcagc acttctataa tagatcagaa ttcacatggt gtagaactct caatgacatg
     2461 aatggagggt agtcctcagt aaattactca ttccttagtc aataccagca tttttccagt
     2521 gagaaaacta tcttgacagg atagtggaaa aaccttcagg cagcttttat gtcaaaaaag
     2581 tgagacaggg atgaaaactc taaaaagcca ttgatgagat gtatagctgg gggacaaaac
     2641 ataaagccat caagcacgtg cttgagaaaa aaattataat tttgaataaa gactttctac
     2701 ttaaaatatg tgggttgaaa tgtacaattc tgaaataacc tgggaatatt gaatgcagaa
     2761 ttatgtaaga agtaataaga ttaaattagt actgtcaaaa ata
//
