LOCUS       NM_182524               2872 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 595 (ZNF595), transcript variant
            1, mRNA.
ACCESSION   NM_182524
VERSION     NM_182524.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2872)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2872)
  AUTHORS   Razin,S.V., Borunova,V.V., Maksimenko,O.G. and Kantidze,O.L.
  TITLE     Cys2His2 zinc finger protein family: classification, functions, and
            major members
  JOURNAL   Biochemistry (Mosc) 77 (3), 217-226 (2012)
   PUBMED   22803940
  REMARK    Review article
REFERENCE   3  (bases 1 to 2872)
  AUTHORS   Berg,J.M.
  TITLE     Zinc finger domains: hypotheses and current knowledge
  JOURNAL   Annu Rev Biophys Biophys Chem 19, 405-421 (1990)
   PUBMED   2114117
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA746784.1, BX537887.1 and
            AC253576.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_182524.3.
            
            Summary: This gene encodes a protein belonging to the Cys2His2 zinc
            finger protein family, whose members function as transcription
            factors that can regulate a broad variety of developmental and
            cellular processes. Alternative splicing of this gene results in
            multiple transcript variants. [provided by RefSeq, Oct 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036110.1, BX537887.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000610261.6/ ENSP00000477392.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DA746784.1         37-48
            13-2402             BX537887.1         1-2390
            2403-2525           BX537887.1         2392-2514
            2526-2526           AC253576.2         156759-156759       c
            2527-2872           BX537887.1         2516-2861
FEATURES             Location/Qualifiers
     source          1..2872
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..2872
                     /gene="ZNF595"
                     /note="zinc finger protein 595"
                     /db_xref="GeneID:152687"
                     /db_xref="HGNC:HGNC:27196"
     exon            1..171
                     /gene="ZNF595"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..2115
                     /gene="ZNF595"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 595 isoform a"
                     /protein_id="NP_872330.1"
                     /db_xref="CCDS:CCDS75075.1"
                     /db_xref="GeneID:152687"
                     /db_xref="HGNC:HGNC:27196"
                     /translation="MELVTFRDVAIEFSPEEWKCLDPAQQNLYRDVMLENYRNLVSLG
                     FVISNPDLVTCLEQIKEPCNLKIHETAAKPPAICSPFSQDLSPVQGIEDSFHKLILKR
                     YEKCGHENLQLRKGCKRVNECKVQKGVNNGVYQCLSTTQSKIFQCNTCVKVFSKFSNS
                     NKHKIRHTGEKPFKCTECGRSFYMSHLTQHTGIHAGEKPYKCEKCGKAFNRSTSLSKH
                     KRIHTGEKPYTCEECGKAFRRSTVLNEHKKIHTGEKPYKCEECGKAFTRSTTLNEHKK
                     IHTGEKPYKCKECGKAFRWSTSLNEHKNIHTGEKPYKCKECGKAFRQSRSLNEHKNIH
                     TGEKPYTCEKCGKAFNQSSSLIIHRSIHSEQKLYKCEECGKAFTWSSSLNKHKRIHTG
                     EKPYTCEECGKAFYRSSHLAKHKRIHTGEKPYTCEECGKAFNQSSTLILHKRIHSGQK
                     PYKCEECGKAFTRSTTLNEHKKIHTGEKPYKCEECGKAFIWSASLNEHKNIHTGEKPY
                     KCKECGKAFNQSSGLIIHRSIHSEQKLYKCEECGKAFTRSTALNEHKKIHSGEKPYKC
                     KECGKAYNLSSTLTKHKRIHTGEKPFTCEECGKAFNWSSSLTKHKIIHTGEKSYKCEE
                     CGKAFNRPSTLTVHKRIHTGKEHS"
     exon            172..298
                     /gene="ZNF595"
                     /inference="alignment:Splign:2.1.0"
     exon            299..394
                     /gene="ZNF595"
                     /inference="alignment:Splign:2.1.0"
     exon            395..2872
                     /gene="ZNF595"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2160..2165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF595"
                     /note="hexamer: AATAAA"
     polyA_site      2186
                     /gene="ZNF595"
                     /note="major polyA site"
     regulatory      2313..2318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF595"
                     /note="hexamer: AGTAAA"
     polyA_site      2335
                     /gene="ZNF595"
     regulatory      2845..2850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF595"
                     /note="hexamer: AATAAA"
     polyA_site      2872
                     /gene="ZNF595"
ORIGIN      
        1 gttttcctct ggctcctgcg agggcttggt ttagggcttc agctctctgc gttctcggct
       61 ccgggaggcc tcggtgattc agccacagcc tctgcctccc gttgctctgt gacctgaggg
      121 tattggacaa tttgtagcta agactcccgg ataccctgaa gtcgggaaat ggaactcgta
      181 acattcaggg atgtggccat agaattctcc cctgaagagt ggaaatgtct ggaccctgcc
      241 cagcagaatt tgtatagaga tgtgatgttg gagaactaca ggaacctggt ctccctgggt
      301 tttgtgatct ctaacccaga cctggtcacc tgtctggagc aaataaaaga gccctgcaat
      361 ttgaagatac atgagacagc agccaaaccc ccagctatat gttctccttt cagccaagac
      421 ctttcaccag tgcaggggat agaagattca ttccacaaac ttatactgaa aagatacgag
      481 aaatgtggac atgagaattt acaattaaga aaaggctgta aacgtgtgaa tgagtgtaag
      541 gtgcagaaag gagttaataa tggagtttac cagtgcttgt caactaccca gagcaaaata
      601 tttcaatgta atacatgtgt taaagttttt agtaaatttt caaattcaaa caaacataag
      661 ataagacata ctggagagaa accctttaaa tgtacagaat gtggcagatc gttttacatg
      721 tcacacctaa ctcaacatac aggaattcat gctggagaga aaccctacaa atgtgaaaaa
      781 tgtggcaaag cctttaatag gtccacatca cttagtaaac ataagagaat tcatactgga
      841 gagaaaccct acacatgtga agaatgtggc aaagccttta gacggtccac agttctgaac
      901 gaacataaga aaattcatac tggagagaaa ccctacaaat gtgaagaatg tggcaaagcc
      961 tttacaaggt ccacaacact gaatgaacac aagaaaattc atactggaga gaaaccctac
     1021 aaatgtaaag aatgtggcaa agcctttaga tggtccacaa gcctgaatga acataagaat
     1081 attcatactg gagagaaacc ctacaaatgt aaagaatgtg gcaaagcctt tagacagtcc
     1141 aggagcctga atgaacataa aaatattcat actggcgaaa aaccctacac atgtgaaaaa
     1201 tgtggcaaag cttttaacca atcctcaagt cttattatac acaggagcat tcattctgaa
     1261 caaaaacttt acaaatgtga agaatgtggc aaagccttta cttggtcctc atcccttaat
     1321 aaacataaga gaattcatac tggagagaaa ccctacacat gtgaagaatg tggcaaagct
     1381 ttttataggt cctcacacct tgctaaacat aagagaattc atactggaga gaaaccctac
     1441 acgtgcgaag aatgtggcaa agcttttaac caatcctcaa ctcttatatt acacaagaga
     1501 atccattctg ggcaaaaacc ttacaaatgt gaagaatgtg gcaaagcctt tacacggtcc
     1561 acaacactga acgaacataa gaaaattcat actggcgaga aaccctacaa atgtgaagaa
     1621 tgtggcaaag ctttcatatg gtccgcaagc ctgaatgaac ataagaatat tcatactgga
     1681 gagaaaccct acaaatgtaa agaatgtggc aaagctttta accaatcctc aggccttatt
     1741 atacacagga gcattcattc tgaacaaaaa ctttacaaat gtgaagaatg tggcaaagcc
     1801 tttactcggt ccacagccct gaatgaacat aagaaaattc attctggaga gaaaccctac
     1861 aaatgcaaag aatgtggcaa agcctataac ttatcctcaa cccttactaa acataagaga
     1921 attcatactg gagagaaacc cttcacatgt gaagaatgtg gcaaagcctt caattggtcc
     1981 tcatccctta ctaaacataa gataattcat actggagaga aatcctacaa atgtgaagaa
     2041 tgtggcaaag cttttaatcg gccctcaacc cttactgtac acaagcgaat tcatactggc
     2101 aaggaacata gttgaatgac atttctagta atctctaatt ccagtgtctt tacacagcaa
     2161 ataaattgga gaatattgct cccatataaa cttgtattat ttttcttatt ttaaattttt
     2221 taaaatttct gtaggtacat agtatgtgta tctattcatg gcttatttgg attattttga
     2281 tacaggcata tgacatgtaa ttatcacatc agagtaaatg agttattctt cacaagcatt
     2341 tgttctttgt attacacaca gtccagttat acactttaat tttttttttt tttttttttt
     2401 ttgagacaga gtctcgttct gtcgcccagg ctggagcgca gtggtgcgat cttggctcac
     2461 tgcaacctcc acctgctggg ttcaagcaat tctcctgcct cagcctcatg agtagctgtg
     2521 actaccggca ggtgccacca tgcccagcta attttttgta ttttcagtag agacagggtt
     2581 tcacaatgct ggccaggctg ttctcgaact cctgagctca tgatccaccc acctcggcct
     2641 cccaaagtgc tgggattacg ggtgtgagcc atcgtacctg gccactttaa ttatttttaa
     2701 atgtgcaatt atttttttac tacaggttat tttatgatta taataagtat atgagtataa
     2761 ttataattca cacatttcta agtcatgaat gcttttaaaa aatgttccat atttatcttt
     2821 gaacatgtag catctctttc cgcaaataaa tgcagacttt ggttttgatt ta
//
