LOCUS       NM_015871                638 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 593 (ZNF593), mRNA.
ACCESSION   NM_015871
VERSION     NM_015871.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 638)
  AUTHORS   Fan,J., Li,H., Xie,R., Zhang,X., Nie,X., Shi,X., Zhan,J., Yin,Z.,
            Zhao,Y., Dai,B., Yuan,S., Wen,Z., Chen,C. and Wang,D.W.
  TITLE     LncRNA ZNF593-AS Alleviates Contractile Dysfunction in Dilated
            Cardiomyopathy
  JOURNAL   Circ Res 128 (11), 1708-1723 (2021)
   PUBMED   33550812
  REMARK    GeneRIF: LncRNA ZNF593-AS Alleviates Contractile Dysfunction in
            Dilated Cardiomyopathy.
REFERENCE   2  (bases 1 to 638)
  AUTHORS   Liang,X., Zuo,M.Q., Zhang,Y., Li,N., Ma,C., Dong,M.Q. and Gao,N.
  TITLE     Structural snapshots of human pre-60S ribosomal particles before
            and after nuclear export
  JOURNAL   Nat Commun 11 (1), 3542 (2020)
   PUBMED   32669547
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 638)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 638)
  AUTHORS   Bassler,J., Klein,I., Schmidt,C., Kallas,M., Thomson,E.,
            Wagner,M.A., Bradatsch,B., Rechberger,G., Strohmaier,H., Hurt,E.
            and Bergler,H.
  TITLE     The conserved Bud20 zinc finger protein is a new component of the
            ribosomal 60S subunit export machinery
  JOURNAL   Mol Cell Biol 32 (24), 4898-4912 (2012)
   PUBMED   23045392
REFERENCE   5  (bases 1 to 638)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
REFERENCE   6  (bases 1 to 638)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 638)
  AUTHORS   Hayes,P.L., Lytle,B.L., Volkman,B.F. and Peterson,F.C.
  TITLE     The solution structure of ZNF593 from Homo sapiens reveals a zinc
            finger in a predominantly unstructured protein
  JOURNAL   Protein Sci 17 (3), 571-576 (2008)
   PUBMED   18287285
  REMARK    GeneRIF: The tertiary structure of the zinc finger domain of ZNF593
            is composed of a beta-hairpin that positions the cysteine side
            chains for zinc coordination, followed by an atypical kinked
            alpha-helix containing the two histidine side chain ligands.
REFERENCE   8  (bases 1 to 638)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   9  (bases 1 to 638)
  AUTHORS   Terunuma,A., Shiba,K. and Noda,T.
  TITLE     A novel genetic system to isolate a dominant negative effector on
            DNA-binding activity of Oct-2
  JOURNAL   Nucleic Acids Res 25 (10), 1984-1990 (1997)
   PUBMED   9115366
REFERENCE   10 (bases 1 to 638)
  AUTHORS   Prashar,Y. and Weissman,S.M.
  TITLE     Analysis of differential gene expression by display of 3' end
            restriction fragments of cDNAs
  JOURNAL   Proc Natl Acad Sci U S A 93 (2), 659-663 (1996)
   PUBMED   8570611
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA124660.1 and AI083892.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015871.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.69718.1, BG705897.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374266.7/ ENSP00000363384.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-525               DA124660.1         12-536
            526-638             AI083892.1         5-117               c
FEATURES             Location/Qualifiers
     source          1..638
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..638
                     /gene="ZNF593"
                     /gene_synonym="ZT86"
                     /note="zinc finger protein 593"
                     /db_xref="GeneID:51042"
                     /db_xref="HGNC:HGNC:30943"
                     /db_xref="MIM:616698"
     exon            1..276
                     /gene="ZNF593"
                     /gene_synonym="ZT86"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..481
                     /gene="ZNF593"
                     /gene_synonym="ZT86"
                     /note="zinc finger protein T86"
                     /codon_start=1
                     /product="zinc finger protein 593"
                     /protein_id="NP_056955.2"
                     /db_xref="CCDS:CCDS275.2"
                     /db_xref="GeneID:51042"
                     /db_xref="HGNC:HGNC:30943"
                     /db_xref="MIM:616698"
                     /translation="MGRSRRTGAHRAHSLARQMKAKRRRPDLDEIHRELRPQGSARPQ
                     PDPNAEFDPDLPGGGLHRCLACARYFIDSTNLKTHFRSKDHKKRLKQLSVEPYSQEEA
                     ERAAGMGSYVPPRRLAVPTEVSTEVPEMDTST"
     exon            277..339
                     /gene="ZNF593"
                     /gene_synonym="ZT86"
                     /inference="alignment:Splign:2.1.0"
     exon            340..638
                     /gene="ZNF593"
                     /gene_synonym="ZT86"
                     /inference="alignment:Splign:2.1.0"
     regulatory      615..620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF593"
                     /gene_synonym="ZT86"
                     /note="hexamer: AATAAA"
     polyA_site      638
                     /gene="ZNF593"
                     /gene_synonym="ZT86"
                     /note="major polyA site"
ORIGIN      
        1 gatcggcccg gaagtgctca cacgtgtgct ccctgccctg ctcctggccc cttggccggc
       61 cgggctgttt ctggccatgg gtcgctcccg ccggacaggc gcgcaccgag cgcactctct
      121 agcccggcag atgaaggcga agcggcggcg gccggacttg gatgagattc accgcgagct
      181 gcggcctcag ggatccgcac gaccccagcc cgacccaaac gccgagttcg accccgacct
      241 gccagggggc ggtctgcacc gctgtctggc ctgcgcgagg tacttcatcg attccaccaa
      301 cctgaagacc cacttccgat ccaaagacca caagaaaagg ctgaagcagc tgagcgtcga
      361 gccctacagt caggaagagg cggagagggc agcgggtatg ggatcctatg tgccccccag
      421 gcggctggca gtgcccacgg aagtgtccac tgaggtccct gagatggata cctctacctg
      481 acatggcctg aagatgcagg gcagaggaat tgcccatgga cagtgacgca aggactaggc
      541 tgggagggag cgtgccaacc ccttttgcct ctgggtttgg ggagcggagg gcctcttctt
      601 ggtgccctgc cccaaataaa ggaactggac aaagagaa
//
