LOCUS       NM_016089               3367 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens zinc finger protein 589 (ZNF589), mRNA.
ACCESSION   NM_016089
VERSION     NM_016089.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3367)
  AUTHORS   Burton,E.M., Akinyemi,I.A., Frey,T.R., Xu,H., Li,X., Su,L.J.,
            Zhi,J., McIntosh,M.T. and Bhaduri-McIntosh,S.
  TITLE     A heterochromatin inducing protein differentially recognizes self
            versus foreign genomes
  JOURNAL   PLoS Pathog 17 (3), e1009447 (2021)
   PUBMED   33730092
  REMARK    GeneRIF: A heterochromatin inducing protein differentially
            recognizes self versus foreign genomes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3367)
  AUTHORS   Venturini,L., Stadler,M., Manukjan,G., Scherr,M.,
            Schlegelberger,B., Steinemann,D. and Ganser,A.
  TITLE     The stem cell zinc finger 1 (SZF1)/ZNF589 protein has a
            human-specific evolutionary nucleotide DNA change and acts as a
            regulator of cell viability in the hematopoietic system
  JOURNAL   Exp Hematol 44 (4), 257-268 (2016)
   PUBMED   26738774
  REMARK    GeneRIF: The stem cell zinc finger 1 (SZF1)/ZNF589 protein has a
            human-specific evolutionary nucleotide DNA change and acts as a
            regulator of cell viability in the hematopoietic system
REFERENCE   3  (bases 1 to 3367)
  AUTHORS   Wang,W., Cai,J., Wu,Y., Hu,L., Chen,Z., Hu,J., Chen,Z., Li,W.,
            Guo,M. and Huang,Z.
  TITLE     Novel activity of KRAB domain that functions to reinforce nuclear
            localization of KRAB-containing zinc finger proteins by interacting
            with KAP1
  JOURNAL   Cell Mol Life Sci 70 (20), 3947-3958 (2013)
   PUBMED   23665872
REFERENCE   4  (bases 1 to 3367)
  AUTHORS   Peng,H., Zheng,L., Lee,W.H., Rux,J.J. and Rauscher,F.J. 3rd.
  TITLE     A common DNA-binding site for SZF1 and the BRCA1-associated zinc
            finger protein, ZBRK1
  JOURNAL   Cancer Res 62 (13), 3773-3781 (2002)
   PUBMED   12097288
REFERENCE   5  (bases 1 to 3367)
  AUTHORS   Liu,C., Levenstein,M., Chen,J., Tsifrina,E., Yonescu,R.,
            Griffin,C., Civin,C.I. and Small,D.
  TITLE     SZF1: a novel KRAB-zinc finger gene expressed in CD34+
            stem/progenitor cells
  JOURNAL   Exp Hematol 27 (2), 313-325 (1999)
   PUBMED   10029171
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104190.3 and AY258146.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016089.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY258146.1, SRR1660803.111045.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354698.8/ ENSP00000346729.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC104190.3         130153-130154
            3-3367              AY258146.1         1-3365
FEATURES             Location/Qualifiers
     source          1..3367
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..3367
                     /gene="ZNF589"
                     /gene_synonym="SZF1"
                     /note="zinc finger protein 589"
                     /db_xref="GeneID:51385"
                     /db_xref="HGNC:HGNC:16747"
                     /db_xref="MIM:616702"
     exon            1..111
                     /gene="ZNF589"
                     /gene_synonym="SZF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1163
                     /gene="ZNF589"
                     /gene_synonym="SZF1"
                     /note="KRAB-zinc finger protein SZF1-1; stem cell zinc
                     finger protein 1"
                     /codon_start=1
                     /product="zinc finger protein 589"
                     /protein_id="NP_057173.2"
                     /db_xref="CCDS:CCDS43085.1"
                     /db_xref="GeneID:51385"
                     /db_xref="HGNC:HGNC:16747"
                     /db_xref="MIM:616702"
                     /translation="MWAPREQLLGWTAEALPAKDSAWPWEEKPRYLGPVTFEDVAVLF
                     TEAEWKRLSLEQRNLYKEVMLENLRNLVSLAESKPEVHTCPSCPLAFGSQQFLSQDEL
                     HNHPIPGFHAGNQLHPGNPCPEDQPQSQHPSDKNHRGAEAEDQRVEGGVRPLFWSTNE
                     RGALVGFSSLFQRPPISSWGGNRILEIQLSPAQNASSEEVDRISKRAETPGFGAVTFG
                     ECALAFNQKSNLFRQKAVTAEKSSDKRQSQVCRECGRGFSRKSQLIIHQRTHTGEKPY
                     VCGECGRGFIVESVLRNHLSTHSGEKPYVCSHCGRGFSCKPYLIRHQRTHTREKSFMC
                     TVCGRGFREKSELIKHQRIHTGDKPYVCRD"
     exon            112..164
                     /gene="ZNF589"
                     /gene_synonym="SZF1"
                     /inference="alignment:Splign:2.1.0"
     exon            165..291
                     /gene="ZNF589"
                     /gene_synonym="SZF1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..3367
                     /gene="ZNF589"
                     /gene_synonym="SZF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3325..3330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF589"
                     /gene_synonym="SZF1"
                     /note="hexamer: AATGAA"
     polyA_site      3367
                     /gene="ZNF589"
                     /gene_synonym="SZF1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcattcta atccgtttca cacacggtgc tgctacctcg tttgcttcgt gcgtgcgtgc
       61 gcgcgcagat gtgggccccg cgggagcagc tactgggctg gactgcggaa gctctgcctg
      121 ccaaggattc tgcctggccc tgggaagaga agcctagata tctgggacca gtgactttcg
      181 aggatgtggc tgtgcttttc actgaggcag agtggaagag actgagcctt gagcagagga
      241 acctatacaa agaagtgatg ctggaaaatc tcaggaatct ggtctcattg gcagaatcaa
      301 agccagaagt ccatacctgc ccttcttgcc ctctggcctt tggcagtcag cagttcctca
      361 gccaagatga gctacacaat catcctattc caggtttcca tgcaggaaat caactccacc
      421 caggaaatcc ctgcccagag gatcagccac agtcacaaca tccttctgat aaaaatcaca
      481 ggggggctga agcagaagat caacgagtgg aaggaggcgt cagacccttg ttttggagta
      541 caaatgaaag gggggcttta gtgggtttct ctagcctgtt ccagagacca ccaataagct
      601 cttggggagg caacagaata ttagagatac agctcagtcc agcccagaat gcaagctctg
      661 aggaagtaga cagaatttcc aagagggcag aaaccccagg gtttggagca gtcacgtttg
      721 gggagtgtgc actagctttt aaccagaagt caaacctgtt cagacagaag gcagtcacag
      781 cagaaaaatc ttcagacaaa aggcagtcac aggtgtgcag ggagtgtggg cgaggcttta
      841 gcaggaagtc acagctcatc atacaccaga ggacacacac aggagaaaag ccttatgtct
      901 gcggagagtg tgggcgaggc tttatagttg agtcagtcct ccgcaaccac ctgagtacac
      961 actccgggga gaaaccttat gtgtgcagcc attgtgggcg aggctttagc tgcaagccat
     1021 acctcatcag acatcagagg acacacacaa gggagaaatc gtttatgtgc acagtgtgtg
     1081 ggcgaggctt tcgtgaaaag tcagagctca ttaagcacca gagaattcac acgggggata
     1141 agccttatgt gtgcagagat tgaggccgag gctttgtaag gagatcatgt ctcaacacac
     1201 accagaggat acattcagat gagaagcctt ttgtttgcag agagtgtggg cgaggctttc
     1261 gtgctaaatc aactctcctc ctacaccagt ggacacattc agaggtgaaa cctcacgtgt
     1321 gtgaggagtg tgggcatgga tttagccaga agtcgtcgct caaatcacat cggagaacac
     1381 actcagggga gaagccttat gtgtgtgggg aatgtgggcg gggatttagc cggaggatag
     1441 tcctcaatgg acactggagg acacacacgg gagagaagcc ttacacgtgc tttgagtgtg
     1501 ggcgaaactt tagcctcaag tccgctctta gtgtacatca gaggatacac tctggggaga
     1561 agccttatgc atgcacggag tgtgggcaag gctttatcac gaaatcacag ctcatcagac
     1621 accagaggac acacacagga gaaaagcctt atgtctgcgg agagtgtggg cgaggcttta
     1681 tagctcagtc aaccctccac taccaccgga gtacacactc caaggaaaaa ccttatgtgt
     1741 gcagccagtg tgggcgaggc ttttgtgata aatcaactct cctcgcacac gagcagacac
     1801 attcagggga gaagccttat gtgtgtgggg aatgtgggcg gggatttggc cggaagatac
     1861 tcctcaacag acactggagg acacacacag gagagaaacc ttacgcatgc atcgagtgtg
     1921 ggcgaaactt tagccacaag tccactctca gcttacatca gaggatacac tcgggggaga
     1981 agccttatgc atgcgtggag tgtgggcaaa gctttaggag aaagtcacag ctcatcatac
     2041 accagaagat acactcgggg aaaagcttta gaggtgcaag gagtgaggat gtgattttag
     2101 caacaagtca gccatcagcc acaccagcgg aaatgcttag ggagaagcct tgtttgtaag
     2161 gtaatgtgga cagagctgta cgtggacatc attacttgtc acgtgtcaga ggacacactc
     2221 gggagaaacc ttcatggagt gagagtaagg tgttggctgg aagtggcccc ttaagagata
     2281 cttggagtca aatctatcca ctgtacgccc accccactct tgttctaaga gctttgggga
     2341 cagtcttttg accccttaca ttcctttaga tgtgaagatg acagagatct aacttctgag
     2401 agcagaggtg tcaagtgacg gtccccttgg aggaatggtc tttgcatctg actacttcct
     2461 tctgcaactg tgttcttcca ttagcttcca tgacactctc ctgctttatt tttttctaca
     2521 tctctagcct ttgctgtttc ctctcctacc ccacctttag attttactca gagttcagtc
     2581 tccagcccta caatctgagg gacaccttta ccaggtcccc ttcctaaccc tccagtccca
     2641 aatccaagat tctttaacca cactctaaaa gttcttcaga ctcaggactt aaacatagcc
     2701 acgccacctt ggccttcaat gacagggatc tagcaatgct gcatcatcag ccttccaata
     2761 ccaggtttaa gggtatttta aacacagctc ctcttaaatc ctccaatctc agtacccagt
     2821 gttttagcca tgctcgggtg gctaaattac atccaggaat ggtgccaggg cctttagcca
     2881 tttgtctctc ctcacactcc agggcccata tggcccaggt tctgacagtt tgccttactc
     2941 ccttgggctg gggctagccc tacctgatac cctgtgtcaa tgagtgtacc ttggagagct
     3001 atccactcag gccccagtgc ctctatttgc taagggactc tgccacagaa aagaagggga
     3061 gagatgttca tgtaacctca aaatacttag gcttggtttt gatgctagag aggaaaaagg
     3121 acttggagag agagaaggaa tggctggtcc agaggctttt gtccactccc tctcactgga
     3181 agtggttgat ctccagggaa tccccaaggt tagcctgctt aggggaaggg ctaggggtac
     3241 ctggaatgta ggatctcccc catgcctggc ctaccaccct aatgtgtctg gaattggtgg
     3301 gttcttggtc ttgctgactt caagaatgaa gccgtggacc ctcacggtga gtgttacaat
     3361 tcttaaa
//
