LOCUS       NM_032828               6885 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 587 (ZNF587), transcript variant
            1, mRNA.
ACCESSION   NM_032828 XM_351219
VERSION     NM_032828.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6885)
  AUTHORS   Wu,T., Han,N., Zhao,C., Huang,X., Su,P. and Li,X.
  TITLE     The long non-sacoding RNA TMEM147-AS1/miR-133b/ZNF587 axis
            regulates the Warburg effect and promotes prostatic carcinoma
            invasion and proliferation
  JOURNAL   J Gene Med 24 (11), e3453 (2022)
   PUBMED   36181243
  REMARK    GeneRIF: The long non-sacoding RNA TMEM147-AS1/miR-133b/ZNF587 axis
            regulates the Warburg effect and promotes prostatic carcinoma
            invasion and proliferation.
REFERENCE   2  (bases 1 to 6885)
  AUTHORS   Liu,J., Yan,S., Hu,J., Ding,D., Liu,Y., Li,X., Pan,H.S., Liu,G.,
            Wu,B. and Liu,Y.
  TITLE     MiRNA-4537 functions as a tumor suppressor in gastric cancer and
            increases the radiosensitivity of gastric cancer cells
  JOURNAL   Bioengineered 12 (1), 8457-8467 (2021)
   PUBMED   34670480
  REMARK    GeneRIF: MiRNA-4537 functions as a tumor suppressor in gastric
            cancer and increases the radiosensitivity of gastric cancer cells.
REFERENCE   3  (bases 1 to 6885)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 6885)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   5  (bases 1 to 6885)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   6  (bases 1 to 6885)
  AUTHORS   Petroni,D., Bartolini,E., Chiaramonte,R., Ottolenghi,S. and Comi,P.
  TITLE     Computer sequence analysis of human highly conserved zinc finger
            modules
  JOURNAL   DNA Seq 9 (3), 163-169 (1998)
   PUBMED   10520746
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA334859.1, BC126239.1, AC010326.7 and AA524202.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032828.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB266983.1, BC126237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339656.8/ ENSP00000345479.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                DA334859.1         49-140
            93-2139             BC126239.1         1-2047
            2140-6884           AC010326.7         14945-19689
            6885-6885           AA524202.1         16-16               c
FEATURES             Location/Qualifiers
     source          1..6885
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..6885
                     /gene="ZNF587"
                     /gene_synonym="ZF6"
                     /note="zinc finger protein 587"
                     /db_xref="GeneID:84914"
                     /db_xref="HGNC:HGNC:30955"
     exon            1..213
                     /gene="ZNF587"
                     /gene_synonym="ZF6"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..1908
                     /gene="ZNF587"
                     /gene_synonym="ZF6"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein zfp6"
                     /codon_start=1
                     /product="zinc finger protein 587 isoform 1"
                     /protein_id="NP_116217.1"
                     /db_xref="CCDS:CCDS12964.1"
                     /db_xref="GeneID:84914"
                     /db_xref="HGNC:HGNC:30955"
                     /translation="MAAAVPRRPTQQGTVTFEDVAVNFSQEEWCLLSEAQRCLYRDVM
                     LENLALISSLGCWCGSKDEEAPCKQRISVQRESQSRTPRAGVSPKKAHPCEMCGLILE
                     DVFHFADHQETHHKQKLNRSGACGKNLDDTAYLHQHQKQHIGEKFYRKSVREASFVKK
                     RKLRVSQEPFVFREFGKDVLPSSGLCQEEAAVEKTDSETMHGPPFQEGKTNYSCGKRT
                     KAFSTKHSVIPHQKLFTRDGCYVCSDCGKSFSRYVSFSNHQRDHTAKGPYDCGECGKS
                     YSRKSSLIQHQRVHTGQTAYPCEECGKSFSQKGSLISHQLVHTGEGPYECRECGKSFG
                     QKGNLIQHQQGHTGERAYHCGECGKSFRQKFCFINHQRVHTGERPYKCGECGKSFGQK
                     GNLVHHQRGHTGERPYECKECGKSFRYRSHLTEHQRLHTGERPYNCRECGKLFNRKYH
                     LLVHERVHTGERPYACEVCGKLFGNKHSVTIHQRIHTGERPYECSECGKSFLSSSALH
                     VHKRVHSGQKPYKCSECGKSFSECSSLIKHRRIHTGERPYECTKCGKTFQRSSTLLHH
                     QSSHRRKAL"
     exon            214..343
                     /gene="ZNF587"
                     /gene_synonym="ZF6"
                     /inference="alignment:Splign:2.1.0"
     exon            344..6885
                     /gene="ZNF587"
                     /gene_synonym="ZF6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6853..6858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF587"
                     /gene_synonym="ZF6"
                     /note="hexamer: ATTAAA"
     regulatory      6857..6862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF587"
                     /gene_synonym="ZF6"
                     /note="hexamer: AATATA"
     polyA_site      6880
                     /gene="ZNF587"
                     /gene_synonym="ZF6"
                     /note="major polyA site"
     polyA_site      6885
                     /gene="ZNF587"
                     /gene_synonym="ZF6"
                     /note="major polyA site"
ORIGIN      
        1 agtagcggct gtgtatcggc gatgcgggtg tttccccagt ttgtggcccc tgagtgctgg
       61 gtgggaccgc ggtgactgaa cctagaaggt ggagaggaat cgtcctcggt gcccagaggc
      121 ggctctgcag ccccgtgacg gcgaccactg ctcccgggcc gtgcttcccc aagtagtccg
      181 atggcagcgg ctgtgccgag gcgcccaact cagcagggca ctgtgacctt tgaagatgtg
      241 gctgtgaact tttcccagga ggagtggtgt cttcttagtg aggctcagag gtgcttgtac
      301 cgtgatgtga tgctagagaa cctggctctc atatcctcgc tgggttgttg gtgtggatca
      361 aaagatgagg aggcaccttg taagcagaga atttctgtac aaagagagtc tcagagcagg
      421 actcctaggg caggtgtttc tcctaagaag gctcacccct gtgaaatgtg tggcctcatc
      481 ttggaggatg tttttcactt tgctgaccac caggaaactc atcacaagca gaagctgaac
      541 aggagtggag catgtggaaa aaacttggat gacactgcat accttcatca gcaccagaag
      601 cagcatattg gagagaaatt ctacagaaag agtgtcagag aagcatcgtt tgtaaagaaa
      661 cgtaagctca gggtgtcaca ggagccattt gtcttccgcg agtttgggaa ggacgttctg
      721 cccagttcag gattgtgcca agaagaagct gctgtagaga agacagacag tgaaactatg
      781 catggcccac cctttcagga gggaaaaact aattacagtt gtggaaaacg cacaaaagcc
      841 ttcagcacca aacactcagt tattccacac cagaaacttt tcactagaga tggatgttat
      901 gtgtgcagtg attgtggaaa atcctttagc agatatgtca gcttcagtaa tcatcagcga
      961 gatcacactg caaaaggacc ttatgattgt ggagagtgtg ggaaatctta tagtcgaaag
     1021 agcagcctta ttcaacatca gcgagtccac actggacaga cagcttatcc ctgtgaggag
     1081 tgcgggaaat cttttagtca gaagggcagc cttattagcc atcagcttgt tcacactgga
     1141 gaagggcctt atgagtgtag agaatgtggg aaatcttttg gtcaaaaggg taacctcatt
     1201 caacatcagc aaggtcacac tggagagaga gcttatcact gtggggaatg tgggaaatct
     1261 tttcgtcaga agttctgctt tattaaccat cagcgtgttc acactggaga aaggccttac
     1321 aagtgtggag aatgtgggaa atcttttggt caaaagggca acctcgttca ccatcagcga
     1381 ggtcatactg gagaaaggcc ctatgagtgc aaggaatgtg ggaaatcatt taggtacaga
     1441 tcccacctca ctgaacacca gagacttcac actggggaaa gaccttacaa ttgtagggaa
     1501 tgtgggaaat tatttaacag gaagtatcat cttctggttc atgagagagt tcacactgga
     1561 gaaaggccat atgcgtgtga ggtatgtggg aaattatttg gcaataagca cagcgtgact
     1621 atacatcaga ggattcacac tggagaaagg ccgtatgaat gcagtgaatg tgggaaatca
     1681 tttctttcca gctctgcgct tcatgttcat aaaagagttc attctggaca aaagccttat
     1741 aagtgcagtg aatgtggaaa atccttttct gaatgttcca gtctcattaa acacaggaga
     1801 attcacactg gagaaaggcc ttatgaatgc accaaatgtg gaaaaacatt tcagcgaagc
     1861 tctaccctcc ttcatcatca gagttcacac aggagaaagg ccttatgagt gcagtgaata
     1921 tgggaaatcg tttgctgaag catcccgtct cgttaaacac aggagagttc atactggaga
     1981 aaggccttat gagtgctgtc aatgtggaaa acatcagaat gtctgctgtc ctcggtctta
     2041 agcgacttcg tgttgagatg gagtcttgtt ctgtcaccca ggctggagtg cagtggtgca
     2101 gtcttggctc gctgcaactt gggcctcctg ggttcatgca atcctcctac ctcagcctcc
     2161 tgagtagctg ggattatgag tacacaccac cacgcccagc taatttttgt gtttttagtg
     2221 gagatggggt tttaccatgt tggccaggct ggtctcaaac tcctgacctc aagtgatcca
     2281 cccaccttga ctcccaaagt gctgaaatta caggcatgag cctctgcacc tggccttcat
     2341 tcttttcgta ttgcttagaa tatgacatgc tgaaccaggc atggtggctc atgcttgtaa
     2401 acctgatgct ttgggaggac aaggtggttc attggaggcc aggagttaga gatcagcctg
     2461 ggcaacatag ccagacctcc tctctacaaa aagaaaaaag aatgacatgc ttcttgtttt
     2521 tgtctgttat aaatgaaact gctatatttg aatgcagttg ttcatgtagg tatgtttcac
     2581 tatggtaata tggtggtgtg cagtgcctga gtcacgtgat agattaaagt acaactcttt
     2641 tttgagacag agtctcactc tgtcacccag gcgggagtta ggtggcatga tttcggctca
     2701 ctgcaacctc tgcctcccaa gttcaactga ttcttctgcc tcagcctccc gagtagcagg
     2761 gattaccggt gtgcaccacc atgcctggat aacttttttt tttatttcta ttagcaatgg
     2821 ggtttcacca tgctggccag gcttgttatg aactgacctc aagtgatctg cctgcctcag
     2881 cttctcaggt gtgacctact gtgcttggcc taatgtacaa ctttttaagc aatgccaaac
     2941 tatgacttaa gaatgaaatt attgctcatt tgtatatcta tctaccatca gtgtccaaga
     3001 atttctgttc tatcttacca agagggagta tggttagtat ttgaaattgt ttattatttt
     3061 aataagtggt tataactttt gagtcagtgg tttatgtttt gcattttttt tgttttgaga
     3121 caaagtctcg ctctgtctcc caggctagag taccgtggca caatctcagc tcattgcaac
     3181 ctctgcttcc tgggctcaag cactctgccc acctcagcct ccagagtagc tggaaataca
     3241 ggtatgcacc accacaactg gataactttt gtattttctg tagagagggt tttacctttt
     3301 tgcccagtct gatcgcgaac tcctgggctc aggcgatcca cttgcctagg ctccaaaagt
     3361 gcttggtcta caggggtgag gcaccctgcc tggcctcacc tgtaggcttg ttttttaaaa
     3421 tgaattttat ctatttccca tttcattaat atatttaaaa ataatgaaat aacaaagacg
     3481 tatgttggac ttcattcatt cttcagtgat gtcactttgc tgcaaggaat atttggtttt
     3541 cttttttttt tttttttcca gatggagtct agctctgtct cctaagctac agtgaagtgg
     3601 catgatctcg gcccactgca acctccacct cctgtgttca agcgattctg cctcagcctc
     3661 ctgagtagct gggactacag gcatgtgcca ttatacctgg ctaattttat ttatttattt
     3721 tagtagagat ggggtttcac catgttaccc aggctgctct ctaccttctg agctcaagtg
     3781 atccacctgc ctcggcctcc caaagtgctg ggattacagg tgtcagccac tgtacctggc
     3841 tgaatacttg gttttcagta ccacaagaac tatgagctgg ttatccactt catgtggaat
     3901 cataagcgtc ccaaagtgac aatacatata gattgccagg cagtgaaaca gttaagatgc
     3961 caccatagct ttcttttcaa catctttcta agattacctt actatttctt ttgttccaag
     4021 tttgtacttc ctcacagttc tcacatatgg aaaggataca cactttgtag aaacaagaac
     4081 tttatgttat ccaagttcta ggatagccat gagctccaat tatctcagag ctctgagtcc
     4141 tctactcaat acccattgag atttatgtgt tctgaggctt ttgtcttcta gctacttact
     4201 tcattctcca tgggtaacgt cattcatcca cattaactaa tttcctcact ccaagctctt
     4261 ttctagagat aatctccagt ccctgtgcag aaactgtcat tgcactttct gctgaaatgg
     4321 cagtttcttc tcagcaaggt gagattatgg aatccagaat cttttttcag gggtcacatg
     4381 cccatttccc cacttgcatg aatgtcgaca ctgcagccac agttttggcc gtaaatgtga
     4441 atttggcaag taaccactgt tcccagggaa atgtcccaat cagaagaaga ttatctggga
     4501 cactgatact gacagggaga tgggacattc tgagggaccc ggaggcaggg tgccacctcc
     4561 tcaacttccc tgagggctgc ctagaatctg tttcctctca ctctgaatta ttcttcctct
     4621 tatggctgac caaaaacatg gaacctcaca aagtccactg taacagcttt atatttgtga
     4681 agtgaagaac atgaagacag tttcaagcaa agttattgag tggacacttt gtgttttttt
     4741 tgagaagtct cactctttca cccaggctgg agtgcagtgg cacgatctcg gctcactgca
     4801 actccacctc ccgggttcac gccattctct tgcctcagcc tcctgagtag ctgggaccac
     4861 aagcgcccac cacgtcagct taattttttt gttttgtttc ttgagacaga gtcttgctct
     4921 cttgcccagg ttggagtgcc gtgtcgcaat ctcagctcac tgcaacttct acctcctgga
     4981 ttcaagcact tctccttgcc tcagccacct ctttagctgg gattacaggt gcgtgccacc
     5041 acacccagct aatttttgta tttttagcag agaccaggtt tcaccatgtt ggtcaggctg
     5101 gtctcaaact cctgacctcg tgatccaccc acctcggcct cccaaagtgc tggaattaca
     5161 ggcgtgagcc actgcacctg gcctgtattc ttttctttag tagagacggg gttttactgt
     5221 atttgccagg atggtctcga tctccagacc tcgtgatccg cccgccttag cctcccaaag
     5281 tgctgggatt ataggcgtga gccaacacgc cctggccact tcttgtcttt gcaacatttt
     5341 ttagatatgt atttgtgttt tttggggagc ttaatttgct aatggaatct ctgttatttt
     5401 cctaacatgc ttggtggata caagagttaa gacttcctgt cccgtttagt gtaacaaaag
     5461 aaagttaaga aatgtggata aaagattgta agttagaaat ggcaagataa tcagctatat
     5521 gaagaatctt ggccaggtgt ggtggctgag gcctgtaatc ccaccacttt gggaggctga
     5581 ggtgggcgga tcacaaggtc aggagttcaa gaccaccctg gccaatattg tgaattcctg
     5641 tctctactaa aaatacaaaa attagtcggg catggtggcg ggtgcctgta gtcccagcta
     5701 ctcgggaggc tgaggccaga aaatcggttg aacctgggag gtggaaggtg cactgagcca
     5761 atatcacacc agtgcactcc aacctggtga cagagagaca catcatctca aaaaaaaaaa
     5821 aaaaactcaa tccataaatg ttatacttta taactttata acagcatgtt atatgggctt
     5881 agatattatc cctaaatttt tttttttttt tttttttttg agacagagtc tcactctgtc
     5941 acccaggctg aagtgcaatg gcatggtctc ggctcactgc aacctccgcc tcccaggttc
     6001 aagtgattct cttgcctcag cctcccgagt agctgggcct ataggttccc tccaccacgc
     6061 ccagctaatt tttgtatttt tagtagagat gggctttcac tacgttagcc aggctggtct
     6121 caaactcctg acctcatgat ccacccccct cggcctccta aagtgctggg attacaggca
     6181 tctgccaccg cactcggctt atccctagaa atcctatgat agcatgatgt ataggcacct
     6241 aaaggcatgg cacttgagaa atgtgaataa gattgtaagt tacaaatagc aaggtacagt
     6301 cagatgttaa cagtctcagc ccctaaatgt caccttgtat tacagcatgt tatataagca
     6361 catacaggca catacatgaa atagtgatac ttcattctca gtaatatctt catccttctc
     6421 actggaaaga tctttgatga tttttaatca acataggagt ttcaatgata tctagaagtt
     6481 taaaagggct cgttcaaaca aattatgacc acacacactg aagagtatgt ttgtctcttg
     6541 tggtgtaaat ttttttttat tacaccaaat tatgttcaca caaaaccttt gtaatcaggg
     6601 ggaattaaag agccttcctg gaaaatggag gttgcaatca gccgagatgg tgccatcgca
     6661 ctctagcctg gggaatagag tgagatcctg cctcaaaaaa aacaaaaaaa ttctttattt
     6721 tctccataaa ctacagttta tataagcaaa agtttcagta ctaagcaatt ttagtctctg
     6781 cagtctcttg tcttgaatta atacaacttt tgttaattct cttatgaagt taatcttcct
     6841 gcttgtatgt gaattaaata tatgtcaaac tttttttgta caaaa
//
