LOCUS       NM_173548               2308 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens zinc finger protein 584 (ZNF584), transcript variant
            1, mRNA.
ACCESSION   NM_173548
VERSION     NM_173548.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2308)
  AUTHORS   Khakpour,G., Noruzinia,M., Izadi,P., Karami,F., Ahmadvand,M.,
            Heshmat,R., Amoli,M.M. and Tavakkoly-Bazzaz,J.
  TITLE     Methylomics of breast cancer: Seeking epimarkers in peripheral
            blood of young subjects
  JOURNAL   Tumour Biol 39 (3), 1010428317695040 (2017)
   PUBMED   28349825
  REMARK    GeneRIF: total of 1799 differentially methylated regions were
            identified including SLC6A3, Rab40C, ZNF584, and FOXD3 whose
            significant methylation differences were confirmed in breast cancer
            patients through quantitative real-time polymerase chain
            reaction.Methylation of those aforementioned genes in white blood
            cells of our young patients may highlight their potential as early
            epimarkers
REFERENCE   2  (bases 1 to 2308)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012313.7, DC350090.1, BC033149.1 and AK290068.1.
            
            On Nov 22, 2018 this sequence version replaced NM_173548.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033149.1, SRR3476690.1112192.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306910.9/ ENSP00000306756.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AC012313.7         66856-66880
            26-47               DC350090.1         1-22
            48-1918             BC033149.1         1-1871
            1919-1923           AK290068.1         1879-1883
            1924-2308           BC033149.1         1877-2261
FEATURES             Location/Qualifiers
     source          1..2308
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..2308
                     /gene="ZNF584"
                     /note="zinc finger protein 584"
                     /db_xref="GeneID:201514"
                     /db_xref="HGNC:HGNC:27318"
     exon            1..517
                     /gene="ZNF584"
                     /inference="alignment:Splign:2.1.0"
     CDS             500..1765
                     /gene="ZNF584"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 584 isoform 1"
                     /protein_id="NP_775819.1"
                     /db_xref="CCDS:CCDS12979.1"
                     /db_xref="GeneID:201514"
                     /db_xref="HGNC:HGNC:27318"
                     /translation="MAGEAEAQLDPSLQGLVMFEDVTVYFSREEWGLLNVTQKGLYRD
                     VMLENFALVSSLGLAPSRSPVFTQLEDDEQSWVPSWVDVTPVSRAEARRGFGLDGLCR
                     VEDERAHPEHLKSYRVIQHQDTHSEGKPRRHTEHGAAFPPGSSCGQQQEVHVAEKLFK
                     CSDCGKVFLKAFALLDHLITHSEERPFRCPTGRSAFKKSAHINPRKIHTGETAHVCNE
                     CGKAFSYPSKLRKHQKVHTGIKPFKCSDCGKTFNRKDALVLHQRIHTGERPYECSKCG
                     KTFSVLSTLIRHRKVHIGERPYECTECGKFFKYNNSFILHQRVHTGERPFECKQCGKG
                     YVTRSGLYQHWKVHTGERPYECSLCGKTFTTRSYRNRHQQFHTEERSYECTECGKAFK
                     HSSTLLQHKKVHTPERRQEDRAHGKVVSC"
     exon            518..668
                     /gene="ZNF584"
                     /inference="alignment:Splign:2.1.0"
     exon            669..791
                     /gene="ZNF584"
                     /inference="alignment:Splign:2.1.0"
     exon            792..2308
                     /gene="ZNF584"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2277..2282
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF584"
                     /note="hexamer: AATAAA"
     polyA_site      2308
                     /gene="ZNF584"
                     /note="major polyA site"
ORIGIN      
        1 gccttggcaa cgacccagcc gcgccgcgag gagagccggg aatggaggtc gtggcgtgag
       61 gggcgccgag cgaggggagg cgcgggccac gggagttccg ggagttccgg cgttgcccgg
      121 cagtccgcag tcctcggcgg gaaggctgtc ccggcgcctc aggcagctct gcgtgggccg
      181 gggtgacttc ctcgcgatcc cctgcgcgag gtgaagggca gggacctttg ccgcgccttc
      241 cacgcgccgt gccccaccgg cgagtggctc catcttcctc agacttatcg ctcgcggaca
      301 ggcgccgtgg gtctcccggg cctccgtacc gtcctccttc ccagcggctc cgggaagcgg
      361 ttccctgtct tcggacgcat ttcacccgcg cggggagagc ttcccgggaa ggttccacgg
      421 cggccgaggg tttccgcgcc cgggacgcgt ttcggctgag gccgtgggtc cagtccacgg
      481 gttctgcccg cacggtccaa tggccgggga ggcggaggct cagttggacc catcattgca
      541 gggcttggtg atgtttgagg atgtgacggt atatttctcc agggaggagt gggggctcct
      601 taatgtgacc cagaagggcc tataccggga tgtgatgctg gagaactttg cactcgttag
      661 ctcactggga cttgcacctt cgagatcccc tgtgtttacc cagctggagg atgatgaaca
      721 gtcgtgggtg cccagctggg tggatgtgac tccagtcagc agagcagaag ccaggagagg
      781 ttttggtctt gatggtttgt gtagagtgga ggatgagaga gcccatcctg agcatctaaa
      841 gagctacaga gtcatccagc accaggacac tcatagtgag gggaaaccaa gaaggcacac
      901 tgagcatggg gcagctttcc cacctggttc cagttgtggg caacagcaag aagtccatgt
      961 ggcagagaag ctgttcaaat gcagtgactg tgggaaggtg ttcttaaagg cctttgccct
     1021 ccttgaccat ctgataacgc attctgaaga gagacccttc agatgcccaa caggcagaag
     1081 tgctttcaag aagtcagctc atattaaccc ccgaaaaatt cacactggag aaacagccca
     1141 tgtgtgtaat gaatgtggga aggccttcag ttacccgtct aagctgagga aacaccagaa
     1201 ggttcacaca ggcataaaac cttttaagtg tagtgactgt ggtaaaacct tcaaccgcaa
     1261 agacgcactt gttctacacc agaggattca cactggagaa aggccttacg agtgcagcaa
     1321 atgtggtaaa accttcagtg ttctgtctac cctcattcgg caccggaaag tgcacattgg
     1381 agaaaggccc tatgagtgta cagaatgtgg gaagttcttt aaatacaata atagcttcat
     1441 tcttcaccag agagttcaca ctggagaaag gccttttgaa tgcaagcaat gtgggaaagg
     1501 ctacgtgacc cgttcaggcc tctatcagca ctggaaagtc cacactgggg aacggcccta
     1561 tgaatgtagc ctgtgtggga aaaccttcac taccagatcc taccgcaatc ggcaccagca
     1621 gttccacact gaagagaggt cttatgaatg tacagagtgt gggaaggcct tcaaacatag
     1681 ttccaccctc cttcagcaca agaaagtcca tactccagaa aggcgtcagg aggacagggc
     1741 acatgggaag gtcgttagct gctagcaccg tgttcatcag gaaaggtctt attccagaaa
     1801 ggaggttaag gagagtggcc gtgagagtgc catccgaaag aagctaaacc ttgcacatcc
     1861 caacacccac cccagggaga gttcccgtgt gtgcctggtg tgtgggacgc tttcgggagc
     1921 cacattgcac tctgacttgc ctggggctgt tggcagtgtc acatcactga gtttatccac
     1981 cgccatccac ctctatccac cccataaggt ccctacagca agtgggacag cagaccttgt
     2041 gctccttgct ctaaacagta gagaatcgtt aatagtggag cccaaaacag gcctcattcc
     2101 ctacccttga ctggtttagc tgtggacatg acccacctct ggccggagga gctgagctgg
     2161 tatctgctgg gggcttcctg ggaaggttta ccattttcat ggaaatggtt gacattacac
     2221 atggtatttg tcatgcccta gcatggactg tctcatactg ctctggacta tgtggtaata
     2281 aaggctttat tgtttaagcc gcttaaaa
//
