LOCUS       NM_001320371            3061 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens zinc finger protein 582 (ZNF582), transcript variant
            1, mRNA.
ACCESSION   NM_001320371 XM_006723044
VERSION     NM_001320371.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3061)
  AUTHORS   Luo,H., Lian,Y., Tao,H., Zhao,Y., Wang,Z., Zhou,J., Zhang,Z. and
            Jiang,S.
  TITLE     Relationship between p16/ki67 immunoscores and PAX1/ZNF582
            methylation status in precancerous and cancerous cervical lesions
            in high-risk HPV-positive women
  JOURNAL   BMC Cancer 24 (1), 1171 (2024)
   PUBMED   39304838
  REMARK    GeneRIF: Relationship between p16/ki67 immunoscores and PAX1/ZNF582
            methylation status in precancerous and cancerous cervical lesions
            in high-risk HPV-positive women.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3061)
  AUTHORS   Yang,W., Zhang,Z., Li,L., Zhang,K., Xu,Y., Xia,M., Zhou,J.,
            Gong,Y., Chen,J. and Gong,K.
  TITLE     ZNF582 overexpression restrains the progression of clear cell renal
            cell carcinoma by enhancing the binding of TJP2 and ERK2 and
            inhibiting ERK2 phosphorylation
  JOURNAL   Cell Death Dis 14 (3), 212 (2023)
   PUBMED   36966163
  REMARK    GeneRIF: ZNF582 overexpression restrains the progression of clear
            cell renal cell carcinoma by enhancing the binding of TJP2 and ERK2
            and inhibiting ERK2 phosphorylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3061)
  AUTHORS   Wu,N., Zhang,X., Zhu,M., Fang,C., Liu,X., Wang,Y., Li,H., Liu,S.,
            Ting,H., Qin,C., Liao,Q., Cai,J. and Wang,J.
  TITLE     ZNF582 promoter methylation predicts cervical cancer
            radiosensitivity and ZNF582 protein overexpression reduces
            radiosensitivity by cell cycle arrest in S phase
  JOURNAL   Epigenetics 17 (12), 1786-1799 (2022)
   PUBMED   35642528
  REMARK    GeneRIF: ZNF582 promoter methylation predicts cervical cancer
            radiosensitivity and ZNF582 protein overexpression reduces
            radiosensitivity by cell cycle arrest in S phase.
REFERENCE   4  (bases 1 to 3061)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3061)
  AUTHORS   Zhao,Y., Hong,X.H., Li,K., Li,Y.Q., Li,Y.Q., He,S.W., Zhang,P.P.,
            Li,J.Y., Li,Q., Liang,Y.L., Chen,Y., Ma,J., Liu,N. and Chen,Y.P.
  TITLE     ZNF582 hypermethylation promotes metastasis of nasopharyngeal
            carcinoma by regulating the transcription of adhesion molecules
            Nectin-3 and NRXN3
  JOURNAL   Cancer Commun (Lond) 40 (12), 721-737 (2020)
   PUBMED   33038291
  REMARK    GeneRIF: ZNF582 hypermethylation promotes metastasis of
            nasopharyngeal carcinoma by regulating the transcription of
            adhesion molecules Nectin-3 and NRXN3.
            Erratum:[Cancer Commun (Lond). 2022 Mar;42(3):281-283. doi:
            10.1002/cac2.12264.. PMID: 35129313]
REFERENCE   6  (bases 1 to 3061)
  AUTHORS   Chang,C.C., Huang,R.L., Liao,Y.P., Su,P.H., Hsu,Y.W., Wang,H.C.,
            Tien,C.Y., Yu,M.H., Lin,Y.W. and Lai,H.C.
  TITLE     Concordance analysis of methylation biomarkers detection in
            self-collected and physician-collected samples in cervical neoplasm
  JOURNAL   BMC Cancer 15, 418 (2015)
   PUBMED   25985991
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3061)
  AUTHORS   Liou,Y.L., Zhang,Y., Liu,Y., Cao,L., Qin,C.Z., Zhang,T.L.,
            Chang,C.F., Wang,H.J., Lin,S.Y., Chu,T.Y., Zhang,Y. and Zhou,H.H.
  TITLE     Comparison of HPV genotyping and methylated ZNF582 as triage for
            women with equivocal liquid-based cytology results
  JOURNAL   Clin Epigenetics 7 (1), 50 (2015)
   PUBMED   25945131
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3061)
  AUTHORS   Lin,H., Chen,T.C., Chang,T.C., Cheng,Y.M., Chen,C.H., Chu,T.Y.,
            Hsu,S.T., Liu,C.B., Yeh,L.S., Wen,K.C., Huang,C.Y. and Yu,M.H.
  TITLE     Methylated ZNF582 gene as a marker for triage of women with Pap
            smear reporting low-grade squamous intraepithelial lesions - a
            Taiwanese Gynecologic Oncology Group (TGOG) study
  JOURNAL   Gynecol Oncol 135 (1), 64-68 (2014)
   PUBMED   25134998
  REMARK    GeneRIF: This is the first study to show that ZNF582 methylation
            analysis of cervical swabs may be a promising choice in the
            positive triage of cytological diagnoses of low-grade squamous
            intraepithelial lesions
REFERENCE   9  (bases 1 to 3061)
  AUTHORS   Chang,C.C., Huang,R.L., Wang,H.C., Liao,Y.P., Yu,M.H. and Lai,H.C.
  TITLE     High methylation rate of LMX1A, NKX6-1, PAX1, PTPRR, SOX1, and
            ZNF582 genes in cervical adenocarcinoma
  JOURNAL   Int J Gynecol Cancer 24 (2), 201-209 (2014)
   PUBMED   24407576
  REMARK    GeneRIF: Methylation levels of ZNF582 in uterine cervix
            adenocarcinomas is significantly higher than those in normal
            cervical tissues.
REFERENCE   10 (bases 1 to 3061)
  AUTHORS   Huang,R.L., Chang,C.C., Su,P.H., Chen,Y.C., Liao,Y.P., Wang,H.C.,
            Yo,Y.T., Chao,T.K., Huang,H.C., Lin,C.Y., Chu,T.Y. and Lai,H.C.
  TITLE     Methylomic analysis identifies frequent DNA methylation of zinc
            finger protein 582 (ZNF582) in cervical neoplasms
  JOURNAL   PLoS One 7 (7), e41060 (2012)
   PUBMED   22815913
  REMARK    GeneRIF: ZNF582 is frequently methylated in cervical
            intraepithelial neoplasia 3 and worse lesions
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006116.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 10, 2021 this sequence version replaced NM_001320371.3.
            
            Summary: The protein encoded by this gene is a zing finger protein
            and putative transcription factor that is highly methylated in
            cervical cancers. Two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Feb
            2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.44084.1,
                                           SRR1803614.78837.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000586929.6/
                                                ENSP00000465619.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               AC006116.1         117558-117872       c
            316-404             AC006116.1         116082-116170       c
            405-531             AC006116.1         114713-114839       c
            532-627             AC006116.1         114339-114434       c
            628-3061            AC006116.1         107089-109522       c
FEATURES             Location/Qualifiers
     source          1..3061
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..3061
                     /gene="ZNF582"
                     /note="zinc finger protein 582"
                     /db_xref="GeneID:147948"
                     /db_xref="HGNC:HGNC:26421"
                     /db_xref="MIM:615600"
     exon            1..315
                     /gene="ZNF582"
                     /inference="alignment:Splign:2.1.0"
     exon            316..404
                     /gene="ZNF582"
                     /inference="alignment:Splign:2.1.0"
     CDS             396..1949
                     /gene="ZNF582"
                     /codon_start=1
                     /product="zinc finger protein 582"
                     /protein_id="NP_001307300.2"
                     /db_xref="CCDS:CCDS33121.1"
                     /db_xref="GeneID:147948"
                     /db_xref="HGNC:HGNC:26421"
                     /db_xref="MIM:615600"
                     /translation="MSLGSELFRDVAIVFSQEEWQWLAPAQRDLYRDVMLETYSNLVS
                     LGLAVSKPDVISFLEQGKEPWMVERVVSGGLCPVLESRYDTKELFPKQHVYEVESPQW
                     EIMESLTSYGLECSSFQDDWECRNQFDRQQGNPDRHFHQMIIRHEEMPTFDQHASLTF
                     YQKIHTREKPFGYNKCRKDFWQKELLINHQGIYTNEKPYKCKECGKAFKYGSRLIQHE
                     NIHSGKKPYECKECGKAFNSGSNFIQHQRVHTGEKPYECKDCEKAFSRSSQLIEHQRT
                     HTGEKPYQCKECGKAFNRISHLKVHYRIHTGEKPYACKECGKTFSHRSQLIQHQTVHT
                     GRKLYECKECGKAFNQGSTLIRHQRIHTGEKPYECKVCGKAFRVSSQLKQHQRIHTGE
                     KPYQCKVCGRAFKRVSHLTVHYRIHTGEKPYECKECGKAFSHCSQLIHHQVIHTEKKP
                     YEYKECEKTLSHDSTTVQPQRMHNRETHVNIINVEKPSISSYPLLIIREFMLASNHMN
                     GSNGESPLA"
     exon            405..531
                     /gene="ZNF582"
                     /inference="alignment:Splign:2.1.0"
     exon            532..627
                     /gene="ZNF582"
                     /inference="alignment:Splign:2.1.0"
     exon            628..3061
                     /gene="ZNF582"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3039..3044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF582"
                     /note="hexamer: AATAAA"
     polyA_site      3061
                     /gene="ZNF582"
                     /note="major polyA site"
ORIGIN      
        1 gcgcacggcg aatccaccgg taccgtggtg gaagcgcgcc ctgggctgcc gggggcgcgg
       61 ccgcggtggc acttggaccc gaggaggcgg caggtgagag gttccggagc tttccaggcg
      121 ctctggggtc cagcaggagc tggtgcccgg gccggttggg tctcaggcct gagaagaacg
      181 cagacgtctc gcctcatcgt cgctctgtgg ctttaccggc gtgagactac atttcccgcc
      241 ggccctcgcg gcgtgcgctt tctggcgccc cctttctgct tccagcctca tagcccaggt
      301 gcatggaccc cttagctcta ccgtcgcagg actctgccct tccccaagag aggaaccaga
      361 aggaggacct atcagccctt gaaattctaa aagtcatgtc ccttgggtca gaattgttca
      421 gggatgtggc catagtcttc tcccaagaag aatggcagtg gttggcacct gctcagaggg
      481 atttgtacag agacgtgatg ttggagacct acagcaacct ggtctcactg ggtcttgccg
      541 tttccaaacc tgatgtgatc tccttcctag agcaaggcaa agagccctgg atggtggaga
      601 gagtggtgtc tggaggcctg tgtccagtat tggagtccag atatgatacc aaggaattat
      661 ttccaaagca gcatgtttat gaagtcgaat caccccaatg ggagataatg gaaagcctta
      721 caagttatgg tcttgagtgt tcaagtttcc aagatgattg ggaatgcaga aaccagtttg
      781 acagacaaca gggaaatcca gacagacatt tccatcagat gatcatcaga catgaagaaa
      841 tgcccacttt tgaccagcat gcatccctta ctttttatca gaaaattcat actagagaaa
      901 aaccttttgg gtataataaa tgtagaaaag acttctggca aaaggaactc cttattaatc
      961 atcaaggaat ttatactaat gagaaaccct ataaatgtaa ggaatgtggg aaggccttta
     1021 aatatggctc acgactaatt caacatgaga atattcattc tggtaagaaa ccatatgaat
     1081 gtaaggaatg tggaaaggcc ttcaattctg gttcaaattt tatacaacat cagagagttc
     1141 atactggtga gaaaccgtat gaatgtaaag attgtgagaa ggcctttagt cgaagctcac
     1201 agttgattga acatcagcga actcacacag gcgagaaacc ctatcagtgt aaggaatgtg
     1261 gcaaggcctt caatcggatc tcacatctta aagtacatta tagaattcat actggtgaaa
     1321 aaccctatgc atgcaaggaa tgtgggaaaa cctttagtca tcgttctcag ttgattcaac
     1381 atcagactgt tcatactggc aggaaactct atgaatgtaa ggaatgtggg aaggctttta
     1441 atcaaggctc aactcttata cgacatcaga gaattcatac cggtgagaaa ccctatgagt
     1501 gcaaagtatg tggaaaggcc tttagagtga gctcacaact caagcaacat cagagaattc
     1561 acactggaga gaaaccctac caatgtaagg tatgtggtag ggccttcaaa cgggtctcac
     1621 atcttactgt acattacaga attcatacag gtgaaaagcc atatgaatgt aaggaatgtg
     1681 ggaaggcttt tagtcattgc tcacaattga ttcatcatca ggttattcac actgagaaaa
     1741 agccctatga atataaggaa tgtgagaaga ccttgagtca tgattcaact accgttcaac
     1801 ctcagagaat gcataataga gaaacacatg tgaatataat aaatgtagaa aagccttcca
     1861 tcagcagtta ccccttacta atcatcagag aatttatgtt ggcaagcaac catatgaatg
     1921 gaagtaatgg ggaaagccca ttagcctagg ctaattgtga ctgtgactta cttctccctc
     1981 ttggagaaag acttgaagaa tgtaatgcca gtgacaatgc cttcattcag aggtaagcct
     2041 ttatcctaag tctgaaaatt catatcaaag aaaattttat ggatgtaaat tgttcagatc
     2101 ataattgtca aaaatgctgg gaaaggttgg gagaaatttt atttctaaca cattccagaa
     2161 ccacattttc taaccacagt gtagtaattt tatcaagagc aaaagttata gttttcttac
     2221 aagttaaaaa aacagccaga ttatcatttg cttaacaaag aaatcatgca attaccataa
     2281 atggtaatga aaagaatgaa ttgagagttt aacatgccaa gagatgtgaa atgtggccaa
     2341 agagatgtga gggtaagggg aaagccaaag ctacactgga ggaattttta tagcctttga
     2401 atgcatgcat atacatgaaa atctgaaaga taaactcata tgcactaaac atgctattca
     2461 agtctaccaa acatccaggc agtgaaagaa gaaagtaaca gaaaatgatg aaataaagag
     2521 accatcttac aataatctca gtttttgttt ctttctgatc cagaaataat ctaaatttag
     2581 gagaatattt cttaatttcc acattgttac attgttttat gtgactggca cagacaacca
     2641 ttggttgtca tcccagcagc catacccaat tccccttgtt attggcagca tctgtgtctt
     2701 gccttggact ctgagaatat cagatgctaa ttttccagtc tcctgtgcag cacagtatgg
     2761 ccagtatctc ccagtgttgc tcagtggaat ctgccggggc ttctgggaaa gattttcctc
     2821 attcagaaga gacaggttta tcatgaagac ttcctcctct ctcacttcct gcttttaaac
     2881 atttttatat aagaacatga tgcctgaagc tgctgcagct gtcttggaac caagaagaga
     2941 aaaaagtgga cctcagagaa gctgacccag agcctgagaa gactcagcta ctaggccaat
     3001 tctggaactg cctttttgat gccttgttat ctgagaaaaa taaaacttga ttgctcagtt
     3061 a
//
