LOCUS       NM_016535               1197 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 581 (ZNF581), mRNA.
ACCESSION   NM_016535
VERSION     NM_016535.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1197)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1197)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1197)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1197)
  AUTHORS   Kovacs,I.A., Luck,K., Spirohn,K., Wang,Y., Pollis,C., Schlabach,S.,
            Bian,W., Kim,D.K., Kishore,N., Hao,T., Calderwood,M.A., Vidal,M.
            and Barabasi,A.L.
  TITLE     Network-based prediction of protein interactions
  JOURNAL   Nat Commun 10 (1), 1240 (2019)
   PUBMED   30886144
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1197)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF151023.2 and BC010097.2.
            
            On Nov 23, 2018 this sequence version replaced NM_016535.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010097.2, AF151023.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270451.6/ ENSP00000270451.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1196              AF151023.2         30-1225
            1197-1197           BC010097.2         1198-1198
FEATURES             Location/Qualifiers
     source          1..1197
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..1197
                     /gene="ZNF581"
                     /gene_synonym="HSPC189"
                     /note="zinc finger protein 581"
                     /db_xref="GeneID:51545"
                     /db_xref="HGNC:HGNC:25017"
     exon            1..126
                     /gene="ZNF581"
                     /gene_synonym="HSPC189"
                     /inference="alignment:Splign:2.1.0"
     exon            127..1197
                     /gene="ZNF581"
                     /gene_synonym="HSPC189"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..739
                     /gene="ZNF581"
                     /gene_synonym="HSPC189"
                     /codon_start=1
                     /product="zinc finger protein 581"
                     /protein_id="NP_057619.1"
                     /db_xref="CCDS:CCDS12932.1"
                     /db_xref="GeneID:51545"
                     /db_xref="HGNC:HGNC:25017"
                     /translation="MLVLPSPCPQPLAFSSVETMEGPPRRTCRSPEPGPSSSIGSPQA
                     SSPPRPNHYLLIDTQGVPYTVLVDEESQREPGASGAPGQKKCYSCPVCSRVFEYMSYL
                     QRHSITHSEVKPFECDICGKAFKRASHLARHHSIHLAGGGRPHGCPLCPRRFRDAGEL
                     AQHSRVHSGERPFQCPHCPRRFMEQNTLQKHTRWKHP"
     regulatory      1175..1180
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF581"
                     /gene_synonym="HSPC189"
                     /note="hexamer: AATAAA"
     polyA_site      1197
                     /gene="ZNF581"
                     /gene_synonym="HSPC189"
                     /note="major polyA site"
ORIGIN      
        1 ctctttcggc cggcgccgcc agttcctggg gcacacccag aggtcccctt ctcgccgccg
       61 cctgcaactg cgagggtagc ccggggccgc ttggagtcgc ccggacctga gaggctgctg
      121 cactgggcct cagccagccc tccggatgct ggtgctgcca tccccctgcc ctcagcctct
      181 ggcattttcc tccgttgaga ccatggaggg ccctccccgt cggacttgcc gctccccaga
      241 acctggacct tcctcctcca tcggatctcc ccaggcttca tctcctccaa ggcccaacca
      301 ctacctgctt attgacactc agggtgtccc ctacacagtg ctggtggacg aggagtcaca
      361 gagggagcca ggggccagtg gggctccagg ccagaaaaag tgctacagct gccccgtgtg
      421 ctcaagggtc ttcgagtaca tgtcctacct tcagcgacac agcatcaccc actcggaggt
      481 aaagcccttc gagtgtgaca tctgtgggaa ggcattcaag cgcgccagcc acttggcacg
      541 gcaccattcc attcacctgg cgggtggtgg gcggccccac ggctgcccgc tctgccctcg
      601 ccgcttccgg gatgcgggtg agctggccca gcacagccgg gtgcactctg gggaacgccc
      661 gtttcagtgt ccacactgcc ctcgccgctt tatggagcag aacacactgc agaaacacac
      721 gcggtggaag catccatgag ccgggctgcc gggtgcccca ggtaccacag gactttgcag
      781 ggagcctgga ctcctgtcca gacacctggt gagagcctga ggctggtgtt cagggccctg
      841 gacacagaca cagagcagcc gcatctcaaa ggcagagccc tgcctgaagg aggaatccgt
      901 gagtaatctt caggtcctcc gtgttctgga gctgagatgg gaatgagccc ctacacagaa
      961 tggagtcctc tagcctaaag atatcagctg ttccatggca gagccttgac tggatggagg
     1021 tggggagtgt ggtgtgtaaa gtctctggcc tcataaaagg tggctgtggg tcgtcaggaa
     1081 tctgcgccat cttcctgggg cttctgcgct gttgttgggg aagggacccc agtcctgcct
     1141 tccacccccc aaccaggcct gagactgatc aaacaataaa cacgtttccc actctga
//
