LOCUS       NM_207115               1156 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 580 (ZNF580), transcript variant
            2, mRNA.
ACCESSION   NM_207115
VERSION     NM_207115.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1156)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1156)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   3  (bases 1 to 1156)
  AUTHORS   Luo,Y., Zhao,Y., Li,X., Zhao,J. and Zhang,W.
  TITLE     ZNF580 mediates eNOS expression and endothelial cell
            migration/proliferation via the TGF-beta1/ALK5/Smad2 pathway
  JOURNAL   Mol Cell Biochem 393 (1-2), 199-207 (2014)
   PUBMED   24771066
  REMARK    GeneRIF: These results suggest that ZNF580 mediates eNOS expression
            and endothelial cell migration/proliferation via the
            TGF-b1/ALK5/Smad2 pathway, and thus plays a crucial role in
            vascular endothelial cells.
REFERENCE   4  (bases 1 to 1156)
  AUTHORS   DangLi,R., HeKong,W., JiQin,L., MingHua,Z. and WenCheng,Z.
  TITLE     ROS-induced ZNF580 expression: a key role for H2O2/NF-kappaB
            signaling pathway in vascular endothelial inflammation
  JOURNAL   Mol Cell Biochem 359 (1-2), 183-191 (2012)
   PUBMED   21830064
  REMARK    GeneRIF: H2O2 upregulates the expression of ZNF580 via the
            NF-kappaB signaling pathway, and overexpression of ZNF580 plays a
            critical role in augmenting the release of pro-inflammatory
            cytokine IL-8.
REFERENCE   5  (bases 1 to 1156)
  AUTHORS   Luo,Y., Hu,W., Xu,R., Hou,B., Zhang,L. and Zhang,W.
  TITLE     ZNF580, a novel C2H2 zinc-finger transcription factor, interacts
            with the TGF-beta signal molecule Smad2
  JOURNAL   Cell Biol Int 35 (11), 1153-1157 (2011)
   PUBMED   21599657
  REMARK    GeneRIF: ZNF580 is a binding partner of Smad2 and is involved in
            the signal transduction of the transforming growth factor-beta
            signalling pathway.
REFERENCE   6  (bases 1 to 1156)
  AUTHORS   Hoffmann,C.J., Hohberg,M., Chlench,S., Maroski,J., Drab,M.,
            Siegel,G., Pries,A.R. and Zakrzewicz,A.
  TITLE     Suppression of zinc finger protein 580 by high oxLDL/LDL-ratios is
            followed by enhanced expression of endothelial IL-8
  JOURNAL   Atherosclerosis 216 (1), 103-108 (2011)
   PUBMED   21310414
  REMARK    GeneRIF: ZNF580 is a novel factor in the lipoprotein-dependent
            regulation of endothelial IL-8 expression and monocyte arrest.
REFERENCE   7  (bases 1 to 1156)
  AUTHORS   Sun,H.Y., Wei,S.P., Xu,R.C., Xu,P.X. and Zhang,W.C.
  TITLE     Sphingosine-1-phosphate induces human endothelial VEGF and MMP-2
            production via transcription factor ZNF580: novel insights into
            angiogenesis
  JOURNAL   Biochem Biophys Res Commun 395 (3), 361-366 (2010)
   PUBMED   20382120
  REMARK    GeneRIF: These results elucidate the important role that ZNF580
            plays in the process of migration and proliferation of endothelial
            cells, which provides a foundation for a novel approach to regulate
            angiogenesis.
REFERENCE   8  (bases 1 to 1156)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008735.9, AL359054.1, BU179609.1 and AF184939.1.
            
            On Nov 23, 2018 this sequence version replaced NM_207115.1.
            
            Transcript Variant: This variant (2) represents use of an alternate
            promoter and 5' UTR, compared to variant 1. Variants 1, 2, and 3
            all encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL359054.1, SRR1163655.278522.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325333.10/ ENSP00000320050.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC008735.9         35322-35345         c
            25-187              AL359054.1         94-256
            188-774             BU179609.1         74-660
            775-838             AL359054.1         844-907
            839-850             BU179609.1         725-736
            851-1037            AL359054.1         917-1103
            1038-1156           AF184939.1         1588-1706
FEATURES             Location/Qualifiers
     source          1..1156
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..1156
                     /gene="ZNF580"
                     /note="zinc finger protein 580"
                     /db_xref="GeneID:51157"
                     /db_xref="HGNC:HGNC:29473"
                     /db_xref="MIM:617888"
     exon            1..182
                     /gene="ZNF580"
                     /inference="alignment:Splign:2.1.0"
     exon            183..1156
                     /gene="ZNF580"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..713
                     /gene="ZNF580"
                     /note="LDL-induced EC protein"
                     /codon_start=1
                     /product="zinc finger protein 580"
                     /protein_id="NP_996998.1"
                     /db_xref="CCDS:CCDS12931.1"
                     /db_xref="GeneID:51157"
                     /db_xref="HGNC:HGNC:29473"
                     /db_xref="MIM:617888"
                     /translation="MLLLPPRPPHPRSSSPEAMDPPPPKAPPFPKAEGPSSTPSSAAG
                     PRPPRLGRHLLIDANGVPYTYTVQLEEEPRGPPQREAPPGEPGPRKGYSCPECARVFA
                     SPLRLQSHRVSHSDLKPFTCGACGKAFKRSSHLSRHRATHRARAGPPHTCPLCPRRFQ
                     DAAELAQHVRLH"
     regulatory      1137..1142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF580"
                     /note="hexamer: AATAAA"
     polyA_site      1156
                     /gene="ZNF580"
                     /note="major polyA site"
ORIGIN      
        1 gccttttccc agggactccg ccaacccctc gcacccccgc gcccccagtc cccgcgtccc
       61 cggcgccgcc ggcccggagc tgcccggaag tctcggttcc gccgccggcg ctcgccaggg
      121 gaagcccggg gccgcccggg acctcggccc gttcctccgg acccgagagg ccgccgcacg
      181 ggctgccgct ccagatgctg ctgctgccgc cgcggccacc ccaccctcgg tcctcctctc
      241 cggaggccat ggacccaccg ccccccaagg ctcccccttt ccccaaggcg gaaggcccct
      301 cctccactcc ttcctcggcg gcggggcccc gacccccgcg gctgggccgc cacctcctca
      361 tcgacgccaa tggggtcccc tacacataca cggtgcagct ggaggaggag ccccggggcc
      421 cgccccagcg cgaggcgccc ccaggagagc ccggccctcg caagggctac agctgcccgg
      481 agtgcgcccg tgtctttgcc agccctctgc ggctgcagag ccaccgcgtg tcgcactcgg
      541 acctcaagcc cttcacgtgc ggcgcctgcg gcaaggcctt caagcgctcc agccacctgt
      601 cgcggcatcg cgccacgcac cgcgcccgcg ccgggccgcc gcacacctgc ccgctctgcc
      661 cacgccgctt ccaggacgcc gcggagctgg cgcagcacgt gcgcctccac taagctcgag
      721 acccggcctg tgctgccctg cccgtctcag ggccaccaag tctgacccac acagcgtcac
      781 tcactcccac acacaccccc tggctctgct gaggttactg ccttaccctg ggcctcagtt
      841 tccccacctt ccaaagggag gagcatcatt ccttccttac cccctttcta gctgtgtgat
      901 gtagaccaaa gtcgttgccc ctccctgggc ctgggaacca gtcggaactg ggttccagtc
      961 cagctgtgct gtgtgagcct gtgcaagtga catgacctct ctaaaccttg gttttctgct
     1021 ctctggagcg gtgaaccggt ggttgtctgc ggggaagaga tgataaagag cacgggcacg
     1081 gtctggttca tttctgtatc tacccccctt ccgcccacgc ccccgaccct ttgctcaata
     1141 aacattccgc actcca
//
