LOCUS       NM_001099694            6768 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 578 (ZNF578), transcript variant
            1, mRNA.
ACCESSION   NM_001099694 XM_001127226 XM_001131451
VERSION     NM_001099694.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6768)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010332.7, BX955279.1, AC022150.6, AK055946.1 and BC115704.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001099694.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DC372079.1, AK299106.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145313
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000421239.7/ ENSP00000459216.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC010332.7         99841-99863
            24-633              BX955279.1         2-611
            634-845             AC022150.6         20308-20519
            846-1564            AK055946.1         1-719
            1565-2215           BC115704.1         710-1360
            2216-2980           AK055946.1         1371-2135
            2981-6764           AC022150.6         22655-26438
            6765-6768           AC022150.6         26439-26442
FEATURES             Location/Qualifiers
     source          1..6768
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..6768
                     /gene="ZNF578"
                     /note="zinc finger protein 578"
                     /db_xref="GeneID:147660"
                     /db_xref="HGNC:HGNC:26449"
     exon            1..55
                     /gene="ZNF578"
                     /inference="alignment:Splign:2.1.0"
     exon            56..146
                     /gene="ZNF578"
                     /inference="alignment:Splign:2.1.0"
     exon            147..248
                     /gene="ZNF578"
                     /inference="alignment:Splign:2.1.0"
     exon            249..330
                     /gene="ZNF578"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..2040
                     /gene="ZNF578"
                     /note="Putative chemokine-related protein B42"
                     /codon_start=1
                     /product="zinc finger protein 578"
                     /protein_id="NP_001093164.1"
                     /db_xref="CCDS:CCDS54310.1"
                     /db_xref="GeneID:147660"
                     /db_xref="HGNC:HGNC:26449"
                     /translation="MLHEEAAQKRKGKEPGMALPQGRLTFRDVAIEFSLAEWKFLNPA
                     QRALYREVMLENYRNLEAVDISSKRMMKEVLSTGQGNTEVIHTGMLQRHESYHTGDFC
                     FQEIEKDIHDFEFQSQKDERNGHEASMPKIKELMGSTDRHDQRHAGNKPIKDQLGLSF
                     HLHLPELHIFQPEEKIANQVEKSVNDASSISTSQRISCRPETHTPNNYGNNFFHSSLL
                     TQKQEVHMREKSFQCNETGEAFNCSSFVRKHQIIHLGEKQYKFDICGKVFNEKRYLAR
                     HRRCHTSEKPYKCNECGKSFSYKSSLTCHRRCHTGEKPYKCNECGKSFSYKSSLTCHH
                     RCHTGEKPYKCNECGKSFSYKSSLRCHRRLHTGIKPYKCNECGKMFGQNSTLVIHKAI
                     HTGEKPYKCNECGKAFNQQSHLSRHHRLHTGEKPYKCNDCGKAFIHQSSLARHHRLHT
                     GEKSYKCEECDRVFSQKSNLERHKIIHTGEKPYKCNECHKTFSHRSSLPCHRRLHSGE
                     KPYKCNECGKTFNVQSHLSRHHRLHTGEKPYKCKVCDKAFMCHSYLANHTRIHSGEKP
                     YKCNECGKAHNHLIDSSIKPCMSS"
     exon            331..457
                     /gene="ZNF578"
                     /inference="alignment:Splign:2.1.0"
     exon            458..6768
                     /gene="ZNF578"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4363..4368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF578"
                     /note="hexamer: AATAAA"
     polyA_site      4386
                     /gene="ZNF578"
                     /note="major polyA site"
     regulatory      6742..6747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF578"
                     /note="hexamer: AATAAA"
     polyA_site      6768
                     /gene="ZNF578"
                     /note="major polyA site"
ORIGIN      
        1 agtttcctga agacccggaa gccgatcgcg tggggagccg gtcttggagc agcgggatta
       61 gcttctaaag tctctttcat ctctcctaag gaagaagcct agaagaggag gaagaggaaa
      121 gaaaaggagt caggaatgcc tcttagatat ctcttccaaa tgcatgatga aaaaggtggg
      181 aagattactt gagccaggga gttgaaggct gcagtgagcc ctgtttttgc caccacactc
      241 cagcttggga ttgatttcta aagactcatg ttacatgagg aagcagctca gaagaggaaa
      301 ggaaaggagc caggcatggc tcttcctcag ggacgcttga ctttcaggga tgtggctata
      361 gaattctcat tggcagagtg gaaattcctg aaccctgcgc agagggcttt gtacagggaa
      421 gtgatgttgg agaactacag gaacctggag gctgtggata tctcttccaa acgcatgatg
      481 aaggaggtct tgtcaacagg gcaaggcaat acagaagtga tccacacagg gatgttgcaa
      541 agacatgaaa gttatcacac tggagatttt tgcttccagg aaattgaaaa agatattcat
      601 gactttgagt ttcagtcaca aaaagatgaa agaaatggcc atgaagcatc catgccaaaa
      661 atcaaagagt tgatgggtag cacagaccga catgatcaaa ggcatgctgg aaacaagcct
      721 attaaagatc agcttggatt aagctttcat ttgcatcttc ctgaactcca catatttcag
      781 cccgaagaga aaattgctaa tcaagtggag aagtctgtca acgatgcttc ctcaatttca
      841 acatcccaaa gaatttcttg taggcctgaa acacatactc ctaataacta tgggaataat
      901 tttttccatt catcattact cacacaaaaa caggaagtac acatgagaga aaaatctttc
      961 caatgtaatg agactggcga agcctttaat tgtagctcat ttgtaaggaa acatcagata
     1021 atccatttag gagaaaaaca atataaattt gatatatgtg gcaaagtctt taatgagaag
     1081 cgataccttg cacgccatcg tagatgtcac actagtgaga aaccttacaa gtgtaatgaa
     1141 tgtggaaagt ccttcagtta caagtcatcc ctgacatgcc atcgtagatg tcacactggt
     1201 gagaaacctt acaagtgtaa tgaatgtgga aagtccttca gttacaagtc atcccttaca
     1261 tgccatcata ggtgtcacac tggtgagaaa ccttacaagt gtaatgaatg tggaaagtcc
     1321 ttcagttaca agtcatccct tagatgccat cgtagacttc atactggaat aaaaccttac
     1381 aagtgtaatg agtgtggcaa gatgtttggt caaaattcaa cccttgtaat tcataaggca
     1441 attcatactg gagagaaacc ttacaagtgt aatgaatgtg gcaaggcttt taatcaacaa
     1501 tcacaccttt cacgtcatca tagacttcat actggagaga aaccttacaa gtgtaatgac
     1561 tgtggtaagg cttttattca tcagtcaagc cttgcacgtc atcatagact tcatactgga
     1621 gagaaatctt acaaatgtga agaatgtgac agagttttca gtcagaaatc aaaccttgag
     1681 agacacaaga taattcatac tggagagaaa ccttacaagt gtaatgagtg tcacaagacc
     1741 ttcagtcaca ggtcatctct tccatgccat cgtagacttc atagtggtga gaaaccttac
     1801 aagtgtaatg aatgtgggaa gacttttaat gtacagtcac acctttcacg tcatcataga
     1861 cttcatactg gagagaaacc ttacaaatgt aaggtttgtg acaaggcttt catgtgccat
     1921 tcttatctgg caaaccatac tagaattcat agcggagaga aaccttacaa gtgtaatgag
     1981 tgtggtaagg ctcacaatca cttgattgat tcatcaatca agccttgcat gtcatcatag
     2041 acttcatact ggagagaaac cttacaaatg tgaagcatgt gacaaagttt tcagtcacag
     2101 atcacgcctt aaaagacata ggagaattca tactggagag aaaccttaca agtgtaatga
     2161 gtgtggcaaa gcctttagtg accagtcaac acttaccatc aggccattca tggtgtaggg
     2221 aaacttgact aatgtaatga ttgtcacaaa gtcttcagta acgctacaac gattgcaaat
     2281 cattggagaa tccataatga agagagatct tccgagtgta ataaatgtgg caaatttttc
     2341 agacatcgtt cataccttgc agttcatcag tgaactcata ctggagagaa accttacaaa
     2401 tgtcatgact gtggcaaggt cttcagtcaa gcttcatcct atgcaaaaca taggagaatt
     2461 catgcaggag agaaatgtca caagtgtgat gagtgttgca aagcctttac ttcatgttca
     2521 cacctcatta gacatcagag aatccctact ggagagaaat cttacaaatg tcatcagtgt
     2581 ggcaaggtct tcagtccgag gtcactcctt gcagaacatc agaaaattca tttttgagat
     2641 aactgttccc aatgcagtga gtatagcaaa ccatcaagca ttaattgaca ttggagtcaa
     2701 ttcagcattg acttgagttt gtgttgactt aacattgagt tcaagcctta attgacatgc
     2761 aggtgtttat gataagagga ttgggccagg tgcagtggat cacgcctgta atcccagcac
     2821 attgggaggc caaggcacat aggtcacttg aggtcaagag tttgaaacaa gcatggccaa
     2881 gagatgtgag ccagttttcc cagcctgttt attattattt tttgagatgg agtgttgctc
     2941 ttgctgccca ggctagagtg caatggtgcg atcttgactc acagcaacct ccgcctcctg
     3001 ggttcaagcg attcctctgc ctcagcctcc ctagttgctg ggattacagg tatatgccac
     3061 gacgcctggc taattttttg tatttttagt agggaaaggg tttctccatg ttggtcaggc
     3121 tggtctcaaa ctcccgatct caggtgatcc gcccacctca gcctcccaaa gtgatgagat
     3181 tacaggcata tgccaccgcg cctggcattg tttcttcttt tccttttttt tttttttttt
     3241 tttttttgag atagtacttt ttaaagagat agtacttttt tgagatagta cttttttaaa
     3301 gggatatacc atagtagttt taaaagggat atcaggctgg gtgtggcagc tcacgccggt
     3361 aatcccagca ctttgggagg ccaaggcagg cagataacaa agtcaggaga ttgagaccgt
     3421 cctggctaac acggtgaaac ctcgtctcta ctaaaaatac aaaaacttag ccgggcatgg
     3481 tggtgggcac ctgtagtctc agctactcag ggggctgagg ctggacaatg gtgtgaaccc
     3541 aggaggcggt gcttgcaggg agccgagatc gtgccactgc actccaggct gggcgacaga
     3601 gtgagagtct gtctcaaaaa aaaaaaaaaa aagatatcaa acccggggtg tctcatccca
     3661 cagcactttg gaagactgaa gtgagtggat catctaagat cagagttcaa gagcaccctg
     3721 gctaacatgg tgaaacccca tctctactaa aaatacaaaa gttagccagg ggtgggggtg
     3781 tgcaccttta gttccagcta cttgggacac tgaggcatga gaatcactta aacctgggag
     3841 gtagaggtta cagcgaatca aaaccgtgcc actgtactgc agcgaggttg gcagagtgag
     3901 tctccatctc aaacaaacaa atgaaaaaaa cagacatcaa aaatgctttt gttctcgttg
     3961 tgtcatagac ttcccttttt tttccttctg gttcctcttc agttctctat ttattttttc
     4021 ttttttgcag attgagtttg agatatatct tagttttaat agttttattt cttaacacat
     4081 aatgacttct gaaagatgcc tttgcagcat cctgtaatca gctcacatca ttcgtttctg
     4141 tacttgtata ttttccagtt gttttccggt tgaccccaaa attcgtgaga tttttttcct
     4201 acaacaattt caaaagagtt gctgtttgaa attagttgca tccagttcag atcgaggtct
     4261 gcatgctttc tagtctttgt tatttattgg aaggctgtgg tacctactac ttaagtttga
     4321 ttgttgcagt gtgtacttgg taaagatgtc agtgaccttt taaataaaca tcaaaatgta
     4381 gtttaagcag ttagtctgtt tttcagtttt ctttccttat gtcatttttt aaaatcttga
     4441 gctgggagct atttattgtg tgtttccctc aaggccctgt ggtccattct ggaaaaatgt
     4501 tgaaacatgg gctggagtgg catagagcgc tgctccaaaa gcacccatgt attcttttct
     4561 tttttggaaa tggagtctcg ctctgtcagc ttggatggag tgcagtggtg cgatctcagc
     4621 tcactgcaac ctctacctcc ttggatcaag tgatgctcct gcctcagtct cctgaggagc
     4681 tggaattaca ggcacccacc agcacaccca gctagttttt gtatttttag tagagacagg
     4741 gtttcaccat gtttgtcagg ctggtctcaa actcctgacc tcgcgatcca cccgactcag
     4801 cctcccactg tgatgggatt acaggcatga gctaccacgt cgagactctt tttttttttt
     4861 ttttttagat ggagttttgc ttttgttgct gaggctggag tgcaatggtg cgatctggtg
     4921 tcactccaat gtcttcctcc tgggttcaag tgatttctcc tgcctcatcc tactgagtag
     4981 ttgggattac aggtgccctc caccactccc ggctcatttt ttgcattttt agtagagaca
     5041 gggtttcatc atgttggcag gctggtcttg aactcctgac ttcaggtgat ctgcccacct
     5101 cgacctccca aaatgctagg attacaagcg tgagccattg tgcctgacca ctcatgtatt
     5161 cttgattgaa ataatttgct tatttcttag ttctacagct gaccctcttt cactgtttcc
     5221 aaggtcaata gctgtgtgtt cacacttctg cattttataa atgttcctgt gagttttttg
     5281 taaggaagaa ttaactgtca ggaatcaatg tcatcagaac cttgcaaaag aagtttcttt
     5341 agcccaggtt tgtgaaagag gtttctctaa ttttcaagga tgggggtgat aagagcaacc
     5401 tttgccatta gcccttccag gaccccatgt aagactttag acaccttctc actcatctca
     5461 gaccttctca gggtaacttg gtgaaaatgt cttccgatct gagccccagt gagcctccct
     5521 gcaacttggc gacgaggggc ttgaccagaa aaggtcaacc cgagtgtccc tgaccgttga
     5581 aatgattggc aaaatggagt gcgtgtctgg gtgtggcttt tttttttttg aggagtgccc
     5641 agttgtgatt agaattttca atgggatgca gtgccctaaa aatgaaaaac aaaagcagaa
     5701 gaatggaaga aatagaggta gactcagaca cagagaccat cttcaaggcc tttctctgta
     5761 tgaggacatc acagcaaaat ctaaagcagg tcacgtcaat ccctggcagg gaaccctcca
     5821 ccggcttccc gtgttcccca ggacaaaagc ccaacccctc actgtggctc cacagccccg
     5881 tgtgcagggc ccctgccagt gtccagcctc ctcctggcag cttgccctca tctcatgact
     5941 ccctctgccc cagtcacatt tgcttttctc ttttcccaaa catcaaaacc cttcctgtct
     6001 caggtcattg tccctgctct taccctatgt accctgtccc tttctcctcc ttcaggtcta
     6061 ggctcagagc tctctcccat gccctcccac ccctggtctc aagctcctga gctcaagtga
     6121 tctacccacc tcggcctcct agagtgctgg gatgacaggc atgagccact gcaaccagcc
     6181 tctgcatggg gtttcctcaa ctttaggtct gtgccctgaa ggggagctca ttccagccca
     6241 gttcccaact gctgcagcat gtgtgtgtgg gcttctccag aaggggagcc agagtttccc
     6301 tgtaggagtt tatcctccat ggtgaggagg gccgcagggg ggactgtatt tgctcagggt
     6361 gaggtctcct ttgtgtcagg cctctgagcc caagctaagc catcgtatcc cctgtcacct
     6421 gcacgtatac atccagatgg cctgaagcaa ctgaagatcc acgaaagaag tgaaaatacc
     6481 cttaagtgat gacattccac cattgtgatt tatttctgca ccatcttgac tgatcaatgt
     6541 gctttgtaat ctcccccacc cttcagaagg ctctttgtaa tcctccccac ccttgagaat
     6601 ggacttggtg agatccaccc cctgcctgca aagcattgcc cctaactcca ccgcctgtcc
     6661 caaaagctac aagaactaat gataatccca ccatactttg ctgactctct tttcacactc
     6721 agcccgcctg cacccaggtg aaataaacag cctcgttgct cacacaaa
//
