LOCUS       NM_001370449            8291 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens zinc finger protein 577 (ZNF577), transcript variant
            6, mRNA.
ACCESSION   NM_001370449 XM_011527408
VERSION     NM_001370449.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8291)
  AUTHORS   Lorenzo,P.M., Izquierdo,A.G., Diaz-Lagares,A., Carreira,M.C.,
            Macias-Gonzalez,M., Sandoval,J., Cueva,J., Lopez-Lopez,R.,
            Casanueva,F.F. and Crujeiras,A.B.
  TITLE     ZNF577 Methylation Levels in Leukocytes From Women With Breast
            Cancer Is Modulated by Adiposity, Menopausal State, and the
            Mediterranean Diet
  JOURNAL   Front Endocrinol (Lausanne) 11, 245 (2020)
   PUBMED   32390948
  REMARK    GeneRIF: ZNF577 Methylation Levels in Leukocytes From Women With
            Breast Cancer Is Modulated by Adiposity, Menopausal State, and the
            Mediterranean Diet.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8291)
  AUTHORS   Helleboid,P.Y., Heusel,M., Duc,J., Piot,C., Thorball,C.W.,
            Coluccio,A., Pontis,J., Imbeault,M., Turelli,P., Aebersold,R. and
            Trono,D.
  TITLE     The interactome of KRAB zinc finger proteins reveals the
            evolutionary history of their functional diversification
  JOURNAL   EMBO J 38 (18), e101220 (2019)
   PUBMED   31403225
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK093036.1, AL832871.1, AK289479.1, AI004737.1 and AC074141.3.
            
            On May 8, 2019 this sequence version replaced XM_011527408.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.125514.1,
                                           SRR1803615.38283.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2162568
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000638348.2/ ENSP00000491936.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AK093036.1         1-176
            177-1599            AL832871.1         161-1583
            1600-3172           AK289479.1         617-2189
            3173-3340           AI004737.1         7-174               c
            3341-8291           AC074141.3         14631-19581         c
FEATURES             Location/Qualifiers
     source          1..8291
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..8291
                     /gene="ZNF577"
                     /note="zinc finger protein 577"
                     /db_xref="GeneID:84765"
                     /db_xref="HGNC:HGNC:28673"
     exon            1..1131
                     /gene="ZNF577"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1330
                     /gene="ZNF577"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1409
                     /gene="ZNF577"
                     /inference="alignment:Splign:2.1.0"
     CDS             1350..2807
                     /gene="ZNF577"
                     /note="isoform a is encoded by transcript variant 6"
                     /codon_start=1
                     /product="zinc finger protein 577 isoform a"
                     /protein_id="NP_001357378.1"
                     /db_xref="CCDS:CCDS12842.2"
                     /db_xref="GeneID:84765"
                     /db_xref="HGNC:HGNC:28673"
                     /translation="MKNATIVMSVRREQGSSSGEGSLSFEDVAVGFTREEWQFLDQSQ
                     KVLYKEVMLENYINLVSIGYRGTKPDSLFKLEQGEPPGIAEGAAHSQICPGFVIQSRR
                     YAGKDSDAFGGYGRSCLHIKRDKTLTGVKYHRCVKPSSPKSQLNDLQKICAGGKPHEC
                     SVCGRAFSRKAQLIQHQRTERGEKPHGCGECGKTFMRKIQLTEHQRTHTGEKPHECSE
                     CGKAFSRKSQLMVHQRTHTGEKPYRCSKCGKAFSRKCRLNRHQRSHTGEKLYGCSVCG
                     KAFSQKAYLTAHQRLHTGDKPYKCSDCGRTFYFKSDLTRHQRIHTGEKPYECSECEKA
                     FRSKSKLIQHQRTHTGERPYSCRECGKAFAHMSVLIKHEKTHIRETAINSLTVEKPSS
                     RSHTSLYMSELIQEQKTVNTVPIEMPSSGTPPLLNKSERLVGRNVVIVEQPFPRNQAF
                     VVNQEFEQRISLTNEVNVAPSVINYILYLTDIVSE"
     exon            1410..1536
                     /gene="ZNF577"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1632
                     /gene="ZNF577"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..8291
                     /gene="ZNF577"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3322..3327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF577"
                     /note="hexamer: AACAAA"
     polyA_site      3340
                     /gene="ZNF577"
                     /note="major polyA site"
     regulatory      4990..4995
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF577"
                     /note="hexamer: AATAAA"
     polyA_site      5009
                     /gene="ZNF577"
     regulatory      8265..8270
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF577"
                     /note="hexamer: AATAAA"
     polyA_site      8291
                     /gene="ZNF577"
ORIGIN      
        1 gaaacttgcg agtgtcgcgt ctgcagtgtg tggggttcgc ggggcggcgg gtagaggcga
       61 gtgtttagag acttcgggtc cctgactcgc ctccagcagt ggagacaggt catcggtctg
      121 gtctgcgtgg gcttctggga atgtttcagg ggcagggaga gcgcgctttt ttttttctgt
      181 tgttcgctag cgcgtgaggt ccgtgttgcg gggagctctc ggggagtcct cgctcggagt
      241 tcgtttcgca gtcgtgttgg agttcccaga gtctgggagc ccatggtctc cgcattggaa
      301 ccagtgcttg ggaggtcttc gttgcacagt agcgctaggg cgtcgtggtg gggaagcgaa
      361 tcgtgtcagt gttggagact gctctgggca gttcgtgttc attgcttatc acatgcgtac
      421 ttaaaaaggg gtctgctggt ccccttgctt ccctgctgct gtatattctg tagaaaatgg
      481 gttttcaggt tcattgcgac ccaagtaata acatccccat cattttaaat actcctccag
      541 aaaataactc tggtttagtg tatttcatgt ttaatgttgg gatcaggtgt ctaggtattg
      601 gtataatttt attcgtcttt aataacatct tgtcaacttc gtattcccat attacatgct
      661 ctttgagagt tttttaaatt gctgcagttt catcaagtgg ttgctttaat ttgggtagaa
      721 ttgatgtaga tctagataca acactttcag gaacatgtga tggatttcta ttaacccaat
      781 atttttattt gtttgactat ctgtagtgtt tttccatacg tatcttggac atttctggtt
      841 atgcttattt ctacatagtt aatacttttt gttgtaaatc gtgacttttt ttttgcataa
      901 gacccctccc cctttccttt tttgttccta attttactta gttgacaaga acagaagtta
      961 aaaatatata tgtttattct gtcacttcat tgtactcatg tcattacata taacttataa
     1021 attgacgtct tttttctagt tgagcatttt tgtcatctgc aaataatttt agccaggtgg
     1081 caagtgtatg gactgtggag taagaagtac ctgcctctgc ctctgacttg ggttctggcc
     1141 tataggaaca agacattttc agtaatggaa gaaggagctt ccaggctggg gaagatcatc
     1201 atttccagtg gtagcttgac ctgagatgat acctgaccac cacttctggg aaggcccaga
     1261 atagacagaa gagagagaac atactagagt tgctagcccc taagagttga acgaaatggg
     1321 caaggcccag ctgaaataac aggaaacaca tgaaaaatgc cacgattgta atgtctgtga
     1381 ggagagagca aggcagttct tcaggggagg ggtcattgtc attcgaagat gtggctgtgg
     1441 gcttcaccag ggaggagtgg cagtttttgg accagtctca gaaggtcttg tacaaggaag
     1501 taatgttgga gaactacatc aacctagtat caatagggta tcgaggcacc aagccagatt
     1561 cgctcttcaa gttggagcaa ggagaacccc cagggatagc agaaggagca gcccacagtc
     1621 aaatctgtcc aggttttgta atccagagta gaagatatgc aggaaaagat tctgatgcat
     1681 ttggtggata tgggagatca tgcctccata tcaagcgtga caaaactctt actggagtta
     1741 aataccatag atgtgttaaa cccagcagcc ctaaatcaca gctcaatgac ctacaaaaaa
     1801 tttgtgcagg agggaaacca catgaatgca gtgtgtgcgg gagagccttc tccaggaaag
     1861 cacagcttat tcaacatcag agaactgaaa gaggagagaa accccatgga tgtggtgaat
     1921 gtgggaaaac attcatgagg aagattcagc tcactgagca tcagagaact cacacaggag
     1981 agaagcccca tgaatgtagt gaatgtggaa aagccttctc cagaaagtca cagctcatgg
     2041 tccatcagag aacccataca ggagagaaac cctacagatg cagcaaatgc ggaaaagcct
     2101 tcagccggaa gtgccggctc aatagacatc agcgatcaca tactggagag aaactctatg
     2161 ggtgcagtgt gtgtgggaaa gccttttctc agaaggcata cctcactgca caccagagac
     2221 ttcacacagg agataagcct tataaatgca gtgattgtgg aagaaccttc tattttaagt
     2281 cagacctgac cagacatcag aggattcata cgggagagaa accttatgaa tgtagtgagt
     2341 gtgaaaaagc ctttagaagc aagtcgaagc tcattcagca tcagcgtact cacactggag
     2401 agagaccata ttcatgcaga gaatgtggca aagcctttgc ccacatgtca gtcctcatta
     2461 aacatgagaa aactcacata agagagacag ccataaattc actgacggtg gagaaacctt
     2521 cctcaaggag tcatacctcc ttatacatga gcgaactcat acaagagcaa aagactgtga
     2581 acacagtacc tatagaaatg ccttcctcag gaaccccgcc attgttaaac aagagtgagc
     2641 gcctagtggg cagaaatgta gtgattgtgg aacaaccttt tccaagaaat caagcctttg
     2701 tagttaatca ggaatttgaa cagagaataa gcctcacaaa tgaagtgaat gtggccccat
     2761 cagtaataaa ttatatcttg tatcttacag atattgtatc agaataaatc ttctgatacc
     2821 agaaaggtgg gaaaatcttt agtaggaatc ctccagccat tatatcccag agagctcatt
     2881 tagggctgaa acactgtgga ggcagtggtt gtggaggaca tttctgtgag aagtcaaacc
     2941 tgttaaacac cattgaaatc atgttgggta gaaatgcagc tgttatgagg aagtctttac
     3001 ctggagatga tatctcaatt ggtatcaaaa gaattcttac aggaatattt atgaaagatt
     3061 gtgatggtgc ttttagcgct aaattgtgcc tcgtgtgcca aagaaacata gacaactgta
     3121 gaggcaatgg atatggaaaa catttttcgt aaaatatggg agaatttgta gaaaagaaaa
     3181 actcttgaaa gtaagaaatg atggcaactc accaaattaa ctcatgtatc atacttttat
     3241 gtcttgagag tcttggaggg acgtgtttaa tgaaatcttg aaccccagga atagtattat
     3301 gtaatgaaaa cctatgaata taacaaatat ggaagtaaaa ttgtgttagt tttttatgag
     3361 tgttgcacca aactaacaca aatttaatgg cttaaaacaa cacaaaatca ttatcttaca
     3421 gttctggagg actgaagtcc aaatgcatct cacggggcta catcaagctg ttgacagggc
     3481 tgcttttctt tttggaggct ctaggggagc gtctttcttt gcccttccag cttctagaag
     3541 ctgcccaaat tctgtggttt ggggcctcct ttcaaaacca gcaatggcca atcagtctta
     3601 catcactcaa acacttgagt gttctgtctc cctcttccat gtttgaggac ccttgtgatt
     3661 acactgtgaa aacccagata agccaggata atctccctat cttattatga ggcaagtatg
     3721 ttaagatttt attctataat cagagaatct tatgctatga ttgttatatg tgagcattat
     3781 agatgctctt gaaatgttaa aatcacatca gcactggaaa ataactccta aatgtccaaa
     3841 aagaacatga gatttatggt gcttgaaatg ttgctaaacg taaatttgta tctattctga
     3901 aattatataa attaacctac ctggccaggc acagtggctc acacctgtaa tctcagcact
     3961 ttgggaggcc aaggcaggaa gatcacttga gcccgcaagt ttgagaccac cctgggcaac
     4021 atagcgagac tacctctaca aaaaaaaaaa aaaataataa tagctggaca tggtggtgtg
     4081 tgcctatagt cccagctact tgggaggctg aggcaagatg attgcttgag tccaggagtt
     4141 ctaggctgca gtgactgcag tgagctatga tcatgccact gcactacagc gtgggtgaca
     4201 gaataagact ctgactctaa aaaagggggg aaaagaaact aacatacttc attatgagta
     4261 cggaatgcat atgacataat gcacctggat attgactaac tttttcatag ccaacccaaa
     4321 cagtcccttt ttcttttaca gtaaatgtct aatgtatata atctcctgcc ttaaatatct
     4381 aaaaaagatg cacaaaatat atgaatgaac ttcatcagac attgagaagt aaagggctta
     4441 ggacagcttt ccatgacaga aaggaaacaa tgagatgagc cttatgattg ccccagctta
     4501 gtgcctggag aaagtttcca gtctgcagga ttgggaggag aaacccaagc agatcccagc
     4561 catctctctg aattgagaca gagtttaggg tttgaggaat tcaaggtggc ccaaattcat
     4621 gaattggatt attggagaag agctgcactc aagaattgag agttctgtag agtttccccc
     4681 acaagccttt tgagtcataa tcagcatatg tatgtgagaa acccccccta ggctggagga
     4741 agaacaggaa gaaatgaaca cgcagaaaaa tccttggatt acacacaagc atttccacca
     4801 gctggagtgg aaacgcctcc taacatttgg agaatcacag tggaccttaa gtaaggagta
     4861 ttgcctctgt gggtggctca gatttgctct acagtaaagg ctgcctcgaa ctctcctcac
     4921 aaagcataca tgcaagccat gaaaaggcca tactttccaa gtaagttagc aattttccaa
     4981 acagagacta ataaagaaat agaaagcaat ctaccagtca gtaattgacc atgtctggca
     5041 tccaatacaa acttacccag gtgtgcaaag aagcaggaaa atataacccc ataacatgaa
     5101 gaaaactcag tagagaccca gaagtggcac acttatagca gaaaaggatg ttagaaatag
     5161 ctgctataaa tgtcccatat gaatcaagtg gattataaaa actataattt actgatgggt
     5221 tccccccacc tgaacaaggg gcagatgaag ctcagtctac gcactggacc caatgcccct
     5281 aggatgttaa tcctcccagg gagggaccag aaggaggcaa ttaccagcaa tcagcaccag
     5341 gttccctgag agggagaagc aagctcagct gaatttgtgc agtgtagtct acccggtgtt
     5401 tagcccctct ttgccttctc tgggaactga ggcttttgaa cagggctgct gagcttccta
     5461 ggaagtgtag tttggccatg ggcagtgctt gagacacctg tgctgggcag ttgaggttta
     5521 tgggaagtac agttaggagg cctaacaact tattctagtt agcggctggt gtgtcttgac
     5581 tgtttagccc ctgtaggggt ttctggcaca catctgcctt tggccatttt tctccacatt
     5641 gaaggggtcc agcccgtcca cacctgtggg tgtttctcgt caggggggac gagagactga
     5701 gaaaagaaat aagaaataag acacagagac aaagtagaga aagaacagtg gccccagggg
     5761 accggtgctc agcatatgga ggacccgcac cggcactggt ctctgagttc cctcagcatt
     5821 tgttgatcac tatctctacc atctcggaga gggggatgtg gcaggactat agggtaatgg
     5881 tggggagagg gtcagcagga aacatgagcg aaggactctg tgtcataaat aagtttaagg
     5941 aaaggtgctg tgcctcgatg tgcacatagg ccagatttat gtttgacttt acacaaatat
     6001 ctcagtgcag taaagaacag tatcgctgcc agcatgtctc acatccagcc ataaggtggt
     6061 tttctcctat ctcagcaaat agaatgtacg attgggtttc acaccaagac attccattcc
     6121 cagggacgag caagagacag atgccttcct cttatctcaa ctgcaaagag gccttcctct
     6181 ttcactaatc ctcctcagca cagacccttt atgggtatcg ggcttgggga cggtcaggtc
     6241 tttcccttcc cacgaggcca tatctcaggc tgtctcagtg gggagaaacc ttggacgata
     6301 cccaggcttt cttgggcaga ggtccctgcg gccttccgca gtgcattgtg tccctgggta
     6361 ctcgagactg gagaatggtg atgactttta ccaagcatac tgcctgcaaa cacattttaa
     6421 caaagcacat cctgcacagc cctaaatcta gtaaaccttg agtcaacaca gcacatgttt
     6481 ctgcgagcac agggttgagg ctagggttac agattaacag catctcaagg cagaataatt
     6541 tctcttagta cagatcaaaa tagagtttct tatgtcttcc tttttctaca tagacacagt
     6601 agcagtctga tctatctttc tttcccccac acacatgagt gaattctatc tgggtgttca
     6661 aggcagttga agacggtagt agtcagaacc ttagccggtg cttgctgggg cttctgtagg
     6721 caacattatg agggaattgg ccttgggcat attaattctg agctcatctg gcagttctgc
     6781 tttggctggg gcagtctttg gtgggtcaga cccagtcggt tcttggtgag tctgccctgc
     6841 tgtgtggctg aggtgggaag cagtcctaca gaatcccatt gttgtgtggg acatgtttgc
     6901 ccttgttctt cctgctctca tgggccagat ggatcccatg ttggaggctg gggaggggac
     6961 tcagggcatg ggtcttacct aaccttactc tgctgacttt ctccttttac accccagatg
     7021 aaactttttt aggtgtgtag gtgtctgtgt cctatggagt gtccggaact ggcctattaa
     7081 caactgcatc actgttaaca gaaagcttct agaacagtgt ctacaatgca gtgctttgag
     7141 gactaagtca gcaactttta aaaagaactt ctattacaag tgggaagatg atttatgtat
     7201 aaagaaattt gacacactta aaaacctaca actgctggtg cacagattta cagattccat
     7261 ccactttgtc ttgattccca gtttagaact tgggtctgta aatactagaa cctgccagac
     7321 ctcagagtag aaatccagtg tcagctctcc caccagaact tgcctggctc tgatcccatg
     7381 caagggagaa gacattccag gttctcattg cctttttctg tatctgtatt taggggtggg
     7441 ggtagaggac tagaaattcc tcattggtgc tgattagtct gacctctgag ggctttttcc
     7501 aaccctagct ttgttctttt tgtttgtttg cttgtttttg ttttttgttt atttgagatg
     7561 gagtttcgct cttttgccca ggctggagtg cagtggcgta atcgtgggtc actgcaacct
     7621 ccaccttccg gtttcaagtg attgtcctgc ctcagcttcc tgagtagctg ggattacagg
     7681 tgcctgccac cacacccggc taattttttt tttttttttt gtatttttag tagagacggg
     7741 gtttcatcat gttggccagt ctggtctcga actcctgacc ttgtgatccg cccacctcag
     7801 cctcccaaag tgctgggatt acaggtgtga gccaccgcgc ctggccagct ttgtgttttt
     7861 aaaaagttgt ccttcattaa gggagggaaa ttgagtaatt gtcacaattc taaaagctgg
     7921 gcctctctct gacatgtctt cttttctctt gaaaagagat cttttgtccg atgttcagaa
     7981 tcagaaaaga caatatctag atcatacctt agaaatgata tccttttcct aagaaccgaa
     8041 gaaaaaaacg ataaaagccc cggtgaggtt ttgcttcttt cttttgcctt tctttccaat
     8101 gactttgcaa ggcttaagac aaataactat taaatggaaa tacatacatt tgtaatttaa
     8161 aaatttaagg aaaactaaac agaaaccata aaatcaagat tcaggtaaag gtggaatgag
     8221 gaaatgtagc ttcatacaga gtgccttaag tgtgaataca ggtgaataaa tatgtaagaa
     8281 tgtatgatgt a
//
