LOCUS       NM_001145347            2576 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 576 (ZNF576), transcript variant
            2, mRNA.
ACCESSION   NM_001145347
VERSION     NM_001145347.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2576)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   2  (bases 1 to 2576)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2576)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP358040.1, BC002981.1 and AC006276.1.
            
            On May 17, 2019 this sequence version replaced NM_001145347.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.270629.1,
                                           SRR1660809.110063.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336564.5/ ENSP00000337852.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BP358040.1         10-39
            31-405              BC002981.1         1-375
            406-2576            AC006276.1         20203-22373
FEATURES             Location/Qualifiers
     source          1..2576
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..2576
                     /gene="ZNF576"
                     /note="zinc finger protein 576"
                     /db_xref="GeneID:79177"
                     /db_xref="HGNC:HGNC:28357"
     exon            1..149
                     /gene="ZNF576"
                     /inference="alignment:Splign:2.1.0"
     exon            150..249
                     /gene="ZNF576"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..677
                     /gene="ZNF576"
                     /codon_start=1
                     /product="zinc finger protein 576"
                     /protein_id="NP_001138819.1"
                     /db_xref="CCDS:CCDS12625.1"
                     /db_xref="GeneID:79177"
                     /db_xref="HGNC:HGNC:28357"
                     /translation="MEDPNPEENMKQQDSPKERSPQSPGGNICHLGAPKCTRCLITFA
                     DSKFQERHMKREHPADFVAQKLQGVLFICFTCARSFPSSKALITHQRSHGPAAKPTLP
                     VATTTAQPTFPCPDCGKTFGQAVSLRRHRQMHEVRAPPGTFACTECGQDFAQEAGLHQ
                     HYIRHARGEL"
     exon            250..2576
                     /gene="ZNF576"
                     /inference="alignment:Splign:2.1.0"
     regulatory      808..813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF576"
                     /note="hexamer: AATAAA"
     polyA_site      833
                     /gene="ZNF576"
                     /note="major polyA site"
     regulatory      1403..1408
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF576"
                     /note="hexamer: ATTAAA"
     polyA_site      1423
                     /gene="ZNF576"
ORIGIN      
        1 aaaactgagg cctgggagca ggaacctgta ggcagcgctt gagggtagcg ggatagcagc
       61 tgcaagcgcg cgtgggaggc gggggctctg ggcggaacaa aaatcacagg atgtcagagg
      121 atgtttcccg ggaagaactg ggataaagga agggtcccag caccatggag gacccgaacc
      181 ctgaagagaa catgaagcag caggattcac ccaaggagag aagtccccag agcccaggag
      241 gcaacatctg ccacctgggg gccccgaagt gcacccgctg cctcatcacc ttcgcagatt
      301 ccaagttcca ggagcgtcac atgaagcggg agcacccagc ggacttcgtg gcccagaagc
      361 tgcagggggt cctcttcatc tgcttcacct gcgcccgctc cttcccctcc tccaaagccc
      421 taatcaccca ccagcgcagc cacggtccag ccgccaagcc caccctgccg gttgcaacca
      481 ctactgccca gcccaccttc ccttgtcctg actgtggcaa gacctttggg caggctgttt
      541 ctctgaggcg gcaccgccag atgcatgagg tccgtgcccc tcctggcacc ttcgcctgca
      601 cagagtgcgg tcaggacttt gctcaggaag cagggctgca tcaacactac attcggcatg
      661 cccgggggga gctctgagtg cagcttaagc ctctccacgg tgacgggtgg ctctgtggct
      721 ggtaggactc acccatgata tggggtgcag gaactctggg ggccctgaag gatttgcttc
      781 cctcccctgg gaaggcagag ggctcttaat aaagaggacc cagaagattc ttatttagag
      841 cttcagtctt tggagcacac agggccttcg tgagacagtg aaatcagata ataatgagat
      901 cttttgttaa aaaaaaaaaa tgggaaggga gtgcgggaga gaaatggttt gtgtctccct
      961 tattcccagt taaataccta gctgcagatt gtgccatcac ccttcattct tcccagatgg
     1021 atgccatggg ctatgggagc aaattgccct ggacctttgc ctgaatgggg gcaggaaagg
     1081 tgaggtgttg ctggcctgta atgccaccag gtgagttcca gatgtggagc aacttgggct
     1141 tttggggatg gggcagcaaa gttgggagct ggaccccaat tgagtggggg tagcaattgg
     1201 agtccttgtg tctcttttcc accccctgcc atcctcactt agaggggcca tggcactaga
     1261 tggcactagt cccccgataa tttatgtctc gttgaaataa ttttgtatat cattctagtc
     1321 ctgaaatatt tttttcatat gtgtaggtga aatggtatga ataagctaac aggaatagta
     1381 tctaaaaaca gaaaacatcc atattaaaat gtctaaacag ggagctctgg cttttgagtg
     1441 ggaatttcca gagaacataa gggtgtgggc aggtggggga actcaggcca gagttggcct
     1501 cgctttgtgg ggaaactggt ttggaatcaa acagagatac cttctgtttc gggttttatt
     1561 tggccaacac tgggagattt cccattaaga tcctattttc agctctcttg aaaggcccaa
     1621 cctaggctga cattgtcagc aggggcagga cagaagttac aacaggctgg agggagcagt
     1681 gggtgtcacc ctcaactgga gatgagtccc accaggccag ttttaccccc ttagttacct
     1741 gccctgcacc tgcagacaat ggtcgatgcc ttgcatataa tacttataga ctctgtttat
     1801 gttgagggat gtttttaaag cccacaggtg aggtggatgt ggtagactga tcactgtctc
     1861 tgtttttagc taggcacaca gtagctgaaa agactgcatt tcccagattc ctttgcagct
     1921 agatgtggcc ttgtgactga tttctggcta aattcctggg tagaacagtc aagcttaaga
     1981 aagggacggc tgggcacagt ggctcacgcc tgtaatccca gcactttgtg aggctgaggc
     2041 cggtggatca cctgaggtca ggagtttgag accagcctgg ccaacatggt gaaaccctgt
     2101 ctctaccaaa aatacaaaaa ttagccgggt gtggtggcat atgcctgtaa tcccagctac
     2161 ttgggaggct gaggcaggag aattgcttga acctgggaga caggttgcag tgagccaaga
     2221 tcgtgccatt gcacttcagc ctgggtgaca gagtgagact gtttaaaaaa aaagaaaaga
     2281 aagggacata ccttttttcc accttcctaa ctgtaatacg gaaatggtat ccagccatct
     2341 cagaccataa ggataagagc aacacgtggg aagacagagc aacaagatag gagcctgggt
     2401 ctctcgtcaa tttcaaggag cacagccacc ataccagccc acttccatat tgctatctaa
     2461 gaaagaaact tctatcttat ttaagccacc attattttgg gtctctgtca catgcaacag
     2521 aatttacagc ctaagacagg ggtctgcaaa ctatggccaa ctctagcctg ctgcct
//
