LOCUS       NM_174945               1666 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 575 (ZNF575), transcript variant
            1, mRNA.
ACCESSION   NM_174945
VERSION     NM_174945.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1666)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1666)
  AUTHORS   Cardenas,A., Faleschini,S., Cortes Hidalgo,A., Rifas-Shiman,S.L.,
            Baccarelli,A.A., DeMeo,D.L., Litonjua,A.A., Neumann,A., Felix,J.F.,
            Jaddoe,V.W.V., El Marroun,H., Tiemeier,H., Oken,E., Hivert,M.F. and
            Burris,H.H.
  TITLE     Prenatal maternal antidepressants, anxiety, and depression and
            offspring DNA methylation: epigenome-wide associations at birth and
            persistence into early childhood
  JOURNAL   Clin Epigenetics 11 (1), 56 (2019)
   PUBMED   30925934
  REMARK    GeneRIF: Results found DNA methylation of the ZNF575 gene in infant
            cord blood to be associated with maternal antidepressant use in
            pregnancy in two independent cohorts. This association persists
            into early childhood.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1666)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018758.2.
            
            On Nov 30, 2019 this sequence version replaced NM_174945.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK301820.1, SRR14038194.3895982.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314228.10/ ENSP00000315870.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-334               AC018758.2         165101-165434
            335-442             AC018758.2         165708-165815
            443-607             AC018758.2         166250-166414
            608-1666            AC018758.2         166942-168000
FEATURES             Location/Qualifiers
     source          1..1666
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..1666
                     /gene="ZNF575"
                     /note="zinc finger protein 575"
                     /db_xref="GeneID:284346"
                     /db_xref="HGNC:HGNC:27606"
     exon            1..334
                     /gene="ZNF575"
                     /inference="alignment:Splign:2.1.0"
     exon            335..442
                     /gene="ZNF575"
                     /inference="alignment:Splign:2.1.0"
     exon            443..607
                     /gene="ZNF575"
                     /inference="alignment:Splign:2.1.0"
     CDS             529..1266
                     /gene="ZNF575"
                     /codon_start=1
                     /product="zinc finger protein 575"
                     /protein_id="NP_777605.1"
                     /db_xref="CCDS:CCDS12623.1"
                     /db_xref="GeneID:284346"
                     /db_xref="HGNC:HGNC:27606"
                     /translation="MLERGAESAAGATDPSPTGKEPVTKEAPHQGPPQKPSQSAPGPT
                     ASAGSPPRPRRRPPPQRPHRCPDCDKAFSYPSKLATHRLAHGGARPHPCPDCPKAFSY
                     PSKLAAHRLTHSGARPHPCPHCPKSFGHRSKLAAHLWTHAPTRPYPCPDCPKSFCYPS
                     KLAAHRHTHHATDARPYPCPHCPKAFSFPSKLAAHRLCHDPPTAPGSQATAWHRCSSC
                     GQAFGQRRLLLLHQRSHHQVEHKGERD"
     exon            608..1666
                     /gene="ZNF575"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1645..1650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF575"
                     /note="hexamer: AATACA"
     polyA_site      1666
                     /gene="ZNF575"
                     /note="major polyA site"
ORIGIN      
        1 agcttcgcgc ttgctcacga acttgcctgc ctggctggcg cacccagccc ctccttccat
       61 tccttcttcc ccctctctgc agcctctgcc agcccgcact gcgcatgctt tctgacgccc
      121 cctttggtcc agcgtgggag gaggggatgg aaatgaggtt gggctaagca gcttgcgcgc
      181 gctcccttgc ctgccctccc ccgacgccgg acgcgcgccg ggcggggcag ctccgctggt
      241 ccgagggcag tgcagcagcg gcgacagcgg ctgcggccgt ggccgtggcg ggaggagccg
      301 gaagccccgc ccccggggag gggccgtcct gcaggtcccc cctctatcct ccacggcccc
      361 atccaagcca gggatgaaat ttaacggcaa gaagggcgca gttgacgcgg cgtcaatgaa
      421 ctgagactaa gtcaaaagcc gggccctcca accctatccc catcagcctg gtcatcaccg
      481 gcgtcacccc cgccccgcgc cctgccccta ggttcctgtg ccagcaagat gctggagcga
      541 ggcgcggagt ccgcggccgg ggctaccgat cctagtccca ctggcaagga accagtgacc
      601 aaagaagctc cccaccaggg cccaccgcag aagcccagcc agtcagctcc agggcccacc
      661 gcgtccgcgg gctcgcctcc ccggcctcgc cggcggcccc cgccccagcg cccgcaccgc
      721 tgccccgact gtgacaaggc cttctcgtac ccgtccaagc tggccacgca ccgcttagca
      781 cacggaggcg cccgacccca cccatgccca gactgcccca aggccttctc ctacccctcc
      841 aagctggcag cccaccgcct cacgcacagc ggcgcccgcc cgcacccgtg cccacactgc
      901 ccgaagtcct ttggccaccg ctccaagctg gcggctcacc tctggaccca cgcacccacc
      961 cgcccctacc cgtgccccga ctgccccaag tccttctgct acccttccaa gctggcggcc
     1021 caccgccaca cgcaccacgc caccgacgcc cgcccctatc cttgcccgca ttgccccaag
     1081 gctttctcat ttccctccaa gctggccgcc catcgcctat gtcacgaccc cccaaccgcg
     1141 cccggcagcc aggcgactgc ctggcaccga tgctccagct gcggccaggc ctttggccag
     1201 agacgcttac tgctccttca tcaacgcagc caccaccagg tggagcacaa gggggagaga
     1261 gactgagccc tcccttggct cactgtcccc ttctgccgcc agccctagcc agtaagaggt
     1321 gggatttcta agaccgactg tatgagctcg cctcttccag atagctggca gagggcaggg
     1381 caagggattg gccatttata ctgggctcga gctcagaagc ccgaggaact ctttgctccc
     1441 ctgctttggg gagatctcaa accatggacg tggagctgtg gtttgacagc gctggctctg
     1501 cttctcccca cacacttaca tggcaaaggt aaaaagtctg ctactatcgt gggttgatga
     1561 ggattgtggg caaacaggct ctcttgttaa aagtttaaac tggtgtctcc actttggcca
     1621 tatgacggta tctaagaaat tgaaaataca tacatgcttg tctcaa
//
