LOCUS       NM_022752               3087 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 574 (ZNF574), transcript variant
            1, mRNA.
ACCESSION   NM_022752
VERSION     NM_022752.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3087)
  AUTHORS   Zhang,J., Wu,X. and Huang,L.
  TITLE     ZNF574 Promotes Ovarian Cancer Cell Proliferation and Migration
            through Regulating AKT and AMPK Signaling Pathways
  JOURNAL   Ann Clin Lab Sci 52 (4), 611-620 (2022)
   PUBMED   36197766
  REMARK    GeneRIF: ZNF574 Promotes Ovarian Cancer Cell Proliferation and
            Migration through Regulating AKT and AMPK Signaling Pathways.
REFERENCE   2  (bases 1 to 3087)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3087)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3087)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA404303.1, BC001184.1 and AF447880.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022752.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.125501.1,
                                           SRR1660807.252467.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359044.5/ ENSP00000351939.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                DA404303.1         29-111
            84-3084             BC001184.1         1-3001
            3085-3087           AF447880.1         3058-3060
FEATURES             Location/Qualifiers
     source          1..3087
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..3087
                     /gene="ZNF574"
                     /gene_synonym="FP972"
                     /note="zinc finger protein 574"
                     /db_xref="GeneID:64763"
                     /db_xref="HGNC:HGNC:26166"
     exon            1..121
                     /gene="ZNF574"
                     /gene_synonym="FP972"
                     /inference="alignment:Splign:2.1.0"
     exon            122..3087
                     /gene="ZNF574"
                     /gene_synonym="FP972"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..2832
                     /gene="ZNF574"
                     /gene_synonym="FP972"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 574 isoform 1"
                     /protein_id="NP_073589.4"
                     /db_xref="CCDS:CCDS12596.1"
                     /db_xref="GeneID:64763"
                     /db_xref="HGNC:HGNC:26166"
                     /translation="MTEESEETVLYIEHRYVCSECNQLYGSLEEVLMHQNSHVPQQHF
                     ELVGVADPGVTVATDTASGTGLYQTLVQESQYQCLECGQLLMSPSQLLEHQELHLKMM
                     APQEAVPAEPSPKAPPLSSSTIHYECVDCKALFASQELWLNHRQTHLRATPTKAPAPV
                     VLGSPVVLGPPVGQARVAVEHSYRKAEEGGEGATVPSAAATTTEVVTEVELLLYKCSE
                     CSQLFQLPADFLEHQATHFPAPVPESQEPALQQEVQASSPAEVPVSQPDPLPASDHSY
                     ELRNGEAIGRDRRGRRARRNNSGEAGGAATQELFCSACDQLFLSPHQLQQHLRSHREG
                     VFKCPLCSRVFPSPSSLDQHLGDHSSESHFLCVDCGLAFGTEALLLAHRRAHTPNPLH
                     SCPCGKTFVNLTKFLYHRRTHGVGGVPLPTTPVPPEEPVIGFPEPAPAETGEPEAPEP
                     PVSEETSAGPAAPGTYRCLLCSREFGKALQLTRHQRFVHRLERRHKCSICGKMFKKKS
                     HVRNHLRTHTGERPFPCPDCSKPFNSPANLARHRLTHTGERPYRCGDCGKAFTQSSTL
                     RQHRLVHAQHFPYRCQECGVRFHRPYRLLMHRYHHTGEYPYKCRECPRSFLLRRLLEV
                     HQLVVHAGRQPHRCPSCGAAFPSSLRLREHRCAAAAAQAPRRFECGTCGKKVGSAARL
                     QAHEAAHAAAGPGEVLAKEPPAPRAPRATRAPVASPAALGSTATASPAAPARRRGLEC
                     SECKKLFSTETSLQVHRRIHTGERPYPCPDCGKAFRQSTHLKDHRRLHTGERPFACEV
                     CGKAFAISMRLAEHRRIHTGERPYSCPDCGKSYRSFSNLWKHRKTHQQQHQAAVRQQL
                     AEAEAAVGLAVMETAVEALPLVEAIEIYPLAEAEGVQISG"
     regulatory      3066..3071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF574"
                     /gene_synonym="FP972"
                     /note="hexamer: AATAAA"
     polyA_site      3087
                     /gene="ZNF574"
                     /gene_synonym="FP972"
                     /note="major polyA site"
ORIGIN      
        1 gagagcgagg ctacggagca ggcgagaggc gacggcgaga gctagagcgg gcgcagcgtt
       61 agggtggccg tgcaagggga gccgtggccc gggcccgggg cgtgcgagac ggcggaagca
      121 gcccagggcc ttgctgccgc catgactgag gaatcagagg agacagtcct gtacattgag
      181 caccgctatg tctgctctga gtgcaaccag ctgtatggat cactggaaga ggtgcttatg
      241 caccaaaact cccacgtgcc ccagcagcac tttgagctgg tgggcgtggc tgatcccgga
      301 gtcactgtgg ccacagacac agcttcaggc acgggcctct atcagaccct tgtgcaggag
      361 agccagtacc agtgcctgga gtgtggtcaa ctgctgatgt cacccagcca gctcctggag
      421 caccaggagc tgcacctgaa gatgatggca ccccaggagg cagtgccagc tgagccatca
      481 cctaaggcac cacccctgag ctccagcacc atccactacg agtgtgtgga ttgcaaggct
      541 ctctttgcca gccaggagct ctggctgaac caccggcaga cgcacctccg ggccacaccc
      601 accaaggctc ctgcccctgt tgtcctgggg tccccagttg ttctagggcc tcctgtgggc
      661 caggcccgag tggctgtgga gcactcatac cgaaaggcag aagagggtgg ggaaggggcg
      721 actgtcccat ctgccgctgc caccaccact gaggtagtga ctgaggtgga gctgctcctc
      781 tacaagtgct ctgagtgctc ccagctcttc cagctgccgg cggatttcct ggagcaccag
      841 gccactcact tccctgctcc tgtacccgag tctcaggagc ctgccttaca gcaggaggtg
      901 caggcctcgt cacctgcaga ggtgcctgtg tctcagcctg accccttgcc agcttctgac
      961 cacagttacg agctgcgcaa tggtgaagcc attgggcggg atcgccgggg gcgcagggcc
     1021 cggaggaaca acagtggaga agcaggcggg gcagccacac aggagctctt ctgctcagcc
     1081 tgtgaccagc tctttctctc accccaccag ctacagcagc acctgcggag tcaccgggag
     1141 ggcgtcttta agtgccccct gtgcagtcgt gtcttcccta gcccttccag tctggaccag
     1201 caccttggag accatagcag cgagtcacac ttcctgtgtg tagactgtgg cctggccttc
     1261 ggcacagagg ccctcctcct ggcccaccgg cgagcccaca ccccgaatcc tctgcattca
     1321 tgtccatgtg ggaagacctt tgtcaacctt accaagttcc tttatcaccg gcgtactcat
     1381 ggggtagggg gtgtccctct gcccacaaca ccagtcccac cagaggaacc tgtcattggt
     1441 ttccctgagc cagccccagc agagactgga gagccagagg cccctgagcc ccctgtgtct
     1501 gaggagacct cagcagggcc cgctgcccca ggcacctacc gctgcctcct gtgcagccgt
     1561 gaatttggaa aggccttgca gctgacccgg caccaacgtt ttgtgcatcg gctggagcgg
     1621 cgccataaat gcagcatttg tggcaagatg ttcaagaaga agtctcacgt gcgtaaccac
     1681 ctgcgcacac acacagggga gcggcccttc ccctgccctg actgctccaa gcccttcaac
     1741 tcacctgcca acctggcccg ccaccggctc acacacacag gagagcggcc ctaccggtgt
     1801 ggggactgtg gcaaggcttt cacgcaaagc tccacactga ggcagcaccg cttggtgcat
     1861 gcccagcact tcccctaccg ctgccaggaa tgtggggtgc gttttcaccg tccttaccgc
     1921 ctgctcatgc accgctacca tcacacaggt gaatacccct acaagtgtcg cgagtgcccc
     1981 cgctccttct tgctgcgtcg gctgctggag gtgcaccagc tcgtggtcca tgccgggcgc
     2041 cagccccacc gctgcccatc ctgtggggct gccttcccct cctcactgcg gctccgggag
     2101 caccgctgtg cagccgctgc tgcccaggcc ccacggcgct ttgagtgtgg cacctgtggc
     2161 aagaaagtgg gctcagctgc tcgactgcag gcacacgagg cggcccatgc agctgctggg
     2221 cctggagagg tcctggctaa ggagccccct gcccctcgag ccccacgggc cactcgtgca
     2281 ccagttgcct ctccagcagc ccttggaagc actgctacag catcccctgc ggcccctgcc
     2341 cgccgccggg gtctagagtg cagcgagtgc aagaagctgt tcagcacaga gacgtcactg
     2401 caggtgcacc ggcgcatcca cacaggtgag cggccatacc catgtccaga ctgtggcaaa
     2461 gcgttccgtc agagtaccca cctgaaagac caccggcgcc tgcacacagg tgagcggccc
     2521 tttgcctgtg aagtgtgtgg caaggccttt gccatctcca tgcgcctggc agaacatcgc
     2581 cgcatccaca caggcgaacg accctactcc tgccctgact gtggcaagag ctaccgctcc
     2641 ttctccaacc tctggaagca ccgcaagacc catcagcagc agcatcaggc agctgtgcgg
     2701 cagcagctgg cagaggcgga ggctgccgtt ggcctggccg tcatggagac tgctgtggag
     2761 gcgctacccc tggtggaagc cattgagatc taccctctgg ccgaggctga gggggtccag
     2821 atcagtggct gactctgccc gacttcctct ttggcacctc cattccctgt tgctgaaggc
     2881 cctccagcat ccccttaagc atctgtacat actgtgtccc ttcctcttcc catccccacc
     2941 accttgtaag ttctaaattg gatttattct ctcgtgaggg gggtgctctg gggtccttga
     3001 cacacataaa ggtgcccccc caccttccac ctcttagcac tggtgacccc aaaaatgaaa
     3061 ccatcaataa agactgagtt gccagca
//
