LOCUS       NM_001172690            2253 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 573 (ZNF573), transcript variant
            3, mRNA.
ACCESSION   NM_001172690
VERSION     NM_001172690.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2253)
  AUTHORS   Cai,R., Zhao,F., Zhou,H., Wang,Z., Lin,D., Huang,L., Xie,W.,
            Chen,J., Zhou,L., Zhang,N. and Huang,C.
  TITLE     A tumor-associated autoantibody panel for the detection of
            non-small cell lung cancer
  JOURNAL   Front Oncol 12, 1056572 (2022)
   PUBMED   36531074
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP274132.1, BC042170.2 and AK055483.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001172690.1.
            
            Transcript Variant: This variant (3) lacks three alternate exons
            and uses an upstream start codon, compared to variant 1. The
            resulting isoform (3) has a longer and distinct N-terminus,
            compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.536173.1, BP274132.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000536220.7/ ENSP00000440464.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-430               BP274132.1         1-430
            431-1437            BC042170.2         389-1395
            1438-2253           AK055483.1         1451-2266
FEATURES             Location/Qualifiers
     source          1..2253
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..2253
                     /gene="ZNF573"
                     /note="zinc finger protein 573"
                     /db_xref="GeneID:126231"
                     /db_xref="HGNC:HGNC:26420"
     exon            1..43
                     /gene="ZNF573"
                     /inference="alignment:Splign:2.1.0"
     exon            44..134
                     /gene="ZNF573"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..2063
                     /gene="ZNF573"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="zinc finger protein 573 isoform 3"
                     /protein_id="NP_001166161.1"
                     /db_xref="CCDS:CCDS59381.1"
                     /db_xref="GeneID:126231"
                     /db_xref="HGNC:HGNC:26420"
                     /translation="MFPVLEPHQVGLIRSYNSKTMTCFQELVTFRDVAIDFSRQEWEY
                     LDPNQRDLYRDVMLENYRNLVSLGGHSISKPVVVDLLERGKEPWMILREETQFTDLDL
                     QCEIISYIEVPTYETDISSTQLQSIYKREKLYECKKCQKKFSSGYQLILHHRFHVIER
                     PYECKECGKNFRSGYQLTLHQRFHTGEKPYECTECGKNFRSGYQLTVHQRFHTGEKTY
                     ECRQCGKAFIYASHIVQHERIHTGGKPYECQECGRAFSQGGHLRIHQRVHTGEKPYKC
                     KECGKTFSRRSNLVEHGQFHTDEKPYICEKCGKAFRRGHQLTVHQRVHTGKKPYECKE
                     CGKGYTTASYFLLHQRIHKGGKPYECKECKKTFTLYRNLTRHQNIHTGEKLFECKQCG
                     KTYTTGSKLFQHQKTHTGEKPYECKECGKAFSLYGYLKQHQKIHTGMKHFECKECKKT
                     FTLYRNLTRHQNIHTGKKLFECQECGKAYSTGSNLIQHRKTHTGEKPYKCKECGKTFS
                     LHGYLNQHQKIHTGMKPYECKVCRKTFTFYRNLTLHQSIHTDEKPFECKECGKTFRRS
                     SHLTAHQSIHADKKPYECKECGKAFKMYGYLTQHQKIHTGGKPYECKECGKAFSRASN
                     LVQHERIHTGEKPYVCKQCGKTFRYGSALKAHQRIHRSIKV"
     exon            135..267
                     /gene="ZNF573"
                     /inference="alignment:Splign:2.1.0"
     exon            268..360
                     /gene="ZNF573"
                     /inference="alignment:Splign:2.1.0"
     exon            361..2253
                     /gene="ZNF573"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatctatggc ttcccttccg ttttcgcgtg gttcttttgc aagctctgga ttctctggag
       61 tttgaatgtt tccagtattg gaaccccacc aagtaggact gatcaggtct tacaattcta
      121 aaaccatgac ctgttttcag gaattagtga cattcaggga tgtggccata gacttctctc
      181 ggcaggagtg ggaatacctg gaccctaatc agagggactt atacagggat gtgatgttgg
      241 agaactatag aaacctggta tcactgggag gacattccat ttctaaacca gttgtggttg
      301 atttactgga gcgaggaaaa gagccctgga tgattttgag ggaagaaaca cagttcacag
      361 atttggattt acagtgtgag ataatcagct acatagaagt acccacttat gaaacagata
      421 tatcctctac acaacttcag agcatatata agagagagaa actctatgaa tgtaagaaat
      481 gtcagaagaa atttagtagt ggttatcaac ttattctaca tcacaggttt catgtcattg
      541 agagacccta tgaatgcaaa gagtgtggga agaactttcg tagtggctat caacttactc
      601 tacatcaaag atttcatact ggtgagaaac cctatgaatg tacagaatgt gggaagaact
      661 ttagaagtgg ttatcagctg actgtgcatc agagatttca tactggtgag aaaacctatg
      721 aatgtaggca gtgtgggaag gcctttatat atgcctcaca cattgttcaa catgagagaa
      781 ttcacactgg tgggaagccg tatgaatgtc aggagtgtgg gagggccttt agtcaaggtg
      841 gacatcttag aattcatcag agagttcata ctggcgaaaa accatataaa tgtaaggaat
      901 gtgggaagac ttttagtagg cgctcaaatc ttgttgaaca tgggcagttt catactgatg
      961 agaagccata catatgtgag aaatgtggaa aggcctttag aagaggtcac cagcttactg
     1021 tacatcagag agttcacact ggtaaaaagc catatgagtg taaagaatgt gggaagggct
     1081 ataccactgc ctcatacttt cttctacatc agagaattca taaaggtgga aaaccctatg
     1141 aatgtaagga gtgtaagaaa acctttactt tgtatagaaa tcttactcgg catcagaata
     1201 ttcatactgg tgagaaactt tttgaatgca agcaatgtgg gaagacctat actactggtt
     1261 caaaactctt tcaacatcag aaaactcata ctggcgagaa accctatgaa tgcaaggaat
     1321 gcggaaaggc ctttagcttg tatggctacc ttaaacaaca tcagaaaatt catactggca
     1381 tgaaacactt tgaatgtaag gagtgtaaaa aaacctttac tttgtataga aatcttactc
     1441 gacatcagaa tattcacact ggtaagaaac tttttgaatg tcaggaatgt gggaaggcct
     1501 atagtactgg ctcaaacctt attcaacatc ggaaaactca tactggtgag aaaccctata
     1561 aatgtaagga atgtggcaag acctttagct tgcatggata tcttaatcaa catcagaaaa
     1621 ttcatactgg tatgaaaccc tatgaatgta aggtatgtag aaaaaccttt actttctata
     1681 gaaatcttac tctacatcaa agtattcata ctgatgagaa accttttgaa tgtaaggaat
     1741 gtgggaagac ctttagacgt agttcacacc ttactgcaca tcagagcatt catgctgata
     1801 aaaaacccta tgaatgtaaa gaatgtggaa aggcctttaa aatgtatggc taccttaccc
     1861 aacatcagaa aattcatact ggtggaaaac cttatgaatg taaagaatgt gggaaggcct
     1921 tcagtcgtgc ttcaaacctt gttcaacatg agagaattca tactggtgag aaaccctatg
     1981 tgtgtaagca gtgtgggaaa accttcagat atggttcagc ccttaaagcc catcagagaa
     2041 ttcataggag cataaaagtg taagaccgta aagagtacga gcgcgccatt catcatcaga
     2101 cagcccacac tggtgagaaa tgatggaatg ttagtcttat aggtatggct ttagcaattg
     2161 agagagttca aaatgcagat cttgccacat tagaaagcat tcaatgtcag tcctgtttta
     2221 atggaatatc tgactattca atggtaaatt aag
//
