LOCUS       NM_173480               1970 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 57 (ZNF57), transcript variant 1,
            mRNA.
ACCESSION   NM_173480
VERSION     NM_173480.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1970)
  AUTHORS   Wang,H., Sica,R.A., Kaur,G., Galbo,P.M. Jr., Jing,Z.,
            Nishimura,C.D., Ren,X., Tanwar,A., Etemad-Gilbertson,B., Will,B.,
            Zheng,D., Fooksman,D. and Zang,X.
  TITLE     TMIGD2 is an orchestrator and therapeutic target on human acute
            myeloid leukemia stem cells
  JOURNAL   Nat Commun 15 (1), 11 (2024)
   PUBMED   38167704
  REMARK    GeneRIF: TMIGD2 is an orchestrator and therapeutic target on human
            acute myeloid leukemia stem cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1970)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1970)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1970)
  AUTHORS   Liu,W., Yuan,W., Li,X., Zhuang,J., Mo,X., Dai,G., Wang,Y., Chen,J.,
            Wan,Y., Li,Y., Zhu,X., Chen,Y., Luo,S., Jiang,Z., Shi,Y., Chen,F.,
            Cao,L., Ye,X., Fan,X., Zhu,P., Zhang,K. and Wu,X.
  TITLE     ZNF424 Induces Apoptosis and Inhibits Proliferation in Lung
            Carcinoma Cells
  JOURNAL   Curr Mol Med 18 (2), 109-115 (2018)
   PUBMED   29974829
  REMARK    GeneRIF: These are the first data to associate ZNF424 with
            tumorigenesis and demonstrate an inhibitory role in lung cancer,
            indicating the potential of ZNF424 expression as a diagnostic
            marker of lung tumorigenesis.
REFERENCE   5  (bases 1 to 1970)
  AUTHORS   Wang,Y., Zhou,J., Ye,X., Wan,Y., Li,Y., Mo,X., Yuan,W., Yan,Y.,
            Luo,N., Wang,Z., Fan,X., Deng,Y. and Wu,X.
  TITLE     ZNF424, a novel human KRAB/C2H2 zinc finger protein, suppresses
            NFAT and p21 pathway
  JOURNAL   BMB Rep 43 (3), 212-218 (2010)
   PUBMED   20356463
  REMARK    GeneRIF: ZNF424 protein may act as a transcriptional repressor that
            suppresses NFAT and p21 pathway to mediate cellular functions.
REFERENCE   6  (bases 1 to 1970)
  AUTHORS   Lichter,P., Bray,P., Ried,T., Dawid,I.B. and Ward,D.C.
  TITLE     Clustering of C2-H2 zinc finger motif sequences within telomeric
            and fragile site regions of human chromosomes
  JOURNAL   Genomics 13 (4), 999-1007 (1992)
   PUBMED   1505991
REFERENCE   7  (bases 1 to 1970)
  AUTHORS   Bray,P., Lichter,P., Thiesen,H.J., Ward,D.C. and Dawid,I.B.
  TITLE     Characterization and mapping of human genes encoding zinc finger
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9563-9567 (1991)
   PUBMED   1946370
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EF534355.1.
            
            On Nov 23, 2018 this sequence version replaced NM_173480.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF534355.1, SRR3476690.631813.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306908.10/ ENSP00000303696.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1970              EF534355.1         31-2000
FEATURES             Location/Qualifiers
     source          1..1970
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1970
                     /gene="ZNF57"
                     /gene_synonym="ZNF424"
                     /note="zinc finger protein 57"
                     /db_xref="GeneID:126295"
                     /db_xref="HGNC:HGNC:13125"
     exon            1..121
                     /gene="ZNF57"
                     /gene_synonym="ZNF424"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1786
                     /gene="ZNF57"
                     /gene_synonym="ZNF424"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 424"
                     /codon_start=1
                     /product="zinc finger protein 57 isoform 1"
                     /protein_id="NP_775751.1"
                     /db_xref="CCDS:CCDS12098.1"
                     /db_xref="GeneID:126295"
                     /db_xref="HGNC:HGNC:13125"
                     /translation="MDSVVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFRNLASVD
                     DGTQFKANGSVSLQDMYGQEKSKEQTIPNFTGNNSCAYTLEKNCEGYGTEDHHKNLRN
                     HMVDRFCTHNEGNQYGEAIHQMPDLTLHKKVSAGEKPYECTKCRTVFTHLSSLKRHVK
                     SHCGRKAPPGEECKQACICPSHLHSHGRTDTEEKPYKCQACGQTFQHPRYLSHHVKTH
                     TAEKTYKCEQCRMAFNGFASFTRHVRTHTKDRPYKCQECGRAFIYPSTFQRHMTTHTG
                     EKPYKCQHCGKAFTYPQAFQRHEKTHTGEKPYECKQCGKTFSWSETLRVHMRIHTGDK
                     LYKCEHCGKAFTSSRSFQGHLRTHTGEKPYECKQCGKAFTWSSTFREHVRIHTQEQLY
                     KCEQCGKAFTSSRSFRGHLRTHTGEKPYECKQCGKTFTWSSTFREHVRIHTQEQLHKC
                     EHCGKAFTSSRAFQGHLRMHTGEKPYECKQCGKTFTWSSTLHNHVRMHTGEKPHKCKQ
                     CGMSFKWHSSFRNHLRMHTGQKSHECQSYSKAFSCQVILSKTSESTH"
     exon            122..248
                     /gene="ZNF57"
                     /gene_synonym="ZNF424"
                     /inference="alignment:Splign:2.1.0"
     exon            249..420
                     /gene="ZNF57"
                     /gene_synonym="ZNF424"
                     /inference="alignment:Splign:2.1.0"
     exon            421..1970
                     /gene="ZNF57"
                     /gene_synonym="ZNF424"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1949..1954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF57"
                     /gene_synonym="ZNF424"
                     /note="hexamer: AATAAA"
     polyA_site      1970
                     /gene="ZNF57"
                     /gene_synonym="ZNF424"
                     /note="major polyA site"
ORIGIN      
        1 ctccctgccg cgcgtgccct gcctaccacg agcggcccgg gagtacctgt acctttcagc
       61 tgcgccggcc gcgaggccac ggagagctcg ccttggagag cccaggagca ggggagacat
      121 ggactcagtg gtctttgagg atgtggctgt ggacttcacc ctggaggagt gggctttgct
      181 ggattctgct cagagggacc tctacagaga tgtgatgctg gagaccttcc ggaacctggc
      241 ctcagtagat gatgggactc aatttaaagc caatgggtca gtttctctgc aggatatgta
      301 cgggcaagaa aaatctaagg aacagacaat accaaacttc acaggaaata attcctgtgc
      361 ctacacttta gaaaaaaatt gtgaaggcta tggcactgaa gaccaccaca aaaatctgag
      421 aaatcatatg gtggacagat tctgtacaca taatgaaggt aatcaatatg gagaagccat
      481 ccatcaaatg ccagatctta ccctgcacaa gaaagtttct gctggagaaa aaccatatga
      541 atgcaccaag tgcaggacag tcttcacgca tctttcttct cttaaaaggc acgtcaagtc
      601 tcactgtgga cgaaaagcac ctccaggtga ggaatgtaag caggcctgca tttgtccctc
      661 acacctacac agtcacggaa gaactgacac tgaggagaag ccgtataagt gtcaagcatg
      721 tgggcaaact ttccaacatc ctcgttacct ctcccaccac gtaaagactc acacagcaga
      781 gaaaacctac aaatgcgagc agtgtcggat ggcgtttaat gggttcgcaa gcttcactag
      841 acatgtgaga actcacacaa aagacaggcc atataaatgt caggaatgtg ggagagcctt
      901 catttatccc tcgacatttc aaagacacat gacaacacac actggagaga agccctataa
      961 atgtcagcac tgtgggaaag ccttcactta cccccaggct tttcaaagac atgagaagac
     1021 gcacacggga gagaagccct atgaatgcaa gcagtgtggg aaaacattca gttggtctga
     1081 aaccttgcga gtccacatga ggatccacac tggggacaaa ctctataaat gtgaacactg
     1141 tgggaaggct tttacctctt ccagatcatt ccaaggtcat ttgaggacgc acactggaga
     1201 gaaaccttat gagtgtaaac aatgtgggaa agccttcact tggtcctcaa cgtttagaga
     1261 acatgtgaga attcacacgc aagagcagct ctataaatgt gaacaatgtg ggaaggcttt
     1321 tacctcttcc agatcattcc gaggtcattt gaggacgcac actggagaga agccttatga
     1381 gtgtaaacaa tgtggaaaaa ccttcacttg gtcctcaacg tttagagaac atgtgagaat
     1441 tcacacgcaa gagcagctcc ataaatgtga acactgtggg aaggccttta cctcttccag
     1501 agcattccaa ggtcatttga ggatgcacac tggagagaag ccttatgagt gtaaacaatg
     1561 tggaaaaacc ttcacttggt cctcaacctt acataatcat gtgaggatgc acactggaga
     1621 gaaacctcac aaatgtaaac aatgtgggat gtccttcaag tggcactcct ccttccggaa
     1681 ccatctgagg atgcacacag gacagaaatc ccacgaatgt cagtcatact caaaagcctt
     1741 cagttgccaa gtcattcttt ctaaaaccag tgagagcaca cactaaagag aaattctata
     1801 actttaatgg ggtaacctca cattaattca tgtataatgc tccagaaaat tcacaccagg
     1861 agagaaatct tacaagtatg atattgtctt tgtcaatacc tcatttgtaa aacagaccca
     1921 ttagtcgtga atttccagct ctttcaaaaa taaatgttta tgtgagaaaa
//
