LOCUS       NM_152484               4066 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 569 (ZNF569), transcript variant
            1, mRNA.
ACCESSION   NM_152484
VERSION     NM_152484.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4066)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4066)
  AUTHORS   Huang,X., Yuan,W., Huang,W., Bai,Y., Deng,Y., Zhu,C., Liang,P.,
            Li,Y., Du,X., Liu,M., Wang,Y. and Wu,X.
  TITLE     ZNF569, a novel KRAB-containing zinc finger protein, suppresses
            MAPK signaling pathway
  JOURNAL   Biochem Biophys Res Commun 346 (3), 621-628 (2006)
   PUBMED   16793018
  REMARK    GeneRIF: ZNF569 protein may act as a transcriptional repressor that
            suppresses MAPK signaling pathway to mediate cellular functions
REFERENCE   3  (bases 1 to 4066)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   4  (bases 1 to 4066)
  AUTHORS   Lichter,P., Bray,P., Ried,T., Dawid,I.B. and Ward,D.C.
  TITLE     Clustering of C2-H2 zinc finger motif sequences within telomeric
            and fragile site regions of human chromosomes
  JOURNAL   Genomics 13 (4), 999-1007 (1992)
   PUBMED   1505991
REFERENCE   5  (bases 1 to 4066)
  AUTHORS   Bray,P., Lichter,P., Thiesen,H.J., Ward,D.C. and Dawid,I.B.
  TITLE     Characterization and mapping of human genes encoding zinc finger
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9563-9567 (1991)
   PUBMED   1946370
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008806.4, CB151734.1, AL833408.1, BC038737.1 and AK122846.1.
            
            On May 17, 2019 this sequence version replaced NM_152484.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY835704.1, AL833408.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145774 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316950.11/ ENSP00000325018.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC008806.4         21603-21609
            8-361               CB151734.1         18-371
            362-685             AL833408.1         356-679
            686-1272            BC038737.1         1128-1714
            1273-3789           AL833408.1         1267-3783
            3790-4056           AK122846.1         3104-3370
            4057-4066           AL833408.1         4052-4061
FEATURES             Location/Qualifiers
     source          1..4066
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..4066
                     /gene="ZNF569"
                     /gene_synonym="ZAP1; Zfp74; ZNF"
                     /note="zinc finger protein 569"
                     /db_xref="GeneID:148266"
                     /db_xref="HGNC:HGNC:24737"
                     /db_xref="MIM:613904"
     exon            1..361
                     /gene="ZNF569"
                     /gene_synonym="ZAP1; Zfp74; ZNF"
                     /inference="alignment:Splign:2.1.0"
     exon            362..522
                     /gene="ZNF569"
                     /gene_synonym="ZAP1; Zfp74; ZNF"
                     /inference="alignment:Splign:2.1.0"
     exon            523..580
                     /gene="ZNF569"
                     /gene_synonym="ZAP1; Zfp74; ZNF"
                     /inference="alignment:Splign:2.1.0"
     CDS             566..2626
                     /gene="ZNF569"
                     /gene_synonym="ZAP1; Zfp74; ZNF"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DNA-binding protein"
                     /codon_start=1
                     /product="zinc finger protein 569 isoform 1"
                     /protein_id="NP_689697.2"
                     /db_xref="CCDS:CCDS12503.1"
                     /db_xref="GeneID:148266"
                     /db_xref="HGNC:HGNC:24737"
                     /db_xref="MIM:613904"
                     /translation="MTESQGTVTFKDVAIDFTQEEWKRLDPAQRKLYRNVMLENYNNL
                     ITVGYPFTKPDVIFKLEQEEEPWVMEEEVLRRHWQGEIWGVDEHQKNQDRLLRQVEVK
                     FQKTLTEEKGNECQKKFANVFPLNSDFFPSRHNLYEYDLFGKCLEHNFDCHNNVKCLM
                     RKEHCEYNEPVKSYGNSSSHFVITPFKCNHCGKGFNQTLDLIRHLRIHTGEKPYECSN
                     CRKAFSHKEKLIKHYKIHSREQSYKCNECGKAFIKMSNLIRHQRIHTGEKPYACKECE
                     KSFSQKSNLIDHEKIHTGEKPYECNECGKAFSQKQSLIAHQKVHTGEKPYACNECGKA
                     FPRIASLALHMRSHTGEKPYKCDKCGKAFSQFSMLIIHVRIHTGEKPYECNECGKAFS
                     QSSALTVHMRSHTGEKPYECKECRKAFSHKKNFITHQKIHTREKPYECNECGKAFIQM
                     SNLVRHQRIHTGEKPYICKECGKAFSQKSNLIAHEKIHSGEKPYECNECGKAFSQKQN
                     FITHQKVHTGEKPYDCNECGKAFSQIASLTLHLRSHTGEKPYECDKCGKAFSQCSLLN
                     LHMRSHTGEKPYVCNECGKAFSQRTSLIVHMRGHTGEKPYECNKCGKAFSQSSSLTIH
                     IRGHTGEKPFDCSKCGKAFSQISSLTLHMRKHTGEKPYHCIECGKAFSQKSHLVRHQR
                     IHTH"
     exon            581..707
                     /gene="ZNF569"
                     /gene_synonym="ZAP1; Zfp74; ZNF"
                     /inference="alignment:Splign:2.1.0"
     exon            708..803
                     /gene="ZNF569"
                     /gene_synonym="ZAP1; Zfp74; ZNF"
                     /inference="alignment:Splign:2.1.0"
     exon            804..4066
                     /gene="ZNF569"
                     /gene_synonym="ZAP1; Zfp74; ZNF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4047..4052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF569"
                     /gene_synonym="ZAP1; Zfp74; ZNF"
                     /note="hexamer: AATAAA"
     polyA_site      4066
                     /gene="ZNF569"
                     /gene_synonym="ZAP1; Zfp74; ZNF"
                     /note="major polyA site"
ORIGIN      
        1 gcaggaagca gcggaacgat tcgattcttc tcagcaccaa gttgcgctcc caatctctca
       61 gagctgggct cgcgggaggc cgctcgtgca aaacctaggc tgagctcccc tgcgcggagc
      121 tgtgagccct ggaacaccgt ggtctgcttc tcaggacgcg caaacagtga agccagtccc
      181 gcccgggtga gccgcggggg cctctgggaa gcgtcgcccc tggtgtaacg gaccgagact
      241 tgtggcgctc tcagccaccg acagcgccgg cctcagtgcc gcctctgtcc cagcccgcgc
      301 cggctctgcc actttggcag cgttaagtgt ggaatcgggg cctgtgtccg cgggcttggt
      361 gagttcttca tatattaagg attcattcat tcatagactc atttattgaa ggctgtctgt
      421 gtaacaggca caatcctagg tgcttgggat atagcagtga acaagagaca aaccccctac
      481 tatcatggta cttacatttt tgtgggctgg ataataaaca agctctactt ctgcaggccc
      541 catcccttcc cagaaagaag aggaaatgac tgagtcccag ggaacagtaa cattcaaaga
      601 tgtggctatc gacttcactc aggaggagtg gaagagattg gatcctgctc agagaaaact
      661 gtaccggaat gtgatgctag aaaactataa caacttaatc acagtaggct atccgttcac
      721 caaacctgat gtgattttca aattggagca agaagaagaa ccatgggtga tggaggaaga
      781 agtattaagg agacactggc aaggagaaat atggggagtt gatgagcatc agaaaaacca
      841 ggacagactt ttgagacaag ttgaagttaa attccagaaa acactgactg aagaaaaagg
      901 caatgaatgt caaaagaaat ttgcaaatgt atttcctctg aactctgatt ttttcccttc
      961 cagacacaat ctctatgagt atgacttatt tggaaagtgt ttagaacata attttgactg
     1021 tcataataat gtgaaatgcc ttatgagaaa ggagcattgt gaatataatg aacctgtgaa
     1081 atcatatggt aatagctcat cccattttgt cattaccccc tttaagtgta atcattgtgg
     1141 aaaaggcttc aatcagactt tggacctcat cagacatctg agaattcata ctggagagaa
     1201 gccctatgaa tgtagtaact gtagaaaagc cttcagtcac aaggaaaaac ttattaaaca
     1261 ttataaaatt cacagtaggg agcagtctta caaatgtaat gaatgtggta aagctttcat
     1321 taaaatgtca aatctcatta gacatcaaag aattcatact ggagagaagc cctatgcatg
     1381 taaggaatgt gagaagtcct tcagccagaa atcaaatctt attgatcatg aaaaaattca
     1441 tactggagag aaaccttatg aatgtaatga gtgtggaaaa gcattcagcc agaagcaaag
     1501 cctcattgca catcagaaag ttcatactgg ggagaaacct tatgcatgta atgaatgtgg
     1561 taaagccttc cctcgaattg catcccttgc tcttcatatg agaagtcata caggagaaaa
     1621 accttataaa tgtgataaat gtggtaaagc cttctctcag ttttccatgc ttattataca
     1681 tgttagaatt catacaggtg aaaaacccta tgaatgtaat gagtgtggaa aagccttctc
     1741 tcaaagctca gcccttactg tacatatgag aagtcacact ggtgagaaac cctatgaatg
     1801 taaggaatgc agaaaagcct tcagccacaa gaaaaacttc attacacacc agaaaattca
     1861 tactagagag aaaccttatg agtgtaatga atgtgggaaa gcttttatac agatgtcaaa
     1921 tcttgttaga caccagagaa ttcatactgg ggaaaaaccc tatatatgta aggaatgtgg
     1981 gaaagccttt agccagaaat caaatctcat tgctcatgaa aaaattcatt ctggagagaa
     2041 accctatgaa tgcaatgaat gtggtaaagc cttcagccaa aagcaaaact tcattacaca
     2101 tcaaaaagtt catactggag agaaacctta tgattgtaat gaatgtggta aagccttctc
     2161 tcaaattgca tcccttaccc ttcatttgag aagtcataca ggggaaaagc cttatgaatg
     2221 tgataaatgt ggtaaagcct tctctcagtg ctcactgctt aatttacata tgagaagtca
     2281 cacaggtgag aagccctatg tatgtaatga atgtgggaaa gccttctctc aaagaacttc
     2341 ccttattgtg cacatgagag gccatacagg tgaaaaaccc tatgaatgta ataaatgtgg
     2401 aaaagccttc tcccaaagct catcccttac tatacatata cgaggacata caggtgagaa
     2461 acccttcgac tgtagtaaat gtggaaaagc cttctctcaa atctcatctc ttacccttca
     2521 tatgagaaaa catacaggtg agaagcccta tcactgtatt gagtgtggca aggctttcag
     2581 ccaaaagtcg caccttgtta gacaccagag aattcatact cattagaaac cctatgaata
     2641 ttgtgaatat ggcaaggcca tctgaaggaa ttaacacctc attgcacatt acatgatcac
     2701 ttccagagta gaaaactatg aatgtgggat agccttctga aaaagccaca aatttatgaa
     2761 acattagaga attcttccaa ggtgacaaat tatataatga aaaagctgtt accagaaact
     2821 ttcagcagac atcttattga taatatttaa tcagcattct cattgaaatc tgaaacaagg
     2881 tatcttccat cagcataaca acacaacact tgagctccta gccaatgtat taagtaagga
     2941 aaacaagtat caacgaagaa ctataaaaat aacttttata caagaaataa ttagaaaatg
     3001 tgttgataga aaacctaaga ataaacacaa caatgagtta ggtctttatc aagttataaa
     3061 atatgttgaa aggcacaaaa gaacacctga aaaatgatat tttgtctgaa aagacttgac
     3121 attgtaaaaa tataatttct ctcccaaatc actaagttta atatacttct gaagtttaca
     3181 tcagttttat tttaaggaac ttcacaaact tatccaaaaa ttttatgtgg aaaagtaaag
     3241 aaacacaaat agctgaaaca aacttgacaa agcaagtaga gaagacacac tctattatta
     3301 gatatatcat gtacttattt aaagctgctg tcatttaaac aatgtattac caagtgaata
     3361 aatcaagcag tagtaagata gtgagcattc atacaaaaat ccaagaagat acaggaattc
     3421 tgtgtatgac agtgctattg aaatcactgg ggaatgaatg gcttatttaa taaatggaag
     3481 gttcatagga gaaaaatttt agctttctac tttatatcat atacaaaaat aaaatccaac
     3541 taaagaccag aatataaaaa gcaaaatttt aaaactatga tgaaagtaga atccgttact
     3601 ttagggtaac aagatttctt taaaaaacat gtaaacatgg aatagtctgt tgaattttgg
     3661 tgtattggcc tcacaggcac ccacaaatgt acacaaagag atatatatca ctgtgttcct
     3721 gaatcatggt ttgtattgcc caaaattgga tataacaaat ttttatcaat tgtggaatag
     3781 atgaataagt gtgatcattt ctgtgataaa atacagaatt tagaaacaaa atctacctat
     3841 agttatatgg atagattaca atatataata ttgagagaaa aaattaaaat gcacaaagga
     3901 acacagtata acatttgtat aatttaataa gatcttgcaa agaacagtac tgtgtattgg
     3961 tcatggatcc atatatgact tggttgcctt ttgggatgtg ggaaaggttt ggtgggagtt
     4021 gttatattta tctgtaatat ttctttaata aaagagtgaa agcaaa
//
