LOCUS       NM_198539               4096 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens zinc finger protein 568 (ZNF568), transcript variant
            1, mRNA.
ACCESSION   NM_198539 XM_351190
VERSION     NM_198539.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4096)
  AUTHORS   Han,C.W., Jeong,M.S. and Jang,S.B.
  TITLE     Influence of the interaction between p53 and ZNF568 on
            mitochondrial oxidative phosphorylation
  JOURNAL   Int J Biol Macromol 275 (Pt 2), 133314 (2024)
   PUBMED   38944084
  REMARK    GeneRIF: Influence of the interaction between p53 and ZNF568 on
            mitochondrial oxidative phosphorylation.
REFERENCE   2  (bases 1 to 4096)
  AUTHORS   Chien,H.C., Wang,H.Y., Su,Y.N., Lai,K.Y., Lu,L.C., Chen,P.C.,
            Tsai,S.F., Wu,C.I., Hsieh,W.S. and Shen,C.K.
  TITLE     Targeted disruption in mice of a neural stem cell-maintaining,
            KRAB-Zn finger-encoding gene that has rapidly evolved in the human
            lineage
  JOURNAL   PLoS One 7 (10), e47481 (2012)
   PUBMED   23071813
  REMARK    GeneRIF: M003-A06 is likely one of the genes contributing to the
            uniqueness of the human brain in comparison to other higher
            primates.
REFERENCE   3  (bases 1 to 4096)
  AUTHORS   Peloso,G.M., Demissie,S., Collins,D., Mirel,D.B., Gabriel,S.B.,
            Cupples,L.A., Robins,S.J., Schaefer,E.J. and Brousseau,M.E.
  TITLE     Common genetic variation in multiple metabolic pathways influences
            susceptibility to low HDL-cholesterol and coronary heart disease
  JOURNAL   J Lipid Res 51 (12), 3524-3532 (2010)
   PUBMED   20855565
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008733.9, BC031218.1, BC111777.1 and BX640681.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198539.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.93500.1,
                                           SRR1803613.284280.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333987.12/ ENSP00000334685.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC008733.9         88804-88812
            10-800              BC031218.1         1-791
            801-2024            BC111777.1         586-1809
            2025-3415           BX640681.1         1692-3082
            3416-3417           AC008733.9         124526-124527
            3418-4096           BX640681.1         3083-3761
FEATURES             Location/Qualifiers
     source          1..4096
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..4096
                     /gene="ZNF568"
                     /gene_synonym="ZFP568"
                     /note="zinc finger protein 568"
                     /db_xref="GeneID:374900"
                     /db_xref="HGNC:HGNC:25392"
                     /db_xref="MIM:617566"
     exon            1..260
                     /gene="ZNF568"
                     /gene_synonym="ZFP568"
                     /inference="alignment:Splign:2.1.0"
     exon            261..330
                     /gene="ZNF568"
                     /gene_synonym="ZFP568"
                     /inference="alignment:Splign:2.1.0"
     exon            331..591
                     /gene="ZNF568"
                     /gene_synonym="ZFP568"
                     /inference="alignment:Splign:2.1.0"
     CDS             516..2450
                     /gene="ZNF568"
                     /gene_synonym="ZFP568"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 568 isoform 1"
                     /protein_id="NP_940941.2"
                     /db_xref="CCDS:CCDS42558.1"
                     /db_xref="GeneID:374900"
                     /db_xref="HGNC:HGNC:25392"
                     /db_xref="MIM:617566"
                     /translation="MTSQSSVISNSCVTMERLSHMMERKAWCSQESALSEEEEDTTRP
                     LETVTFKDVAVDLTQEEWEQMKPAQRNLYRDVMLENYSNLVTVGCQVTKPDVIFKLEQ
                     EEEPWVMEEEMFGRHCPEVWEVDEQIKKQQETLVRKVTSISKKILIKEKVIECKKVAK
                     IFPLSSDIVTSRQSFYDCDSLDKGLEHNLDLLRYEKGCVREKQSNEFGKPFYHCASYV
                     VTPFKCNQCGQDFSHKFDLIRHERIHAGEKPYECKECGKAFSRKENLITHQKIHTGEK
                     PYKCNECGKAFIQMSNLIRHHRIHTGEKPYACKDCWKAFSQKSNLIEHERIHTGEKPY
                     ECKECGKSFSQKQNLIEHEKIHTGEKPYACNECGRAFSRMSSVTLHMRSHTGEKPYKC
                     NKCGKAFSQCSVFIIHMRSHTGEKPYVCSECGKAFSQSSSLTVHMRNHTAEKPYECKE
                     CGKAFSRKENLITHQKIHTGEKPYECSECGKAFIQMSNLIRHQRIHTGEKPYACTVCG
                     KAFSQKSNLTEHEKIHTGEKPYHCNQCGKAFSQRQNLLEHEKIHTGEKPFKCNECGKA
                     FSRISSLTLHVRSHTGEKPYECNKCGKAFSQCSLLIIHMRSHTGEKPFECNECGKAFS
                     QRASLSIHKRGHTGERHQVY"
     exon            592..650
                     /gene="ZNF568"
                     /gene_synonym="ZFP568"
                     /inference="alignment:Splign:2.1.0"
     exon            651..777
                     /gene="ZNF568"
                     /gene_synonym="ZFP568"
                     /inference="alignment:Splign:2.1.0"
     exon            778..873
                     /gene="ZNF568"
                     /gene_synonym="ZFP568"
                     /inference="alignment:Splign:2.1.0"
     exon            874..4096
                     /gene="ZNF568"
                     /gene_synonym="ZFP568"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4002..4007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF568"
                     /gene_synonym="ZFP568"
                     /note="hexamer: ATTAAA"
     polyA_site      4023
                     /gene="ZNF568"
                     /gene_synonym="ZFP568"
                     /note="major polyA site"
     regulatory      4065..4070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF568"
                     /gene_synonym="ZFP568"
                     /note="hexamer: AATAAA"
     polyA_site      4096
                     /gene="ZNF568"
                     /gene_synonym="ZFP568"
                     /note="major polyA site"
ORIGIN      
        1 gttgtcctcg gaaacgtcgc tggcgcggag ggatggttcg gcgctttagg cgtctgtcac
       61 agacctatct gcgggtcgcc ttcacccagc atctcagaaa ctgcgcgcgg gatgaacatt
      121 cgggtgtttc cggcaggtga cgctgccgag tccccgcagc agggggcgag caagggactc
      181 gcggttgacg ggacacggat cctctaaggc ccagagtgtc ccgagtagcg gcagtgggga
      241 gtgctcaggg tacgctaatg atctgtgtct tgtaaagagc atattgctgg gcttacatcc
      301 gtttatcttg tttgactgtt attttaatag gtcctggttc cacaaggata aaacacatct
      361 gcagtgcaaa tagaagtctg aggaacaggt gtcttatcat ggaaggagac ctgacctgag
      421 acctgcctta gaggctggag agtcctgaaa gagagtggac cctggagttg ctggagcttg
      481 tcttgaccct tctgcccaga gcaggcaggg tctgaatgac atctcaatct tcagtgatca
      541 gcaatagctg tgtgacaatg gagcgtttga gccacatgat ggaaaggaaa gcttggtgtt
      601 ctcaagagtc tgccctttcc gaggaagaag aggatacaac caggcctctt gaaacagtga
      661 catttaagga tgtggctgtt gaccttaccc aggaggagtg ggagcaaatg aaacctgctc
      721 aaagaaactt gtatcgagat gtgatgctgg agaactacag caacctagtc acagtgggct
      781 gtcaagtcac caaaccggat gtgatattca agttggagca agaagaggag ccctgggtga
      841 tggaggaaga aatgtttggg aggcactgtc cagaagtttg ggaagttgat gaacagatca
      901 agaagcaaca ggaaacactt gtgaggaaag tcacatccat ctccaagaaa attctgataa
      961 aggaaaaagt cattgaatgt aaaaaagttg cgaaaatatt tcctctgagt tcagacattg
     1021 ttacttcaag acaaagcttc tatgactgtg actcacttga taagggtttg gaacataatt
     1081 tagacttact tagatatgag aaaggctgtg taagagagaa acagagtaat gagtttggga
     1141 aaccatttta ccattgtgca tcctatgttg taaccccctt taagtgtaat cagtgtggac
     1201 aagacttcag tcataaattt gacctcatta gacatgagcg aattcatgct ggagagaaac
     1261 cttacgaatg taaagaatgt ggaaaagcct tcagtaggaa ggaaaatctt attacacatc
     1321 agaaaattca tactggggaa aaaccgtata agtgtaatga atgtggaaaa gctttcattc
     1381 agatgtcaaa ccttattaga caccacagaa ttcatactgg ggagaaacct tatgcatgta
     1441 aggattgttg gaaagccttc agtcagaaat caaatctcat tgaacatgag cgaattcaca
     1501 ctggagagaa accctatgaa tgtaaggaat gtgggaaatc cttcagccag aagcaaaatc
     1561 ttattgagca cgagaaaatt catactgggg agaaacctta tgcatgtaat gaatgtggta
     1621 gagctttttc tcgaatgtca tctgttacgc tacatatgag aagtcacaca ggggagaaac
     1681 cctataaatg taataaatgt ggaaaagctt tctctcaatg ctcagtattt attatacata
     1741 tgagaagtca cactggtgag aaaccctatg tatgtagtga atgtgggaaa gccttctctc
     1801 agagttcatc cctaaccgta catatgcgaa atcatacagc tgagaaaccc tatgaatgta
     1861 aggaatgtgg aaaagccttc agcaggaaag aaaatctcat tacacatcag aaaattcaca
     1921 ctggagagaa accttatgaa tgcagtgaat gtgggaaagc ttttattcag atgtcaaacc
     1981 tcattcgaca ccagagaatt catacgggtg agaaacccta tgcatgtaca gtatgtggaa
     2041 aagcctttag tcagaaatca aacctcactg aacatgagaa aattcatact ggagagaaac
     2101 cttatcattg taatcaatgt gggaaagctt tcagtcagag acaaaatctt cttgagcatg
     2161 aaaaaattca tactggagag aaaccattca aatgtaatga atgtggtaaa gccttctctc
     2221 gaatctcatc cctcactctt catgtgagaa gtcacacagg ggagaaaccc tatgaatgta
     2281 ataaatgtgg gaaagccttt tctcagtgct cattacttat tatacatatg agaagtcata
     2341 ctggtgagaa accctttgaa tgtaatgaat gtgggaaagc attctctcaa agagcatccc
     2401 tttctataca taagagaggt catacaggtg agagacacca agtatattaa atgaaagaag
     2461 gcctcttaaa ttcaacccat gttttactta aaatatcttg gcataagctc aaaaaagcca
     2521 ggatctttat ggaaaaattt taatactttg ttaaaaggtg taagactgga ataaatggaa
     2581 agaaatacca tatacataga tggaaaaacc cagtattata aaaacctcaa ttctgaaaat
     2641 ctatagactg aatgcagttc caaacaaaat caactaagaa ttttctagga tctttcaaaa
     2701 atgattataa aattcatgtg aaatagaagt gtatgaattg ctgcgacaat tttgaaaaga
     2761 atagaggaaa caccctcact gtatgatata aagttatagt catttaaaaa tgtgtgatat
     2821 tagtacatta gtaggtaaat gagcagattt taaagaatag aatatccaga agcagattca
     2881 tgaatatatg tgaactcagt gtatgttaga cctgacatca tgaattagta gggaaatgat
     2941 gacctagtca ataaaattgc tgggaatatt tgactctccg tattggagaa aataaaatta
     3001 caacattacg acatactaaa aaatcaatat tctttttttt tttttttttt ttttgagaca
     3061 agcgtctcac tctgtcgccc aggctggagt acggtggtgc aatctcagct cactgcagcc
     3121 tctgctttcc gggttttttt gttttgtttt gttttgtttt ttgtattttt agtagagacg
     3181 gggtttcacc atgttggcca gggtagtctt gaactcctga cttcaaaagt gatcgccctc
     3241 tttggcctcc caaagtgctg gggtttacag gcttgagcca ctgcacctgg ccaaaaaatt
     3301 aacattctaa aggatttaaa tactggaatt tgaaaagcca aactgtgaaa ccattgggag
     3361 aaaatagatg atattgtcta tgacgttgag gccaaggagc tttttttttt tttttttcaa
     3421 gacaaaagga ctctgtaatt ccacttctag gtatatatac atcctataga aactcacaaa
     3481 taatgcataa gaaatatata tataatatat gtatgtatgt atagccagat gcagtggcac
     3541 atgcctgtaa tcccagctac ttgggaggct gatagaagaa gataacttga ggtcaggagt
     3601 tcaagaccag cctgggaaac atagcaagac cccatctctt aaaaaaaaag aaatatatag
     3661 acatatatct gcattgaaaa caacctaaat attcatcagt ggggtaatgg atgaataaaa
     3721 tatgatatat tcaaatgata gaatagtata cagcacttaa aagcagtgaa ccagatccat
     3781 attgtgtaac atggatagtt aaaacaatgt tgaatgaaaa aaatcaaaat acaaatgaaa
     3841 cattgtgtaa taatatttat gtaaattgga atgaaatcat ttataaagaa caactgtttc
     3901 tattattgaa aattgtatgt aaaactattt aaaatagaat agaaggatac acacccaatt
     3961 attgatagca ttgtctctgg agattgaatt tgaggctgtt gattaaaagg agactttagc
     4021 tttgcttgta gtttttatac cttaaaaaga ctggtagcat ataaaataaa tcttaaaagc
     4081 taattataca caatga
//
