LOCUS       NM_001145344            5250 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens zinc finger protein 566 (ZNF566), transcript variant
            2, mRNA.
ACCESSION   NM_001145344
VERSION     NM_001145344.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5250)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 5250)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092295.2, DC373988.1 and AC092296.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.402312.1,
                                           SRR1803615.188778.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000452939.7/ ENSP00000411526.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC092295.2         34547-34568         c
            23-598              DC373988.1         1-576
            599-5250            AC092296.2         134153-138804       c
FEATURES             Location/Qualifiers
     source          1..5250
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..5250
                     /gene="ZNF566"
                     /note="zinc finger protein 566"
                     /db_xref="GeneID:84924"
                     /db_xref="HGNC:HGNC:25919"
     exon            1..76
                     /gene="ZNF566"
                     /inference="alignment:Splign:2.1.0"
     exon            77..144
                     /gene="ZNF566"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1392
                     /gene="ZNF566"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 566 isoform 1"
                     /protein_id="NP_001138816.1"
                     /db_xref="CCDS:CCDS12494.1"
                     /db_xref="GeneID:84924"
                     /db_xref="HGNC:HGNC:25919"
                     /translation="MAQESVMFSDVSVDFSQEEWECLNDDQRDLYRDVMLENYSNLVS
                     MGHSISKPNVISYLEQGKEPWLADRELTRGQWPVLESRCETKKLFLKKEIYEIESTQW
                     EIMEKLTRRDFQCSSFRDDWECNRQFKKELGSQGGHFNQLVFTHEDLPTLSHHPSFTL
                     QQIINSKKKFCASKEYRKTFRHGSQFATHEIIHTIEKPYECKECGKSFRHPSRLTHHQ
                     KIHTGKKPFECKECGKTFICGSDLTRHHRIHTGEKPYECKECGKAFSSGSNFTRHQRI
                     HTGEKPYECKECGKAFSSGSNFTQHQRIHTGEKPYECKECGNAFSQSSQLIKHQRIHT
                     GEKPYECKECEKAFRSGSDLTRHQRIHTGEKPYECKICGKAYSQSSQLISHHRIHTSE
                     KPYEYRECGKNFNYDPQLIQHQNLYW"
     exon            145..271
                     /gene="ZNF566"
                     /inference="alignment:Splign:2.1.0"
     exon            272..367
                     /gene="ZNF566"
                     /inference="alignment:Splign:2.1.0"
     exon            368..5250
                     /gene="ZNF566"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4073
                     /gene="ZNF566"
                     /note="major polyA site"
     regulatory      5227..5232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF566"
                     /note="hexamer: AATAAA"
     polyA_site      5250
                     /gene="ZNF566"
                     /note="major polyA site"
ORIGIN      
        1 acgcgctggc gggaccctca gggctttacc agcaactacc ccagtgccgg ggagggttct
       61 gctgcttcga aagctgctct acccttctcc aaaagaagag ccaagagaag gtccttttct
      121 acaaatatca gagccatggc tcaggagtca gtgatgttca gtgatgtgtc cgtagacttc
      181 tctcaggagg agtgggaatg cctgaatgat gatcagagag atttatacag agatgtgatg
      241 ttggagaatt acagcaacct ggtttcaatg gggcattcta tttctaaacc aaatgtgatc
      301 tcctacttgg agcaagggaa ggagccctgg ttggctgaca gagagctaac aagaggccag
      361 tggccagtcc tggaatcaag atgtgagacc aagaaattat ttctgaagaa agaaatttat
      421 gaaatagaat caacccagtg ggaaataatg gaaaaactca caagacgtga ttttcagtgc
      481 tccagtttca gagatgattg ggaatgtaat cggcagttta agaaagaact cggctctcag
      541 gggggacatt tcaatcaatt ggtattcact catgaagatc tgcccacttt gagtcaccat
      601 ccatccttca cattacagca aatcattaac agtaaaaaga aattctgtgc atctaaagaa
      661 tataggaaaa cctttagaca tggctcacag tttgctacac atgagataat tcataccatt
      721 gagaagcctt atgaatgtaa ggaatgtgga aagtccttta gacatccctc aagactcact
      781 catcatcaga aaattcatac tggcaagaaa ccctttgaat gtaaggaatg tggaaaaacc
      841 tttatttgtg gctcagacct tactcgacat cacagaattc acactggtga gaaaccctat
      901 gaatgtaagg aatgtgggaa agcctttagt agtggttcaa acttcactcg acatcagaga
      961 attcacacag gtgagaagcc ttatgaatgc aaagaatgcg ggaaggcctt tagtagtggc
     1021 tcaaacttta ctcaacatca gagaattcat actggggaaa aaccctatga atgtaaggaa
     1081 tgtggcaatg cctttagtca gagctcacaa cttattaaac atcaaagaat ccatacaggt
     1141 gagaaacctt acgaatgtaa ggaatgtgaa aaggcttttc gttctggctc agaccttact
     1201 agacatcaga gaattcatac tggggagaaa ccctatgaat gtaagatatg tgggaaggct
     1261 tattctcaga gttcacagct tattagtcat catagaattc atactagtga gaaaccctat
     1321 gaatataggg aatgtggaaa gaactttaat tatgacccac aacttattca gcatcaaaat
     1381 ttgtactggt gatgaaacag aatatatgaa atgtgtaggg aggcttttaa ttatggctca
     1441 aaacagaatt tatcttgtta ataattcctc tagatagaat aatgtagaaa cattttattt
     1501 gtggactaca gcttattcag cctgggaaaa ataatgttgg agaaatactc tatgaataga
     1561 atatactttg gaagccctta actaaacgct tacttctctt gacatcagat aattcagtct
     1621 agcaatatga tagataattc agtctgtcat actgaaaatg acagcacttt taacaccttt
     1681 ctaaccttct taacgtcaga gaatttttgt agaaatgtag tcctgtgatt gtcatttttt
     1741 cccctaattt ctctaattgt tacattctta gtattttaat ccatattaaa tttatatggc
     1801 tataaatttc atctgtttac atcctgattt gtatactatt ttaaaaatac ctttagtacc
     1861 tgggagaagt gacctcttta tttttgaaga tggcttattc tttttgttct ttataacatt
     1921 aaggctttct tattgtaaaa atgttcatga acgacatttt actcaataga gattcttcat
     1981 tatcttcatg gtgttttgtt gtgttactgt aatatcactt atgaaatcct attggtggat
     2041 atcgtagtct cctctagata ttttgccata atacatgcca aaatacaagt ccctgctgga
     2101 cattctccct aagcacatct ttgtatcata tcttttaatt gcagaagtaa tgtgtgaata
     2161 tattttcctt ataaaagatg caaacattac aaaaaggcaa atgtaccctt tgaccatatc
     2221 ccaaaggata gtctttatca gttcattatt tattgctgat catttttctg ttcatatata
     2281 catgcgtgtc tcagtaaaaa ttataaaatg ggggataatt ataataccta cctcataatg
     2341 ctttgtgagg attaaatgaa ttaagatcga taaagtgctt agaattgtgc ctgacatgat
     2401 aaatacatac tcactgaatg ttagtcatcg ttattatatt catcatcatc agtattatta
     2461 tttgtagaaa ggctttttaa cttctgcaga acttagtcac cattaggcag ggtgtttgac
     2521 tgaagaaaga ccctttgaag gtaacaagtt aagaaaattt cccatcatca tgtacttact
     2581 attgaacatg aaataatcct aggtgttggg ggggaaagta ctgtgaataa tgtgtgtgaa
     2641 ggactttatt ccgactaata ctctttttgt cgcattatat acccagtaaa aaagaaaaga
     2701 gaacataagc aaaatattgg tgcactaatg aggaaaaaaa gtatgaaaag agaaacagca
     2761 tcatatttaa aaaatggaca gagatagaaa catagttaca gatttaaaag gttctgttga
     2821 atattatgct tttttctaat atgtttgaaa atttaaacaa aatggttttt aaggaaaata
     2881 tacatcaata ttgactccaa gaaaattagg actcttcaaa gactctcata aacacagaga
     2941 acagggaaaa attagcatgt gatcagttaa ctattactaa tgaagcacca aatccagttt
     3001 ctttctaagg aaaactttat caaatgttca aggaactatt tcagttatat agaagtacac
     3061 atcttggctc acgcctgtaa tcccagcact ttgggaggct gagatggaag gatcatttga
     3121 ggccaggagc ttgagaccag cctggccaac atgttgaaac cccattttta ctcaaaaata
     3181 caaaacttag ccaggcatgg tggcacatgc ctgtaatccc agctactggg gaggctgagg
     3241 caggagaatc acttgaatgc aggaggtgga ggttgcagtg agccaagatc acgccatggc
     3301 acttcagcct gagcgacaga atgagactat taaaaaaaaa aaaaaaaagt ccacagtgta
     3361 gctttgtttg gggttaagtt agtgttttga aatgggcctt ccctgtgctc aaaacatgct
     3421 cagcaagcag ctccccacgc tggacagatc gcatatgtgg aaggatgaag tttatgtctg
     3481 tagaactgtt attttatgcc ccacttcctt ttttcttaga tcctgtgtag acgggtctct
     3541 ctgaacattg tgttacttta ctttactggc ataaggaagt aaaatatttc ataataaatt
     3601 tgagaaaagt agagtgagca aaaatacctg caaatgagag aattactaaa aatggactgt
     3661 tgtaatgttt tgcgttatca aaatgaaaac tgccaaatga gattttgttt actttctttt
     3721 cttgtgtgct tatgtctttt ataaagttct tcatctaaaa ttatagagat agtgcatttg
     3781 cacccaaatt aatgaaacaa taccattaaa gagaaagaaa aggggctggg cacagtggct
     3841 tacgcctgta atcccagtgc tttgggaggc caaggcaggg ggcagcctgg ccaatatagt
     3901 gaaaccccat ctctactaaa aatacaaaaa ttagctgggc gtggtggcat gtgcctgtag
     3961 tcccagctgc tcggaaggct gaggcaggag aatcgcttga acccgggagg cggaggttgc
     4021 agtgagctga gatcctgact gcactccagc ctgcatgaca gagtctcaaa aaatctgtct
     4081 caaaaaaaaa aaaaaaaaag aaagaaaaaa tgattatctt tgcccttctc cgttcctcat
     4141 tccctcccct ctgtcaattt tcttctgaat aatatttaaa ggttgtgtat attacccata
     4201 tatttcttca tgctaaaaca ttaacacaca attattttat tatgttttta cagaaaaatg
     4261 gataactata catttccctg aaatttgctt ttttacattc aactgtacat tttggatttt
     4321 ccttcaatag atgatgatct aacagtcttt ctgatggtta cagtatgttc cacagtgtta
     4381 tttaccaatg ccttttcaac cactttccca attgtgatat tatggattgt ttgcgctttt
     4441 ttgccatcta aaagtaatgc tgcaacaaac actttgtatt cttgtctgtt ttatttctat
     4501 aaaataagct tcccaagtca tttccagtgt ttttgctttg ttttgttttg agacagagtt
     4561 tcactcttgt ttcccaggct ggagtgcaat ggcgcaatct tggcttactg caatctccgc
     4621 ctcccgggtt caagagattc tcctgcctca gcctcccaag tagctggggt tacaggtata
     4681 tgccactacg cctggaaaat tttgtatttt tagtagagac ggcatttttc catgttggtc
     4741 aggctggtct cgaactcctg acctcaggtg atccaccctc ctcggcctcc caaagtgctg
     4801 gcattatagg catgagccac cgcacccggc gtcatttcca gtgttttcta tgtttcctag
     4861 gaaggttttg cttctggaag atttcagagg gcaagagaat aaaggagtgg agtgcagttt
     4921 ttcatatatg tgattctgtg agtgtgtata cacagagatt taatatttta atacatcagg
     4981 aattgattat acgatctaat gcaggatgtc agacttgttt ctatccagga ataaaaccag
     5041 ttatgccaga agtaactatt attcaccttt ctcctactga attaaaatac tatcagttgt
     5101 atattaaatg ctcacatcta tttctgttct ccatattcta gcaatccttg acacttttca
     5161 atagctttta ttacttggaa ataaagatgt atgtatatat tattaatata tagtttatta
     5221 tttggaaata aagatgtttc ttcatgagaa
//
