LOCUS       NM_145276               2699 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 563 (ZNF563), transcript variant
            1, mRNA.
ACCESSION   NM_145276
VERSION     NM_145276.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2699)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC022523.1 and AC012618.7.
            
            On May 17, 2019 this sequence version replaced NM_145276.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.148597.1, BC022523.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144, SAMEA2467147
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293725.10/ ENSP00000293725.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1766              BC022523.1         56-1821
            1767-2699           AC012618.7         133535-134467       c
FEATURES             Location/Qualifiers
     source          1..2699
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..2699
                     /gene="ZNF563"
                     /note="zinc finger protein 563"
                     /db_xref="GeneID:147837"
                     /db_xref="HGNC:HGNC:30498"
     exon            1..154
                     /gene="ZNF563"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1582
                     /gene="ZNF563"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 563 isoform 1"
                     /protein_id="NP_660319.1"
                     /db_xref="CCDS:CCDS12270.1"
                     /db_xref="GeneID:147837"
                     /db_xref="HGNC:HGNC:30498"
                     /translation="MDAVAFEDVAVNFTQEEWALLGPSQKNLYRYVMQETIRNLDCIR
                     MIWEEQNTEDQYKNPRRNLRCHMVERFSESKDSSQCGETFSLIRDSIVNNSICPGEDP
                     CQSAECEEVIMGHLSLNSHIRVDSGHKPHEYQEYGEKPHTHKQRGKAFSYHHSFQSRG
                     RPHTGKKRYECKECGKTFSSRRNLRRHMVVQGGNRPYKCKLCGKAFFWPSLLRMHERT
                     HTGEKPYECKQCSKAFPFYSSYRRHERMHTGEKPYECKQCSKALPDSSSYIRHERTHT
                     GEKPYTCKQCGKAFSVSSSLRRHETTHSAEKPYECKQCGKTFHHLGSFQIHMKRHTGD
                     RPHKCKICGKGFDRPSLVRYHERIHTGEKPYECKQCGKTLSHSSSFRRHMIMHTGGGP
                     HKCKICGKAFVYPSVCQRHEKSHSGEKPYECKQCGKALSHSSSFRRHMVMHTGDGPNK
                     CKVCGKAFVYPSVCQRHEKTHWRETI"
     exon            155..281
                     /gene="ZNF563"
                     /inference="alignment:Splign:2.1.0"
     exon            282..342
                     /gene="ZNF563"
                     /inference="alignment:Splign:2.1.0"
     exon            343..2699
                     /gene="ZNF563"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1634..1639
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF563"
                     /note="hexamer: AATAAA"
     regulatory      1660..1665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF563"
                     /note="hexamer: TATAAA"
     polyA_site      1671
                     /gene="ZNF563"
                     /note="major polyA site"
     polyA_site      1680
                     /gene="ZNF563"
ORIGIN      
        1 agtcgctcgc tgagagacgc cctggaacgt ctgtgtagcc tcagtcgctg agagacgccc
       61 tggaacgtct gtggcagcct ctgtcacagt gggacccgca ctggcagcgg gaggcagagg
      121 gaggaccctg gaacatcccg gaagccggga aatggacgca gtggcctttg aggatgtggc
      181 tgtgaacttc acccaggagg aatgggcttt gctgggtcca tcacagaaga atttatacag
      241 atatgtgatg caagaaacca tcaggaacct ggactgtata agaatgatat gggaagaaca
      301 gaatactgaa gatcagtaca aaaatcctag gagaaatcta agatgtcata tggtagagag
      361 attcagtgaa agtaaagaca gtagtcagtg tggagaaaca tttagcctca ttcgagatag
      421 tattgtgaac aacagcattt gtcctggaga agatccatgt caaagcgctg agtgtgaaga
      481 agtcataatg ggtcatttat cccttaatag ccacatcaga gttgattctg gacacaaacc
      541 acatgagtat caggaatatg gagagaagcc acatacacat aaacaacgtg ggaaagcctt
      601 cagttaccat cactcctttc agtcgcgtgg aaggcctcac actggaaaga aacgctatga
      661 gtgtaaggaa tgtggaaaaa ccttcagttc tcgtagaaac cttcgaagac acatggtagt
      721 gcaaggtgga aatagacctt ataaatgtaa gttgtgtggg aaagcttttt tttggcccag
      781 tttattacgt atgcatgaaa gaactcacac tggagagaaa ccgtatgaat gtaagcagtg
      841 ttctaaagcc tttccttttt acagttccta tcgaagacat gagagaatgc acactgggga
      901 gaaaccgtat gaatgtaagc agtgttctaa agccttgcct gattccagtt cctatataag
      961 acatgaaaga actcacactg gagagaaacc atatacatgt aaacagtgtg ggaaagcctt
     1021 cagtgtttcc agttcccttc gaagacatga aaccactcac agtgcagaga aaccctatga
     1081 gtgtaagcaa tgcgggaaaa catttcatca tcttggaagc tttcagatac acatgaaaag
     1141 gcacactgga gatcgacctc ataaatgtaa gatatgtggg aaaggctttg atcgtcccag
     1201 tttagttcga tatcatgaac gaattcacac tggagagaaa ccctatgaat gcaagcagtg
     1261 tgggaaaacg ttatctcata gctcaagctt tcgaagacac atgataatgc acactggagg
     1321 tggacctcat aaatgcaaga tatgtgggaa agcttttgtt tatcctagtg tatgtcaaag
     1381 acacgaaaag tctcacagtg gagagaaacc ctatgaatgc aagcagtgtg ggaaagcgtt
     1441 atctcatagc tcaagctttc gaagacatat ggtaatgcat acgggagatg ggccgaataa
     1501 atgcaaggta tgtgggaaag cctttgttta tcccagtgta tgtcaaagac atgaaaagac
     1561 tcactggaga gaaacaatat gaatgtaaac tattataaag ccttctatat ttccagttcc
     1621 ctttgatatc atgaataaac ttacactgga cagaaaccct ataaatgtaa atgtgggaaa
     1681 gcctttcata atttttattc ctttcaaaat catgaaatat ctcacactgg agagatgctg
     1741 tatgatataa ggaatgtggg aaagtgatcg attttttttt aacaccattg tcaacataaa
     1801 acaactcaca gagcagaaaa actctgtgag tgtaaaatat gtagggaagc cttcagtcat
     1861 tttggtaact taaaagtaca tgaggctggg cacagtggct cacgcctgta atcccagcac
     1921 ttagggtggg caaattgctt gacctcagga atttgaggcc tgcctgggca aaatggtgaa
     1981 accatgtctc tacaaaaaat agaaaaagta gcaggtgtgg tggtatgccc ctgtagtccc
     2041 agctacttgg gaggctgagg tgggaagatc tcttgagccc aaggggtggg ggttgcagtg
     2101 agccaagatg cactgcaccc cagcctgggc gacagagcca gaccctgtct caaaaaaaaa
     2161 aaaaaagtac atgaaaggat tcactctgga gagaagtcat atgaatgtaa gaaatgtaga
     2221 aaagcattga gttctctcag gtccttgcat agacataaaa ggactcactg gagagatact
     2281 ctataaatgt gtgaaatgta gggaagtatt ctttaatgtt atttcatttc agatagaaat
     2341 aattctcatt ggagataaac cctatgaatg taaacacata gtaaagcctt aattttaagc
     2401 ctcagtttct ttcaaataca gttatcccct aatatttgca ggagcgtggt tctaccaccc
     2461 cctgggcata cataaatcga cacatgccaa gtcctttttt aaaaatgaca tatttggtac
     2521 aaaattaccc ggatgtgatg gcacatgcct gtaatcccag ctactcagga ggctgaggca
     2581 ggataatcac ttgaatccgg gaggcggagg ttgcggtgag ccaagatcgc gccactgcac
     2641 tccagcctgg gcagcaagag caaaacaacc tctgtcacac acacaaaaaa aaaaaaaaa
//
