LOCUS       NM_001384659            3191 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ZNF559-ZNF177 readthrough (ZNF559-ZNF177), transcript
            variant 5, mRNA.
ACCESSION   NM_001384659
VERSION     NM_001384659.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3191)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3191)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   3  (bases 1 to 3191)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   4  (bases 1 to 3191)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3191)
  AUTHORS   Landry,J.R., Medstrand,P. and Mager,D.L.
  TITLE     Repetitive elements in the 5' untranslated region of a human
            zinc-finger gene modulate transcription and translation efficiency
  JOURNAL   Genomics 76 (1-3), 110-116 (2001)
   PUBMED   11549323
REFERENCE   6  (bases 1 to 3191)
  AUTHORS   Baban,S., Freeman,J.D. and Mager,D.L.
  TITLE     Transcripts from a novel human KRAB zinc finger gene contain
            spliced Alu and endogenous retroviral segments
  JOURNAL   Genomics 33 (3), 463-472 (1996)
   PUBMED   8661005
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011451.6.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring zinc finger protein 559
            (ZNF559) and zinc finger protein 177 (ZNF177) genes on chromosome
            19. Alternative splicing results in multiple transcript variants,
            which encode the ZNF177 protein due to either leaky scanning by
            ribosomes, or absence of the ZNF559 start codon. [provided by
            RefSeq, Jan 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR14372080.3079776.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968968, SAMEA2142853 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 7730, 84527
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AC011451.6         145665-145714       c
            51-136              AC011451.6         145113-145198       c
            137-358             AC011451.6         131876-132097       c
            359-447             AC011451.6         131311-131399       c
            448-574             AC011451.6         130574-130700       c
            575-657             AC011451.6         128709-128791       c
            658-744             AC011451.6         104945-105031       c
            745-852             AC011451.6         93470-93577         c
            853-938             AC011451.6         91549-91634         c
            939-1065            AC011451.6         90805-90931         c
            1066-1158           AC011451.6         90274-90366         c
            1159-1241           AC011451.6         89754-89836         c
            1242-3191           AC011451.6         87276-89225         c
FEATURES             Location/Qualifiers
     source          1..3191
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..3191
                     /gene="ZNF559-ZNF177"
                     /note="ZNF559-ZNF177 readthrough"
                     /db_xref="GeneID:100529215"
                     /db_xref="HGNC:HGNC:42964"
     exon            1..50
                     /gene="ZNF559-ZNF177"
                     /inference="alignment:Splign:2.1.0"
     exon            51..136
                     /gene="ZNF559-ZNF177"
                     /inference="alignment:Splign:2.1.0"
     exon            137..358
                     /gene="ZNF559-ZNF177"
                     /inference="alignment:Splign:2.1.0"
     exon            359..447
                     /gene="ZNF559-ZNF177"
                     /inference="alignment:Splign:2.1.0"
     exon            448..574
                     /gene="ZNF559-ZNF177"
                     /inference="alignment:Splign:2.1.0"
     exon            575..657
                     /gene="ZNF559-ZNF177"
                     /inference="alignment:Splign:2.1.0"
     exon            658..744
                     /gene="ZNF559-ZNF177"
                     /inference="alignment:Splign:2.1.0"
     exon            745..852
                     /gene="ZNF559-ZNF177"
                     /inference="alignment:Splign:2.1.0"
     exon            853..938
                     /gene="ZNF559-ZNF177"
                     /inference="alignment:Splign:2.1.0"
     CDS             906..2351
                     /gene="ZNF559-ZNF177"
                     /note="isoform a is encoded by transcript variant 5; zinc
                     finger protein 177"
                     /codon_start=1
                     /product="zinc finger protein 177 isoform a"
                     /protein_id="NP_001371588.1"
                     /db_xref="CCDS:CCDS54214.1"
                     /db_xref="GeneID:100529215"
                     /db_xref="HGNC:HGNC:42964"
                     /translation="MAAGWLTTWSQNSVTFQEVAVDFSQEEWALLDPAQKNLYKDVML
                     ENFRNLASVGYQLCRHSLISKVDQEQLKTDERGILQGDCADWETQLKPKDTIAMQNIP
                     GGKTSNGINTAENQPGEHSLECNHCGKFRKNTRFICTRYCKGEKCYKYIKYSKVFNHP
                     STLRSHVSIHIGEKTLEFTDCRKAFNQESSLRKHLRTPTGQKFQEYEQCDMSFSLHSS
                     CSVREQIPTGEKGDECSDYGKISPLSVHTKTGSVEEGLECNEHEKTFTDPLSLQNCVR
                     THSGEMPYECSDCGKAFIFQSSLKKHMRSHTGEKPYECDHCGKSFSQSSHLNVHKRTH
                     TGEKPYDCKECGKAFTVPSSLQKHVRTHTGEKPYECSDCGKAFIDQSSLKKHTRSHTG
                     EKPYECNQCGKSFSTGSYLIVHKRTHTGEKTYECKECGKAFRNSSCLRVHVRTHTGEK
                     PYKCIQCEKAFSTSTNLIMHKRIHNGQKLHE"
     exon            939..1065
                     /gene="ZNF559-ZNF177"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1158
                     /gene="ZNF559-ZNF177"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1241
                     /gene="ZNF559-ZNF177"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..3191
                     /gene="ZNF559-ZNF177"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2741..2746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF559-ZNF177"
                     /note="hexamer: AATAAA"
     polyA_site      2764
                     /gene="ZNF559-ZNF177"
                     /note="major polyA site"
     regulatory      3161..3166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF559-ZNF177"
                     /note="hexamer: AATAAA"
     polyA_site      3191
                     /gene="ZNF559-ZNF177"
ORIGIN      
        1 atgcgcataa cggccgccat cttaacagcg cgttcccgtt ggcgtctgag gaacagcatc
       61 tctgccttcc tgttcacggt gaccttcgct tggtgtcctc ctggcctcag caacctgaca
      121 attctgtcgt gtcccgagag atggctaatg aatggcgctt gatgacagat gagtaatgcc
      181 tgttgctgaa agattgacgg tatgaggcaa gactcccact actacttaat caagaggaat
      241 tgagattgac ttacccataa gttcagacag tgtctcgaag agactttggg aacaagatat
      301 tcaggcacat ttcactgtta gactcacagg atgctggcca ttggtctttc cctttgtgat
      361 catctttctc aagatgtttt ctgtcttcat gagtcaaaat ttgaagagga aaggatggtg
      421 gctgggtggt tgacaaatta ctctcaggac tcagtgacct ttgaggatgt ggctgtggac
      481 ttcacccagg aggagtggac tttgctggat caaactcaga gaaacttata cagagatgtg
      541 atgctggaga actataagaa tctagttgca gtagattggg agagtcatat taataccaaa
      601 tggtcagcac ctcagcagaa ttttttgcag gggaaaacat ccagtgtggt ggaaatgggc
      661 tgggtataag taagcaagaa gagggcctgg gagaagagtc tgacgagcaa ggggaaggta
      721 gccaaggatg gagtgaaata caggagatgc ggtcttgctg tgttgcctag gctggtctca
      781 aactcctgct ctcaagtgat cctcctgcct cagcctcctg agtacattta tatttaaagt
      841 aattattgat ggctctgcct gcttaggact ctgcccagcc aggaaggaaa cctacaggag
      901 gaagaatggc tgcagggtgg ctgacaacct ggtcacagaa ctcagtaacc ttccaggaag
      961 tggcagtgga cttttcccag gaggagtggg cattgctgga ccctgctcaa aaaaatctat
     1021 acaaagatgt gatgctggag aactttagga acctggcctc agtagggtat cagctctgca
     1081 gacacagtct gatctccaag gtggatcaag aacagctgaa gacagatgaa agaggaattt
     1141 tacaaggtga ctgtgcagac tgggaaactc aacttaaacc aaaagataca attgctatgc
     1201 agaacattcc tgggggaaaa acatccaatg gcataaacac ggcagaaaat caacctggtg
     1261 agcactccct ggagtgtaac cattgtggga aattcagaaa gaacactcgc tttatttgta
     1321 caagatattg caagggagag aaatgctata aatatataaa gtatagcaaa gtcttcaacc
     1381 atccctcaac tcttaggagt catgtgagca ttcacattgg agagaaaact cttgaattta
     1441 ctgattgtag aaaagctttc aatcaagagt catccctcag gaaacactta agaactccca
     1501 caggacagaa gtttcaggag tatgagcaat gtgatatgtc cttcagccta cactcttcct
     1561 gctcagtacg tgagcaaata cctactggag agaaaggtga tgaatgcagt gactatggca
     1621 aaatatctcc ccttagtgtc cacacaaaaa ctggtagtgt ggaggagggt ttggaatgta
     1681 atgaacatga gaaaactttc actgaccctt tgtcccttca gaactgtgtc agaactcact
     1741 ctggagagat gccctatgaa tgcagtgact gtgggaaagc cttcattttt cagtcttccc
     1801 ttaagaaaca catgagatct catactggag agaagcctta tgagtgtgat cactgtggaa
     1861 aatcctttag ccagagctct catctgaatg tgcacaaaag aactcacact ggagagaaac
     1921 cctatgactg taaggaatgt gggaaggctt tcactgttcc ttcatccctt cagaaacatg
     1981 tgagaaccca cactggagag aaaccctatg aatgcagtga ctgtggaaaa gccttcatcg
     2041 atcagtcatc ccttaagaaa cacacacgct ctcacactgg agagaagcct tatgagtgta
     2101 accagtgtgg aaagtccttc agcacaggct cttaccttat tgtgcacaag agaactcaca
     2161 ctggtgagaa aacctatgag tgtaaagaat gtgggaaggc ctttaggaat tcctcttgcc
     2221 tgagggtaca cgtgagaact cacactggag agaagcctta taaatgtatt cagtgtgaaa
     2281 aagcctttag cacaagcact aaccttataa tgcacaagcg aatccacaat ggccagaaac
     2341 tccatgaatg aaatgactca gggaagtgtt tgttgcccct catgcctcct ttctcacttt
     2401 agaacatata ttggagagaa gccctgttat ggtcacctgg aaacagcctt ctggcccaac
     2461 tctggatgcc tgttatactg ggacaaacct tataaatgtt atagctatga ttgtttttat
     2521 cagtgagtat ttcattctta tatgtgtcac aactgtagat cctatgaata ttttagttat
     2581 cttttcagtt taattgcatt gtgaacagaa cacatggtct tcaatatgta gattctgtgt
     2641 gacatagatt tgaacataat tgctggacac tgactgatgt actgtggcag acagaactag
     2701 ttgctgtctc aatatccatt cctcccttct ttcttaaagt aataaaattt accatttagt
     2761 tcaagctggc aatgtggaca gttttcaccc agcttccctt acagctgtga gcggccaaat
     2821 atgttcacat ccctagccca tgcaaagtag gcagaagtca ctggatacag ctgctaagga
     2881 agctcatgga aatgggaata tctcatctgg tgtttttttc ttaactattt gccctttgtc
     2941 ttgtccctta tttcctagaa aatatataca ccaagaggag gacagagaaa ggatactaaa
     3001 tgaaacaaca ggggagatac aatattatct ggttgcacta atcctgtgct gcttatctct
     3061 ggatttcatg ttacatgaga aaaattaact gccatgtggt ttaaaccact cttgtgggaa
     3121 gttcctcttt cagctgattt cagtcccaac tgttacatct aataaatggt caagttttag
     3181 gaatcgttca a
//
