LOCUS       NM_032497               4675 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 559 (ZNF559), transcript variant
            2, mRNA.
ACCESSION   NM_032497
VERSION     NM_032497.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4675)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4675)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF597362.1, AK298169.1, BU608632.1 and AC011451.6.
            
            On Aug 13, 2020 this sequence version replaced NM_032497.2.
            
            Transcript Variant: This variant (2) includes an additional exon in
            its 5' UTR and uses a downstream start codon, compared to variant
            1. The encoded isoform (b) is shorter at the N-terminus, compared
            to isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1499027.1,
                                           SRR11853565.14751.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000603380.6/ ENSP00000474760.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-571               CF597362.1         15-585
            572-2300            AK298169.1         270-1998
            2301-2649           BU608632.1         17-365              c
            2650-4675           AC011451.6         124022-126047       c
FEATURES             Location/Qualifiers
     source          1..4675
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..4675
                     /gene="ZNF559"
                     /gene_synonym="NBLA00121"
                     /note="zinc finger protein 559"
                     /db_xref="GeneID:84527"
                     /db_xref="HGNC:HGNC:28197"
     exon            1..50
                     /gene="ZNF559"
                     /gene_synonym="NBLA00121"
                     /inference="alignment:Splign:2.1.0"
     exon            51..136
                     /gene="ZNF559"
                     /gene_synonym="NBLA00121"
                     /inference="alignment:Splign:2.1.0"
     exon            137..199
                     /gene="ZNF559"
                     /gene_synonym="NBLA00121"
                     /inference="alignment:Splign:2.1.0"
     exon            200..288
                     /gene="ZNF559"
                     /gene_synonym="NBLA00121"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..1872
                     /gene="ZNF559"
                     /gene_synonym="NBLA00121"
                     /note="isoform b is encoded by transcript variant 2;
                     putative protein product of Nbla00121"
                     /codon_start=1
                     /product="zinc finger protein 559 isoform b"
                     /protein_id="NP_115886.1"
                     /db_xref="CCDS:CCDS12211.1"
                     /db_xref="GeneID:84527"
                     /db_xref="HGNC:HGNC:28197"
                     /translation="MVAGWLTNYSQDSVTFEDVAVDFTQEEWTLLDQTQRNLYRDVML
                     ENYKNLVAVDWESHINTKWSAPQQNFLQGKTSSVVEMERNHFGEELFDFNQCEKALSE
                     HSCLKTHRRTYFRKKTCECNQCEKAFRKPSIFTLHKKTDIGEELPNCNQCETAFSQHL
                     HLVCKKTSQNLHLVCKKTHTQEKPYKCSDCEKGLPSSSHLRECVRIYGGERPYTHKEY
                     VETFSHSTALFVHMQTQDGEKFYECKACGKPFTESSYLTQHLRTHSRVLPIEHKKFGK
                     AFAFSPDLAKHIRLRTRGKHYVCNECGKEFTCFSKLNIHIRVHTGEKPYECNKCGKAF
                     TDSSGLIKHRRTHTGEKPYECKECGKAFANSSHLTVHMRTHTGEKPYQCKECGKAFIN
                     SSSFKSHMQTHPGVKPYDCQQCGKAFIRSSFLIRHLRSHSAERPFECEECGKAFRYSS
                     HLSQHKRIHTGERPYKCQKCGQAFSISSGLTVHMRTHTGERPFECQECGKAFTRSTYL
                     IRHLRSHSVEKPYKECGQTFSNSSCLTECV"
     exon            289..415
                     /gene="ZNF559"
                     /gene_synonym="NBLA00121"
                     /inference="alignment:Splign:2.1.0"
     exon            416..498
                     /gene="ZNF559"
                     /gene_synonym="NBLA00121"
                     /inference="alignment:Splign:2.1.0"
     exon            499..4675
                     /gene="ZNF559"
                     /gene_synonym="NBLA00121"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2625..2630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF559"
                     /gene_synonym="NBLA00121"
                     /note="hexamer: AATAAA"
     polyA_site      2649
                     /gene="ZNF559"
                     /gene_synonym="NBLA00121"
                     /note="major polyA site"
     regulatory      4052..4057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF559"
                     /gene_synonym="NBLA00121"
                     /note="hexamer: ATTAAA"
     polyA_site      4094
                     /gene="ZNF559"
                     /gene_synonym="NBLA00121"
     regulatory      4647..4652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF559"
                     /gene_synonym="NBLA00121"
                     /note="hexamer: AATAAA"
     polyA_site      4675
                     /gene="ZNF559"
                     /gene_synonym="NBLA00121"
ORIGIN      
        1 atgcgcataa cggccgccat cttaacagcg cgttcccgtt ggcgtctgag gaacagcatc
       61 tctgccttcc tgttcacggt gaccttcgct tggtgtcctc ctggcctcag caacctgaca
      121 attctgtcgt gtcccgagag atggctaatg aatggcgctt gatgacagat gagtaatgcc
      181 tgttgctgaa agattgacga tcatctttct caagatgttt tctgtcttca tgagtcaaaa
      241 tttgaagagg aaaggatggt ggctgggtgg ttgacaaatt actctcagga ctcagtgacc
      301 tttgaggatg tggctgtgga cttcacccag gaggagtgga ctttgctgga tcaaactcag
      361 agaaacttat acagagatgt gatgctggag aactataaga atctagttgc agtagattgg
      421 gagagtcata ttaataccaa atggtcagca cctcagcaga attttttgca ggggaaaaca
      481 tccagtgtgg tggaaatgga gagaaaccat tttggagagg aactgtttga ctttaaccaa
      541 tgtgaaaaag ccttgagtga acactcatgc cttaagactc acaggagaac ttactttaga
      601 aagaaaacct gtgagtgtaa tcaatgtgaa aaagccttca gaaaaccctc tatctttact
      661 ttacacaaga aaactgatat cggagaggaa cttcctaact gtaatcaatg tgaaacagcc
      721 ttcagccaac atctacatct tgtttgcaag aaaactagcc aaaatctaca tcttgtttgc
      781 aagaaaactc acactcaaga gaaaccatat aaatgcagtg actgtgaaaa aggcttacct
      841 tcctcctcac acctcagaga atgtgtaaga atttatggtg gagagagacc atatactcat
      901 aaggagtatg tcgaaacctt ttctcattct acagcccttt ttgtacacat gcaaactcaa
      961 gatggagaaa aattctatga atgtaaagca tgtgggaaac ccttcactga gtcgtcatat
     1021 cttactcaac atttaagaac tcatagtaga gtgttaccta tagaacataa gaaatttggc
     1081 aaagcctttg ctttttcccc agatcttgct aaacatataa gacttagaac tagaggaaaa
     1141 cactatgttt gtaatgaatg tggcaaagaa tttacttgtt tctcaaaact caacattcac
     1201 ataagggttc acactggaga aaaaccgtat gagtgcaaca aatgtgggaa agccttcact
     1261 gattcatcag gtcttataaa acacaggcga actcacactg gagaaaagcc ttatgaatgt
     1321 aaggaatgtg ggaaagcttt tgctaactct tcacatctta ctgtacatat gagaactcac
     1381 actggtgaga agccttatca atgtaaggaa tgtggaaaag cctttattaa ttcctcttcc
     1441 tttaaaagtc acatgcagac tcatcctggt gtaaaaccct atgactgtca acagtgtggg
     1501 aaagccttca ttcgatcctc atttcttatt cgacatttga gaagtcacag tgcagaaagg
     1561 ccttttgaat gtgaggaatg tgggaaagcc tttagatact cctcgcacct tagtcaacat
     1621 aaaagaatac atacagggga gaggccatat aaatgtcaaa agtgtgggca agccttcagt
     1681 atctcatcag gccttacagt acacatgaga actcacactg gtgaacggcc ctttgaatgt
     1741 caggaatgtg ggaaagcctt tactcggtcc acatatctta ttcgacatct aagaagtcat
     1801 agtgtggaga aaccatataa ggaatgtggg caaaccttta gtaattcctc atgccttact
     1861 gaatgtgtgt gaattggggc tgatacttgg aaagaatgtg gtaaagccac tacttcctca
     1921 cacttactga acatgtactc attcatagtg gcaatgtaca cagtcataag gaatgtggga
     1981 agccttcctt ggtgtctcag atcttaacaa ttccaataga agagaagaca tatgaatgta
     2041 aggaatgtgg gaaaatcttg gctccttcca taggccttac tattcatgtg tctgtgcatc
     2101 ctaggaaaca aactgaacgt aggaaacctg tcgatgctta catcttactg agtctgtttg
     2161 aactcatgct ggagagaaat gctatgaatg tgaggaaggt ggaaaagctt tcattatttt
     2221 cctcgggcct tactgagctt gtgagcacat tggatataaa tgcacgtcct ctggctgtaa
     2281 ggaatgtgtt gaaacctttc actctgcctt ataccttaat attcagctgt gatctcacaa
     2341 gtgtgaaaaa tcttatgaat gtaaaatgtg tggagattct tctttgtttt tagcttccac
     2401 tttgggaaca tgtcaaagca cacattgaga agtcccatga gtgaaagaga tgttggaaag
     2461 cccttgaact tggtcgttag gaaacatcca cactgaagag gaacctgact gtatggaagg
     2521 tcaaaaaggc tgtattaatt tacatgcaaa aagtcacact agaggaatgc catatcagaa
     2581 tgcttttggt aaatatacat gttttaaaga ggttatatat cattaataaa aatatctagc
     2641 tggtctgaag atcctgagtt atctcaattg ttcacggtta cagatggaac tctttattat
     2701 tgaggagttc cactctttcc cccatttgtc actactacac ttccctagtc tttaaaacaa
     2761 ttttaggctg ggtgcagtgg ctcattcctg taatcccagc actttgaaag gccgaagcga
     2821 gtggatcatt tgaggtcagg agttcgagac cagcctggcc aacgtggtga aaccccatct
     2881 ctactaaaaa tacaaaaatt agccaggcat ggtggtacgt gcctgtaatc ccagctactc
     2941 gagaggttga ggcagaattg cttgaacccg ggaggcggaa gctgcagtga gctcagatca
     3001 cgccactgca ctccagcctg gatgatatgg taagaccatc tcaaaaaaag aaaaaaaaat
     3061 taaaatatcc tcagagggtt ttttaatgaa aaacttagtt atagggaatt gaggaacatt
     3121 taggggtaca aattttcact tattgcacac aagaaaattg gtactggcca ggcatgctgg
     3181 ctcacacctt aattccagca atttgggagg ccaaggcaga aggatcactt gagcccagga
     3241 gttcaagacc agcctgggca atatagtgaa acctcatctt gacaaagaat aaataagatt
     3301 aactgggtgt actggtttgt gcctatagtc ccagctattt aggaggctgg ggcaagagga
     3361 ttgcttgagc ctggtcaggg aggcagaggt tgcagtgagc cctgatcgtg ccactacact
     3421 ctagcctggg caacaggatg agaccctgtc tcaaaaaaaa aagaaaattg acgccagcaa
     3481 agaaaaccaa ataaattatt taagtttgcc tttctatatg tctttaaaga ctaatgatat
     3541 tgaacatcac tttcatatgc ttatgagtct ttggtgaagt gtacatttaa tgatcttttt
     3601 tcactgttgc tgagaatctt tggtttgaat tattgaggca ggttctttca gtaagtttga
     3661 gatataattg ccatgtaata aactgcacat gtttttagca tacactttaa gtttggacac
     3721 atacacatat gtgtacatac acaccatcaa gataatgaac atacctatca aaccagatgg
     3781 tttcctcatg cccttttata atttcttctt ctcctcaccc ttccctgcct gtcactctcc
     3841 tgatccactg atttgctttc tcttagaata gacgacttta tattatgtac agtttttata
     3901 taaatggaat catatagtct ggcatctttc aggataattt tttcagatcc atttatgttg
     3961 tagggtccat ttcactgctg aatagtattc cattgcaagg cataccacaa gctatttatc
     4021 catgtgttat ttctaccttt tggctattgc aattaaaact gccttgaata cccatatgca
     4081 gattattctt taaacatgtg cttctgtttc tttaaatagt taagagtgga atgatcagat
     4141 catatgttag tgtacgttta agtttttaag agactgctaa acctttctca agtagttatg
     4201 ccatttgaca tttccatgag cagtatataa gagttgcaat tcttctgcat ccttgccaat
     4261 tattggtatg gtcagtcttt tttattttga ccattttaat aggtgtgtag tagtatctca
     4321 tggttttaat ttgcatttcc ctagtgacta atgatgtctt acatggtttc acgtgcttac
     4381 tggccttctt taagcctttg gggaagagtc tgttcaaatc ttttgcctgt ttatattggc
     4441 tttatttttt atttattttt attttttttt atatagagac agggttttac tctgtctccc
     4501 aggctgaagt gcgtggcacg atcatgtggt tttgcaatat ttattgaatt ttgagagttt
     4561 aaaatttgta atatatttaa tattaaacct attagtgtat ttgatattaa tactttatat
     4621 ttaatataat gtacatttaa atatataata aaacatttca ttttaacaga ggtaa
//
