LOCUS       NM_024341               5759 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 557 (ZNF557), transcript variant
            1, mRNA.
ACCESSION   NM_024341
VERSION     NM_024341.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5759)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 5759)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5759)
  AUTHORS   Ozyildirim,A.M., Wistow,G.J., Gao,J., Wang,J., Dickinson,D.P.,
            Frierson,H.F. Jr. and Laurie,G.W.
  TITLE     The lacrimal gland transcriptome is an unusually rich source of
            rare and poorly characterized gene transcripts
  JOURNAL   Invest Ophthalmol Vis Sci 46 (5), 1572-1580 (2005)
   PUBMED   15851553
REFERENCE   4  (bases 1 to 5759)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD723611.1, BC003020.1 and AC010606.7.
            
            On Nov 23, 2018 this sequence version replaced NM_024341.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer protein (isoform a). Variants 1
            and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK297283.1, SRR1803615.257207.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252840.11/ ENSP00000252840.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-346               CD723611.1         244-589
            347-1369            BC003020.1         340-1362
            1370-5759           AC010606.7         37192-41581         c
FEATURES             Location/Qualifiers
     source          1..5759
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..5759
                     /gene="ZNF557"
                     /note="zinc finger protein 557"
                     /db_xref="GeneID:79230"
                     /db_xref="HGNC:HGNC:28632"
     exon            1..71
                     /gene="ZNF557"
                     /inference="alignment:Splign:2.1.0"
     exon            72..163
                     /gene="ZNF557"
                     /inference="alignment:Splign:2.1.0"
     exon            164..273
                     /gene="ZNF557"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1535
                     /gene="ZNF557"
                     /note="isoform a is encoded by transcript variant 1;
                     CTB-25J19.9"
                     /codon_start=1
                     /product="zinc finger protein 557 isoform a"
                     /protein_id="NP_077317.2"
                     /db_xref="CCDS:CCDS42485.1"
                     /db_xref="GeneID:79230"
                     /db_xref="HGNC:HGNC:28632"
                     /translation="MAAVVLPPTAALSSLFPASQREGHTEGGELVNELLKSWLKGLVT
                     FEDVAVEFTQEEWALLDPAQRTLYRDVMLENCRNLASLGNQVDKPRLISQLEQEDKVM
                     TEERGILSGTCPDVENPFKAKGLTPKLHVFRKEQSRNMKMERNHLGATLNECNQCFKV
                     FSTKSSLTRHRKIHTGERPYGCSECGKSYSSRSYLAVHKRIHNGEKPYECNDCGKTFS
                     SRSYLTVHKRIHNGEKPYECSDCGKTFSNSSYLRPHLRIHTGEKPYKCNQCFREFRTQ
                     SIFTRHKRVHTGEGHYVCNQCGKAFGTRSSLSSHYSIHTGEYPYECHDCGRTFRRRSN
                     LTQHIRTHTGEKPYTCNECGKSFTNSFSLTIHRRIHNGEKSYECSDCGKSFNVLSSVK
                     KHMRTHTGKKPYECNYCGKSFTSNSYLSVHTRMHNRQM"
     exon            274..362
                     /gene="ZNF557"
                     /inference="alignment:Splign:2.1.0"
     exon            363..489
                     /gene="ZNF557"
                     /inference="alignment:Splign:2.1.0"
     exon            490..585
                     /gene="ZNF557"
                     /inference="alignment:Splign:2.1.0"
     exon            586..668
                     /gene="ZNF557"
                     /inference="alignment:Splign:2.1.0"
     exon            669..5759
                     /gene="ZNF557"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5725..5730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF557"
                     /note="hexamer: ATTAAA"
     polyA_site      5759
                     /gene="ZNF557"
                     /note="major polyA site"
ORIGIN      
        1 gtcttgtgag aagagccgcg cttgcagcgt ctgggagaat ctttcggtct ccgcgagagg
       61 tgcttcattc cacgaaaaaa gtataattca agctcagatt tgtgttgaaa ccagcctcaa
      121 gtttcaccta tcctcactga tccgtggact tctgtatgat cagggtgctg tcctgagagc
      181 gctgcgggat aaaggaggag cgtcctgctt cccggctgcc ctgttgctgt cggagtcaca
      241 ggatggcggc tgtcgtcctg cccccaactg ccgctctgtc ttccctgttc ccagcctctc
      301 agcgagaagg acacacagag ggcggagagc tggttaatga gctcctgaaa agctggctaa
      361 agggcttggt gacctttgag gatgtggccg tggagttcac ccaggaggag tgggcattgc
      421 tggaccctgc ccaaaggaca ctgtacaggg acgtgatgct ggagaactgc aggaacctgg
      481 cctcactggg gaaccaagtt gataaaccta ggctgatctc ccagctggag caagaagata
      541 aagtgatgac agaagagaga ggaattctct caggtacctg tccagatgtg gagaatccat
      601 ttaaagccaa agggttaact cctaagctgc atgtttttcg aaaagaacaa tctagaaata
      661 tgaaaatgga gaggaatcat cttggagcaa cactcaacga atgtaatcag tgttttaaag
      721 tcttcagcac aaaatcttcc cttacacggc acaggaagat tcatactgga gaaagaccct
      781 atggctgcag tgaatgtggg aaatcctaca gcagtagatc ttaccttgct gttcataaga
      841 gaatccacaa tggggagaaa ccctatgaat gcaatgactg tgggaaaacc ttcagcagca
      901 gatcttacct tactgttcat aagagaatcc acaatgggga gaaaccctac gaatgcagtg
      961 actgtgggaa aaccttcagc aattcctcat acctcagacc gcacttgaga attcacactg
     1021 gagaaaaacc gtacaaatgt aaccagtgtt ttcgtgagtt ccgcactcag tcaatcttca
     1081 caaggcacaa gagagttcat acgggggagg gtcattatgt atgtaatcag tgtggaaagg
     1141 ctttcggcac gaggtcatct ctttcttcgc actatagcat tcatacaggg gagtaccctt
     1201 acgaatgcca cgattgtggg agaaccttca ggaggaggtc gaatctgaca cagcacataa
     1261 gaactcatac tggagaaaaa ccctacacat gtaatgagtg tgggaaatcc tttaccaata
     1321 gcttttctct tacaattcac aggagaatac ataatggaga gaaatcctat gagtgcagtg
     1381 attgtggaaa atcctttaat gttctctcat ccgttaagaa acacatgaga actcacactg
     1441 gaaaaaaacc ctatgaatgt aattattgcg ggaaatcctt cacaagtaac tcctaccttt
     1501 ctgtgcatac gagaatgcat aataggcaaa tgtgaattca ataactgtgg gaaaagcatt
     1561 cattgatctt tcatgcctca gataacatga gcaaactcta acaagatgta tgaatcacct
     1621 gctactgtgt aacaaattac cccccaaaat tttgtggctt caaacaaaaa cacttgttat
     1681 ctcaaaattt ttgtaggtca ggaattcaga aacaacatag ctctatagtt cttcaggata
     1741 tctcaagagg ttacagtcca gatgtcagca gaactgtaat catccagaat tgttactggt
     1801 gaagggacca cttccaaatg gcttacaagc ccgacaagtg catgctagct gtttccaagg
     1861 gagctgcgct tccaaatcac gtaggcctct caacagggct gagtttcttt atggaagcaa
     1921 cttctcccca aagccagtga tctaaaggag ccaacacaga aagcataatg tcttttatga
     1981 cctagcttca gtgagatatg ttttcatgtc cctgttacat tggtcataca caccaatcct
     2041 gatacaatgt ggaagaacac cacaggaggt atgaacagta gacatttgga accatctgga
     2101 aaacttgcca tgaaatcagt ggaggaaagc cttcagctga ccctcatttt ttttttttta
     2161 agacaatgtc tcactctgtc acccagtctg gagcgcagtg gtgtgatcac agctcactgc
     2221 agcctctact tcctgggatc aagtaattct cctgccccag cctccaatgt agctgggact
     2281 acaggtgcat gacaccatgt ctggctaatt tgtttttttt taaactagag ggagggtttt
     2341 gccatgttgc ccagactagt ctcaaactcc taggttcaag cagtcctttc atcttggcct
     2401 ccagaagtac tgggattaca ggcatgaacc accatgccca gccaacttct aaactgatca
     2461 atatgggagt agcattcaat cacccacagg ttaactcact ctagagagaa atcttgtgag
     2521 tgtaatctgt atggtaaaac tttgagctca aactttcccc ctaccaaaaa aaaagtatct
     2581 actggggagc tgcccaggta atgcagtagc tgtaggaaag ccttcagtga tggcttcagg
     2641 gagtcacatg acaactcaca ataaggggaa accctgtgtg tggcatcaaa aatggaaaac
     2701 caggggacac tcattcctta agtcacattt cggagatcat acaacagagg aatatgttga
     2761 gtatacacag tgttgaaaag cctgtgacac aaacagtcat attaccaagc acaagacagt
     2821 atagtttggt atgctataaa agccttgaat attctctcca tttttaagaa gtgagattca
     2881 tactagaaaa accattgaat tccatcagta ttagaatgtc atttttccac atttttagga
     2941 acctaactca gtgtaagata acaatttata caatttattt tttgagacag ggtttcatct
     3001 gtgcccaggc tgtagtgcag tggtgcaatc ttggcttatt gtaacctctg cctcccaggc
     3061 ttaagggatc ctcccacctc agcctcccaa gtagctggga ctgtaggcat gcaccaccat
     3121 gcctgtctag tttttgtaaa gatggggatt caccatgttt cccaggctgc tctcaaactc
     3181 ctgggctcaa gtgatccacc tgcctcagcc tcccaaaatg ctgggaatac aggaacgagc
     3241 taccactctc agccagaact tcttaagata aaggatgagg gaatgttttc agtgatacct
     3301 cttatattag gaaaaatatg taaatgttcc ttggatgcaa tactcacgag tgtattaatt
     3361 tcagaaaaat tttcagtgat tcctcccttt atgcatgaga gaattcattt agaggaagcc
     3421 ctaggaacgt aatcaatgtt aggatgcctc atctcttaac tgagtggcca cgcagtaact
     3481 tagaacaaaa ggtgtaagtg ctatgaatgt ggaattacct tcatcaatgt ctcatttgta
     3541 ggttgggcca ctagctcgtt cattttcagt cttttaatat aaacatttat ggctatagtg
     3601 gtcctgaaaa tcttactacc tcgttttata tacagtgtat ttattataat tctaaaacat
     3661 caatacacca aatattcaga aaggtatttc caaacagctc ctgagtgatc tagtttgtta
     3721 taatagaaat tagacatttg ccaggtgtgg tggctcacac ctataaacct agcattttgg
     3781 gaggctgagg cgggcagatc accggaggta aggagcttga gaccagcctg gccaacatgg
     3841 tgaaaccccg cttctactaa aaaatacaaa aattagccgg gtgtggtggc aggcatctat
     3901 aatcccagct actcaagagg ctgaggaagg agaatcactt gaacccggga aatggaggtt
     3961 gcagtgagcc aagatcatgc cacttcactc cagcctgggc aaaagagtgc aactctgtct
     4021 caaaaaaaaa aaaatcagac aatatttgat atattttttt ctaatttaat agtattttgc
     4081 cagagtacat ggactttgtg attttggttg ttttctcttt gtgtcctaat atagcaaata
     4141 ctgtttcttt tttttttttt tttttttttt gagacggagt cttgctctgt tgtccaggct
     4201 agaatgcagt ggcgcgattg tggctcactg caagctctgc ctcccagatt cacgccatcc
     4261 tcctgcctca gcctcccgag tagctgggac tacaggtgcc catcaccatg cccggctaat
     4321 ttttcatatt tttagtagaa atggggtttc actgtgttag ccagtatggt ctcaatctcc
     4381 tgacctcgtg atccacctgc ctcggcctcc caaagcactg ggattacagg cgtgagccac
     4441 catgcccggc acaaatactg tttcttaatg ttcattctcc ctacttaaag aaaaagataa
     4501 gttgtcaatg agcagtattg aaaatgtaca gtggggccag gcgccatggc tcatgcctgt
     4561 aatcccagca ctttgggagg ccgaggcagg cggaccacct gaggtcagga gttcaagact
     4621 agcttggcca acgtggtgaa acctcgtctc tactaaaaaa aatacaaaaa ttagctgggc
     4681 gtgatgacag gtgcctgtaa tcccagctac ttgggaggct gaggcaggag aatcgcttga
     4741 gcctgggaag cggaggttgc agtgagccga gattgcacaa ccacactcca gcttgggcga
     4801 cagagtgaga ctccatctca aaaaaagatg tacagtgtac taggctttcc tgaagcttag
     4861 acaggcttta tcccactctg ctggctaaaa gaagtaggaa taacgcactg ggtgagacac
     4921 cgtctggctt attctcatct attttctttt cattcttttg gaaagtggac acaaagcata
     4981 gagttaaaag agcttttttt tttttttttt tttttttctt cactgtggtg ataaaaacca
     5041 cagtgcaggg gctgggcgtg gtggctcacg cctgtaatcc caccactttg ggaggccaag
     5101 gcaggcggat cacctgaggt ggggagttcg agaccagcct gatcaacatg gagaaaacct
     5161 gtctctccta aaaatacaaa attaaccgag catgttggcg catgcctgta atctcagcta
     5221 cttggaaggc tgaggcagga gaattgcttc aaactgggca gaggttgcag tgagccaagg
     5281 ttgacccact gcactccagc ctgggcaaca agagcaaaac tccatctcaa aaaaaaaaaa
     5341 aaagaaagaa acagtgccga aaaatcacaa tgatttgagt tcttcaaaaa cctttgattg
     5401 gctgcattgg ctctgttctg catattacta gacttcttac atgatcacaa gtaaccacta
     5461 attggttaaa accaaagaga gagagagaga gagtgtgtgt gtgtgtgtgt gtgtttggtt
     5521 ggggggtgtt gtgttagctt ccaggtgaat gcattatctg ttaatcctgt ttattgatct
     5581 gtttttataa gtgctccatg attctctgaa aacagtatac tatgtatcta atttttggat
     5641 acaggatgga catacgtact caaactgtgt ttttcaattt gtactgtatt tgtttctctc
     5701 gacctgactt agtgatagag gtatattaaa gtcttccact agcatggtag attaacaaa
//
