LOCUS       NM_152791               8504 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 555 (ZNF555), transcript variant
            1, mRNA.
ACCESSION   NM_152791
VERSION     NM_152791.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8504)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8504)
  AUTHORS   Kim,E., Rich,J., Karoutas,A., Tarlykov,P., Cochet,E., Malysheva,D.,
            Mamchaoui,K., Ogryzko,V. and Pirozhkova,I.
  TITLE     ZNF555 protein binds to transcriptional activator site of 4qA
            allele and ANT1: potential implication in Facioscapulohumeral
            dystrophy
  JOURNAL   Nucleic Acids Res 43 (17), 8227-8242 (2015)
   PUBMED   26184877
  REMARK    GeneRIF: Identification of ZNF555 as a putative transcriptional
            factor highly expressed in human primary myoblasts that interacts
            with the beta-satellite repeats enhancer site and impacts the ANT1
            promoter activity in facioscapulohumeral dystrophy myoblasts.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006130.2.
            
            On Nov 23, 2018 this sequence version replaced NM_152791.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.237165.1, AL832140.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334241.9/ ENSP00000334853.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AC006130.2         21133-21233
            102-228             AC006130.2         30245-30371
            229-412             AC006130.2         31126-31309
            413-8504            AC006130.2         32038-40129
FEATURES             Location/Qualifiers
     source          1..8504
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..8504
                     /gene="ZNF555"
                     /note="zinc finger protein 555"
                     /db_xref="GeneID:148254"
                     /db_xref="HGNC:HGNC:28382"
     exon            1..101
                     /gene="ZNF555"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1985
                     /gene="ZNF555"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 555 isoform 1"
                     /protein_id="NP_690004.4"
                     /db_xref="CCDS:CCDS12096.1"
                     /db_xref="GeneID:148254"
                     /db_xref="HGNC:HGNC:28382"
                     /translation="MDSVVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVD
                     DETQFKASGSVSQQDIYGEKIPKESKIATFTRNVSWASVLGKIWDSLSIEDQTTNQGR
                     NLSRNHGLERLCESNDQCGEALSQIPHLNLYKKIPPGVKQYEYNTYGKVFMHRRTSLK
                     SPITVHTGHKPYQCQECGQAYSCRSHLRMHVRTHNGERPYVCKLCGKTFPRTSSLNRH
                     VRIHTAEKTYECKQCGKAFIDFSSLTSHLRSHTGEKPYKCKECGKAFSYSSTFRRHTI
                     THTGEKPYKCKECAEAFSYSSTFRRHMISHTGEKPHKCKECGEAFSYSSAFRRHMITH
                     TGEKPYECKQCGKTFIYLQSFRRHERIHTGEKPYECKQCGKTFIYPQSFRRHERTHGG
                     EKPYECNQCGKAFSHPSSFRGHMRVHTGEKPYECKQCGKTFNWPISLRKHMRTHTREK
                     PYECKQCGKAFSLSACFREHVRMHPEDKSYECKLCGKAFYCHISLQKHMRRHTAEKLY
                     KCKQCGKAFSWPELLQQHVRTHTVEKPYECKECGKVFKWPSSLPIHMRLHTGEKPYQC
                     KHCGKAFNCSSSLRRHVRIHTTEKQYKCNVGHPPANEFMCSASEKSHQERDLIKVVNM
                     VLPL"
     exon            102..228
                     /gene="ZNF555"
                     /inference="alignment:Splign:2.1.0"
     exon            229..412
                     /gene="ZNF555"
                     /inference="alignment:Splign:2.1.0"
     exon            413..8504
                     /gene="ZNF555"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2039..2044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF555"
                     /note="hexamer: AATAAA"
     polyA_site      2062
                     /gene="ZNF555"
                     /note="major polyA site"
     regulatory      2125..2130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF555"
                     /note="hexamer: AATAAA"
     polyA_site      2158
                     /gene="ZNF555"
     regulatory      3257..3262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF555"
                     /note="hexamer: AATAAT"
     polyA_site      3284
                     /gene="ZNF555"
     regulatory      5695..5700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF555"
                     /note="hexamer: AATAAA"
     regulatory      5715..5720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF555"
                     /note="hexamer: ATTAAA"
     polyA_site      5728
                     /gene="ZNF555"
     polyA_site      5735
                     /gene="ZNF555"
     regulatory      8484..8489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF555"
                     /note="hexamer: ATTAAA"
     polyA_site      8504
                     /gene="ZNF555"
ORIGIN      
        1 gtcctagccg tgagtgcccc gcctgcccct agcggtccct ggcgtcccgg ttcctgtcgc
       61 gctcacctgc gccggtagcg aagaaatcgc cccgggacat ggactcagtg gtctttgagg
      121 atgtggctgt ggacttcacc ctggaggagt gggctttgct ggattctgct cagagggacc
      181 tctacagaga tgtgatgctg gagacctttc agaacctggc ctcagtagat gatgaaactc
      241 aatttaaggc cagtgggtca gtttctcagc aggatattta tggagagaaa atacccaagg
      301 aatctaaaat agccacgttc accagaaatg tttcctgggc ctctgtttta ggaaaaattt
      361 gggacagtct tagcatcgaa gatcaaacca caaaccaggg gagaaatctc agtagaaatc
      421 atgggttgga gagactctgt gaaagtaatg atcaatgtgg agaagccctc agccagattc
      481 cacatcttaa tctgtacaag aaaattccac ctggagtaaa acagtatgaa tacaacacgt
      541 acggaaaagt cttcatgcat cgccgcacat ccctcaagag tcccatcaca gttcacactg
      601 gacacaaacc atatcagtgc caggaatgtg ggcaggccta cagttgtcgt tcacacctaa
      661 gaatgcatgt gagaacccac aatggagaga gaccctatgt gtgtaaatta tgtgggaaaa
      721 cctttcctcg tacttcctcc ctcaatcggc atgtaaggat tcacactgct gagaaaacct
      781 acgaatgtaa gcaatgtggg aaagccttta ttgacttctc aagtcttact agtcatctca
      841 gaagtcacac cggagagaag ccatataagt gtaaggaatg tgggaaagct ttcagttatt
      901 cctcaacgtt tcgaagacac acaataacac acactggcga gaagccatat aaatgtaagg
      961 aatgtgcgga agcctttagt tattcctcaa cttttcgaag acatatgatt tcacacactg
     1021 gagagaagcc acataaatgt aaagaatgtg gggaggcctt cagttattct tcggcttttc
     1081 gaagacacat gataacacac actggagaga aaccctacga atgcaaacaa tgtgggaaaa
     1141 ccttcattta tctccagtcc tttcgaagac atgaaaggat tcacactgga gagaaaccct
     1201 acgaatgcaa acagtgtggg aagaccttca tttatcccca gtcctttcga agacatgaaa
     1261 ggactcatgg tggagagaaa ccctatgaat gcaaccagtg cgggaaagca ttcagtcacc
     1321 cctcctcctt tcgaggacac atgagggtgc acactggaga gaaaccctat gagtgcaagc
     1381 aatgtgggaa aactttcaat tggcccatat ctttacgaaa acatatgaga acacatacta
     1441 gagagaaacc ctatgaatgt aagcagtgtg ggaaagcctt cagcttgtct gcttgctttc
     1501 gagaacatgt gagaatgcac cctgaagaca aatcctatga atgcaagcta tgtgggaaag
     1561 ctttctattg ccacatatcc ttacaaaaac atatgagaag acataccgca gagaaactct
     1621 ataaatgcaa gcagtgtggg aaagctttca gttggcctga acttttgcaa caacatgtga
     1681 gaacgcacac tgtagagaag ccctatgaat gtaaggaatg tgggaaggtc ttcaaatggc
     1741 catcatcttt accaatacat atgagactgc acactggaga gaaaccttat caatgtaagc
     1801 attgtgggaa agcattcaat tgttcctcat ccttaaggcg acatgtgaga atacacacta
     1861 cagaaaaaca gtataagtgt aatgtaggac atcctcctgc aaatgaattc atgtgcagtg
     1921 cttcagaaaa gtcacaccag gagagagatc tgatcaaagt tgtaaatatg gtgttgcctt
     1981 tatgagttcc ttatcctgaa agtggacact caaggagtgt gtctgtagtt catttgcaaa
     2041 taaacattta gttgaaaaat aattctccaa atactctcag ctatcctaca tgaatttgaa
     2101 caggtagttt cttacgattc agtaaataaa actttcatct tagagtgttt tggactcatg
     2161 gatgatttga agtgtatttt taatatgcaa gtaggttcaa gttttattta atttcttaaa
     2221 ttgtaactga cttagtgtga caggtattgg atattacgta tctattatat tttccacctt
     2281 ttttactggg agtattttta ttgtttggcc agaggagcct tattccattt tttaagaagt
     2341 agttggcaga attttgtaat tatgcaaagt tgtttaagga gtatagcctc aaatgaattg
     2401 taatttttaa tgtttgccca ttgctgtttg tctttgcttg tgattgtgaa ttggacagta
     2461 ggctttgact tgtgatgtga cggagaaatc cagagttgca gatagttctt ctgcattgtt
     2521 gtcagtgtgg gtagtgttag gaacttcatt tgctggaatg catttccttt atggttccat
     2581 gtccaaattt accaatagca ataacttgaa tgaaatttag aatgaagaag aagtaagtca
     2641 tcgctgagct tttggggtca cattaaatgg agatggacag atgcataggg gctttgtgaa
     2701 catcaacctt cagcttattt tccagattct tattcctgcc aatcaagagt accatcaaaa
     2761 gaaacactta agtgcttgat ttccactgtg tcagaggtgt agtcttcctc agacatctcc
     2821 attaacttga tattagggat attcctgtgt ggtcagtcac ctagagtctg gatttttctc
     2881 aaaaccctgc atgacctctt gaccactgat tcagactgtc ttgtttggca gtctctgagc
     2941 ttctgattct cccgttctgt agatcttaac atatttgcat ggggtctaat ttatatagtg
     3001 aacaccttgt tatcttaata cttccagtgg ctctgtgatc ctgattccac cacgaaagcc
     3061 acagtgttgc agtcaaagaa gaaaaacaac acatgggact ttgtacccta ttgcattttt
     3121 aagtgtgcct gccgagtcct atgtgagaac aaataccttc ctcatatatt agatttaggg
     3181 agatttctgt tactcagaac taaatgcagt ttcttgatat aggttaaatt attaggtttg
     3241 attatgtatc attaaaaata atgtggattt tgtttcaagg aaaaccttct gtagatattt
     3301 cttagaaata tcctgtttag ctgggcacag tagctcatgc ctgtaatccc tgcactttgg
     3361 gaggcttgag gtcaggagtt tgagaccagc ctggttaaca tggtgaaacc ctgtctctac
     3421 taaaaacaca aaaattagcc aggcatggtg gtgagtacct gtaaccccag ctacttggga
     3481 ggctgagaca ggagaagtgc ttgaacctag gaggcggagg ttgcagtgag ccaagatcac
     3541 accactgcac tccagcctgg gagacgggga aagactccat cacacaagca agaaaagaaa
     3601 aaaaaatcct atttactgtg ctttcaaatt agttgtttag agactatatt aatttcccag
     3661 ggctgccata acaaagtaca aaaactgggt gacataggaa aacaaacttt ttgtttctca
     3721 gttctggacc cagaaatcca gaaacaaggc attggcagga ccatgctttt tctgaagatg
     3781 ctagggaagg atctgtttca gaactcacct agcttctggt agttccttag cttgtggcag
     3841 cataactcta attttcacat ggcattctcc ctgtgtgtgt gtctctccat gtgacaatat
     3901 ttttatacat acacaccact cattgggtta ggccccactc tacttcagta tgattttacc
     3961 ttaactaatt acattggcaa cagctctctt ttcgcatact gaggcaccgc gaattaagat
     4021 ttcaacgtaa aaattttagg agacccaatt caacccataa cactaagaaa tgttattttt
     4081 tgtttaccga gagaattaca gatttcaaat caactttgta attttgataa tttaagcatg
     4141 ttacattttg aatcagtatt accaagtata tacaaataca ggtatttttt catataaatg
     4201 ttatttttaa ttgctgtata cttaacattt gccattaaaa tgattttttt tttttgagac
     4261 agagtctcgc tctgtcaccc aggctggagt gcagtggcac gaccttagct cactgcaacc
     4321 ttcatctccc aggttcagtt gattctcctg cctcagcctc ccgagtagtt gggattacag
     4381 gcatgcacca ccacacccag ctaatttttt tatttttggt agagatgggg tttcaccatg
     4441 ttggccaggc tggtcttgaa ctcctgacct caggtgatct gcccaccttg gcctcccaaa
     4501 gtgttgggat tacaggcatg agccaccaca cccggcctaa aatgatttct tatttgtggt
     4561 taataacaat taaaaagcgg aaataatggt tttgtcaagg ccctctaccc agaaaccacc
     4621 aggatcacac tggtagtcaa agaaaatttg ctgtgttgag ttgaagtttg aacacatgat
     4681 caagaaaggg ctgtggcttg tatcagaggg tgtttaaaag gatttactat cagatttggc
     4741 cttgtgttct gtgattttgg tgagcgttca aggaagccag gctttggtct ggattggatg
     4801 ttctcaggtc atgaatataa ttctctggga actcccaaag ttctcatcta caaagcagaa
     4861 gttaattgga gctgaaaact aatcagtaaa gccacagcag ccagtcatat gggggagaag
     4921 aggggaatgt ttgatggttt ttgtggttta gaggtgagtt ccggaaaaaa agaagacatg
     4981 tttgacatcc tcaaacgaga aaatttttca tgtgttttat aggccaagga ggcagaagct
     5041 tttgttttaa tgagccagaa agccccaaaa gcctatttaa gttttctcag gtatcatttc
     5101 aacctctgaa cttccagaat taactaggga agaggaaaaa catgtaacac cttagagttt
     5161 tattaaagag caaacaatat ccagtaatct ccattacttt ccatgttaac ataagttttc
     5221 ataacgctct atagatgaat gtgatttggc agtcacttgt atttcttaac acccacttac
     5281 ccatcattcc ctcttagatg aaaaaagtta agcacgggga caacagagtc ttgtatattc
     5341 atgtagctca tgatgatgga atcaagtttg aaggcttaac ctgtgcttaa cctatattgg
     5401 gcattgtcaa gacttaaatt tagaacactg gaaagcaagt ataattaatt ttacaaatag
     5461 ggcatcaaat tttacaaaga ctcctaaggc tatatggtat tccttttata agacatggaa
     5521 aaggcaaaga taagggaaac gaacaaatcg ctggttagaa gtaggggatt tgagtacata
     5581 tgggcttaag agtgttctgt catgattgta gtggtgaaaa caagcatttg caaaaactca
     5641 taaggctact cttaaaatag caaattttgt tgtatgtata ttttaaagtt aaacaataaa
     5701 aatgctttca gtttattaaa gaactcaaga ccaggtgcag tggctcatgc ctataatccc
     5761 agcactttgg gaagctgagg cgggaggatt gcttgtggcc aggaggttga ggctgcagtg
     5821 aactatgatc atgcactgca ctctacactg ggcgacagag caagaccctg tctcaaaaaa
     5881 aaaggaatac aaaacattcc tgaaacttga catgtaagtt cgcaataaga cttttcccta
     5941 gctgggcgcg gtgactcatg cctgtaatct caacattttg ggagactgag gcaagaggat
     6001 cacttgaagt caggagctag acaccagtct gggcaacata gcgagacctc aactctacca
     6061 aaaaattaaa aagtgagcca ggcggggtgg tgcacgtctg tggtcccagc tacttggcag
     6121 gctgaagcag gaggatcact tgaggccttg aggagccatg atcgtgccac tgcactccag
     6181 cttgggtgac agagcaagac tgtctcaaaa aataaaaata aaaaaacaag acttccccca
     6241 ccatcttgga attctctgga ggaaatgtag ggctggttga caaggacttg tgcctcgtca
     6301 gaccctgttt gaaacccagt ctgaagtttt gaaacaccca caagggccat acctgacttt
     6361 atctcacgca cataacagga gagaagaagg aggtcttcca gaatctgtct ttgagtttac
     6421 accaggttct tcccatctga tctttgggaa tgctgtggtt ctgaaacata aaacggggac
     6481 cctacacttc ttcccaggaa tatcctgcct gggagcatcc tgatcctgtc ttcagacaag
     6541 gggcatccgc atcttgtttt ctagggcctt tcctgaggcc acttccagct ccaaagttct
     6601 catctcaagc tcagctctgt gtcttcatgc tgggaaacgt ctttatggat ccccaaactc
     6661 ctcttgctgt tgggaacacg tggcagccct gcgttgtgag gtgagagaag aggcagtggc
     6721 agaacccatg ccatggagac acgcccatca gccacagcag ctcctgctac tgcataaatc
     6781 cataggcaca atcacacgcc tcacggtgtc aacatctccc atgacatcac aaagatgccc
     6841 agctgggacc cacctacagt gatggggtga tggggtttca cctataagcg ggcaaacagg
     6901 cactcctcct cactgtccag tcacctgacg tgctttttct gcgcactcag gtcgtgacac
     6961 cccaggaggt gcctatcgcg ccccaagctc ctcacgtgcc tcctccccac agtccaggac
     7021 gcgtcttact aacgcctcac cagagcgcat gcgccctcct caggagcagc ctcaaagcgc
     7081 gcagcctcag cccattggcc tgcgggaagt ggagttcccg aacagaagcc cctcagtctc
     7141 cggaagcccc gcccggcaga ctgttcccag gatgcaacac gggctcgcgt ctaaaagagc
     7201 tgtgctttgt tggggctatc tgggagtttc cgccttccat gaagtgcgca ggcgcactta
     7261 ggcgaggcgg ggcgactcta ggaagtggag acatcaagag tggtactgga agtggcggaa
     7321 gctctcctct tgccctcttc agcttccggt gtggtgggtc ccggatatcg cgtggctgtg
     7381 gcaggtagac agcccgtgct ccagaggcct tcatcttgtg atggcagatg tacttgagta
     7441 gacacgacag acggggaagg accctgatgg tccgagggac cttccacagc aagtagaagg
     7501 cactgctgtg aatatgatgg cgtcagaggt gactgcaaaa aaggacaggg cagctgggcg
     7561 aggaagagat accagtgatg tcctaactga gctccctggg tctggtagtg aggagctcag
     7621 tcttagaata tgagccgtgt caggggctac agcatcatca ctcttgtcct gtcgcagact
     7681 caggctccct gttctcaggt tcttatgtag acagtgaggg ctcagggagg ctcccaccac
     7741 caccaccacc agcaccacca ctccatcaaa acggctgaag gaccttcctt tagggttcgg
     7801 gggatctcct ccttccacaa gggatggatg tgaagacaac tcattctttg atgttcagat
     7861 ggttgtggcc ctctgatgag atgtgtgcac accttgccaa atgcatatgt ctgttgagcc
     7921 tggacattaa gtatttcttg atgttcttct gtgtaacagg tgatgtccta ggtgctgcag
     7981 tgaacagaag agacaaaata tccttgttcc cttgaagcta atgtcgtagg ggcccaaaac
     8041 aaagcaaaca aacaaaaaaa aggaatgcaa gtcaagtaca ctttgtatgg acagtggtaa
     8101 ttcctaagaa ggaaaacaaa gatggactta aggggtgcag agggcctgga ctatgtgtgt
     8161 ctgtgggata gtctgttact acctctggga ctctcatctc ttgagtgtgc ttgggtgtgt
     8221 ccaaccgttt ttcctagtga caaagtctgg gtaattctgt ggggacatat attggtgtat
     8281 ctgggaggtc ccatgtgtct cagtggtggt ccctgttttc aggaaagagt gtctgtgaat
     8341 gtccatgtgt ctcactgcac agctgtgatt tttctgtgtc tctgtgtttt ccagtctttg
     8401 tgtgatgaaa tataaaggcc tagcaggctc agagttatta atgaattgta cttaagcgtt
     8461 gagaggcata tatttattgc actattaaat tcttccaaaa tata
//
