LOCUS       NM_001172775            8501 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens zinc finger protein 555 (ZNF555), transcript variant
            2, mRNA.
ACCESSION   NM_001172775
VERSION     NM_001172775.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8501)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8501)
  AUTHORS   Kim,E., Rich,J., Karoutas,A., Tarlykov,P., Cochet,E., Malysheva,D.,
            Mamchaoui,K., Ogryzko,V. and Pirozhkova,I.
  TITLE     ZNF555 protein binds to transcriptional activator site of 4qA
            allele and ANT1: potential implication in Facioscapulohumeral
            dystrophy
  JOURNAL   Nucleic Acids Res 43 (17), 8227-8242 (2015)
   PUBMED   26184877
  REMARK    GeneRIF: Identification of ZNF555 as a putative transcriptional
            factor highly expressed in human primary myoblasts that interacts
            with the beta-satellite repeats enhancer site and impacts the ANT1
            promoter activity in facioscapulohumeral dystrophy myoblasts.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006130.2.
            
            On May 31, 2019 this sequence version replaced NM_001172775.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site, compared to variant 1. The resulting isoform (2) lacks
            one internal amino acid, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.183694.1,
                                           SRR1803611.114148.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AC006130.2         21133-21233
            102-228             AC006130.2         30245-30371
            229-412             AC006130.2         31126-31309
            413-8501            AC006130.2         32041-40129
FEATURES             Location/Qualifiers
     source          1..8501
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..8501
                     /gene="ZNF555"
                     /note="zinc finger protein 555"
                     /db_xref="GeneID:148254"
                     /db_xref="HGNC:HGNC:28382"
     exon            1..101
                     /gene="ZNF555"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1982
                     /gene="ZNF555"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 555 isoform 2"
                     /protein_id="NP_001166246.1"
                     /db_xref="CCDS:CCDS59329.1"
                     /db_xref="GeneID:148254"
                     /db_xref="HGNC:HGNC:28382"
                     /translation="MDSVVFEDVAVDFTLEEWALLDSAQRDLYRDVMLETFQNLASVD
                     DETQFKASGSVSQQDIYGEKIPKESKIATFTRNVSWASVLGKIWDSLSIEDQTTNQGR
                     NLRNHGLERLCESNDQCGEALSQIPHLNLYKKIPPGVKQYEYNTYGKVFMHRRTSLKS
                     PITVHTGHKPYQCQECGQAYSCRSHLRMHVRTHNGERPYVCKLCGKTFPRTSSLNRHV
                     RIHTAEKTYECKQCGKAFIDFSSLTSHLRSHTGEKPYKCKECGKAFSYSSTFRRHTIT
                     HTGEKPYKCKECAEAFSYSSTFRRHMISHTGEKPHKCKECGEAFSYSSAFRRHMITHT
                     GEKPYECKQCGKTFIYLQSFRRHERIHTGEKPYECKQCGKTFIYPQSFRRHERTHGGE
                     KPYECNQCGKAFSHPSSFRGHMRVHTGEKPYECKQCGKTFNWPISLRKHMRTHTREKP
                     YECKQCGKAFSLSACFREHVRMHPEDKSYECKLCGKAFYCHISLQKHMRRHTAEKLYK
                     CKQCGKAFSWPELLQQHVRTHTVEKPYECKECGKVFKWPSSLPIHMRLHTGEKPYQCK
                     HCGKAFNCSSSLRRHVRIHTTEKQYKCNVGHPPANEFMCSASEKSHQERDLIKVVNMV
                     LPL"
     exon            102..228
                     /gene="ZNF555"
                     /inference="alignment:Splign:2.1.0"
     exon            229..412
                     /gene="ZNF555"
                     /inference="alignment:Splign:2.1.0"
     exon            413..8501
                     /gene="ZNF555"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2036..2041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF555"
                     /note="hexamer: AATAAA"
     polyA_site      2059
                     /gene="ZNF555"
                     /note="major polyA site"
     regulatory      2122..2127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF555"
                     /note="hexamer: AATAAA"
     polyA_site      2155
                     /gene="ZNF555"
     regulatory      3254..3259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF555"
                     /note="hexamer: AATAAT"
     polyA_site      3281
                     /gene="ZNF555"
     regulatory      5692..5697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF555"
                     /note="hexamer: AATAAA"
     regulatory      5712..5717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF555"
                     /note="hexamer: ATTAAA"
     polyA_site      5725
                     /gene="ZNF555"
     polyA_site      5732
                     /gene="ZNF555"
     regulatory      8481..8486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF555"
                     /note="hexamer: ATTAAA"
     polyA_site      8501
                     /gene="ZNF555"
ORIGIN      
        1 gtcctagccg tgagtgcccc gcctgcccct agcggtccct ggcgtcccgg ttcctgtcgc
       61 gctcacctgc gccggtagcg aagaaatcgc cccgggacat ggactcagtg gtctttgagg
      121 atgtggctgt ggacttcacc ctggaggagt gggctttgct ggattctgct cagagggacc
      181 tctacagaga tgtgatgctg gagacctttc agaacctggc ctcagtagat gatgaaactc
      241 aatttaaggc cagtgggtca gtttctcagc aggatattta tggagagaaa atacccaagg
      301 aatctaaaat agccacgttc accagaaatg tttcctgggc ctctgtttta ggaaaaattt
      361 gggacagtct tagcatcgaa gatcaaacca caaaccaggg gagaaatctc agaaatcatg
      421 ggttggagag actctgtgaa agtaatgatc aatgtggaga agccctcagc cagattccac
      481 atcttaatct gtacaagaaa attccacctg gagtaaaaca gtatgaatac aacacgtacg
      541 gaaaagtctt catgcatcgc cgcacatccc tcaagagtcc catcacagtt cacactggac
      601 acaaaccata tcagtgccag gaatgtgggc aggcctacag ttgtcgttca cacctaagaa
      661 tgcatgtgag aacccacaat ggagagagac cctatgtgtg taaattatgt gggaaaacct
      721 ttcctcgtac ttcctccctc aatcggcatg taaggattca cactgctgag aaaacctacg
      781 aatgtaagca atgtgggaaa gcctttattg acttctcaag tcttactagt catctcagaa
      841 gtcacaccgg agagaagcca tataagtgta aggaatgtgg gaaagctttc agttattcct
      901 caacgtttcg aagacacaca ataacacaca ctggcgagaa gccatataaa tgtaaggaat
      961 gtgcggaagc ctttagttat tcctcaactt ttcgaagaca tatgatttca cacactggag
     1021 agaagccaca taaatgtaaa gaatgtgggg aggccttcag ttattcttcg gcttttcgaa
     1081 gacacatgat aacacacact ggagagaaac cctacgaatg caaacaatgt gggaaaacct
     1141 tcatttatct ccagtccttt cgaagacatg aaaggattca cactggagag aaaccctacg
     1201 aatgcaaaca gtgtgggaag accttcattt atccccagtc ctttcgaaga catgaaagga
     1261 ctcatggtgg agagaaaccc tatgaatgca accagtgcgg gaaagcattc agtcacccct
     1321 cctcctttcg aggacacatg agggtgcaca ctggagagaa accctatgag tgcaagcaat
     1381 gtgggaaaac tttcaattgg cccatatctt tacgaaaaca tatgagaaca catactagag
     1441 agaaacccta tgaatgtaag cagtgtggga aagccttcag cttgtctgct tgctttcgag
     1501 aacatgtgag aatgcaccct gaagacaaat cctatgaatg caagctatgt gggaaagctt
     1561 tctattgcca catatcctta caaaaacata tgagaagaca taccgcagag aaactctata
     1621 aatgcaagca gtgtgggaaa gctttcagtt ggcctgaact tttgcaacaa catgtgagaa
     1681 cgcacactgt agagaagccc tatgaatgta aggaatgtgg gaaggtcttc aaatggccat
     1741 catctttacc aatacatatg agactgcaca ctggagagaa accttatcaa tgtaagcatt
     1801 gtgggaaagc attcaattgt tcctcatcct taaggcgaca tgtgagaata cacactacag
     1861 aaaaacagta taagtgtaat gtaggacatc ctcctgcaaa tgaattcatg tgcagtgctt
     1921 cagaaaagtc acaccaggag agagatctga tcaaagttgt aaatatggtg ttgcctttat
     1981 gagttcctta tcctgaaagt ggacactcaa ggagtgtgtc tgtagttcat ttgcaaataa
     2041 acatttagtt gaaaaataat tctccaaata ctctcagcta tcctacatga atttgaacag
     2101 gtagtttctt acgattcagt aaataaaact ttcatcttag agtgttttgg actcatggat
     2161 gatttgaagt gtatttttaa tatgcaagta ggttcaagtt ttatttaatt tcttaaattg
     2221 taactgactt agtgtgacag gtattggata ttacgtatct attatatttt ccaccttttt
     2281 tactgggagt atttttattg tttggccaga ggagccttat tccatttttt aagaagtagt
     2341 tggcagaatt ttgtaattat gcaaagttgt ttaaggagta tagcctcaaa tgaattgtaa
     2401 tttttaatgt ttgcccattg ctgtttgtct ttgcttgtga ttgtgaattg gacagtaggc
     2461 tttgacttgt gatgtgacgg agaaatccag agttgcagat agttcttctg cattgttgtc
     2521 agtgtgggta gtgttaggaa cttcatttgc tggaatgcat ttcctttatg gttccatgtc
     2581 caaatttacc aatagcaata acttgaatga aatttagaat gaagaagaag taagtcatcg
     2641 ctgagctttt ggggtcacat taaatggaga tggacagatg cataggggct ttgtgaacat
     2701 caaccttcag cttattttcc agattcttat tcctgccaat caagagtacc atcaaaagaa
     2761 acacttaagt gcttgatttc cactgtgtca gaggtgtagt cttcctcaga catctccatt
     2821 aacttgatat tagggatatt cctgtgtggt cagtcaccta gagtctggat ttttctcaaa
     2881 accctgcatg acctcttgac cactgattca gactgtcttg tttggcagtc tctgagcttc
     2941 tgattctccc gttctgtaga tcttaacata tttgcatggg gtctaattta tatagtgaac
     3001 accttgttat cttaatactt ccagtggctc tgtgatcctg attccaccac gaaagccaca
     3061 gtgttgcagt caaagaagaa aaacaacaca tgggactttg taccctattg catttttaag
     3121 tgtgcctgcc gagtcctatg tgagaacaaa taccttcctc atatattaga tttagggaga
     3181 tttctgttac tcagaactaa atgcagtttc ttgatatagg ttaaattatt aggtttgatt
     3241 atgtatcatt aaaaataatg tggattttgt ttcaaggaaa accttctgta gatatttctt
     3301 agaaatatcc tgtttagctg ggcacagtag ctcatgcctg taatccctgc actttgggag
     3361 gcttgaggtc aggagtttga gaccagcctg gttaacatgg tgaaaccctg tctctactaa
     3421 aaacacaaaa attagccagg catggtggtg agtacctgta accccagcta cttgggaggc
     3481 tgagacagga gaagtgcttg aacctaggag gcggaggttg cagtgagcca agatcacacc
     3541 actgcactcc agcctgggag acggggaaag actccatcac acaagcaaga aaagaaaaaa
     3601 aaatcctatt tactgtgctt tcaaattagt tgtttagaga ctatattaat ttcccagggc
     3661 tgccataaca aagtacaaaa actgggtgac ataggaaaac aaactttttg tttctcagtt
     3721 ctggacccag aaatccagaa acaaggcatt ggcaggacca tgctttttct gaagatgcta
     3781 gggaaggatc tgtttcagaa ctcacctagc ttctggtagt tccttagctt gtggcagcat
     3841 aactctaatt ttcacatggc attctccctg tgtgtgtgtc tctccatgtg acaatatttt
     3901 tatacataca caccactcat tgggttaggc cccactctac ttcagtatga ttttacctta
     3961 actaattaca ttggcaacag ctctcttttc gcatactgag gcaccgcgaa ttaagatttc
     4021 aacgtaaaaa ttttaggaga cccaattcaa cccataacac taagaaatgt tattttttgt
     4081 ttaccgagag aattacagat ttcaaatcaa ctttgtaatt ttgataattt aagcatgtta
     4141 cattttgaat cagtattacc aagtatatac aaatacaggt attttttcat ataaatgtta
     4201 tttttaattg ctgtatactt aacatttgcc attaaaatga tttttttttt ttgagacaga
     4261 gtctcgctct gtcacccagg ctggagtgca gtggcacgac cttagctcac tgcaaccttc
     4321 atctcccagg ttcagttgat tctcctgcct cagcctcccg agtagttggg attacaggca
     4381 tgcaccacca cacccagcta atttttttat ttttggtaga gatggggttt caccatgttg
     4441 gccaggctgg tcttgaactc ctgacctcag gtgatctgcc caccttggcc tcccaaagtg
     4501 ttgggattac aggcatgagc caccacaccc ggcctaaaat gatttcttat ttgtggttaa
     4561 taacaattaa aaagcggaaa taatggtttt gtcaaggccc tctacccaga aaccaccagg
     4621 atcacactgg tagtcaaaga aaatttgctg tgttgagttg aagtttgaac acatgatcaa
     4681 gaaagggctg tggcttgtat cagagggtgt ttaaaaggat ttactatcag atttggcctt
     4741 gtgttctgtg attttggtga gcgttcaagg aagccaggct ttggtctgga ttggatgttc
     4801 tcaggtcatg aatataattc tctgggaact cccaaagttc tcatctacaa agcagaagtt
     4861 aattggagct gaaaactaat cagtaaagcc acagcagcca gtcatatggg ggagaagagg
     4921 ggaatgtttg atggtttttg tggtttagag gtgagttccg gaaaaaaaga agacatgttt
     4981 gacatcctca aacgagaaaa tttttcatgt gttttatagg ccaaggaggc agaagctttt
     5041 gttttaatga gccagaaagc cccaaaagcc tatttaagtt ttctcaggta tcatttcaac
     5101 ctctgaactt ccagaattaa ctagggaaga ggaaaaacat gtaacacctt agagttttat
     5161 taaagagcaa acaatatcca gtaatctcca ttactttcca tgttaacata agttttcata
     5221 acgctctata gatgaatgtg atttggcagt cacttgtatt tcttaacacc cacttaccca
     5281 tcattccctc ttagatgaaa aaagttaagc acggggacaa cagagtcttg tatattcatg
     5341 tagctcatga tgatggaatc aagtttgaag gcttaacctg tgcttaacct atattgggca
     5401 ttgtcaagac ttaaatttag aacactggaa agcaagtata attaatttta caaatagggc
     5461 atcaaatttt acaaagactc ctaaggctat atggtattcc ttttataaga catggaaaag
     5521 gcaaagataa gggaaacgaa caaatcgctg gttagaagta ggggatttga gtacatatgg
     5581 gcttaagagt gttctgtcat gattgtagtg gtgaaaacaa gcatttgcaa aaactcataa
     5641 ggctactctt aaaatagcaa attttgttgt atgtatattt taaagttaaa caataaaaat
     5701 gctttcagtt tattaaagaa ctcaagacca ggtgcagtgg ctcatgccta taatcccagc
     5761 actttgggaa gctgaggcgg gaggattgct tgtggccagg aggttgaggc tgcagtgaac
     5821 tatgatcatg cactgcactc tacactgggc gacagagcaa gaccctgtct caaaaaaaaa
     5881 ggaatacaaa acattcctga aacttgacat gtaagttcgc aataagactt ttccctagct
     5941 gggcgcggtg actcatgcct gtaatctcaa cattttggga gactgaggca agaggatcac
     6001 ttgaagtcag gagctagaca ccagtctggg caacatagcg agacctcaac tctaccaaaa
     6061 aattaaaaag tgagccaggc ggggtggtgc acgtctgtgg tcccagctac ttggcaggct
     6121 gaagcaggag gatcacttga ggccttgagg agccatgatc gtgccactgc actccagctt
     6181 gggtgacaga gcaagactgt ctcaaaaaat aaaaataaaa aaacaagact tcccccacca
     6241 tcttggaatt ctctggagga aatgtagggc tggttgacaa ggacttgtgc ctcgtcagac
     6301 cctgtttgaa acccagtctg aagttttgaa acacccacaa gggccatacc tgactttatc
     6361 tcacgcacat aacaggagag aagaaggagg tcttccagaa tctgtctttg agtttacacc
     6421 aggttcttcc catctgatct ttgggaatgc tgtggttctg aaacataaaa cggggaccct
     6481 acacttcttc ccaggaatat cctgcctggg agcatcctga tcctgtcttc agacaagggg
     6541 catccgcatc ttgttttcta gggcctttcc tgaggccact tccagctcca aagttctcat
     6601 ctcaagctca gctctgtgtc ttcatgctgg gaaacgtctt tatggatccc caaactcctc
     6661 ttgctgttgg gaacacgtgg cagccctgcg ttgtgaggtg agagaagagg cagtggcaga
     6721 acccatgcca tggagacacg cccatcagcc acagcagctc ctgctactgc ataaatccat
     6781 aggcacaatc acacgcctca cggtgtcaac atctcccatg acatcacaaa gatgcccagc
     6841 tgggacccac ctacagtgat ggggtgatgg ggtttcacct ataagcgggc aaacaggcac
     6901 tcctcctcac tgtccagtca cctgacgtgc tttttctgcg cactcaggtc gtgacacccc
     6961 aggaggtgcc tatcgcgccc caagctcctc acgtgcctcc tccccacagt ccaggacgcg
     7021 tcttactaac gcctcaccag agcgcatgcg ccctcctcag gagcagcctc aaagcgcgca
     7081 gcctcagccc attggcctgc gggaagtgga gttcccgaac agaagcccct cagtctccgg
     7141 aagccccgcc cggcagactg ttcccaggat gcaacacggg ctcgcgtcta aaagagctgt
     7201 gctttgttgg ggctatctgg gagtttccgc cttccatgaa gtgcgcaggc gcacttaggc
     7261 gaggcggggc gactctagga agtggagaca tcaagagtgg tactggaagt ggcggaagct
     7321 ctcctcttgc cctcttcagc ttccggtgtg gtgggtcccg gatatcgcgt ggctgtggca
     7381 ggtagacagc ccgtgctcca gaggccttca tcttgtgatg gcagatgtac ttgagtagac
     7441 acgacagacg gggaaggacc ctgatggtcc gagggacctt ccacagcaag tagaaggcac
     7501 tgctgtgaat atgatggcgt cagaggtgac tgcaaaaaag gacagggcag ctgggcgagg
     7561 aagagatacc agtgatgtcc taactgagct ccctgggtct ggtagtgagg agctcagtct
     7621 tagaatatga gccgtgtcag gggctacagc atcatcactc ttgtcctgtc gcagactcag
     7681 gctccctgtt ctcaggttct tatgtagaca gtgagggctc agggaggctc ccaccaccac
     7741 caccaccagc accaccactc catcaaaacg gctgaaggac cttcctttag ggttcggggg
     7801 atctcctcct tccacaaggg atggatgtga agacaactca ttctttgatg ttcagatggt
     7861 tgtggccctc tgatgagatg tgtgcacacc ttgccaaatg catatgtctg ttgagcctgg
     7921 acattaagta tttcttgatg ttcttctgtg taacaggtga tgtcctaggt gctgcagtga
     7981 acagaagaga caaaatatcc ttgttccctt gaagctaatg tcgtaggggc ccaaaacaaa
     8041 gcaaacaaac aaaaaaaagg aatgcaagtc aagtacactt tgtatggaca gtggtaattc
     8101 ctaagaagga aaacaaagat ggacttaagg ggtgcagagg gcctggacta tgtgtgtctg
     8161 tgggatagtc tgttactacc tctgggactc tcatctcttg agtgtgcttg ggtgtgtcca
     8221 accgtttttc ctagtgacaa agtctgggta attctgtggg gacatatatt ggtgtatctg
     8281 ggaggtccca tgtgtctcag tggtggtccc tgttttcagg aaagagtgtc tgtgaatgtc
     8341 catgtgtctc actgcacagc tgtgattttt ctgtgtctct gtgttttcca gtctttgtgt
     8401 gatgaaatat aaaggcctag caggctcaga gttattaatg aattgtactt aagcgttgag
     8461 aggcatatat ttattgcact attaaattct tccaaaatat a
//
