LOCUS       NM_001102651            3704 bp    mRNA    linear   PRI 07-MAY-2024
DEFINITION  Homo sapiens zinc finger protein 554 (ZNF554), mRNA.
ACCESSION   NM_001102651
VERSION     NM_001102651.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3704)
  AUTHORS   Zhu,C.C., Sun,H.L., Long,T.F., Lyu,Y.Y., Liu,J.L. and Ni,G.T.
  TITLE     ZNF554 Inhibits Endometrial Cancer Progression via Regulating RBM5
            and Inactivating WNT/beta-Catenin Signaling Pathway
  JOURNAL   Curr Med Sci 44 (2), 406-418 (2024)
   PUBMED   38619681
  REMARK    GeneRIF: ZNF554 Inhibits Endometrial Cancer Progression via
            Regulating RBM5 and Inactivating WNT/beta-Catenin Signaling
            Pathway.
REFERENCE   2  (bases 1 to 3704)
  AUTHORS   Guo,Y., Huang,C., Xu,C., Qiu,L. and Yang,F.
  TITLE     Dysfunction of ZNF554 promotes ROS-induced apoptosis and autophagy
            in Fetal Growth Restriction via the p62-Keap1-Nrf2 pathway
  JOURNAL   Placenta 143, 34-44 (2023)
   PUBMED   37804692
  REMARK    GeneRIF: Dysfunction of ZNF554 promotes ROS-induced apoptosis and
            autophagy in Fetal Growth Restriction via the p62-Keap1-Nrf2
            pathway.
REFERENCE   3  (bases 1 to 3704)
  AUTHORS   Balogh,A., Reiniger,L., Hetey,S., Kiraly,P., Toth,E., Karaszi,K.,
            Juhasz,K., Gelencser,Z., Zvara,A., Szilagyi,A., Puskas,L.G.,
            Matko,J., Papp,Z., Kovalszky,I., Juhasz,C. and Than,N.G.
  TITLE     Decreased Expression of ZNF554 in Gliomas is Associated with the
            Activation of Tumor Pathways and Shorter Patient Survival
  JOURNAL   Int J Mol Sci 21 (16), 5762 (2020)
   PUBMED   32796700
  REMARK    GeneRIF: Decreased Expression of ZNF554 in Gliomas is Associated
            with the Activation of Tumor Pathways and Shorter Patient Survival.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3704)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006538.1, DC319914.1, BC000113.1, AK027860.1, AK092136.1,
            AC006130.2 and BF772510.1.
            
            On May 17, 2019 this sequence version replaced NM_001102651.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.55903.1,
                                           SRR1803617.235920.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317243.10/ ENSP00000321132.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC006538.1         175068-175073
            7-95                DC319914.1         1-89
            96-1778             BC000113.1         1-1683
            1779-2100           AK027860.1         3069-3390
            2101-2389           AK092136.1         2147-2435
            2390-3639           AC006130.2         15079-16328
            3640-3704           BF772510.1         1-65                c
FEATURES             Location/Qualifiers
     source          1..3704
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..3704
                     /gene="ZNF554"
                     /note="zinc finger protein 554"
                     /db_xref="GeneID:115196"
                     /db_xref="HGNC:HGNC:26629"
     exon            1..257
                     /gene="ZNF554"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..1821
                     /gene="ZNF554"
                     /codon_start=1
                     /product="zinc finger protein 554"
                     /protein_id="NP_001096121.1"
                     /db_xref="CCDS:CCDS42462.1"
                     /db_xref="GeneID:115196"
                     /db_xref="HGNC:HGNC:26629"
                     /translation="MVTCAHLGRRARLPAAQPSACPGTCFSQEERMAAGYLPRWSQEL
                     VTFEDVSMDFSQEEWELLEPAQKNLYREVMLENYRNVVSLEALKNQCTDVGIKEGPLS
                     PAQTSQVTSLSSWTGYLLFQPVASSHLEQREALWIEEKGTPQASCSDWMTVLRNQDST
                     YKKVALQEEPASGINMIKLIREDGGWKQLEDSHEDPQGLLSQKASLHVVAVPQEKATA
                     WHGFGENGNLSPALVLSQGSSKGNHLCGSELDITSLASDSVLNHHQLGYADRRPCESN
                     ECGNAIRQNSHFIQHGGKMFVYLENGQSLNHGMALTIHNKINTAEKPFECHQCGKVFN
                     RRHSLSEHQRIHTGEKPYECQECGRAFTHSSTLTRHLRTHTGEKPYGCGECGKAFNRI
                     SSLTQHQRIHTGEKPYKCEDCGKSFCQSSYLILHKRTHTGEKPYECSECGKAFSDRSS
                     LNQHERTHTGENPYECKQCGRAFSQRSSLVRHERTHTGEKPYRCQECGKAFSQSSSLV
                     THQKTHSSQKTYKIIDCGKAFYQNRHLIGY"
     exon            258..330
                     /gene="ZNF554"
                     /inference="alignment:Splign:2.1.0"
     exon            331..457
                     /gene="ZNF554"
                     /inference="alignment:Splign:2.1.0"
     exon            458..649
                     /gene="ZNF554"
                     /inference="alignment:Splign:2.1.0"
     exon            650..3704
                     /gene="ZNF554"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2716..2721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF554"
                     /note="hexamer: AACAAA"
     polyA_site      2742
                     /gene="ZNF554"
                     /note="major polyA site"
     regulatory      3650..3655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF554"
                     /note="hexamer: AATACA"
     polyA_site      3674
                     /gene="ZNF554"
ORIGIN      
        1 agtgccgagt ttacctctgc gcgcgtcggg gttggtggcg gcggctgcgg cgagttcctg
       61 aggggcgcct gcggggggcg tccgctccga gcgccgagga gccgagcgga ggaggcgtcc
      121 cagggacacg caggggaggc cggccggcct gcacggggcg ctcccgcctc gggggccctg
      181 tctggcgcct cagcgcgcgc cccgatggtc acctgcgccc acctgggccg gcgcgcgcgg
      241 ctcccggcag ctcagccctc tgcctgccca ggaacctgct tttcccaaga ggagagaatg
      301 gctgctgggt acctgccccg ctggtcccag gaattagtaa cctttgagga cgtgtccatg
      361 gacttctccc aggaggagtg ggagttgctg gagcctgctc agaagaacct gtacagagag
      421 gtgatgctgg agaactacag gaacgtggtc tccctggaag ccttgaagaa ccaatgtact
      481 gatgtgggga ttaaagaggg tccactttcc ccagcacaaa cctcacaagt cactagtctt
      541 tcctcatgga cggggtattt actttttcaa ccagtggctt cttcccactt ggagcaaaga
      601 gaagccctgt ggatagagga aaaaggaact cctcaagcct cctgttcaga ttggatgact
      661 gtactaagaa accaagactc aacttacaag aaggtggctt tgcaggagga accagccagt
      721 ggtataaata tgataaagct tatcagagaa gatgggggat ggaagcagtt agaggacagc
      781 catgaagacc cccaggggct tttgagccaa aaggcatccc ttcacgtagt ggccgttcct
      841 caggagaagg ctactgcatg gcatggattt ggggaaaatg gtaatctgag cccagccctt
      901 gttttatcac agggaagctc taaagggaac cacttgtgtg gcagcgagtt agatattaca
      961 agcttggcat ccgattcagt cttaaaccac catcagctgg gatatgcaga tcggagacct
     1021 tgtgaaagta atgaatgtgg aaatgccatc cgccagaaca gtcactttat tcaacacggg
     1081 gggaagatgt ttgtgtattt ggaaaatggg cagtcattga accacggtat ggccctgact
     1141 atccacaaca aaatcaacac ggcagagaaa ccctttgagt gccaccagtg tgggaaggtg
     1201 ttcaaccgga ggcattcttt gagcgaacat caaagaattc acacggggga gaaaccctac
     1261 gagtgtcagg agtgtgggcg agcctttacg cacagctcca ccctcacgcg ccatctgaga
     1321 actcatactg gagagaagcc ctacgggtgc ggtgagtgcg ggaaagcctt caacaggatc
     1381 tcatcgctga ctcagcatca gaggattcac accggggaaa agccctataa atgtgaagac
     1441 tgtgggaaat ccttctgcca gagctcttac ctgatcttgc acaagaggac acacaccgga
     1501 gagaagccct acgaatgcag tgaatgtgga aaggccttca gtgaccgttc ctctctcaac
     1561 cagcacgagc gaactcacac gggcgagaac ccctatgaat gtaagcagtg tgggagagcc
     1621 ttcagccaga ggtcttccct tgtgaggcac gagagaactc acactggaga gaaaccctac
     1681 aggtgtcagg aatgtgggaa agccttcagc cagagctcat cccttgtcac acatcagaaa
     1741 actcacagca gccagaaaac ctataaaatc attgactgtg ggaaagcgtt ctaccagaac
     1801 agacatctta ttggatatta gcaattgcac gctgctttgt aagccacttt ttagtactct
     1861 gacacataca tgtggttatc ttttgccctg ttgtgatgga taatttgaaa agaagtgggt
     1921 ttatgtcacc ttctcacctt cttataagaa agctctgaga atgggcattt ttgtattttg
     1981 ttgttgttgt tgagatggag tctgccaccc aggctggagt ccagtggcgt gatcatacct
     2041 cactgcagct tcaacttcct gggctcaagt aatcctccca ccccagcctc ccaggtagct
     2101 agtactatag gtgtgcacca ccacgcccag caaattttta aatttattat agagtgggag
     2161 gcagggtgcg gtggctcatg cctataatcc taacacttta ggaggccgag gcgggtggat
     2221 catgaggtca ggagatcgag accatcctgg ctaacacagt gaaaccctgt ctctactaaa
     2281 aatacaaaaa agtagccggg cgtggtggtg ggcgcctgta gtcccaacta ctcaggaggc
     2341 tgaggcagga gaatggtgtg aacccgggag gtggagcttg cagtgagccg agatcgcacc
     2401 actgcactcc agcctgggag acagagcgag actccgtctc aaaaaaaaaa aaaaaattat
     2461 agagttgggg tcttgctaca ttgccaagac tggtcttgaa ctcctggggt caagcatcct
     2521 cctgtcttgg cctcccaaag tgttgggatt agaagcatga gccgctgtgc ccagcctgac
     2581 ggggcctttt agtgggagga gttgccatta cactacgtcc agtaagctcc agactttcgg
     2641 aaaagattgg tggacgggaa tgctgtcatg gatgggatct tgccaagaac catcacgtgt
     2701 taatttagtt gcttaaacaa aaggtgttct gtttcttaac tacttctgtg tctttacttt
     2761 ttatttcatt gttcattgtt tttattttaa tattcttttc tgggtttata tgagacgagt
     2821 tttcactctg ttgctgaggc tgaagtgcag tggcgtgatc atagctccct gtagtcagcc
     2881 ttcatctcct ggactcaagc aatcctccca cctcagcctc tccggtagct gggactacac
     2941 atgtgcaccg ctaccacacc cagctaaatt ttttttttgt atttttgtag tgatgggctt
     3001 tcaccaggtt gcccaggctg gtctcaaact cctgagctca agcaatccac ccaccttggc
     3061 ctcccaaagt gctggtatta caggtgtgag ccaccgtgct ggtattacgg gtgtgagcca
     3121 ctgtgctggg attacgggcg tgagctgccc atgctgggat tacgggtgtg agccaccgtg
     3181 ctggtattac gggtgtgagc caccgtgctg ggattacggg cgtgagccac tgtgctggga
     3241 ttacgggcgc gagccactgt gctgggatta caggtgtgag ccaccctgct gggattatgg
     3301 gtgcgagccg ccgtgctggg attacaggtg tgaaccactg ctcctggcct ttatttcagc
     3361 attctgtttc agtgtttcac attggccact tagctagatc cgtttgtctt ctgcagtact
     3421 gtgctgatcc agagtatatg ctaagacgga aagcgctttg gaggtaaagt ttaaaaaata
     3481 caagggcttc aaaatagtac tagtaatttg atccattcac aaaaggacaa aggctggaca
     3541 gagacgtgaa gaaatgaatc atttacgcaa tgattggggt gttccaatta tgtgtgattt
     3601 tgtgttttct gccgtttcat tttgtattgc cataatcatt ttgacaatga atacaaatca
     3661 aatagcaccc aaaattgtga aggatacgga acctcattga tgag
//
