LOCUS       NM_138347               4560 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 551 (ZNF551), transcript variant
            1, mRNA.
ACCESSION   NM_138347
VERSION     NM_138347.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4560)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   2  (bases 1 to 4560)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   3  (bases 1 to 4560)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK307670.1, BC005868.2 and AC004017.1.
            
            On Nov 22, 2018 this sequence version replaced NM_138347.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.45771.1, BC005868.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282296.10/ ENSP00000282296.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AK307670.1         9-68
            61-2642             BC005868.2         1-2582
            2643-2643           AC004017.1         27396-27396
            2644-3171           BC005868.2         2584-3111
            3172-3172           AC004017.1         27925-27925
            3173-3723           BC005868.2         3113-3663
            3724-4560           AC004017.1         28477-29313
FEATURES             Location/Qualifiers
     source          1..4560
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..4560
                     /gene="ZNF551"
                     /note="zinc finger protein 551"
                     /db_xref="GeneID:90233"
                     /db_xref="HGNC:HGNC:25108"
     exon            1..268
                     /gene="ZNF551"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..2200
                     /gene="ZNF551"
                     /note="isoform 1 is encoded by transcript variant 1; KOX
                     23 protein (56 AA); zinc finger protein KOX23"
                     /codon_start=1
                     /product="zinc finger protein 551 isoform 1"
                     /protein_id="NP_612356.2"
                     /db_xref="CCDS:CCDS12959.2"
                     /db_xref="GeneID:90233"
                     /db_xref="HGNC:HGNC:25108"
                     /translation="MPAPVGRRSPPSPRSSMAAVALRDSAQGMTFEDVAIYFSQEEWE
                     LLDESQRFLYCDVMLENFAHVTSLGYCHGMENEAIASEQSVSIQVRTSKGNTPTQKTH
                     LSEIKMCVPVLKDILPAAEHQTTSPVQKSYLGSTSMRGFCFSADLHQHQKHYNEEEPW
                     KRKVDEATFVTGCRFHVLNYFTCGEAFPAPTDLLQHEATPSGEEPHSSSSKHIQAFFN
                     AKSYYKWGEYRKASSHKHTLVQHQSVCSEGGLYECSKCEKAFTCKNTLVQHQQIHTGQ
                     KMFECSECEESFSKKCHLILHKIIHTGERPYECSDREKAFIHKSEFIHHQRRHTGGVR
                     HECGECRKTFSYKSNLIEHQRVHTGERPYECGECGKSFRQSSSLFRHQRVHSGERPYQ
                     CCECGKSFRQIFNLIRHRRVHTGEMPYQCSDCGKSFSCKSELIQHQRIHSGERPYECR
                     ECGKSFRQFSNLIRHRSIHTGDRPYECSECEKSFSRKFILIQHQRVHTGERPYECSEC
                     GKSFTRKSDLIQHRRIHTGTRPYECSECGKSFRQRSGLIQHRRLHTGERPYECSECGK
                     SFSQSASLIQHQRVHTGERPYECSECGKSFSQSSSLIQHQRGHTGERPYECSQCGKPF
                     THKSDLIQHQRVHTGERPYECSECGKSFSRKSNLIRHRRVHTEERP"
     exon            269..392
                     /gene="ZNF551"
                     /inference="alignment:Splign:2.1.0"
     exon            393..4560
                     /gene="ZNF551"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4536..4541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF551"
                     /note="hexamer: AATAAA"
     polyA_site      4560
                     /gene="ZNF551"
                     /note="major polyA site"
ORIGIN      
        1 ggaacttccg gcgtcctcct cgtggcggtc attttggcct ctgtcctgtt tgtccagccc
       61 gccagtttct gcagtggagg tcgcgactga gggacgggac agagaagtcg cgaaagtggg
      121 ccagaggttc tgcgacacca cctcgggtga gctgcgccag gcccgggata gggactgttg
      181 tgttcgaatg cccgccccgg tcggccgccg ctccccgcct agtccacgga gctcaatggc
      241 ggcagtcgcg ctgagggact cggctcaggg tatgaccttt gaggatgtgg ccatttattt
      301 ctcccaagaa gagtgggagc tccttgatga gtctcagagg ttcctgtact gcgatgtgat
      361 gctggagaac tttgcacatg taacatccct gggttattgc catggaatgg agaatgaggc
      421 gatagcttct gagcagagtg tatctataca ggtcaggact tctaagggca atacacccac
      481 ccagaaaact cacctcagtg agattaagat gtgtgtccca gtcttgaaag acattttgcc
      541 tgcggctgag caccaaacca catcccctgt gcaaaagtca tacttgggta gcacaagcat
      601 gagaggcttc tgcttcagtg ctgaccttca ccagcatcaa aagcattaca atgaagaaga
      661 gccctggaaa aggaaggtgg atgaggctac atttgtgacc ggctgcagat tccatgtgtt
      721 gaattatttc acctgtgggg aggccttccc agcccccacg gacctactcc aacacgaagc
      781 cactcccagt ggtgaggagc cacacagtag cagcagcaag catatacagg catttttcaa
      841 tgcaaaaagt tattacaagt ggggtgaata cagaaaagct tcaagccaca aacacacact
      901 tgttcagcat cagagtgtct gttctgaagg agggctttat gagtgtagca aatgtgagaa
      961 agccttcact tgcaagaaca cacttgttca gcaccagcaa attcacactg gacaaaagat
     1021 gtttgagtgt agtgaatgtg aggaatcctt tagcaaaaag tgccacctaa tcttacacaa
     1081 gataattcac actggagaaa ggccttatga atgcagtgat cgtgagaaag cctttatcca
     1141 taaatctgaa ttcattcacc accagagacg tcacactgga ggagtgcgtc atgagtgtgg
     1201 tgaatgtagg aaaaccttta gctacaaatc taacctcatt gaacaccaga gagttcacac
     1261 tggagaaagg ccttatgaat gtggcgagtg cgggaaatcc tttagacaaa gctctagcct
     1321 ttttcgacac cagagagttc actctggaga aaggccttat cagtgctgtg agtgtgggaa
     1381 atcctttaga caaatcttca atctcattcg acatagaaga gttcacactg gagaaatgcc
     1441 ttatcagtgc agtgattgtg ggaaatcttt tagctgcaaa tcggaactca ttcaacacca
     1501 gagaattcac agtggagaaa gaccttatga atgcagagaa tgtgggaaat cctttagaca
     1561 attctctaac ctcattcgac accgcagcat tcacactggt gataggcctt atgagtgcag
     1621 tgaatgtgag aaatccttta gccgcaaatt tatcctgatt caacaccaaa gagttcacac
     1681 tggagaaaga ccttatgaat gcagtgaatg tggaaaatcc tttacccgca aatctgacct
     1741 cattcaacac cggagaattc atactggcac aagaccttat gagtgcagtg aatgtggcaa
     1801 atcttttaga cagcgctctg gcctcattca gcaccggaga cttcatactg gagaaaggcc
     1861 ttatgaatgt agtgaatgtg gaaagtcttt tagccaaagt gctagcctca ttcaacacca
     1921 gagagttcac actggagaaa ggccttatga atgtagtgaa tgtgggaaat cctttagcca
     1981 gagctctagc ctcattcaac accagagagg tcacactgga gaaagacctt atgagtgcag
     2041 tcaatgtggg aaacccttta cccacaaatc agaccttatt cagcaccaaa gagttcacac
     2101 tggagaaagg ccttatgaat gcagtgaatg tgggaaatcc tttagccgca aatctaacct
     2161 cattcgacat cggagagttc acactgaaga aaggccttaa atgtgaaggg aatgtgctat
     2221 ttctttattc agtataatag cactggagga gactgtggta gccatcttcg taaatttaaa
     2281 ctttgagcac ccacagtggg gtattcttca taagtttcag gtatgtggga agctctgagg
     2341 aggttcattg taatttctaa tctgccgagg cctatagcct gatttatgtc actgccaatt
     2401 tctgaggctg aagccatttc acatttcacc cctaccacct ggcaggtgca caccatgtgc
     2461 atgagtcact tccccacagt gctcagagaa gcaaacctct gtactctccc atttgcttgg
     2521 ggaaattatt aatagcccaa gcatgtaggg tcttcatgtc ttttctctga ctttagagta
     2581 tacacctgac ccagttgtgg tccagagaat ctgagttgtg ctgtcagctt tctaaggatt
     2641 acttttttaa ggaacattgt cggtctcaca tgatgcttgt aatgaatttt tccacattct
     2701 gattcaccag cctggaaact gcttggtgca cattgcttta atttataatg tttttataaa
     2761 ggttttaaaa aaatttacgc acctttaatc ttgggtgttc tattcattgc atagaatgac
     2821 ttgtaagcag aatagtgatg tcagcatgaa ggggtgaata gattttgtgg agatctcaaa
     2881 ctttctgtac tcagaaggga caatgtgatg gcagaagaca gctctttgtt ctgtattgct
     2941 ctaattggcc tgctgcccaa ggcctcaaag taaagactgc caggctttgt gttcctgtat
     3001 tgtggcctgg tgccattttt gtcaggtcag aggtcaccat gaaaaggagg cagttgtgac
     3061 aatccccagt gcttctgtga acgtgaattt tgttcagttg tccacaggag atccacataa
     3121 ttcctagcac tggtgagggg aatctgttgc ccaggtcctg caaaggagcc aggtgccatg
     3181 gcatataagt cagtgtagac tggtgccatt tgttgtcaga ctataggtgt ggaggtgaaa
     3241 ttacaggttc aacagtaatt gggacagaaa ctccaggtaa atggggagtg gagaagactg
     3301 cagtaaatta gatggaatga ctcttctaaa agttcatcta caaattttcc agtgaatatg
     3361 gttgtgtagg atcagtgcat acagaaattc tcaggatctt ctgtttacta tcgctgagat
     3421 cattatcaga aaatagtctg gccgggcatg gtgtaatcct aacactttgg gaggccaagg
     3481 cgggcggatt gcctgagctc aggagttcaa gaccagcctg ggcaacatgg tgaaatccca
     3541 tgtctactaa aatacaaaaa attagccagg cgtggcagca tgcgcctata gtcccagcca
     3601 cttgggaggc tgaggcagga gaatcgcttg aacccagaag gcggaagttg cagtgagctg
     3661 agattgcacc actgcactcc agcccaggca acagagtgag actccgtctc caaaaaaaaa
     3721 aaagaaaata gtctataaag gttttgtggc tccttgtatc ctgtctgggc tgttcacctc
     3781 aaggccattg ctatgcaggt aggagaacaa gaatagagag aaggatcatt ccgcggtcca
     3841 gggatgtggc ttttgtgact cagccaacat tcctattaat tcaggtggca acagccttca
     3901 ttgcttgcca aaatttgctg cccctgaggc aaggttgcct ctctcagggc atgaggagag
     3961 agagagatgg tgaagtccat atcaggttgc caccctgatt aaaaaaaaag gaacatctag
     4021 gctcttaatt ttgagccact ttttaaagct ttttgaaggt ctaatttgta taactgacat
     4081 gcaacaaagt acacgtatcc aaagtgtaca gtttggtaaa gccatgaaac catcattaca
     4141 accataaaaa tgaatttgtg tgtcacccat atatttacct tgtatctttt tataatcttt
     4201 ctcccttccc cagctcttca ggttcaactg atttccttta cagtaaatta gtttgcattt
     4261 tctggagttt ttactgagat acatacacac acacacacac acacacacac acacgtatac
     4321 gcatatacgt atacgtatat atatacatat gtgtttatat atgtgtgtgt gtatatatat
     4381 atacttactg gttttcttca tgctgtataa ttattttgag attcaaaaat gatgaatctt
     4441 tgtattgctg agtatcatgc tgttctatgg ataagtcagt gtttatccat gtgtttaggg
     4501 acatttatat tatttataga tttttgtata ttacaaataa agctgctgta aatacttgaa
//
