LOCUS       NM_001172773            4987 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 548 (ZNF548), transcript variant
            1, mRNA.
ACCESSION   NM_001172773
VERSION     NM_001172773.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4987)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 4987)
  AUTHORS   Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
            Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
            Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
            Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
            Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
            Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
            Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
            Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
            Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
            Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
            Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
            Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
            Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
            Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
            Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
            Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
            Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
            Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
            Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
            Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
            Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
            Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
            Makowski,K.A., Bosak,S. and Malek,J.
  CONSRTM   MGC Project Team
  TITLE     The status, quality, and expansion of the NIH full-length cDNA
            project: the Mammalian Gene Collection (MGC)
  JOURNAL   Genome Res 14 (10B), 2121-2127 (2004)
   PUBMED   15489334
  REMARK    Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
            Morin, Ryan]]
REFERENCE   3  (bases 1 to 4987)
  AUTHORS   Suzuki,Y., Yamashita,R., Shirota,M., Sakakibara,Y., Chiba,J.,
            Mizushima-Sugano,J., Nakai,K. and Sugano,S.
  TITLE     Sequence comparison of human and mouse genes reveals a homologous
            block structure in the promoter regions
  JOURNAL   Genome Res 14 (9), 1711-1718 (2004)
   PUBMED   15342556
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC030788.2, BP244372.1, AC003002.1 and AW449330.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001172773.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA554194.1, SRR1803614.177616.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336128.12/ ENSP00000337555.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BC030788.2         5-34
            31-513              BP244372.1         1-483
            514-2960            BC030788.2         482-2928
            2961-4457           AC003002.1         50702-52198
            4458-4546           AW449330.1         16-104              c
            4547-4987           AC003002.1         52288-52728
FEATURES             Location/Qualifiers
     source          1..4987
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..4987
                     /gene="ZNF548"
                     /note="zinc finger protein 548"
                     /db_xref="GeneID:147694"
                     /db_xref="HGNC:HGNC:26561"
     exon            1..261
                     /gene="ZNF548"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..1884
                     /gene="ZNF548"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 548 isoform 1"
                     /protein_id="NP_001166244.1"
                     /db_xref="CCDS:CCDS54324.1"
                     /db_xref="GeneID:147694"
                     /db_xref="HGNC:HGNC:26561"
                     /translation="MNLTEGPLAMAEMDPTQGRVVFEDVAIYFSQEEWGHLDEAQRLL
                     YRDVMLENLALLSSLGSWHGAEDEEAPSQQGFSVGVSEVTASKPCLSSQKVHPSETCG
                     PPLKDILCLVEHNGIHPEQHIYICEAELFQHPKQQIGENLSRGDDWIPSFGKNHRVHM
                     AEEIFTCMEGWKDLPATSCLLQHQGPQSEWKPYRDTEDREAFQTGQNDYKCSECGKTF
                     TCSYSFVEHQKIHTGERSYECNKCGKFFKYSANFMKHQTVHTSERTYECRECGKSFMY
                     NYRLMRHKRVHTGERPYECNTCGKFFRYSSTFVRHQRVHTGERPYECRECGKFFMDSS
                     TLIKHQRVHTGERPYKCNDCGKFFRYISTLIRHQRIHTGERPYECSVCGELFRYNSSL
                     VKHWRNHTGERPYKCSECGKSFRYHCRLIRHQRVHTGERPYECSECGKFFRYNSNLIK
                     HWRNHTGERPYECRECGKAFSHKHILVEHQKIHSGERPYECSECQKAFIRKSHLVHHQ
                     KIHSEERLVCSMNVGNSLAKTPTSLNIRDFTMEKVYH"
     exon            262..297
                     /gene="ZNF548"
                     /inference="alignment:Splign:2.1.0"
     exon            298..424
                     /gene="ZNF548"
                     /inference="alignment:Splign:2.1.0"
     exon            425..4987
                     /gene="ZNF548"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3111..3116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF548"
                     /note="hexamer: AATATA"
     polyA_site      3132
                     /gene="ZNF548"
                     /note="major polyA site"
     regulatory      3395..3400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF548"
                     /note="hexamer: AATAAA"
     polyA_site      3413
                     /gene="ZNF548"
     regulatory      3641..3646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF548"
                     /note="hexamer: ATTAAA"
     polyA_site      3667
                     /gene="ZNF548"
     regulatory      4518..4523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF548"
                     /note="hexamer: AATAAA"
     polyA_site      4541
                     /gene="ZNF548"
     regulatory      4968..4973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF548"
                     /note="hexamer: ATTAAA"
     polyA_site      4987
                     /gene="ZNF548"
ORIGIN      
        1 gggacttccg ccgtcctcct ggtggtggtc gttttggttc tgtgtggtgt ttcaccaact
       61 tcggcctatg gctctgtctg acgtcaccga agtgacggaa cggaaaagcg cgagaagcgg
      121 ctcggttccc accacggaga ggcgggagtg agtcaactga caagcgctgg ggacagtggc
      181 gtccttgtct tgcctttgtc gctcccgccc cgctcttccc tggctgggct ggcggaggcc
      241 ttgctgatga acctgactga gggtcccctg gcgatggcag aaatggaccc tacacagggc
      301 cgtgtggtct ttgaggacgt ggccatatat ttctcccagg aggagtgggg gcaccttgat
      361 gaggctcaga gattgctgta ccgtgatgtg atgctggaga atttggccct tttgtcctca
      421 ctaggttctt ggcatggagc tgaggatgag gaggcacctt cacagcaagg tttttctgta
      481 ggagtgtcag aggttacagc ttcaaagccc tgtctgtcca gccagaaggt ccaccctagt
      541 gagacatgtg gcccaccctt gaaagacatt ctgtgcctgg ttgagcacaa tggaattcat
      601 cctgagcaac acatatatat ttgtgaggca gagctttttc agcacccaaa gcagcaaatt
      661 ggagaaaatc tttccagagg ggatgattgg ataccttcat ttgggaagaa ccacagagtt
      721 cacatggcag aggagatctt cacatgcatg gagggctgga aggacttacc agccacctca
      781 tgccttctcc agcaccaggg ccctcaaagc gagtggaagc catacaggga cacagaggac
      841 agagaagcct ttcagactgg acaaaatgat tacaaatgta gtgaatgtgg gaaaaccttc
      901 acctgcagct attcatttgt tgagcaccag aaaatccaca caggagaaag gtcttatgaa
      961 tgtaacaaat gtgggaaatt ctttaagtac agtgccaatt tcatgaaaca tcagacagtt
     1021 cacactagtg aaaggactta tgagtgcaga gaatgtggaa aatcctttat gtacaactac
     1081 cgactcatga gacataagcg agttcacact ggagaaaggc cttatgagtg caacacatgt
     1141 gggaaattct ttcggtacag ctccacattt gttagacatc agagagttca caccggagaa
     1201 aggccgtatg agtgcaggga atgtgggaaa ttctttatgg acagctccac actcattaaa
     1261 catcagagag ttcacaccgg agaaagacct tataagtgca atgattgtgg gaaatttttt
     1321 aggtatatct ccacactcat tagacatcag agaattcaca ctggagaaag gccttatgag
     1381 tgcagtgtat gtggggaatt gtttaggtac aactccagcc ttgttaaaca ttggagaaat
     1441 cacactggag aaaggcctta taaatgcagt gaatgtggga aatcatttag gtaccactgc
     1501 aggctcatta gacaccagag agtccacacg ggagaaaggc cttatgagtg cagcgaatgc
     1561 gggaaattct ttcgttacaa ctccaacctc attaaacatt ggagaaatca cactggagaa
     1621 aggccttacg agtgcagaga gtgtgggaaa gcctttagcc acaagcatat acttgttgag
     1681 caccagaaaa tccacagtgg agaaagacct tatgagtgca gcgaatgcca gaaggccttt
     1741 attagaaagt ctcacctggt tcatcaccag aaaatccaca gtgaagagag gcttgtgtgc
     1801 tccatgaatg tggggaattc tttagctaaa actccaacct cattaaacat cagagatttc
     1861 acaatggaga aagtttacca ttgactattg taattgggta gtaatgttat ataaattcca
     1921 catttttatg caactaatct ccagaacatt tttcctctta ccaagaagta aaatgctgta
     1981 cccattaaca acaactcatt ccccttccct acttccccag aaatgtctca actatatttc
     2041 tatactctat ggtacttata tgaggtacca atagatatct atgaatttga tatatatttg
     2101 tacctcatat aagtggattc tacagtattt atcttttgag actggcttat ttcacttagg
     2161 ataaggtctt cacggttcac ccatgttgta taatgtgtca gaatatcctt cctttttagg
     2221 tgaaataata ttctatggta tttatatacc acatttattt atccattcat ctgttagtgg
     2281 atacttgggc tacttccacc ttttgcctat tgaaataatg ctgctatgaa gatgagtgta
     2341 caagtgtcta ttcaagattc tactttcaat tcttataggg tatatactca gaaatggtgg
     2401 tgctggatca tataggattt ctattttttt tttttgtttg tttttgagac agagtcttgc
     2461 tctgtcaccc aggctggagt gcagtgctgt gatcttggct cactgcaagc tccgcctccc
     2521 aggttcatgc cattctcctg cctcaccctc ccgagtagct gggactacag gtgcctgcca
     2581 ccacgcctgg ctaatttttt tgtattttta gtagagacgg ggtttcaccg tgttagccag
     2641 gatggtcctg atctcctgac cttgtgatct gcctgccttg gcctctcaaa gtgctgggat
     2701 tacgggcgtg agccaccgcg cctggccagg atttctattt ttaatatttt tgggaaaatt
     2761 tttccatagt acctgtgcca ttttacattc ccaccagcag tgcacaagga ttgcaatcta
     2821 tatacatcct caccaacatt gttcattttc tatttctgtt tttggggttt tttgtagtgc
     2881 cttttgtttt ggatagcagc tatcttgttg gatgtgaggt ggaatctata gtgtctttca
     2941 tttttatttt gtgaatgatt gatgatgttg aggatctttt catgtgcttg ttaggcattt
     3001 gtgtatctgg aaaaatattc aagtcttttt tttccatttt taatgggact atttgctttt
     3061 tgttgttgag ttgtagttct ttatacattc tggatattaa ctccttacca aatatatgct
     3121 ttttacatat tacctcccag tccataggtt gctttttcgc tctgttgatt gtgtcctttg
     3181 atgaaatttt aagttttgat gtactgttga ctctttctgt ctgtgggttc tgtattcatg
     3241 gatcgaagca accatggatc aaaagtattt ggagcatcca tggattgcag tgatcattaa
     3301 tcaaaaatat ttggaaaaca aaaagggtag ttgcatctgt actaaacatg aacagacatt
     3361 ttttcttgtc attattccct aaactatata gtataataaa tatttacata gcatttacat
     3421 tgtattagaa gttataaata acctaatgat aatctatata ggaagatgtg tgtaggttat
     3481 attcaaacac tatgcctttt tatgtgaggg acctcttgag catcagatga ttttggtatc
     3541 cacaaggggt cctggaatca gtcccccaca gacaccaagg gatgactgta gtgcatttta
     3601 tctattttta cttctgttac ctgggctttt gatgttatat attaaaaaaa attagtatca
     3661 aatccaatgc caagcatttt ccctatgctt tattctaaga attttatatt tgaaggtctt
     3721 acatttaggt cttttttttt tttttctttt ggaggcagag tcttgctctg tcacccagcc
     3781 tggagtgcag tagtggaatc tcagctcact acaacctccg cctcctgggt tcgagccatc
     3841 accccacctc agcctcccaa gtagcttgga ttacaagtgt acaccaccac acctggctaa
     3901 tttttgtatt tttagtagag atggggtttt gccatgttgg ccaggctggt cttaaacttc
     3961 tggccttaag tgatccccct gcctcggcct cccaaattgc tgagattaca ggcaggagtt
     4021 gtaatgcact gtgcctggct acatttagat ctttaatcta cttggggttc atttttgcat
     4081 atggtttaag gcaaaagtcc actttatgtg gctatccagt tttccaagca ccattttttg
     4141 aaaagagcat ctttcctctg ttgagtagtc ttggcacact tgtcaaaatc atttgtccat
     4201 atatgccatg gtttatatgt ggattctcta ttttattggt catatgtctg tctttatgtc
     4261 agtaccacac attttaggtg tgtgtgtgtg agactcagtg ttgaggacaa ggctagtggg
     4321 ctttcacact ccagactgct gtattccagc ccaaattact caaattagcc aatccatggg
     4381 gaacatggaa aacgtagcta atgcaatccg cttgccttac ctaagttgtc ccctgcagcc
     4441 tcaggttgct gttactgtgt ttcagatgca accctctgtg ggaccctacc caagttctct
     4501 cattcttagc tataggtaat aaattgttct gattttgtgt atccaagtga cattgggttg
     4561 tttcttgcta tcagaagaac ccagaaaagt attatgaatc tagtgaatgt tggaaaatct
     4621 ttagccatta gcataacctc atttcgtgcc agcatgttca ccctagagaa aagtagaagt
     4681 gaaggcaatg tcatctttcc ttgttaacat gataactcag tagagcaatg ctttggagat
     4741 tagcttttta gggagagagc cagcagttga gcctcctgca tctgaacatc cacactaggg
     4801 atattgtctg tactgccaga tatatgggaa gattttgtga actgtgttgc agttttcaac
     4861 ttgactgggg cctttcccag agttatgccc ctgccagtgc ctatttaaaa atgtcatctc
     4921 ttttctacca actggcaaag agccatggtg tgtagcattt tagtcacatt aaaatgcagt
     4981 tatggca
//
