LOCUS       NM_178544               8000 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens zinc finger protein 546 (ZNF546), transcript variant
            1, mRNA.
ACCESSION   NM_178544
VERSION     NM_178544.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8000)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   2  (bases 1 to 8000)
  AUTHORS   Lichter,P., Bray,P., Ried,T., Dawid,I.B. and Ward,D.C.
  TITLE     Clustering of C2-H2 zinc finger motif sequences within telomeric
            and fragile site regions of human chromosomes
  JOURNAL   Genomics 13 (4), 999-1007 (1992)
   PUBMED   1505991
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA217689.1, AK292528.1, AK122968.1, AC007842.1 and AF087985.1.
            
            On Nov 22, 2018 this sequence version replaced NM_178544.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC045649.1, AK292528.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000347077.9/ ENSP00000339823.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                DA217689.1         25-52
            29-2859             AK292528.1         1-2831
            2860-3507           AK122968.1         2778-3425
            3508-7346           AC007842.1         134788-138626
            7347-8000           AF087985.1         1-654
FEATURES             Location/Qualifiers
     source          1..8000
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..8000
                     /gene="ZNF546"
                     /gene_synonym="ZNF49"
                     /note="zinc finger protein 546"
                     /db_xref="GeneID:339327"
                     /db_xref="HGNC:HGNC:28671"
     exon            1..98
                     /gene="ZNF546"
                     /gene_synonym="ZNF49"
                     /inference="alignment:Splign:2.1.0"
     exon            99..153
                     /gene="ZNF546"
                     /gene_synonym="ZNF49"
                     /inference="alignment:Splign:2.1.0"
     exon            154..316
                     /gene="ZNF546"
                     /gene_synonym="ZNF49"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..2743
                     /gene="ZNF546"
                     /gene_synonym="ZNF49"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 49; CTC-471F3.6"
                     /codon_start=1
                     /product="zinc finger protein 546 isoform 1"
                     /protein_id="NP_848639.2"
                     /db_xref="CCDS:CCDS12548.1"
                     /db_xref="GeneID:339327"
                     /db_xref="HGNC:HGNC:28671"
                     /translation="MQVDPPLHGPPNDFLIFQIIPLHSLSIMPRFLWILCFSMEETQG
                     ELTSSCGSKTMANVSLAFRDVSIDLSQEEWECLDAVQRDLYKDVMLENYSNLVSLGYT
                     IPKPDVITLLEQEKEPWIVMREGTRNWFTDLEYKYITKNLLSEKNVCKIYLSQLQTGE
                     KSKNTIHEDTIFRNGLQCKHEFERQERHQMGCVSQMLIQKQISHPLHPKIHAREKSYE
                     CKECRKAFRQQSYLIQHLRIHTGERPYKCMECGKAFCRVGDLRVHHTIHAGERPYECK
                     ECGKAFRLHYHLTEHQRIHSGVKPYECKECGKAFSRVRDLRVHQTIHAGERPYECKEC
                     GKAFRLHYQLTEHQRIHTGERPYECKVCGKTFRVQRHISQHQKIHTGVKPYKCNECGK
                     AFSHGSYLVQHQKIHTGEKPYECKECGKSFSFHAELARHRRIHTGEKPYECRECGKAF
                     RLQTELTRHHRTHTGEKPYECKECGKAFICGYQLTLHLRTHTGEIPYECKECGKTFSS
                     RYHLTQHYRIHTGEKPYICNECGKAFRLQGELTRHHRIHTCEKPYECKECGKAFIHSN
                     QFISHQRIHTSESTYICKECGKIFSRRYNLTQHFKIHTGEKPYICNECGKAFRFQTEL
                     TQHHRIHTGEKPYKCTECGKAFIRSTHLTQHHRIHTGEKPYECTECGKTFSRHYHLTQ
                     HHRGHTGEKPYICNECGNAFICSYRLTLHQRIHTGELPYECKECGKTFSRRYHLTQHF
                     RLHTGEKPYSCKECGNAFRLQAELTRHHIVHTGEKPYKCKECGKAFSVNSELTRHHRI
                     HTGEKPYQCKECGKAFIRSDQLTLHQRNHISEEVLCIM"
     exon            317..403
                     /gene="ZNF546"
                     /gene_synonym="ZNF49"
                     /inference="alignment:Splign:2.1.0"
     exon            404..530
                     /gene="ZNF546"
                     /gene_synonym="ZNF49"
                     /inference="alignment:Splign:2.1.0"
     exon            531..626
                     /gene="ZNF546"
                     /gene_synonym="ZNF49"
                     /inference="alignment:Splign:2.1.0"
     exon            627..8000
                     /gene="ZNF546"
                     /gene_synonym="ZNF49"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3906..3911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF546"
                     /gene_synonym="ZNF49"
                     /note="hexamer: AATAAA"
     polyA_site      3931
                     /gene="ZNF546"
                     /gene_synonym="ZNF49"
                     /note="major polyA site"
     regulatory      7980..7985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF546"
                     /gene_synonym="ZNF49"
                     /note="hexamer: AATAAA"
     polyA_site      8000
                     /gene="ZNF546"
                     /gene_synonym="ZNF49"
                     /note="major polyA site"
ORIGIN      
        1 agtgttgcct ggaccccaag ggccctttac attgcgttct taacggttca gtcaccttaa
       61 ccgttattat tcacttgcgg gcgagaagtc cgagctaggg atcctgaaaa ggagggaaca
      121 attgttgtag caggtctaaa agttcaggtc caggaaatgg aaacattgct ttgcttttcc
      181 tgaattgtcc agtgacctat cccaggcctt cctttccagt gaacaatgga ccatgcaggt
      241 ggaccctcct cttcacgggc ctccaaatga ctttctcatt tttcaaatca ttcctctgca
      301 ctcactttct ataatgcccc ggtttctctg gattctgtgc ttctccatgg aggaaactca
      361 aggagaactg acaagttctt gtggttctaa aaccatggcc aatgtatctt tggcatttag
      421 ggatgtgtcc atagacctct cccaagagga gtgggagtgc ctggacgctg tgcagaggga
      481 cttgtacaag gatgtgatgt tggagaacta cagcaacctg gtctcactgg gatataccat
      541 tcctaagcca gatgtgatta ctttattgga gcaagagaaa gagccctgga tagtaatgag
      601 ggaagggaca aggaattggt tcacagattt ggaatacaag tatattacca agaatttgct
      661 ttcagaaaag aatgtttgca aaatctattt atctcaattg cagacagggg aaaaaagtaa
      721 aaacaccatc catgaggaca ccattttcag aaatggtttg cagtgtaaac atgaatttga
      781 gagacaagag agacatcaga tgggatgcgt tagtcaaatg ctaatccaaa aacaaatatc
      841 tcatcctcta catccaaaaa ttcatgctag agagaaatca tatgaatgta aggaatgtag
      901 aaaggccttt agacaacagt cataccttat tcaacatctg agaattcaca ctggtgagag
      961 accctataaa tgtatggaat gtggaaaggc cttttgtcga gtgggagacc ttagagtaca
     1021 tcacacaatc catgctgggg agagacccta tgaatgtaaa gaatgtggga aggcctttag
     1081 acttcattat caccttactg aacatcagag aatacattct ggtgtgaaac cctacgagtg
     1141 taaggaatgt gggaaagcct ttagtcgtgt tagagacctt agagtacatc agacaattca
     1201 tgctggagag agaccttatg aatgtaaaga atgtgggaag gcctttagac ttcattatca
     1261 actaactgaa catcaaagaa ttcatactgg tgagaggcct tatgaatgta aggtttgtgg
     1321 caagaccttt agggtacaac gacatattag tcaacatcag aaaattcata ctggtgtcaa
     1381 accctataaa tgtaatgaat gtgggaaggc ctttagtcat ggctcatacc ttgttcaaca
     1441 tcagaaaatt catactggtg aaaaacccta cgaatgtaaa gaatgtggta agtcctttag
     1501 ttttcatgca gaacttgctc gacatcgtag aattcatact ggtgagaaac cctatgaatg
     1561 tagagaatgt ggaaaagcct ttcgtcttca aacggaactt actcggcatc atagaactca
     1621 tactggtgag aaaccctatg aatgtaagga atgtgggaag gcctttattt gtggttatca
     1681 acttacttta catctgagaa ctcacaccgg tgagattccc tatgaatgta aggaatgtgg
     1741 aaaaaccttc agtagtcgct atcatctcac tcaacactac agaattcata ctggtgagaa
     1801 accctacata tgtaacgaat gtggaaaagc ctttcgtctt caaggagaac ttacccgaca
     1861 tcacagaatt catacatgtg agaaacccta tgaatgtaag gaatgtggga aggcttttat
     1921 tcatagcaat caatttattt cacaccagcg aattcacacc agtgagagca cctacatatg
     1981 taaagaatgt gggaagattt ttagtcgtcg ctataatctt actcaacatt ttaaaattca
     2041 tactggtgaa aaaccctaca tatgtaatga atgtgggaaa gcctttcgat ttcaaacaga
     2101 acttactcag catcacagaa ttcatactgg tgaaaaaccc tataaatgta cagaatgtgg
     2161 gaaggccttt attcgtagca ctcatctcac gcaacatcac agaattcata ctggtgagaa
     2221 accctacgaa tgtacggaat gtgggaagac gtttagtcgg cactatcatc ttactcaaca
     2281 tcacagaggc catactggtg agaagcccta catatgtaat gaatgtggga atgcttttat
     2341 ttgcagttat cgacttacat tacatcaaag aattcacact ggtgagcttc catatgaatg
     2401 taaggaatgt ggaaagacct ttagtcgtcg gtatcatctt actcaacatt ttagacttca
     2461 tactggtgag aaaccttata gctgtaaaga atgtgggaat gcctttcgtc ttcaagcaga
     2521 acttactcga catcacatag ttcacacggg tgagaaaccc tataaatgta aagaatgtgg
     2581 gaaagccttc agtgttaatt cagaacttac tcgacatcac agaattcata ctggtgaaaa
     2641 accctatcaa tgtaaagaat gtggaaaagc ctttattcgt agtgatcaac ttactttaca
     2701 tcagagaaat catattagtg aggaagtcct atgcataatg taaagagaat acgatggcct
     2761 ttagaaaatg ccctttagca gagaatttgt aatttaagaa attttctgtt tgttacggaa
     2821 catgtgggaa tcccttttac ttcatgctca caatttatca gaaattattt cgtatgttaa
     2881 agagtcgaaa gactatagca tcactcagtc cctgttagac tttagaagat tgatactgat
     2941 gcactgcatc ccaaaccatc aagggccttt tcccctacaa actgttgttg aacagtgctt
     3001 ctctaaaatg caataataat gggccaggtg aagtggctca cacctgtaat cccagcactg
     3061 tggaaagaca ggagttcgaa accagcctgg gcaacatagt gagaccctgc ctcatggctt
     3121 tagtgagcca tgattgtgcc actgcactcc agcttggtga cagagtgaga tcctgtctct
     3181 aaataaataa ataaaatgcg ggccaggcac agtggctcac acctgtaatc ccagcactat
     3241 gggaggccca ggtgagcaga tcacctgagg tcaggagttc aagaccagcc tggccaacat
     3301 ggtgaaaccc cttctctact aaaatacaca aattagctag gcattgtggg gggtgcctgt
     3361 aatcccagct actcaggagg ctgaggcagg aaaattgcat gaacctaagt ggcagaggtt
     3421 gcagtgagct gagatcgcac cactgcactc tagcttgggc aacagagcaa gactctgtct
     3481 cttaaataaa taaataaata gattaccaga aaaatgaaaa gaaaaaaaca gacatacaaa
     3541 ataaaagccc cagtttttta ttatggtatt taactgagtt aactctgtca gattgctgca
     3601 aacatttcta aatacttgct cttggtatct ataacttttg cagagaccag aagcaaacaa
     3661 tttgtgggcc agtgtcaaca catggaccac actttatata gcactgtaac ggaaaatgat
     3721 tctgttaatg taatgaacat gggaaagacc agccttggcc tatctttatg atatatataa
     3781 ataatataat tctcataatt ccacctctgc ctatgtggtg tttggcaaaa catgcccctg
     3841 tgccttggtt tttaaaatgg taataacagt accacctaat agtatttttg tgaggatgaa
     3901 atgctaataa aagataaaac ctttaaaaga gtatttggca cacagcattt tatcaataaa
     3961 tattgcttta tttttttcat tggggataca tttagtacat tcatgtgaga ggaaggccct
     4021 gtgggtgtaa gaaatttgta aaaactgtcc attacctttc actccttatt tagattggaa
     4081 taattaactg gagataatat ccagtaaaat agattaaact tccatttata aagtcagaac
     4141 ctatctctga aaattaatgt gagaaagaaa tctctagatt tgatgggtgt gaagattatg
     4201 agagtaaagt tttgaagact cagggatagc tgtaatgctt ttttcttttt ataacccaaa
     4261 aagcaggtat gtcagtcgct ttttctgccc acaatgataa attaaaaaca gccactatcc
     4321 atttggaaaa cttaaaagaa taatgaacag ttatgttcta tctagattca gcaattgtta
     4381 atatgttgtc acatttggtt tgcttataca taatatttac atattttgct gtagtatttg
     4441 agtataaatt gcagatacta taacacatca catctaagaa taaaggctgc ctcctactta
     4501 attgctatat aacaattgtc caacctgtct gtgccccagg gcagctttga atgcagtcca
     4561 acagaaattt gtaagctgtc ttaaaacatg agattttttt tgtgattttt tttaagctca
     4621 tccgccattg ttagcacatt ttatgtgtag cccaagataa ttcttcttcc agtgtaaccc
     4681 agggaagcca aaagatttga cccccagtaa cttcacacct aaggagatta gcaataattc
     4741 cataatctgt aatattcagt ctgtgttcat attctcagtt gtgttcattc ttttcatttg
     4801 tgtaaacaat gcttttcata ggttattttt aaattcagga accaaattca tgaattacat
     4861 ttgtgcattg ttcgtctctt ttaaagtaag aatggccctt ccccccacaa ctttattgca
     4921 acattgactt tttttttttt tttttttttt tttttttgag atggagtctc tgtcgcccag
     4981 gctggagtgc agtggtgcga tcttggctca ctgcaagctc cgcctcccgg gttcaggcaa
     5041 ttctgcctca gcctccccag tagctgggac tacaggcgcc ttcaaccatg cccggctaat
     5101 tttttgtatt tttagtagag acggggtttc accatgttag ccaggacggt ctcgatctcc
     5161 tgacctggtg atctgcccgc ctcagcctcc caaagtgctg ggattacagg catgagccac
     5221 cgcacccggc cttcccaaag tatttttaaa tgtgcttttt tatccccagt atttcccatt
     5281 aactggaatt tgggattaga gacccaatta gggacagatt aaatattttg gcaagaatac
     5341 ttaatgggag aaattttgta tttcaatttg taacccatta ggtggcatac aatgtcatta
     5401 taccactatg gtatccttag ttcattcact tggtgtagca gaacatacat tccaaagatg
     5461 gccacaccaa tatatcccat tctgcatgtt catcttacaa tgtgatacca acactcccca
     5521 agaggtagag ctcatggtcc ttccttttga atctggccag gtgggcctgt gtttatggca
     5581 ggaataacac tgtgatttcc acgactaagt cataaaaggc aatacagctt ctgcctgacc
     5641 cacttgggat gaagcccagc caccatgcta tgaagatgcc aagtaatcac atagaaaagc
     5701 taagtaaagc tgtcctgatt acagctgtaa ttgaggtaac agccgggatc cagcaccaag
     5761 tgtatgaggg tatgagcctt cagatgattc taacccttag ccttcaggct atcctagctg
     5821 gtgctaagtg gagcagagaa aagctttccc ccatgagcct gcccaaattg cagatttacg
     5881 tttaaaatat ggcctgtttt aagccactaa gttttggagt agtttgccac acagcgatag
     5941 gtaactgaaa tacttgcttc atatggtaat caccaggttt ctctgttgta gagctaaata
     6001 tttcttttaa tttagtaaac gatctgtaga gtagtacttt ggcatttcgg aaatttaaaa
     6061 tctccaataa tataatgaca ctagatcaaa aagaaaatga aaccataaag gacaatttag
     6121 aaatgaatgg taagatcaga atttgtgaat gtggccaaac ctgtgctcag tgaaaaatca
     6181 gtaacctgtt aatatattca ggaaacaaat attgagggcc agcactttgt ttctcctgct
     6241 caccactcta ctcccagtga cttaatactg tctctttaac atagtaatca cttataaaac
     6301 tgttaaaaga atgaagaagc attaaactca agaaactaag ggaaaaataa gtcaatataa
     6361 gaaagaaggg aggatcatta aaaggagtta atgaatttga aaataaaata gacttattaa
     6421 ggctttgtga aaaaatatta atacttgatt ttagtatagc taatcaaagg aaaaagataa
     6481 ttacagcatt gtgaatgaga attggatgta agtacagatg gaggagatat tttttgtttt
     6541 attgaaaatt tcaaggagga agtaatatca aaatttcact agctctttct acactgatat
     6601 tataatcctg ataatacaac agatgaggat agttcttaaa aggcaaaaat gtaggtgagt
     6661 cattacgaag aaagcagaaa ttctaaacca tcagcacatt cattcaaaaa cctagtaaag
     6721 caattaagca aaataatttg tttacttgga ctgtccaggg atagatctgt tctagttttc
     6781 caaattaatg atgggaaagg aagagctgat ccagtccaag tatcttcaag atccatgttc
     6841 tcagtttttc ttagctttaa atggccaaat tgtggcttag attggatatg ataatttcct
     6901 caatgcttaa cactgagcac aatttttcac atatttgaaa tcaaggtgta tcttacaatt
     6961 tatggcatct gacaatactt ccaaccaggt ggcagtcatc aagcagtttt gtgaaaagcc
     7021 ttcccggtaa gaatacaaaa gcatctgcac caaaatatat agatttaatg gcatgtaggg
     7081 gtttgcgtga atatatacag ttgaaattca attcttcctt aaaaataatt gtaactcatt
     7141 tctttaagac taccatacta ccactttcct caacttggac taatgtccat tgtcaaccaa
     7201 aatgtctgtg atctcatgga tccattatga tttgcaactc caggtccatt ttatgcaaat
     7261 aagacagcca taatatatca ttgtacaagt catttactat ctaattatat cattgctcaa
     7321 catttgcaaa ttatttttac aaataacaat aattggatgt aacaaaaagc agagtatttt
     7381 gagacgtata ttaatgcaaa atattgttaa tgtatcagtg gattgttcct ccaaagtacc
     7441 agtgccttaa cacaacatat ctaaaagaac atctctggga acagtagtac ttaatggcaa
     7501 cttgagaatt ggtttgtggg cacacagcct tgtgaagttt tgaatactaa atcccttttt
     7561 taaaaaagtg cttattatca ggctatcaat caaaagattt gagtctttca gtaaagaaaa
     7621 tttgcttaat tttatctagt gcatgataaa ctttactaag gaagtctcat tcagaatatc
     7681 taatattttg gatgtgagcc cacactggaa atgccataac caaaaaagag tgaccctaaa
     7741 gatagaatat tcagatctaa tggcagatgc ttagctatgc tgggaaagga agtgaattgt
     7801 atattgctct gctgctcaca tattcctctg caataaattg ctggcccagt ttagttttta
     7861 tatactcact actatactaa tgaggatggc tcaatttttt atttgaacgt actataatga
     7921 atttaaactt tcattggtat ttatgtttta acaggttttc actatttcaa atatacttca
     7981 ataaatatcc ttgtctgtga
//
