LOCUS       NP_848639                836 aa            linear   PRI 27-APR-2025
DEFINITION  zinc finger protein 546 isoform 1 [Homo sapiens].
ACCESSION   NP_848639
VERSION     NP_848639.2
DBSOURCE    REFSEQ: accession NM_178544.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 836)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   2  (residues 1 to 836)
  AUTHORS   Lichter,P., Bray,P., Ried,T., Dawid,I.B. and Ward,D.C.
  TITLE     Clustering of C2-H2 zinc finger motif sequences within telomeric
            and fragile site regions of human chromosomes
  JOURNAL   Genomics 13 (4), 999-1007 (1992)
   PUBMED   1505991
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA217689.1, AK292528.1, AK122968.1, AC007842.1 and AF087985.1.
            
            On Jul 10, 2008 this sequence version replaced NP_848639.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC045649.1, AK292528.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000347077.9/ ENSP00000339823.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..836
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     Protein         1..836
                     /product="zinc finger protein 546 isoform 1"
                     /note="zinc finger protein 49; CTC-471F3.6"
                     /calculated_mol_wt=98275
     Region          60..120
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          <215..375
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          219..239
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(224,226,228,230..231,234..235,238,252,254,258..259,
                     262..263,266,280,282,284,286..287,290..291,294)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          247..267
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          275..295
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          303..323
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          331..351
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          359..379
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          383..823
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          387..407
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(392,394,396,398..399,402..403,406,420,422,426..427,
                     430..431,434,448,450,452,454..455,458..459,462)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          415..435
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          443..463
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          471..491
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          499..519
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(504,506,508,510..511,514..515,518,532,534,538..539,
                     542..543,546,560,562,564,566..567,570..571,574)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          527..547
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          555..575
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          583..603
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(588,590,592,594..595,598..599,602,616,618,622..623,
                     626..627,630,644,646,648,650..651,654..655,658)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          611..631
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          639..659
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          667..687
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          695..715
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          723..743
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(728,730,732,734..735,738..739,742,756,758,762..763,
                     766..767,770,784,786,788,790..791,794..795,798)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          751..771
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          779..799
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          807..827
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..836
                     /gene="ZNF546"
                     /gene_synonym="ZNF49"
                     /coded_by="NM_178544.5:233..2743"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS12548.1"
                     /db_xref="GeneID:339327"
                     /db_xref="HGNC:HGNC:28671"
ORIGIN      
        1 mqvdpplhgp pndflifqii plhslsimpr flwilcfsme etqgeltssc gsktmanvsl
       61 afrdvsidls qeewecldav qrdlykdvml enysnlvslg ytipkpdvit lleqekepwi
      121 vmregtrnwf tdleykyitk nllseknvck iylsqlqtge kskntihedt ifrnglqckh
      181 eferqerhqm gcvsqmliqk qishplhpki hareksyeck ecrkafrqqs yliqhlriht
      241 gerpykcmec gkafcrvgdl rvhhtihage rpyeckecgk afrlhyhlte hqrihsgvkp
      301 yeckecgkaf srvrdlrvhq tihagerpye ckecgkafrl hyqltehqri htgerpyeck
      361 vcgktfrvqr hisqhqkiht gvkpykcnec gkafshgsyl vqhqkihtge kpyeckecgk
      421 sfsfhaelar hrrihtgekp yecrecgkaf rlqteltrhh rthtgekpye ckecgkafic
      481 gyqltlhlrt htgeipyeck ecgktfssry hltqhyriht gekpyicnec gkafrlqgel
      541 trhhrihtce kpyeckecgk afihsnqfis hqrihtsest yickecgkif srrynltqhf
      601 kihtgekpyi cnecgkafrf qteltqhhri htgekpykct ecgkafirst hltqhhriht
      661 gekpyectec gktfsrhyhl tqhhrghtge kpyicnecgn aficsyrltl hqrihtgelp
      721 yeckecgktf srryhltqhf rlhtgekpys ckecgnafrl qaeltrhhiv htgekpykck
      781 ecgkafsvns eltrhhriht gekpyqckec gkafirsdql tlhqrnhise evlcim
//
