LOCUS       NM_213598               3690 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 543 (ZNF543), mRNA.
ACCESSION   NM_213598
VERSION     NM_213598.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3690)
  AUTHORS   Hashemabadi,M., Sasan,H., Amandadi,M., Esmaeilzadeh-Salestani,K.,
            Esmaeili-Mahani,S. and Ravan,H.
  TITLE     CRISPR/Cas9-Mediated Disruption of ZNF543 Gene: An Approach Toward
            Discovering Its Relation to TRIM28 Gene in Parkinson's Disease
  JOURNAL   Mol Biotechnol 65 (2), 243-251 (2023)
   PUBMED   35467255
  REMARK    GeneRIF: CRISPR/Cas9-Mediated Disruption of ZNF543 Gene: An
            Approach Toward Discovering Its Relation to TRIM28 Gene in
            Parkinson's Disease.
REFERENCE   2  (bases 1 to 3690)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3690)
  AUTHORS   Liu,R., Hu,B., Li,Q., Jing,X., Zhong,C., Chang,Y., Liao,Q.,
            Lam,M.F., Leung,J.C., Lai,K.N. and Wang,Y.
  TITLE     Novel genes and variants associated with IgA nephropathy by
            co-segregating with the disease phenotypes in 10 IgAN families
  JOURNAL   Gene 571 (1), 43-51 (2015)
   PUBMED   26095808
  REMARK    GeneRIF: Data indicate 3 variants in 3 novel genes myc target 1
            protein (MYCT1), caspase recruitment domain family member 8 (CARD8)
            and zinc finger protein 543 (ZNF543), associated with familial IgA
            nephropathy (IgAN).
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005261.2, DA994943.1 and AK131547.1.
            
            On Nov 22, 2018 this sequence version replaced NM_213598.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.208174.1, AK131547.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321545.5/ ENSP00000322545.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AC005261.2         148248-148272
            26-37               DA994943.1         1-12
            38-1185             AK131547.1         1-1148
            1186-3208           AC005261.2         156042-158064
            3209-3690           AK131547.1         3171-3652
FEATURES             Location/Qualifiers
     source          1..3690
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..3690
                     /gene="ZNF543"
                     /note="zinc finger protein 543"
                     /db_xref="GeneID:125919"
                     /db_xref="HGNC:HGNC:25281"
                     /db_xref="MIM:616847"
     exon            1..400
                     /gene="ZNF543"
                     /inference="alignment:Splign:2.1.0"
     CDS             383..2185
                     /gene="ZNF543"
                     /codon_start=1
                     /product="zinc finger protein 543"
                     /protein_id="NP_998763.2"
                     /db_xref="CCDS:CCDS33130.1"
                     /db_xref="GeneID:125919"
                     /db_xref="HGNC:HGNC:25281"
                     /db_xref="MIM:616847"
                     /translation="MAASAQVSVTFEDVAVTFTQEEWGQLDAAQRTLYQEVMLETCGL
                     LMSLGCPLFKPELIYQLDHRQELWMATKDLSQSSYPGDNTKPKTTEPTFSHLALPEEV
                     LLQEQLTQGASKNSQLGQSKDQDGPSEMQEVHLKIGIGPQRGKLLEKMSSERDGLGSD
                     DGVCTKITQKQVSTEGDLYECDSHGPVTDALIREEKNSYKCEECGKVFKKNALLVQHE
                     RIHTQVKPYECTECGKTFSKSTHLLQHLIIHTGEKPYKCMECGKAFNRRSHLTRHQRI
                     HSGEKPYKCSECGKAFTHRSTFVLHHRSHTGEKPFVCKECGKAFRDRPGFIRHYIIHT
                     GEKPYECIECGKAFNRRSYLTWHQQIHTGVKPFECNECGKAFCESADLIQHYIIHTGE
                     KPYKCMECGKAFNRRSHLKQHQRIHTGEKPYECSECGKAFTHCSTFVLHKRTHTGEKP
                     YECKECGKAFSDRADLIRHFSIHTGEKPYECVECGKAFNRSSHLTRHQQIHTGEKPYE
                     CIQCGKAFCRSANLIRHSIIHTGEKPYECSECGKAFNRGSSLTHHQRIHTGRNPTIVT
                     DVGRPFMTAQTSVNIQELLLGKEFLNITTEENLW"
     exon            401..527
                     /gene="ZNF543"
                     /inference="alignment:Splign:2.1.0"
     exon            528..623
                     /gene="ZNF543"
                     /inference="alignment:Splign:2.1.0"
     exon            624..3690
                     /gene="ZNF543"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3554..3559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF543"
                     /note="hexamer: ATTAAA"
     polyA_site      3573
                     /gene="ZNF543"
     regulatory      3662..3667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF543"
                     /note="hexamer: AGTAAA"
     regulatory      3668..3673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF543"
                     /note="hexamer: AATAAT"
     polyA_site      3683
                     /gene="ZNF543"
     polyA_site      3690
                     /gene="ZNF543"
                     /note="major polyA site"
ORIGIN      
        1 gtcgcgtgac gtcatctccg tgagcaggat tggccctgga acagtgtggg gcctggaccg
       61 ctgggtaggc gcgtccagcg gcctgagcag gggagggtaa tgaggctgtt acgcgccttc
      121 tccgcatctt ggcgggagcc tgacgccccg cttcttccct aacggggtgt tccaccggcg
      181 cctgccgagg cctaggcctc cgcagccgcc ctccgtctcc tcagccccga cgctgcgccc
      241 gctttgtgcg catttttctc tggggaaact gaggctccga gtgcgaaagt cagccgaggt
      301 cgccccgccc aggacagaga agggctgggg gtcggctgag ccgcggcatt cccgggcccc
      361 gctagggctg cagggtctca ggatggcagc ctcggcgcag gtgtctgtga cctttgagga
      421 tgtggctgtg acattcaccc aggaggagtg gggacagttg gatgcagccc agagaacctt
      481 gtatcaggag gtgatgctgg agacctgcgg acttctcatg tctctgggct gtcctttgtt
      541 caaaccagag ctgatctacc agttggatca cagacaggag ctatggatgg ctacaaaaga
      601 cctctcccaa agctcctatc caggtgacaa cacaaaaccc aagaccacag agcctacctt
      661 ttctcacctg gccttgcctg aggaagtctt actccaggaa caactgacac aaggagcctc
      721 aaagaactcc caattagggc aatccaagga tcaggatggg ccatctgaaa tgcaagaagt
      781 ccacttgaaa atagggatag gcccccagcg ggggaagctg ctggagaaaa tgagttctga
      841 acgtgatggt ttggggtcag atgatggtgt atgtacaaag attacacaga aacaagtttc
      901 aacagaaggt gatctctatg aatgtgattc acatggacca gttacagatg ccttgattcg
      961 cgaagagaaa aattcctata aatgtgagga atgcgggaaa gtgtttaaaa agaatgccct
     1021 ccttgttcag catgaacgga ttcacactca agtgaagccc tatgaatgca cagagtgtgg
     1081 gaaaaccttt agcaagagca ctcatcttct tcagcacctc atcatccaca ctggggagaa
     1141 gccctataag tgcatggagt gtgggaaggc ttttaaccgc aggtcacacc tcacacggca
     1201 ccagcggatt cacagtggag agaagcctta taagtgcagt gaatgtggaa aggccttcac
     1261 ccaccgctcc acttttgtct tgcatcacag gagccacact ggagaaaaac cctttgtgtg
     1321 caaagagtgt ggcaaagcct ttcgagatag gccaggtttc attcgacact acatcatcca
     1381 cacgggagag aagccctatg agtgcattga gtgtgggaag gccttcaacc gccggtcata
     1441 cctcacgtgg caccaacaga ttcacactgg agtgaaaccc tttgaatgca acgagtgtgg
     1501 aaaagctttt tgcgagagtg cagacctcat tcaacactac attatccaca ctggggagaa
     1561 gccctataag tgcatggagt gtgggaaggc gttcaaccgt aggtcacacc tcaagcagca
     1621 tcaacggatt cacactgggg agaagcctta tgaatgcagt gaatgtggaa aggccttcac
     1681 ccactgctcc acttttgtct tgcataaaag gacccacaca ggagaaaaac cctatgaatg
     1741 caaagaatgt ggaaaagcct ttagtgatag ggcagacctc attcgccact tcagcatcca
     1801 cactggagag aaaccctatg agtgcgtgga gtgtggaaag gccttcaacc gcagctcaca
     1861 cctcacgagg caccaacaga ttcacactgg agagaaaccc tatgaatgca tccagtgtgg
     1921 gaaagccttt tgccggagcg caaaccttat tcgacactcc atcattcaca ctggagagaa
     1981 gccgtatgaa tgcagtgagt gtggaaaggc ttttaatcgc ggctcatccc tcacacatca
     2041 tcaaaggatt catactggga gaaaccctac cattgtaaca gatgtgggaa gaccttttat
     2101 gactgcacag acttcagtca acatccagga acttttatta gggaaagagt ttttgaatat
     2161 caccactgaa gaaaatctgt ggtgaaaggg aacatcttac catctggcca ttcacactga
     2221 agagaaactt cataagcatc ctctctttga gaaaacgtgt aatagatgat catttgtcgt
     2281 ctaaacaatc aagttagaaa ttgaaccagc ctggagtctt attctccacc tgagaattca
     2341 cccatgagag agacccagtg gttgctatgc acttaggaaa actttcagcc acatctttct
     2401 tcttagttta cagtgaaata ttatctcagg gatatttttt tttttttttt gagacggagt
     2461 ctcgctctgt cgcccaggct ggagtgcagt ggcgggatct cggctcactg caagctccgc
     2521 ctcccgggtt cacgccattc tcctgcctca gcctcccaag tagctgggac tacaggcacc
     2581 cgccactacg cctggctaat tttttgtatt tttagtagag acggggtttc accgttttag
     2641 ccgggatggt ctcgatctcc tgacctcgtg atccgcccgc ctcagcctcc caaagtgctg
     2701 ggattacagg cgtgagccac cgcgcccggc catctcaggg atatttaaac aaaggaagag
     2761 gaaatatagg gaagagaaag aaaccacagc ttcttttaga cttgtctgac aagcctatgg
     2821 caattttgtc gtccctttgt tattttatgt gggagaggga aatgtttcag aaacgaaaga
     2881 tctcatcccc tttatttttc tgtgtatgca ttcactgctg cccagtgtca gaacagttat
     2941 acaaacgagg gcttgaaaac attttgtgaa aacttgctta gtcctgcaac gttctccact
     3001 ctcgaggtgc agaagcatac atctttataa aaaatatgga ggcttgagtt atgaaacact
     3061 tttataagga gataaggatg tacatatgtt tggacacatt gtccacttca gatgcttgtt
     3121 taaaaaaatg tttcaccatg tgtctttacc caatacacat actttttctt gatgtggatt
     3181 tacttttttt tttttttttt aagttttcct gggataggga tgatagtgta attgttcatg
     3241 cccacagtaa tcctgggaat cttagttttt tcctatgatt gtggtttctc agcttcttta
     3301 cctctccttt gagttaggtc cacctcagtt ttctaaaggt caaattaagg cccccccaaa
     3361 aatacagtat gtagctgaat tcctttgaaa gatcatgata aactcagaag aacaaacata
     3421 gaaggaatgt catttttaat ctttttaaag agtgtgtgaa aattcacttt aactggaatt
     3481 ttaacaggca agccggcatg catatatgta gggatgtgtg actttcacag ttgtcaccat
     3541 ggacttaggc ttgattaaaa tgctacacat ttagagcgtt ttgtaattcc ttttttatat
     3601 ttttaagact agattttgag ccatgtgata gttttacctc atattaaata tattgtacag
     3661 aagtaaaaat aatcatgtat tcactttgaa
//
