LOCUS       NM_001277075            4886 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens zinc finger protein 541 (ZNF541), mRNA.
ACCESSION   NM_001277075
VERSION     NM_001277075.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4886)
  AUTHORS   Horisawa-Takada,Y., Kodera,C., Takemoto,K., Sakashita,A.,
            Horisawa,K., Maeda,R., Shimada,R., Usuki,S., Fujimura,S., Tani,N.,
            Matsuura,K., Akiyama,T., Suzuki,A., Niwa,H., Tachibana,M., Ohba,T.,
            Katabuchi,H., Namekawa,S.H., Araki,K. and Ishiguro,K.I.
  TITLE     Meiosis-specific ZFP541 repressor complex promotes developmental
            progression of meiotic prophase towards completion during mouse
            spermatogenesis
  JOURNAL   Nat Commun 12 (1), 3184 (2021)
   PUBMED   34075040
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4886)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4886)
  AUTHORS   Castillo,A., Kramer,N., Schwartz,C.E., Miles,J.H., DuPont,B.R.,
            Rosenfeld,J.A. and Graham,J.M. Jr.
  TITLE     19q13.32 microdeletion syndrome: three new cases
  JOURNAL   Eur J Med Genet 57 (11-12), 654-658 (2014)
   PUBMED   25230004
REFERENCE   4  (bases 1 to 4886)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010331.8, HY033195.1, DT932577.1 and AL136846.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001277075.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.589567.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391901.8/ ENSP00000375770.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC010331.8         50871-50906         c
            37-294              HY033195.1         2-259
            295-497             AC010331.8         33429-33631         c
            498-1138            DT932577.1         68-708
            1139-1942           AC010331.8         22656-23459         c
            1943-4886           AL136846.1         1-2944
FEATURES             Location/Qualifiers
     source          1..4886
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..4886
                     /gene="ZNF541"
                     /note="zinc finger protein 541"
                     /db_xref="GeneID:84215"
                     /db_xref="HGNC:HGNC:25294"
                     /db_xref="MIM:619942"
     exon            1..66
                     /gene="ZNF541"
                     /inference="alignment:Splign:2.1.0"
     exon            67..213
                     /gene="ZNF541"
                     /inference="alignment:Splign:2.1.0"
     exon            214..618
                     /gene="ZNF541"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..4352
                     /gene="ZNF541"
                     /codon_start=1
                     /product="zinc finger protein 541"
                     /protein_id="NP_001264004.1"
                     /db_xref="CCDS:CCDS46133.2"
                     /db_xref="GeneID:84215"
                     /db_xref="HGNC:HGNC:25294"
                     /db_xref="MIM:619942"
                     /translation="MDQYSLGDEGALPSEMHLPSFSESQGLNCSDTLNRDLGPNTRGF
                     LYAGLSGLDPDPSLPTPDMSSEVLEDNLDTLSLYSGKDSDSVKLLEEYADSESQASLQ
                     DLGLGVLKAKEADEGGRATSGSARKGKRQHSSPQNPLLDCSLCGKVFSSASSLSKHYL
                     THSQERKHVCKICSKAFKRQDHLTGHMLTHQKTKPFVCIEQGCSKSYCDYRSLRRHYE
                     VHHGLCILKEAPPEEEACGDSPHAHESAGQPPPSSLRSLVPPEARSPGSLLPHRDLLR
                     RIVSSIVHQKTPSPGPAPAGASDSEGRNTACPCPASSGSSSCTPAGPHAAPAALDTEL
                     PEEPCLPQKEPATDVFTAPNSRAAENGAPDPPEPEPDTALLQARSTAECWPEGGSVPA
                     CLPLFRGQTVPASSQPSSHSFQWLRNLPGCPKSKGNNVFVVHKPSAVPSREGSESGPG
                     PSSGSPSEESPPGPGGGLEDALPFPAALLRVPAEAPSDPRSASGEDDPCAPKKVKVDC
                     DSFLCQNPGEPGLQEAQKAGGLPADASPLFRQLFLKSQEPLVSHEQMQVFQMITKSQR
                     IFSHAQVAAVSSQLPAPEGKPAALRPLQGPWPQQPPPLAPAVDSLHAGPGNPEAEGSP
                     ARRRKTTPGVPREASPGSTRRDAKGGLKVAAVPTPLAAPSLDPSRNPDISSLAKQLRS
                     SKGTLDLEDIFPSTGQRQTQLGGEEPPGASLPGKQAPAENGAASRITKGEKGPACSRG
                     GGYRLLGNPRAPRFSGFRKEKAKMDMCCAASPSQVAMASFSSAGPPADPSKSKLTIFS
                     RIQGGNIYRLPHPVKEENVAGRGNQQNGSPTDWTKPRSTFVCKNCSQMFYTEKGLSSH
                     MCFHSDQWPSPRGKQEPQVFGTEFCKPLRQVLRPEGDRHSPPGTKKPLDPTAAAPLVV
                     PQSIPVVPVTRHIGSMAMGQEKDGEERDSKESSQQRKRKKRPPPSTAGEPGPAGCHQS
                     RLRSPMFLVDCLLKGLFQCSPYTPPPMLSPIREGSGVYFNTLCSTSTQASPDQLISSM
                     LDQVDGSFGICVVKDDTKISIEPHINIGSRFQAEIPELQERSLAGTDEHVASLVWKPW
                     GDMMISSETQDRVTELCNVACSSVMPGGGTNLELALHCLHEAQGNVQVALETLLLRGP
                     HKPRTHLLADYRYTGSDVWTPIEKRLFKKAFYAHKKDFYLIHKMIQTKTVAQCVEYYY
                     IWKKMIKFDCGRAPGLEKRVKREPEEVERTEEKVPCSPRERPSHHPTPKLKTKSYRRE
                     SILSSSPNAGSKRTPELLGSAESQGIFPCRECERVFDKIKSRNAHMKRHRLQDHVEPI
                     IRVKWPVKPFQLKEEELGADIGPLQW"
     exon            619..859
                     /gene="ZNF541"
                     /inference="alignment:Splign:2.1.0"
     exon            860..2714
                     /gene="ZNF541"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..2773
                     /gene="ZNF541"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2933
                     /gene="ZNF541"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3107
                     /gene="ZNF541"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3405
                     /gene="ZNF541"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..3469
                     /gene="ZNF541"
                     /inference="alignment:Splign:2.1.0"
     exon            3470..3612
                     /gene="ZNF541"
                     /inference="alignment:Splign:2.1.0"
     exon            3613..3716
                     /gene="ZNF541"
                     /inference="alignment:Splign:2.1.0"
     exon            3717..3792
                     /gene="ZNF541"
                     /inference="alignment:Splign:2.1.0"
     exon            3793..3881
                     /gene="ZNF541"
                     /inference="alignment:Splign:2.1.0"
     exon            3882..4022
                     /gene="ZNF541"
                     /inference="alignment:Splign:2.1.0"
     exon            4023..4198
                     /gene="ZNF541"
                     /inference="alignment:Splign:2.1.0"
     exon            4199..4886
                     /gene="ZNF541"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4869..4874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF541"
                     /note="hexamer: ATTAAA"
     polyA_site      4886
                     /gene="ZNF541"
                     /note="major polyA site"
ORIGIN      
        1 gggaggccgc tgggagcccc gcgaggcgcc aggcgcgagg cccggcgcgc gagcccccgg
       61 gggcggggca aaagaaattg ggagtatcct gcatttacca ctcagtgttc caggaggaca
      121 tatccagtgg tctgcttgtc acctgaaccc cctccctgtg gggcctaaac tgggtcctcc
      181 tgttccctgg agattcacta acttgctctt ctggaattag ttgccatcaa gggctctctc
      241 ctccctgtct ccttacatgg ttttgcttat ctggagagta gcttttggcc aagacctggc
      301 agtggagagc catggaccag tacagccttg gagacgaggg tgccctccca tcagaaatgc
      361 acctcccttc attttcagag agccaagggc tcaactgcag cgacaccctc aaccgggatt
      421 tgggtcccaa cacgcgaggc tttctttatg ctggcctgag tggtctggac ccggacccca
      481 gcctcccaac gcctgacatg tccagcgagg tgctggagga caacttagac accttgtccc
      541 tgtactccgg gaaggacagt gattctgtga agctgctgga ggagtacgca gattcggagt
      601 ctcaggcatc cttacaagac ctggggctag gtgtgcttaa ggctaaagag gctgacgaag
      661 gaggaagggc cacctcgggg agtgccagga aaggaaagcg gcagcacagt tcccctcaaa
      721 acccacttct ggactgcagc ctgtgcggga aggtgttcag cagcgccagt tctctgagca
      781 agcactacct gacacacagc caggaaagga agcacgtctg caaaatctgc agcaaggcct
      841 ttaagcgcca ggaccacctg accgggcaca tgctcaccca ccagaagaca aagcccttcg
      901 tgtgcatcga gcagggctgc agcaagagct actgcgacta ccgctctctg cgccggcact
      961 acgaggtcca tcacggcctg tgcatcctga aggaagcccc cccggaggaa gaggcctgcg
     1021 gggactcccc ccacgcccac gagtcggccg gccagccgcc ccccagcagc ctgcggtccc
     1081 tggtgccccc agaggccagg tcccccggct ccctcctgcc ccaccgggac ctcctgcgcc
     1141 gcatcgtgag tagcatcgtc caccagaaga ccccttctcc tggcccagcc ccggcggggg
     1201 cttcagacag cgaagggagg aacactgcct gtccctgccc cgcctcatcg gggtcctcgt
     1261 cctgcacccc agccggcccc cacgcggccc cagcagcgct ggacaccgag cttcccgagg
     1321 agccttgcct cccacagaaa gagccggcca ctgacgtgtt cacagcccct aattccaggg
     1381 ccgccgagaa cggcgccccc gacccgccag agccggagcc agataccgcg ctgctccagg
     1441 cccggtccac cgcggagtgc tggcccgaag gcggctccgt gcctgcctgc ctgcctctct
     1501 tccgaggcca gacggtccct gccagttccc agccatcgag ccacagcttc cagtggctcc
     1561 ggaacctgcc gggctgtccc aaaagcaaag gcaacaacgt gtttgttgtc cacaagccct
     1621 cggccgtgcc ctcgcgggag ggctccgagt ctggcccggg acccagcagc ggaagcccct
     1681 cggaggagtc cccgcccggc cccggcggtg gcctggagga tgctctgccc ttccctgccg
     1741 cgctcctcag ggtccccgcg gaggccccga gcgaccccag gtcggccagc ggggaagatg
     1801 acccctgcgc ccccaagaag gtcaaggtcg actgcgactc cttcctgtgc cagaaccccg
     1861 gggagcccgg cctccaggag gcccagaagg caggcgggct ccctgcggat gcctcgccgc
     1921 tcttccgcca gctcttcctc aagtcgcagg aacctcttgt gagccacgag cagatgcagg
     1981 tgttccagat gatcaccaag tcccagcgga tcttctccca tgcccaggtg gcagcagtct
     2041 cctcccagct ccctgcgccc gagggcaaac cagccgccct gaggccgctg caggggccgt
     2101 ggccgcagca gcccccacca ctggctcctg ctgtggactc tctccacgcc ggccctggaa
     2161 accccgaggc agagggctcc ccagcccgca ggagaaaaac cacacccggg gttcccagag
     2221 aggcctcccc cggcagcacg agacgagacg caaagggggg actgaaagtg gccgcggttc
     2281 caacgcccct tgcagcaccg tctctggacc cttccaggaa tccagacatc tcttctctgg
     2341 ccaagcagct gcgatcctct aaagggacct tggacctgga ggacatcttc ccctccacag
     2401 gccaacggca gacccagtta ggtggggagg agccaccagg agcctcgctg ccagggaagc
     2461 aggccccagc cgagaatggc gcggcttcaa ggatcacaaa aggtgaaaag ggcccagcct
     2521 gctcccgggg tggaggctac cggctcttgg gcaaccccag ggccccgcga ttctccggct
     2581 tccggaaaga gaaggcgaag atggatatgt gctgtgcggc ttctccgagc caggtagcca
     2641 tggcctcctt ctcatcggcc gggcccccgg cagatccctc caagtccaag ctgacaatat
     2701 tcagcagaat ccagggtgga aacatctaca ggctccccca tccggtgaag gaagagaatg
     2761 tggcaggcag aggtaaccag caaaacggca gtcccacaga ctggacgaag cccaggagca
     2821 cttttgtctg caagaactgc agccagatgt tttatacgga gaaagggctg agcagccaca
     2881 tgtgttttca cagcgaccag tggccgtcac ctcgagggaa gcaggaaccg caggtgtttg
     2941 gcacagagtt ttgcaagccg ctaagacagg tgctgaggcc agaaggggac aggcatagtc
     3001 ccccaggaac caagaagccc ttggacccca cagctgcagc ccctttggtg gtcccccaat
     3061 cgatccccgt ggttccagtg acccgacaca tagggagcat ggccatggga caagagaaag
     3121 acggggagga gcgagacagc aaggagagca gccagcagag aaagcggaag aagcggcccc
     3181 caccctccac ggctggggag cctggccctg caggatgcca ccagagccgc ctgcggtcac
     3241 ccatgttcct ggtggactgc ctcctgaagg gcttattcca gtgctccccc tacacaccac
     3301 ccccaatgct cagccccatc cgggagggct ctggggtgta cttcaacacc ctctgttcca
     3361 cgtccactca ggccagccct gaccagctca tcagctccat gctcgatcaa gtggatgggt
     3421 cctttggcat ctgtgtggtg aaggatgaca ccaaaatcag cattgagcca catatcaata
     3481 taggaagccg gtttcaggca gagatcccgg aactccagga gagatccctg gctggaactg
     3541 acgagcatgt agcttctctg gtctggaagc catggggaga tatgatgatc agctcagaga
     3601 cacaggatag agtgaccgag ctctgcaatg tggcatgctc cagcgtgatg ccaggagggg
     3661 gcaccaacct ggagctcgct ctgcactgcc tgcacgaggc tcagggcaac gttcaggtcg
     3721 ccctggagac tcttctgctc cgagggcccc acaagccacg gacacacctg ctcgctgact
     3781 atcgctacac aggttcagac gtctggaccc ctatagagaa gaggcttttt aagaaggcgt
     3841 tctatgccca caagaaggac ttctacttga tacacaagat gatccagaca aagacggtag
     3901 ctcagtgcgt tgagtattat tacatctgga aaaaaatgat caagtttgac tgtggccgag
     3961 ccccagggct agaaaagagg gtcaagagag agccggagga agtggaaagg acagaggaaa
     4021 aggtcccatg cagccctcgg gagagaccca gccaccatcc aactcccaag ttaaagacca
     4081 agagttatag gagggagtcc atcctcagct ccagcccaaa tgcaggctcc aagcggaccc
     4141 ccgagctgtt gggaagtgca gagagccagg gcatttttcc atgcagagag tgtgaaaggg
     4201 tgtttgacaa gatcaagagt cgaaatgccc atatgaagcg gcaccgcctt caggaccacg
     4261 tggagcccat catcagggtg aagtggccag tgaagccctt ccagctaaag gaagaggagc
     4321 tgggagctga catcggcccc ctgcagtggt gactcccgtg gcagcaagtc cgaatggggc
     4381 ctccagtgct gcccctcctc ccttcggcct ctccagggcg tttggggcac ccctctgcct
     4441 ccccccaccc tccctgtccc ctgttggcca acctgcctgc aaacatggag ggcatttggc
     4501 cacagatagg caggaggagc tcagttgtcg gacagctatg cagtccctgt ccggtggtgc
     4561 tggaggctcc actctcctta ggttcatagt ctctcccctt ctttcccttc cacttctaga
     4621 gcagggaggc ttggggaggg gaaaatttag ctctgggtag ctcttaaatc ttagcctcag
     4681 ttgtggggtt tggtttcatg tgttagataa ggccaagact tagagaatca gtgggaaaaa
     4741 accttgagat ctccaacacg ctgggcccct ccctggggcg gggactctac cttccagatt
     4801 cagtccctag tcttgcgatg aattctgcat tgttcggtgt tttttgtaca tgtcaactcg
     4861 taaatctgat taaattgggt tcttga
//
