LOCUS       NM_001172225            3191 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens zinc finger protein 540 (ZNF540), transcript variant
            1, mRNA.
ACCESSION   NM_001172225
VERSION     NM_001172225.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3191)
  AUTHORS   Xiang,Z., Yuan,W., Luo,N., Wang,Y., Tan,K., Deng,Y., Zhou,X.,
            Zhu,C., Li,Y., Liu,M., Wu,X. and Li,Y.
  TITLE     A novel human zinc finger protein ZNF540 interacts with MVP and
            inhibits transcriptional activities of the ERK signal pathway
  JOURNAL   Biochem Biophys Res Commun 347 (1), 288-296 (2006)
   PUBMED   16815308
  REMARK    GeneRIF: Taken together, these results suggest that ZNF540 may act
            as a transcriptional repressor in MAPK signaling pathway to mediate
            cellular functions.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC017940.1, AL832315.1 and BE464266.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001172225.2.
            
            Transcript Variant: This variant (1) encodes isoform a. Both
            variants 1 and 2 encode the same isoform (a), which is longer than
            isoform b.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.269908.1,
                                           SRR1803611.276137.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316433.9/ ENSP00000324598.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-902               BC017940.1         1-902
            903-3107            AL832315.1         943-3147
            3108-3191           BE464266.1         4-87                c
FEATURES             Location/Qualifiers
     source          1..3191
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..3191
                     /gene="ZNF540"
                     /gene_synonym="Nbla10512"
                     /note="zinc finger protein 540"
                     /db_xref="GeneID:163255"
                     /db_xref="HGNC:HGNC:25331"
                     /db_xref="MIM:613903"
     exon            1..220
                     /gene="ZNF540"
                     /gene_synonym="Nbla10512"
                     /inference="alignment:Splign:2.1.0"
     exon            221..301
                     /gene="ZNF540"
                     /gene_synonym="Nbla10512"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..2275
                     /gene="ZNF540"
                     /gene_synonym="Nbla10512"
                     /note="isoform a is encoded by transcript variant 1;
                     putative protein product of Nbla10512; CTD-3064H18.6"
                     /codon_start=1
                     /product="zinc finger protein 540 isoform a"
                     /protein_id="NP_001165696.1"
                     /db_xref="GeneID:163255"
                     /db_xref="HGNC:HGNC:25331"
                     /db_xref="MIM:613903"
                     /translation="MAHALVTFRDVAIDFSQKEWECLDTTQRKLYRDVMLENYNNLVS
                     LGYSGSKPDVITLLEQGKEPCVVARDVTGRQCPGLLSRHKTKKLSSEKDIHEISLSKE
                     SIIEKSKTLRLKGSIFRNEWQNKSEFEGQQGLKERSISQKKIVSKKMSTDRKRPSFTL
                     NQRIHNSEKSCDSHLVQHGKIDSDVKHDCKECGSTFNNVYQLTLHQKIHTGEKSCKCE
                     KCGKVFSHSYQLTLHQRFHTGEKPYECQECGKTFTLYPQLNRHQKIHTGKKPYMCKKC
                     DKGFFSRLELTQHKRIHTGKKSYECKECGKVFQLIFYFKEHERIHTGKKPYECKECGK
                     AFSVCGQLTRHQKIHTGVKPYECKECGKTFRLSFYLTEHRRTHAGKKPYECKECGKSF
                     NVRGQLNRHKTIHTGIKPFACKVCEKAFSYSGDLRVHSRIHTGEKPYECKECGKAFML
                     RSVLTEHQRLHTGVKPYECKECGKTFRVRSQISLHKKIHTDVKPYKCVRCGKTFRFGF
                     YLTEHQRIHTGEKPYKCKECGKAFIRRGNLKEHLKIHSGLKPYDCKECGKSFSRRGQF
                     TEHQKIHTGVKPYKCKECGKAFSRSVDLRIHQRIHTGEKPYECKQCGKAFRLNSHLTE
                     HQRIHTGEKPYECKVCRKAFRQYSHLYQHQKTHNVI"
     exon            302..428
                     /gene="ZNF540"
                     /gene_synonym="Nbla10512"
                     /inference="alignment:Splign:2.1.0"
     exon            429..524
                     /gene="ZNF540"
                     /gene_synonym="Nbla10512"
                     /inference="alignment:Splign:2.1.0"
     exon            525..3191
                     /gene="ZNF540"
                     /gene_synonym="Nbla10512"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3086..3091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF540"
                     /gene_synonym="Nbla10512"
                     /note="hexamer: AATAAA"
     polyA_site      3111
                     /gene="ZNF540"
                     /gene_synonym="Nbla10512"
                     /note="major polyA site"
     regulatory      3171..3176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF540"
                     /gene_synonym="Nbla10512"
                     /note="hexamer: AATAAA"
     polyA_site      3191
                     /gene="ZNF540"
                     /gene_synonym="Nbla10512"
ORIGIN      
        1 agctaagatc gggtccggcg ctccagaaca gaacgatccc tgaggctccc ttgctcgaac
       61 tgtgggactt accctactat ggtccgagcc taccctattt cattatactc aagtaacgcc
      121 ccagaaattc cagagaatct cacacaaaga ggttgagtct tgccgtggtg ccttcagggg
      181 aatgtcatcc cgggctagaa gagctgcaaa aggctgtcag gcttctcaga actttgcttc
      241 tccagcagaa taatcctgcg gaagactgag cagttcttgt gagtgtaaaa ccatggccca
      301 tgcattggtg acgttcaggg atgtggctat agacttctct cagaaggaat gggagtgcct
      361 ggacactacc cagaggaaat tgtacagaga tgtgatgttg gagaattata ataacttggt
      421 ctcactggga tattctggct caaagccaga tgtgattacc ttactggagc aagggaaaga
      481 gccctgcgtg gtggcgaggg atgtgacagg aagacagtgc cccggtttgt tatccaggca
      541 taagaccaag aaattatctt cagaaaagga cattcatgaa atcagtttat ccaaagagag
      601 tataatagaa aaaagtaaaa ctcttcgtct gaaaggatcc atttttagaa atgagtggca
      661 gaacaaaagt gagtttgagg gtcaacaggg acttaaagaa agatctatca gtcaaaagaa
      721 aatcgtctct aaaaaaatgt caactgatag aaaacgtccc tcttttactc tgaatcagag
      781 aattcacaat agtgagaaaa gctgtgactc acacttggtt caacatggga aaatagattc
      841 tgatgtgaaa catgattgta aagaatgtgg gagtactttt aataatgtct atcagcttac
      901 tctccatcag aaaattcata ctggtgaaaa atcctgtaaa tgtgagaaat gtgggaaagt
      961 ttttagtcat agctatcaac ttactctgca tcagagattt catactggtg agaaacccta
     1021 tgaatgtcaa gaatgtggga agacctttac tctttaccca caacttaatc gacatcagaa
     1081 aattcacact ggtaaaaaac cctatatgtg taagaaatgt gataagggtt tttttagtag
     1141 attagaactt actcaacata aaagaattca tactggtaag aaatcttatg aatgtaaaga
     1201 atgtggaaaa gtttttcaac ttattttcta ctttaaagaa catgagagaa ttcatacagg
     1261 taagaaaccc tatgaatgta aggagtgtgg gaaagctttt agtgtatgcg gacaacttac
     1321 ccgtcatcag aaaattcata ctggtgtaaa accctacgaa tgtaaggaat gtggaaagac
     1381 ctttagactt agtttttacc ttactgaaca cagaagaact catgcaggta agaaacctta
     1441 tgaatgtaag gagtgtggga aatcatttaa tgtgcgtgga cagcttaatc ggcataaaac
     1501 aatccatact ggtataaaac cttttgcatg taaggtgtgt gagaaggctt ttagttatag
     1561 tggtgacctc agagtacatt ctagaattca tactggagag aaaccatatg aatgtaagga
     1621 atgcgggaaa gcctttatgc ttcgttcagt ccttactgaa catcagagac ttcatactgg
     1681 tgtgaagccc tacgaatgta aggaatgtgg gaagaccttt cgagttcgtt ctcaaattag
     1741 tctacataag aaaattcata ctgatgtgaa gccctacaaa tgtgtacgat gtgggaagac
     1801 ctttagattt ggtttctacc ttactgaaca ccagagaatt cacactggtg aaaagcccta
     1861 taaatgtaaa gaatgtggaa aggcctttat tcgtagaggg aatcttaaag aacatctgaa
     1921 aattcattct ggtttaaaac cctatgactg taaagaatgt gggaagtcct ttagtcggcg
     1981 tgggcagttc actgaacatc agaaaattca tacgggtgta aaaccataca aatgtaaaga
     2041 atgtgggaag gcctttagtc gtagtgtaga ccttagaata catcaaagaa ttcatactgg
     2101 tgagaaaccc tatgagtgta aacaatgtgg gaaggccttt agacttaatt cacaccttac
     2161 tgaacatcag agaattcaca ctggtgagaa accctatgag tgtaaggtat gtagaaaggc
     2221 ctttagacaa tattcacatc tttatcaaca tcagaaaact cataatgtaa tttaatataa
     2281 gaaaaggttt ccatgtcatg ctctatttat agaatatcaa aatatttatg gccagaagtt
     2341 ctgtcaatgt gttgatgttt ttttacacat attaacttaa taaatgtatg agtcttaaat
     2401 acctcttagt tctcattaaa tttaggaaaa ttcacactag aaaataaagc tgttaatgta
     2461 acagttgtgg aaaagtgttc tagcaacagc atatacttat catcattgcc tttccactac
     2521 tctactatct gtgtgatatt agacaaaata tttgcttctt ggtacctcag ctgtaaaatg
     2581 aaacacacct aaaagtgtgg ttgtttccaa catgtataat acagcaacaa ctatctggcc
     2641 caaactgctt tggattaata ttggatatta ctgtttttat tatcatcaac attattatta
     2701 gtggatttct taataggaag atgcaatgga gatgacaaat ttggaaaaac cactcatcac
     2761 ttacatttca tgaagtactt ctttgataaa atctgttatg ggctgaatgt ttgtgttccc
     2821 gtaacaattc ctatgttgaa acacgaatcc caaggtgatg gtatttgaag gtagggcctt
     2881 taggaggaaa ttaggtcatg agggtggagc cttcatgagt ggaattactg cctttataag
     2941 aagaagccaa agagccagct agctctttca accacatgag gttacagcaa gaagtcagca
     3001 gtctacagtg caaaagaggg ccttcaccag aacccaagca tgctggcacc ttgaccttgg
     3061 actttcagcc tccaaaactg tgagaaataa acctcagttg tttataagcc actgagtcta
     3121 cgatattttg ttatgcagcc cagataacta aggcactcca ttagaatata aataaaatgt
     3181 aaagatctaa a
//
